401,169 results match your criteria stroke


Community-based interventions to prevent stroke in low-income and middle-income countries: a protocol for a systematic review and meta-analysis.

BMJ Open 2022 Aug 8;12(8):e063181. Epub 2022 Aug 8.

Health Systems and Population Studies Division, ICDDRB, Dhaka, Bangladesh

Introduction: Stroke is the second leading cause of death and morbidity across the globe. In low-income and middle-income countries (LMICs), it has become an overwhelming burden over the past few decades. This burden is escalating at a much greater pace compared with that of high-income countries. Read More

View Article and Full-Text PDF

Effects of Cross-Education on Neural Adaptations Following Non-Paretic Limb Training in Stroke: A Scoping Review with Implications for Neurorehabilitation.

J Mot Behav 2022 Aug 8:1-14. Epub 2022 Aug 8.

Brain Plasticity Laboratory, Department of Physical Therapy, University of Illinois at Chicago, Chicago, IL, USA.

Current stroke rehabilitation interventions focus on intensive task specific training of the paretic limb, which may not be feasible for individuals with higher levels of impairment or in the early phase of stroke. Cross-education, a mechanism that improves strength or skill of the untrained limb following unilateral motor training, has high clinical relevance for stroke rehabilitation. Despite its potential benefits, our knowledge on the application and efficacy of cross-education in stroke is limited. Read More

View Article and Full-Text PDF

Carotid Endarterectomy is Safe in Octogenarians.

J Vasc Surg 2022 Aug 5. Epub 2022 Aug 5.

Division of Vascular Surgery, Department of Surgery, University of California San Francisco-Fresno.

Background: Carotid endarterectomy (CEA) demonstrates superior results for stroke risk reduction in patients with symptomatic and asymptomatic high-grade carotid stenosis. However, this benefit has long been questioned in the elderly and high-risk populations. This study aims to provide high volume single institution data with long term follow up examining risk factors for post-operative stroke and stroke free survival based on age in asymptomatic and symptomatic patients undergoing CEA. Read More

View Article and Full-Text PDF

Application of Umami Tastants on Sodium Reduction in Food: an Evidence Analysis Center Scoping Review.

J Acad Nutr Diet 2022 Aug 5. Epub 2022 Aug 5.

Sr. Scientific Director, EAC, Academy of Nutrition and Dietetics. 120 S. Riverside Plaza, Suite 2190; Chicago, Illinois 60606-6995. Electronic address:

Background: Sodium chloride intake far exceeds guidelines by health and regulatory agencies. Acknowledging the positive relationship between sodium intake and blood pressure, interest in substances which assist in sodium reduction while contributing a savory taste such as umami are highly investigated.

Objective: The objective of this scoping review was to identify and characterize studies investigating umami tastants on sodium reduction in food with the goal of informing future research. Read More

View Article and Full-Text PDF

Focal vibration of the plantarflexor and dorsiflexor muscles improves poststroke spasticity: a randomized single-blind controlled trial.

Ann Phys Rehabil Med 2022 Aug 5:101670. Epub 2022 Aug 5.

Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.. Electronic address:

Background: Post-stroke spasticity is a cause of gait dysfunction and disability. Focal vibration (FV) of agonist-antagonist upper limb muscle pairs reduces flexor spasticity; however, its effects on ankle plantarflexor spasticity are uncertain.

Objective: To assess the effects of focal vibration administered by a trained operator to the ankle plantarflexor and dorsiflexor muscles on post-stroke lower limb spasticity. Read More

View Article and Full-Text PDF

Elevated plasma zonulin and CAF22 are correlated with sarcopenia and functional dependency at various stages of Alzheimer's diseases.

Neurosci Res 2022 Aug 5. Epub 2022 Aug 5.

Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Cardiovascular Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272 United Arab Emirates. Electronic address:

Age-related muscle decline, termed sarcopenia, is closely linked to dementia; however, its causative factors in patients with Alzheimer's disease (AD) are poorly characterized. We investigated the plasma biomarkers of increased intestinal permeability (zonulin) and neuromuscular junction (NMJ) disruption (c-terminal agrin fragment -22; CAF22), in healthy controls (n=53) and patients with early, mild, and moderate AD (n=46-56/group). We also evaluated the body composition, handgrip strength (HGS), and short physical performance battery (SPPB) as markers of sarcopenia and functional capacity, respectively. Read More

View Article and Full-Text PDF

Anti-inflammatory effects of siponimod on astrocytes.

