37,411 results match your criteria stroke model


A Pilot Behavioural and Neuroimaging Investigation on Photothrombotic Stroke Models in Rhesus Monkeys.

J Neurosci Methods 2021 Jul 19:109291. Epub 2021 Jul 19.

National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. Electronic address:

Background: Ischemic stroke leads to a long-term disability in humans and no efficient clinical therapy exists to date. The middle cerebral artery occlusion (MCAO) model in non-human primates has shown to be of value for translational stroke research. New method In the current study, a photothrombotic (PT) stroke model was established in rhesus monkeys with either a proximal or distal segment of middle cerebral artery (MCA) thrombosis. Read More

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Telestroke for acute ischaemic stroke: A systematic review of economic evaluations and a de novo cost-utility analysis for a middle income country.

J Telemed Telecare 2021 Jul 22:1357633X211032407. Epub 2021 Jul 22.

Deakin Health Economics, Institute for Health Transformation, 2104Deakin University, Australia.

Introduction: Telemedicine can alleviate the problems faced in rural settings in providing access to specialist stroke care. The evidence of the cost-effectiveness of this model of care outside high-income countries is limited. This study aimed to conduct: (a) a systematic review of economic evaluations of telestroke and (b) a cost-utility analysis of telestroke, using China as a case study. Read More

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Polydiacetylene Liposome Microarray toward Facile Measurement of Platelet Activation in Whole Blood.

ACS Sens 2021 Jul 22. Epub 2021 Jul 22.

Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.

The necessity of a simple measurement of platelet activation has been increasing in clinical medicine to regulate the proper dose of the antiplatelet drugs for patients having clinical outcomes in acute situations such as angina pectoris, stroke, or peripheral vascular disease or procedures involving angioplasty or coronary thrombolysis. We developed a self-signaling polydiacetylene (PDA) liposome microarray to detect activated platelets from whole blood samples in a single step. A specific antibody, 9F9 antibody, to platelet-bound fibrinogen was selected and conjugated to the PDA liposome microarray to quantify the fibrinogen-bound platelets. Read More

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[Post-stroke cognitive deficits and dementia].

Ther Umsch 2021 Aug;78(6):305-311

Universitätsklinik für Neurologie, Inselspital, Universitätsspital und Universität Bern.

Post-stroke cognitive deficits and dementia Prediction of stroke outcome remains challenging due to a large inter-individual variability. For a long time, research on stroke outcome has been mainly confined to post-stroke motor deficits, whereas post-stroke cognitive decline has been less investigated though being an often reason for dependency and disability. Post-stroke cognitive impairment demonstrate high inter-individual variability, which is expected to increase further due to the increasing life expectancy and number of patients with pre-stroke brain pathology and cognitive deficits. Read More

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Near infrared light amplifies endothelial progenitor cell accumulation after stroke.

Cond Med 2019 Aug;2(4):170-177

Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

Damage-associated molecular pattern signals may play key roles in mediating non-cell autonomous effects of pre and post-conditioning. Here, we show that near-infrared (NIR) light stimulation of astrocytes increases a calcium-dependent secretion of the prototypical DAMP, HMGB1, which may then accelerate endothelial progenitor cell (EPC) accumulation after stroke. Conditioned media from NIR-stimulated astrocytes increased EPC proliferation in vitro, and blockade of HMGB1 with siRNA diminished the effect. Read More

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Surgical Risk Factors for Ischemic Stroke Following Coronary Artery Bypass Grafting. A Multi-Factor Multimodel Analysis.

Front Cardiovasc Med 2021 5;8:622480. Epub 2021 Jul 5.

Cardiac Surgery Unit, Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.

Ischemic stroke after coronary artery bypass (CABG) has been often linked to aortic manipulation during surgery. The objective of the study was to estimate the rate of postoperative ischemic stroke within 30 days from CABG by surgical risk factors alone or in combination. The multinomial propensity score for multiple treatments was used to create six models with a total of 16,255 consecutive patients undergoing isolated CABG. Read More

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Adherence to a Healthy Lifestyle and the Risk of All-Cause Mortality and Cardiovascular Events in Individuals With Diabetes: The ARIC Study.

