362,777 results match your criteria stroke


Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study.

Prostaglandins Leukot Essent Fatty Acids 2021 Apr 24;169:102283. Epub 2021 Apr 24.

Department of Mathematics and Statistics, Dordt University, Sioux Center, Iowa, United States.

Background: The roles of omega-3 (n3) fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] and low-dose aspirin in the primary prevention of ischemic cardiovascular disease (CVD) are controversial. Since omega-3 (n3) fatty acids and aspirin affect cyclooxygenase activity in platelets, there could be a clinically-relevant effect of aspirin combined with a particular n3 fatty acid level present in each individual.

Methods: RBC EPA+DHA, arachidonic acid (AA) and docosapentaenoic acid (DPA) were measured in 2500 participants without known CVD in the Framingham Heart Study. Read More

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The Venous Occlusion Image Score: A Novel Quantitative Scoring Instrument for Cerebral Venous Sinus Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 5;30(7):105845. Epub 2021 May 5.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, P R China. Electronic address:

Purpose: This study aims to test the validity of a new quantitative scoring instrument-the Venous Occlusion Image Score (VOIS), and assess the diagnostic and prognostic value of VOIS for cerebral venous sinus thrombosis (CVST).

Methods: The VOIS divided the major cerebral venous sinuses and internal jugular veins into nine parts of interest. CT venography and DSA source images and reconstruction were extracted from the database, then interpreted and scored independently according to VOIS by a panel of three reviewers. Read More

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Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome.

J Stroke Cerebrovasc Dis 2021 May 4;30(7):105800. Epub 2021 May 4.

Stroke Unit, Neurology Unit, Department of Neuroscience, Ospedale Civile, Azienda Ospedaliera Universitaria di Modena, Via Giardini 1355, Modena, Emilia Romagna 41126, Italy. Electronic address:

Objectives: Many studies showed that platelet reactivity testing can predict ischemic events after carotid stenting or ischemic stroke. The aim of our study was to assess the role of early platelet function monitoring in predicting 90-days functional outcome, stent thrombosis and hemorrhagic transformation in patients with ischemic stroke treated with endovascular procedures requiring emergent extracranial stenting.

Materials And Methods: We performed a retrospective study on consecutive patients with acute anterior circulation stroke admitted to our hospital between January 2015 and March 2020, in whom platelet reactivity testing was performed within 10 days from stenting. Read More

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Predictive Factors of Perioperative Stroke-Related Mortality Following Vascular Surgery: A Retrospective Analysis.

J Stroke Cerebrovasc Dis 2021 May 4;30(7):105833. Epub 2021 May 4.

Departments of Neurology and Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. Electronic address:

Objective: Vascular surgical procedures have one of the highest risks of perioperative stroke and stroke-related mortality, yet the independent risk factors contributing to this increased mortality have not been described. Perioperative strokes are thought to result from a combination of embolism and hypoperfusion mechanisms. The purpose of this study is to describe the independent predictors of perioperative stroke-related mortality in the vascular surgical population using the Pennsylvania Health Care Cost Containment Council (PHC4) database which collects cause of death data. Read More

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The Financial Impact of the COVID-19 Pandemic on Neurosurgery Practice in Spring 2020.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX USA. Electronic address:

Background: The COVID-19 pandemic has changed healthcare delivery across the United States. However, few analyses are specifically dedicated to quantifying the financial impact of the pandemic on practicing neurosurgeons. The authors present a survey analysis to address this need. Read More

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Mechanical thrombectomy in distal residual occlusions of the middle cerebral artery after large vessel recanalization in acute stroke: 2b or not 2b? A pragmatic approach in real-life scenarios.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Hopital Foch, Department of Diagnostic and Interventional Neuroradiology, Suresnes, Île-de-France, FR.