Neurosci Res 2022 Aug 5. Epub 2022 Aug 5.

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine. Electronic address:

Siponimod, which is approved to treat active secondary progressive multiple sclerosis, acts as a functional antagonist of sphingosine-1-phosphate (S1P) receptor 1 (S1P) and an agonist of S1P. S1P antagonization, which inhibits lymphocyte egress from lymphoid tissues and subsequent infiltration into the central nervous system (CNS), is considered the main therapeutic mechanism of siponimod. In addition, siponimod's direct effects on CNS glial cells are another potential neuroprotective mechanism because siponimod can penetrate the blood-brain barrier and CNS glial cells express S1P receptors. Read More

View Article and Full-Text PDF

The Busan Regional CardioCerebroVascular Center Project's Experience Over a Decade in the Treatment of ST-segment Elevation Myocardial Infarction.

J Prev Med Public Health 2022 Jul 24;55(4):351-359. Epub 2022 Jun 24.

Department of Cardiology, Busan Regional CardioCerebroVascular Center, Dong-A University Hospital, Busan, Korea.

Objectives: The Regional CardioCerebroVascular Center (RCCVC) project was initiated to improve clinical outcomes for patients with acute myocardial infarction or stroke in non-capital areas of Korea. The purpose of this study was to evaluate the outcomes and issues identified by the Busan RCCVC project in the treatment of ST-segment elevation myocardial infarction (STEMI).

Methods: Among the patients who were registered in the Korean Registry of Acute Myocardial Infarction for the RCCVC project between 2007 and 2019, those who underwent percutaneous coronary intervention (PCI) for STEMI at the Busan RCCVC were selected, and their medical data were compared with a historical cohort. Read More

View Article and Full-Text PDF

Construction of the Mobility to Participation Assessment Scale for Stroke (MPASS) and Testing Its Validity and Reliability in Persons With Stroke in Thailand.

J Prev Med Public Health 2022 Jul 13;55(4):334-341. Epub 2022 Jun 13.

Faculty of Physical Therapy, Srinakharinwirot University, Nakhonnayok, Thailand.

Objectives: This study was conducted to develop the Mobility to Participation Assessment Scale for Stroke (MPASS) and assess its content validity, internal consistency, inter-rater and intra-rater reliability, and convergent validity in people with stroke living in the community.

Methods: The MPASS was developed using published data on mobility-related activity and participation timing in elderly individuals, and then reviewed by community physical therapists. Content validity was established by reaching a consensus of experienced physical therapists in a focus group. Read More

View Article and Full-Text PDF

Reversible cerebral artery constriction accompanied with stroke-like episode in MELAS: A case series.

J Neurol Sci 2022 Jul 19;441:120345. Epub 2022 Jul 19.

Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao), Shandong University, Qingdao, Shandong 266035, China; Brain Science Research Institute, Shandong University, Jinan, Shandong 250012, China. Electronic address:

Objective: The pathophysiology of stroke-like episode (SLE) in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) was uncertain, though mitochondrial metabolic crisis of cortical neurons and mitochondrial proliferation in small vessels of brain have been considered. However, the involvement of major cerebral vessels was debated. We aimed to investigate whether major cerebral vessels participate in SLE. Read More

View Article and Full-Text PDF

Gadolinium-enhanced MR improved motion sensitized driven equilibrium (iMSDE) for intracranial vessel imaging in giant cell arteritis.

J Stroke Cerebrovasc Dis 2022 Aug 5;31(10):106697. Epub 2022 Aug 5.

Department of Neurology, Kokura Memorial Hospital, Fukuoka, Japan.

Background: Giant cell arteritis (GCA) generally affects extracranial large and medium-sized vessels. It rarely causes intracranial vessel stenosis, presenting as cerebral infarction (CI). Consequently, accurate diagnosis of CI induced by GCA is often challenging. Read More

View Article and Full-Text PDF

Radionuclide Imaging of the Molecular Mechanisms Linking Heart and Brain in Ischemic Syndromes.