Front Nutr 2021 5;8:698608. Epub 2021 Jul 5.

Department of Emergency Medicine and National Clinical Research Center for Geriatrics, Research Laboratory of Emergency Medicine, Disaster Medicine Center, West China Hospital, Sichuan University, Chengdu, China.

The relationship between combined healthy lifestyle and cardiovascular (CV) events in diabetes is unclear. We aim to investigate the association between a healthy lifestyle score (HLS) and the risk of mortality and CV events in diabetes. We examined the associations of six lifestyle factors scores (including healthy diet, moderate alcohol and regular coffee intakes, never smoking, physical activity, and normal weight) with diabetes in the Atherosclerosis Risk in Communities (ARIC) study of 3,804 participants with diabetes from the United States at baseline. Read More

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A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample.

Front Neurol 2021 5;12:656478. Epub 2021 Jul 5.

Neuroscience Group of Antioquia, The University of Antioquia, Medellín, Colombia.

The differential diagnosis among the behavioral variant of frontotemporal dementia FTD (bvFTD) and the linguist one primary progressive aphasia (PPA) is challenging. Presentations of dementia type or variants dominated by personality change or aphasia are frequently misinterpreted as psychiatric illness, stroke, or other conditions. Therefore, it is important to identify cognitive tests that can distinguish the distinct FTD variants to reduce misdiagnosis and best tailor interventions. Read More

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Sex -Specific Differences in the Association Between Metabolic Syndrome and Carotid Intima-Media Thickness Among a Low-Income Population in China: A Cross-Sectional Study.

Diabetes Metab Syndr Obes 2021 15;14:3263-3272. Epub 2021 Jul 15.

Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.

Introduction: Carotid atherosclerosis is a well-established biomarker associated with future cardiovascular disease and stroke. We explored the influence of sex on the relationship between metabolic syndrome (MetS) and its components with carotid intima-media thickness (CIMT) among a low-income population in China, which has a high incidence of stroke.

Methods: This population-based study recruited participants aged ≥45 years from rural areas of Tianjin, China between April 2014 and January 2015. Read More

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5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.

Mol Psychiatry 2021 Jul 21. Epub 2021 Jul 21.

Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HT to hypothalamic arcuate nucleus (5-HT → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT and 5-HT receptors, whereas activation of 5-HT to ventral tegmental area (5-HT → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT receptors. Read More

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Ephedrine alleviates middle cerebral artery occlusion-induced neurological deficits and hippocampal neuronal damage in rats by activating PI3K/AKT signaling pathway.

Bioengineered 2021 Dec;12(1):4136-4149

Encephalopathy, Beijing University of Traditional Chinese Medicine, Dong Zhi Men Hospital, Tongzhou Hospital Area, Beijing, China.

Inflammation and oxidative stress are crucial in ischemic stroke. Ephedrine (EPH) has been proven to have anti-inflammatory and anti-oxidative stress effects. The present study analyzes whether EPH possessed neuroprotective effects and explored the underlying mechanisms of EPH based on an experimental model of middle cerebral artery occlusion (MCAO). Read More

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December 2021

Home infusions of natalizumab for people with multiple sclerosis: a pilot randomised crossover trial.

Ann Clin Transl Neurol 2021 Jul 21. Epub 2021 Jul 21.

Neurology & Stroke Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objective: The delivery of healthcare at home has expanded to intravenous infusions of monoclonal antibodies. A recently developed model of care for home infusions of natalizumab for people with relapsing-remitting multiple sclerosis was evaluated. This pilot study of home infusions of natalizumab and usual care (attendance in a hospital out-patients' clinic) compared safety, feasibility, patient satisfaction, effectiveness and costs. Read More

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Combined association of skeletal muscle mass and grip strength with cardiovascular diseases in patients with type 2 diabetes.

J Diabetes 2021 Jul 20. Epub 2021 Jul 20.

Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea.

Background: Appendicular skeletal muscle mass (ASM) and grip strength (GS) have been suggested to be related to cardiovascular diseases (CVDs), but their association with type 2 diabetes (T2D) remains unclear. Therefore, we examined the combined association of ASM and GS with the prevalence of CVD in patients with T2D.

