Neuroreport 2021 Jul 19. Epub 2021 Jul 19.
Graduate Institute of Biomedical Sciences School of Medicine, China Medical University, Taichung Department of Primary Care Medicine, Taipei Medical University Hospital, Taipei Graduate Institute of Clinical Medical Science, China Medical University Department of Anesthesiology, China Medical University Hospital Drug Development Center, China Medical University Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan.
Although N-methyl-D-aspartate receptor (NMDAR) antagonism has been shown to have a neuroprotective effect in many preclinical stroke models, the efficacy of this antiexcitotoxicity strategy in clinical trials in stroke patients has been disappointing. Interestingly, it has been reported that NMDAR antagonism is not neuroprotective in C57BL/6 mice subjected to distal middle cerebral artery occlusion (dMCAO), supporting the notion that whether these treatments are neuroprotective depends on the type of cerebral ischemia. However, because C57BL/6 mice are inherently resistant to excitotoxicity, the reported lack of neuroprotection could also be explained by the difference in the mouse strain studied rather than the stroke model used. Read More