Circ Cardiovasc Imaging 2020 Aug 28;13(8):e011303. Epub 2020 Jul 28.

Department of Nuclear Medicine, Hannover Medical School, Germany.

For the heart and the brain, clinical observations suggest that an acute ischemic event experienced by one organ is associated with an increased risk for future acute events and chronic dysfunction of the reciprocal organ. Beyond atherosclerosis as a common systemic disease, various molecular mechanisms are thought to be involved in this interaction. Molecular-targeted nuclear imaging may identify the contribution of factors, such as the neurohumoral, circulatory, or especially the immune system, by combining specific radiotracers with whole-body acquisition and global as well as regional multiorgan analysis. Read More

View Article and Full-Text PDF

Sex differences in the functional topography of association networks in youth.

Proc Natl Acad Sci U S A 2022 Aug 8;119(33):e2110416119. Epub 2022 Aug 8.

Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104.

Prior work has shown that there is substantial interindividual variation in the spatial distribution of functional networks across the cerebral cortex, or functional topography. However, it remains unknown whether there are sex differences in the topography of individualized networks in youth. Here, we leveraged an advanced machine learning method (sparsity-regularized non-negative matrix factorization) to define individualized functional networks in 693 youth (ages 8 to 23 y) who underwent functional MRI as part of the Philadelphia Neurodevelopmental Cohort. Read More

View Article and Full-Text PDF

Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-κB signal responses.

Proc Natl Acad Sci U S A 2022 Aug 8;119(33):e2123097119. Epub 2022 Aug 8.

Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.

Targeting nuclear factor-kappa B (NF-κB) represents a highly viable strategy against chemoresistance in cancers as well as cell death. Ubiquitination, including linear ubiquitination mediated by the linear ubiquitin chain assembly complex (LUBAC), is emerging as a crucial mechanism of overactivated NF-κB signaling. Ovarian tumor family deubiquitinase OTULIN is the only linear linkage-specific deubiquitinase; however, the molecular mechanisms of how it counteracts LUBAC-mediated NF-κB activation have been largely unknown. Read More

View Article and Full-Text PDF

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1.

Proc Natl Acad Sci U S A 2022 Aug 8;119(33):e2204706119. Epub 2022 Aug 8.

Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.

Oropouche orthobunyavirus (OROV; ) is a mosquito-transmitted virus that causes widespread human febrile illness in South America, with occasional progression to neurologic effects. Host factors mediating the cellular entry of OROV are undefined. Here, we show that OROV uses the host protein low-density lipoprotein-related protein 1 (Lrp1) for efficient cellular infection. Read More

View Article and Full-Text PDF

External validation and extension of the Early Prediction of Functional Outcome after Stroke (EPOS) prediction model for upper limb outcome 3 months after stroke.

PLoS One 2022 8;17(8):e0272777. Epub 2022 Aug 8.

Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Objective: The 'Early Prediction of Functional Outcome after Stroke' (EPOS) model was developed to predict the presence of at least some upper limb capacity (Action Research Am Test [ARAT] ≥10/57) at 6 months based on assessments on days 2, 5 and 9 after stroke. External validation of the model is the next step towards clinical implementation. The objective here is to externally validate the EPOS model for upper limb outcome 3 months poststroke in Switzerland and extend the model using an ARAT cut-off at 32 points. Read More

View Article and Full-Text PDF

Cancer-related stroke: Exploring personalized therapy strategies.

Brain Behav 2022 Aug 8:e2738. Epub 2022 Aug 8.

Department of Neurological Rehabilitation, Xuzhou Central Hospital, Xuzhou city, P.R. China.

Background: Cancer and ischemic stroke are two common diseases that threaten human health and have become the main causes of death in the world. It is estimated that one-in-ten patients with ischemic stroke have concomitant cancer, and this incidence is expected to increase as improvements in medical technology extends the life expectancy of cancer patients.