Methods: A total of 1,230 patients with T2D were recruited and divided into four groups based on the sex-specific median values of ASM/body mass index (SM) and GS: high SM/high GS (HSM/HGS), high SM/low GS (HSM/LGS), low SM/high GS (LSM/HGS), and low SM/low GS (LSM/LGS). Read More

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Technical Note: Comparison of Convolutional Neural Networks for Detecting Large Vessel Occlusion on Computed Tomography Angiography.

Med Phys 2021 Jul 21. Epub 2021 Jul 21.

Department of Computer Science, Vanderbilt University, Nashville, TN, 37235, USA.

Purpose: Artificial intelligence diagnosis and triage of large vessel occlusion may quicken clinical response for a subset of time-sensitive acute ischemic stroke patients, improving outcomes. Differences in architectural elements within data-driven convolutional neural network (CNN) models impact performance. Foreknowledge of effective model architectural elements for domain-specific problems can narrow the search for candidate models and inform strategic model design and adaptation to optimize performance on available data. Read More

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Deep learning to automate the labelling of head MRI datasets for computer vision applications.

Eur Radiol 2021 Jul 20. Epub 2021 Jul 20.

School of Biomedical Engineering & Imaging Sciences, Kings College London, Rayne Institute, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.

Objectives: The purpose of this study was to build a deep learning model to derive labels from neuroradiology reports and assign these to the corresponding examinations, overcoming a bottleneck to computer vision model development.

Methods: Reference-standard labels were generated by a team of neuroradiologists for model training and evaluation. Three thousand examinations were labelled for the presence or absence of any abnormality by manually scrutinising the corresponding radiology reports ('reference-standard report labels'); a subset of these examinations (n = 250) were assigned 'reference-standard image labels' by interrogating the actual images. Read More

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Induction of Photothrombotic Stroke in the Sensorimotor Cortex of Rats andPreparation of Tissue for Analysis of Stroke Volume andTopographical Cortical Localization of Ischemic Infarct.

Bio Protoc 2018 May 20;8(10):e2861. Epub 2018 May 20.

Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

The photothrombotic model of stroke is commonly used in research as it allows the ischemic infarct to be targeted to specific regions of the cortex with high reproducibility and well-defined infarct borders. Unlike other models of stroke, photothrombosis allows the precise size and location of infarct to be tightly controlled with minimal surgical invasion. Photothrombosis is induced when a circulating photosensitive dye is irradiated , resulting in focal disruption of the endothelium, activation of platelets and occlusion of the microvasculature ( Watson , 1985 ; Dietrich , 1987 ; Carmichael, 2005). Read More

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The Survival Status and Predictors of Mortality Among Stroke Patients at North West Ethiopia.

Risk Manag Healthc Policy 2021 14;14:2983-2994. Epub 2021 Jul 14.

Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Introduction: Stroke is one of the commonest non-communicable disease types that has a great public health impact both in developed and developing countries. However, in Ethiopia, the long-term survival status of stroke patients is not very understood. This study aimed at assessing survival status and predictors of mortality among stroke patients at Felege Hiwot comprehensive specialized hospital from September 1, 2014, to August 31, 2019, Bahirdar, North West Ethiopia. Read More

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TNFα increases tyrosine hydroxylase expression in human monocytes.

NPJ Parkinsons Dis 2021 Jul 20;7(1):62. Epub 2021 Jul 20.

Department of Neuroscience, University of Florida, Center for Translational Research in Neurodegenerative Disease, Norman Fixel Institute for Neurological Diseases, Gainesville, FL, USA.

Most, if not all, peripheral immune cells in humans and animals express tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis. Since TH is typically studied in the context of brain catecholamine signaling, little is known about changes in TH production and function in peripheral immune cells. This knowledge gap is due, in part, to the lack of an adequately sensitive assay to measure TH in immune cells expressing lower TH levels compared to other TH expressing cells. Read More

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NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage.