Discussion: Cancer-related stroke (CRS) refers to unexplained ischemic stroke in patients with active cancer that cannot be explained by current stroke mechanisms. Read More

View Article and Full-Text PDF

Platelet count and clinical outcomes among ischemic stroke patients with endovascular thrombectomy in DIRECT-MT.

Clin Chem Lab Med 2022 Aug 8. Epub 2022 Aug 8.

Department of Neurosurgery, Naval Medical University Changhai Hospital, Shanghai, P.R. China.

Objectives: The prognostic role of baseline platelet count (PLT) in acute ischemic stroke patients with large vessel occlusion undergoing endovascular thrombectomy is unclear. Whether PLT modifies alteplase treatment effect on clinical outcome in those patients is also uncertain.

Methods: We derived data from a multicenter randomized clinical trial (DIRECT-MT) comparing intravenous alteplase before endovascular treatment vs. Read More

View Article and Full-Text PDF

Smoking cessation for secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev 2022 Aug 8;8:CD014936. Epub 2022 Aug 8.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Smoking is a leading cause of cardiovascular disease (CVD), particularly coronary heart disease (CHD). However, quitting smoking may prevent secondary CVD events in people already diagnosed with CHD.  OBJECTIVES: To examine the impact of smoking cessation on death from CVD and major adverse cardiovascular events (MACE), in people with incident CHD. Read More

View Article and Full-Text PDF

Carotid artery disease: knowing the numbers.

Br J Hosp Med (Lond) 2022 Jul 26;83(7):1-6. Epub 2022 Jul 26.

Department of Vascular Surgery, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.

Ischaemic stroke and transient ischaemic attack are of particular interest to the vascular surgeon as over one-third of all strokes are caused by thromboembolism from a stenotic carotid artery, making carotid artery stenosis the leading cause of stroke. If detected early, stenosis can be managed medically, surgically or endovascularly. However, treatment decisions depend on the timing of the transient ischaemic attack and the degree of stenosis, and must be balanced against procedural risk. Read More

View Article and Full-Text PDF

Serious adverse event rates and reoperation after arthroscopic shoulder surgery: population based cohort study.

BMJ 2022 Jul 6;378:e069901. Epub 2022 Jul 6.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.

Objective: To provide clinicians and patients with accurate risk estimates of serious adverse events after common elective shoulder arthroscopic procedures, including reoperation within one year.

Design: Population based cohort study.

Setting: Hospital Episode Statistics for NHS England, including civil registration mortality data from the Office for National Statistics. Read More

View Article and Full-Text PDF

The physical environment is essential, but what does the design and structure of stroke units look like? A descriptive survey of inpatient stroke units in Sweden.

Scand J Caring Sci 2022 Aug 8. Epub 2022 Aug 8.

School of Health and Welfare, Dalarna University, Falun, Sweden.

Background: The design of the physical environment is a critical factor in patient care and is known to influence health, well-being, clinical efficiency, and health-related outcomes. To date, there has been no general review of the physical environment of modern Swedish stroke units.

Aim: To explore the physical environment of inpatient stroke units in Sweden and describe the design and structure of these units. Read More

View Article and Full-Text PDF

Prevalence of atrial fibrillation in a regional Victoria setting, findings from the crossroads studies (2001-2003 and 2016-2018).

Aust J Rural Health 2022 Aug 8. Epub 2022 Aug 8.

Department of Rural Health, University of Melbourne, Shepparton, Vic., Australia.

Objective: To estimate the prevalence of atrial fibrillation (AF) in regional Victoria at two time points (2001-2003 and 2016-2018), and to assess the use of electrocardiogram rhythm strips in a rural, community-based study for AF investigation.

Design: Repeated cross-sectional design involving survey of residents of randomly selected households and a clinic. Predictors of AF were assessed using Firth penalised logistic regression, as appropriate for rare events. Read More

View Article and Full-Text PDF

Network pharmacology approach to investigate the multitarget mechanisms of Zhishi Rhubarb Soup on acute cerebral infarction.

Pharm Biol 2022 Dec;60(1):1394-1406

Nanjing Chinese Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing City, People's Republic of China.

Context: Zhishi Rhubarb Soup (ZRS) is a traditional Chinese medicine formula used in the clinic to treat acute cerebral infarction (ACI) for many years. However, the exact mechanism of the treatment remains unclear.

Objective: This study elucidates the multitarget mechanisms underlying the effects of ZRS on ACI using network pharmacology analysis and verify its effect by performing animal experiments. Read More

View Article and Full-Text PDF
December 2022

Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway.

Pharm Biol 2022 Dec;60(1):1469-1477

College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangdong, China.

Context: Paeoniflorin (PF) and calycosin-7-glucoside (CG, Pall. extract) have demonstrated protective effects in ischaemic stroke.

Objective: To investigate the synergistic effects of PF + CG on ischaemia/reperfusion injury and . Read More

View Article and Full-Text PDF
December 2022

Cardiovascular disease risk in women living with HIV.

Curr Opin HIV AIDS 2022 Sep 5;17(5):270-278. Epub 2022 Jul 5.

Department of Global Health, University of Washington School of Medicine.

Purpose Of Review: To synthesize current evidence on the impact of cardiovascular disease among women living with HIV (WLWH) with a particular focus on disease prevalence, mechanisms and prevention.

Recent Findings: HIV-related cardiovascular disease risk is 1.5-fold to 2-fold higher for women than for men. Read More

View Article and Full-Text PDF
September 2022

Cerebral Collateral Circulation in the Era of Reperfusion Therapies for Acute Ischemic Stroke.

Stroke 2022 Aug 8:101161STROKEAHA121037869. Epub 2022 Aug 8.

Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, the Netherlands. (S.M.U.V., H.B.v.d.W.).

Clinical outcomes of patients with acute ischemic stroke depend in part on the extent of their collateral circulation. A good collateral circulation has also been associated with greater benefit of intravenous thrombolysis and endovascular treatment. Treatment decisions for these reperfusion therapies are increasingly guided by a combination of clinical and imaging parameters, particularly in later time windows. Read More

View Article and Full-Text PDF

Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis.

Stroke 2022 Aug 8:101161STROKEAHA122039579. Epub 2022 Aug 8.

Department of Neurology, Duke University, Durham, NC (B.M.G.).

Background: High level evidence for direct oral anticoagulants (DOACs) in patients with cerebral venous thrombosis is lacking. We performed a systematic review and meta-analysis to assess the efficacy and safety of DOACs versus vitamin K antagonists in patients with cerebral venous thrombosis.

Methods: This systematic review was registered in PROSPERO (CRD42021228800). Read More

View Article and Full-Text PDF

[Effect of acupuncture on CREB/BDNF/TrkB signaling pathway of hippocampus in rats with post-stroke depression].

Zhongguo Zhen Jiu 2022 Aug;42(8):907-13

Department of Encephalopathy, Second Affiliated Hospital of Anhui University of CM, Hefei 230061, China.

Objective: To observe the regulative effect of acupuncture on the depression-like behavior and cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/tyrosine protein kinase B (TrkB) signaling pathway of hippocampus in rats with post-stroke depression (PSD), and to explore its possible mechanism on improving PSD.

Methods: A total of 36 SPF SD rats were randomized into a sham operation group, a model group and a Tongdu Tiaoshen group, 12 rats in each group. The compound method of Zea Longa suture-occlusion and chronic unpredictable mild stress (CUMS) was used to establish the PSD model in rats of the model group and the Tongdu Tiaoshen group. Read More

View Article and Full-Text PDF

[Effect of staged acupuncture on serum irisin level and neurological rehabilitation in patients with ischemic stroke].

Zhongguo Zhen Jiu 2022 Aug;42(8):857-62

School of Nursing, Wenzhou Medical University, Wenzhou 325005, Zhejiang Province.

Objective: To observe the effect of staged acupuncture on serum irisin level, neurological deficit, balance ability and spasticity in patients with ischemic stroke.

Methods: Sixty patients with ischemic stroke were randomly divided into a staged acupuncture group and a routine acupuncture group, 30 cases in each group; another 30 healthy subjects were selected as a normal group. The patients with ischemic stroke were treated with aspirin (100 mg each time, once a day, changing to 50 mg for prophylactic dose after 4 weeks). Read More

View Article and Full-Text PDF