J Neuroinflammation 2021 Jul 20;18(1):163. Epub 2021 Jul 20.

Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

Background: The NLRP3 inflammasome is a critical mediator of several vascular diseases through positive regulation of proinflammatory pathways. In this study, we defined the role of NLRP3 in both the acute and delayed phases following subarachnoid hemorrhage (SAH). SAH is associated with devastating early brain injury (EBI) in the acute phase, and those that survive remain at risk for developing delayed cerebral ischemia (DCI) due to cerebral vasospasm. Read More

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Acupuncture inhibits mammalian target of rapamycin, promotes autophagy and attenuates neurological deficits in a rat model of hemorrhagic stroke.

Acupunct Med 2021 Jul 20:9645284211028873. Epub 2021 Jul 20.

Heilongjiang University of Chinese Medicine, Harbin, China.

Background: Intracerebral hemorrhage (ICH) accounts for approximately 15% of all stroke cases. Previous studies suggested that acupuncture may improve ICH-induced neurological deficits. Therefore, we investigated the effects of acupuncture on neurological deficits in an animal model of ICH. Read More

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Endovascular Therapy for Acute Ischemic Stroke in Patients With Prestroke Disability.

J Am Heart Assoc 2021 Jul 21:e020783. Epub 2021 Jul 21.

Department of Neurosurgery Hyogo College of Medicine Nishinomiya Japan.

Background Outcomes after stroke as a result of large-vessel occlusion in patients with prestroke disability were compared between endovascular therapy (EVT) and medical management. Methods and Results Of 2420 patients with acute stroke with large-vessel occlusion in a prospective, multicenter, nationwide registry in Japan, patients with prestroke modified Rankin Scale scores 2 to 4 with occlusion of the internal carotid artery, or M1 of the middle cerebral artery were analyzed. The primary effectiveness outcome was the favorable outcome, defined as return to at least the prestroke modified Rankin Scale score at 3 months. Read More

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Stroke injury induced by distal middle cerebral artery occlusion is resistant to N-methyl-D-aspartate receptor antagonism in FVB/NJ mice.

Neuroreport 2021 Jul 19. Epub 2021 Jul 19.

Graduate Institute of Biomedical Sciences School of Medicine, China Medical University, Taichung Department of Primary Care Medicine, Taipei Medical University Hospital, Taipei Graduate Institute of Clinical Medical Science, China Medical University Department of Anesthesiology, China Medical University Hospital Drug Development Center, China Medical University Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan.

Although N-methyl-D-aspartate receptor (NMDAR) antagonism has been shown to have a neuroprotective effect in many preclinical stroke models, the efficacy of this antiexcitotoxicity strategy in clinical trials in stroke patients has been disappointing. Interestingly, it has been reported that NMDAR antagonism is not neuroprotective in C57BL/6 mice subjected to distal middle cerebral artery occlusion (dMCAO), supporting the notion that whether these treatments are neuroprotective depends on the type of cerebral ischemia. However, because C57BL/6 mice are inherently resistant to excitotoxicity, the reported lack of neuroprotection could also be explained by the difference in the mouse strain studied rather than the stroke model used. Read More

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Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats.

Neuroreport 2021 Jul 19. Epub 2021 Jul 19.

State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Ischemic stroke continues to be a major global health problem associated with considerable mortality and morbidity. Thus, it is still targeted by researchers for developing new strategies or drugs to alleviate the lesion of stroke. In the present study, both the permanent occlusion of the middle cerebral artery (MCAO) model and the restoration of cerebral blood flow after middle cerebral artery occlusion (CI/R) model were set up for evaluating the efficiency of salvianolic acid B and ginsenoside Rg1 combination (SalB-Rg1). Read More

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Image-based patient-specific flow simulations are consistent with stroke in pediatric cerebrovascular disease.

Biomech Model Mechanobiol 2021 Jul 20. Epub 2021 Jul 20.

Translational Imaging Group, Texas Children's Hospital, Houston, TX, USA.

Moyamoya disease (MMD) is characterized by narrowing of the distal internal carotid artery and the circle of Willis (CoW) and leads to recurring ischemic and hemorrhagic stroke. A retrospective review of data from 50 pediatric MMD patients revealed that among the 24 who had a unilateral stroke and were surgically treated, 11 (45.8%) had a subsequent, contralateral stroke. Read More

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Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007-2018.

Cancers (Basel) 2021 Jul 5;13(13). Epub 2021 Jul 5.

CIBER of Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.

Many adult cancer patients present one or more physical comorbidities. Besides interfering with treatment and prognosis, physical comorbidities could also increase the already heightened psychological risk of cancer patients. To test this possibility, we investigated the relationship between physical comorbidities with depression symptoms in a sample of 2073 adult cancer survivors drawn from the nationally representative National Health and Nutrition Examination Survey (NHANES) (2007-2018) in the U. Read More

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Association of Chronic Liver Disease and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage.

Stroke 2021 Jul 20:STROKEAHA121034136. Epub 2021 Jul 20.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China (Y.Z., L.L., L.J., C.Y., Y.C., F.F.).

Background And Purpose: Chronic liver disease (CLD) is a risk factor for increased morbidity and mortality in acutely ill patients. For patients with aneurysmal subarachnoid hemorrhage (aSAH), the association between CLD and mortality remains unknown.

Methods: In this retrospective cohort study, we analyzed consecutive aSAH patients admitted to the West China Hospital between 2009 and 2019. Read More

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Endovascular Treatment Effect Diminishes With Increasing Thrombus Perviousness: Pooled Data From 7 Trials on Acute Ischemic Stroke.

Stroke 2021 Jul 20:STROKEAHA120033124. Epub 2021 Jul 20.

Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, the Netherlands. (M.K., M.L.T., K.M.T., B.G.D., H.A., G.Z., H.A.M., C.B.L.M.M.).

Background And Purpose: Thrombus perviousness estimates residual flow along a thrombus in acute ischemic stroke, based on radiological images, and may influence the benefit of endovascular treatment for acute ischemic stroke. We aimed to investigate potential endovascular treatment (EVT) effect modification by thrombus perviousness.

Methods: We included 443 patients with thin-slice imaging available, out of 1766 patients from the pooled HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke trials) data set of 7 randomized trials on EVT in the early window (most within 8 hours). Read More

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Comparison of balloon guide catheters and standard guide catheters for acute ischemic stroke: A systematic review and meta-analysis.

World Neurosurg 2021 Jul 16. Epub 2021 Jul 16.

Nested Knowledge, Inc, 1430 Avon St N, St. Paul, MN, USA; Superior Medical Experts, 1430 Avon St N, St. Paul, MN, USA; Duke University Law School, Durham, NC, USA. Electronic address:

Background: Balloon guide catheters (BGC) are designed to induce flow arrest during mechanical thrombectomy (MT) procedures for acute ischemic stroke due to large vessel occlusion, and have been associated with improved clinical and angiographic outcomes. We conducted a systematic review and meta-analysis evaluating the relative technical and clinical outcomes associated with BGC vs. non-BGC approaches. Read More

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Spontaneous transient brain states in EEG source space in disorders of consciousness.

Neuroimage 2021 Jul 17;240:118407. Epub 2021 Jul 17.

Department of Neurology and Stroke, University of Tübingen, Hoppe-Seyler-Str. 3, Tübingen 72076, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Electronic address:

Spontaneous transient states were recently identified by functional magnetic resonance imaging and magnetoencephalography in healthy subjects. They organize and coordinate neural activity in brain networks. How spontaneous transient states are altered in abnormal brain conditions is unknown. Read More

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Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats.

Brain Res Bull 2021 Jul 16;175:16-25. Epub 2021 Jul 16.

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China. Electronic address:

Poststroke cognitive impairment (PSCI) occurs frequently after stroke, but lacks effective treatments. Previous studies have revealed that high-frequency repetitive transcranial magnetic stimulation (rTMS) has a beneficial effect on PSCI and is often used with other cognitive training methods to improve its effect. This study aimed to evaluate the effect of different combinations of rTMS and cognitive training (rTMS-COG) on PSCI and identify the optimal combination protocol. Read More

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