Background: AND PURPOSE: Recent studies have suggested that a recanalization grade of modified thrombolysis in cerebral infarction (mTICI) ≥2c is strongly related with good clinical outcome rather than the current therapeutic angiography target ≥2b. In order to achieve better recanalization, additional further maneuvers on distal residual vessel occlusion may be required. The aim of this paper was to evaluate the safety and efficacy of rescue treatment in residual vessel occlusions (RVOs) after recanalization of large vessel occlusions in the anterior circulation. Read More

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Recent developments in next-generation occlusion devices.

Acta Biomater 2021 May 5. Epub 2021 May 5.

Center for Composite Materials and Structures, Harbin Institute of Technology (HIT), P.O. Box 3011, No. 2 Yikuang Street, Harbin 150080, People's Republic of China. Electronic address:

Transcatheter closure has been widely accepted as a highly effective way to treat abnormal blood flows and/or embolization of thrombus in the heart. It allows the closure of four types of congenital heart defects (CHDs) and stroke-associated left atrial appendage (LAA). The four types of CHDs include atrial septal defect (ASD), patent foramen ovale (PFO), patent ductus arteriosus (PDA), and ventricular septal defect (VSD). Read More

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Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.

Pharmacol Res 2021 May 5:105650. Epub 2021 May 5.

College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 280 Waihuan East Road, Panyu District, Guangdong 510006, P.R. China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, P.R. China. Electronic address:

Stroke is one of the leading causes of death worldwide. Hemorrhagic transformation (HT) is a common serious complication of ischemic stroke (IS) and is related to poor prognosis. Hyperglycemia after stroke is associated with the occurrence of HT and seriously affects the clinical treatment of stroke. Read More

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Delayed egress of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice.

Brain Behav Immun 2021 May 5. Epub 2021 May 5.

Department of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, United States; Department of Neurology, Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, Kentucky, USA. Electronic address:

Objective: Stroke is a debilitating disorder with significant annual mortality and morbidity rates worldwide. Immune cells are recruited to the injured brain within hours after stroke onset and can exhibit either protective or detrimental effects on recovery. However, immune cells, including CD8 T cells, persist in the injured brain for weeks, suggesting a longer-term role for the adaptive immune system during functional recovery. Read More

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Association between Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism with the risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of 53 Studies.

Gene 2021 May 5:145696. Epub 2021 May 5.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Background And Aims: Hemorrhagic stroke (HS) results in significant mortality and disability worldwide. Angiotensin Convertase Enzyme (ACE) is responsible for blood pressure regulation and vascular homeostasis. Our objective was to conduct a comprehensive meta-analysis for ascertaining the association of ACE I/D polymorphism with HS since a number of studies depicted inconclusive evidence. Read More

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Outcomes of rotational atherectomy for severely calcified coronary lesions: A single center 5-year experience.

Catheter Cardiovasc Interv 2021 May 8. Epub 2021 May 8.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.

Objectives: The aim of this study was to investigate the influences of accumulated experience on rotational atherectomy (RA) operation regarding to in-hospital outcomes in the drug-eluting stent (DES) era.

Methods: Between 2015 and 2019, 540 de novo lesions with calcified coronary lesions treated by RA and DES implantation at our center were retrospectively assessed. In-hospital major adverse cardiac events (MACE) were defined as all cause death, cardiac death, target vessel revascularization, and stroke. Read More

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Types of Physical Activity Recommended by Primary Care Providers for Patients at Risk for Cardiovascular Disease.

Prev Chronic Dis 2021 May 6;18:E43. Epub 2021 May 6.

Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

Primary care providers (PCPs) are uniquely positioned to promote physical activity for cardiovascular health. We sought to determine the types of physical activity that PCPs most often recommend to patients at risk for cardiovascular disease (CVD) and how these recommendations vary by PCPs' physical activity counseling practices. We examined the types of physical activity (walking, supervised exercise sessions, or other) PCPs most often suggested for CVD prevention among respondents to the 2018 DocStyles survey (N = 1,088). Read More

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Association with clinic risk factors of Percheron artery infarction and magnetic resonance imaging involvement patterns.

Acta Neurol Belg 2021 May 8. Epub 2021 May 8.

Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

Radiological imaging is important in the diagnosis of the artery of Percheron (AOP) infarction. This study aimed to discuss the magnetic resonance imaging (MRI) findings of this abnormal variant of arterial supply. Patients who presented to our hospital with stroke symptoms between 2010 and 2019 and underwent brain MRI were evaluated retrospectively. Read More

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Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation.

Transl Stroke Res 2021 May 8. Epub 2021 May 8.

Department of Neurology, The Second Affiliated Hospital; Key Laboratory of Cerebral Microcirculation in Universities of Shandong; Brain Science Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.

Oxidative stress and neuroinflammatory response after the ischemic injury are important pathophysiologic mechanisms that cause brain tissue loss and neurological deficit. This study aims to observe the expression and role of carbonyl reductase 1 (CBR1), an NADPH-dependent oxidoreductase with specificity for carbonyl compounds such as 4-hydroxynonenal (4-HNE), in the brain after ischemic injury and to investigate the influence of CBR1 on ischemia-induced neuroinflammation. CBR1 expresses in the neurons, astrocyte, and microglia in the normal brain. Read More

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Impact of intravenous alteplase on sub-angiographic emboli in high-resolution diffusion-weighted imaging following successful thrombectomy.

Eur Radiol 2021 May 8. Epub 2021 May 8.

Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Objective: Thrombus microfragmentation causing peripheral emboli (PE) during mechanical thrombectomy (MT) may modulate treatment effects, even in cases with successful reperfusion. This study aims to investigate whether intravenous alteplase is of potential benefit in reducing PE after successful MT.

Methods: Patients from a prospective study treated at a tertiary care stroke center between 08/2017 and 12/2019 were analyzed. Read More

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Habitual flavonoid intake and ischemic stroke incidence in the Danish Diet, Cancer, and Health Cohort.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Australia.

Background: Flavonoid-rich foods have antiinflammatory, antiatherogenic, and antithrombotic properties that may contribute to a lower risk of ischemic stroke.

Objectives: We aimed to investigate the relationship between habitual flavonoid consumption and incidence of ischemic stroke in participants from the Danish Diet, Cancer and Health Study.

Design: In this prospective cohort study, 55,169 Danish residents without a prior ischemic stroke [median (IQR) age at enrolment of 56 y (52-60)], were followed for 21 y (20-22). Read More

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Impact of P-wave indices in prediction of atrial fibrillation-Insight from loop recorder analysis.

Ann Noninvasive Electrocardiol 2021 May 7:e12854. Epub 2021 May 7.

University Hospital St Josef Hospital, Cardiology and Rhythmology, Ruhr University, Bochum, Germany.

Background: Several P-wave indices are associated with the development of atrial fibrillation (AF). However, previous studies have been limited in their ability to reliably diagnose episodes of AF. Implantable loop recorders allow long-term, continuous, and therefore more reliable detection of AF. Read More

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Coincidental SARS-CoV-2 infection and mRNA vaccination: a case report addressing the most important clinical questions.

Infection 2021 May 7. Epub 2021 May 7.

Department of Neurology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

The case describes the coincidental mRNA vaccination and SARS-CoV-2 infection of a 31-year-old physician addressing the theoretical considerations and recommendations for further actions in such a particular constellation that we will expect more often in the near future. Read More

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Use of Non-Vitamin K Antagonist Oral Anticoagulants Among Patients with Nonvalvular Atrial Fibrillation and Multimorbidity.

Adv Ther 2021 May 7. Epub 2021 May 7.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK.

Introduction: Non-valvular atrial fibrillation (NVAF) is often accompanied by multiple comorbid conditions, which increase the associated risks and complexity of patient management. This study evaluated the risk of stroke/systemic embolism (SE) and major bleeding (MB) among multimorbid patients with NVAF who were prescribed non-vitamin K antagonist oral anticoagulants (NOACs) or warfarin.

Methods: A retrospective study of patients with NVAF and high multimorbidity who initiated apixaban, dabigatran, rivaroxaban, or warfarin from 1 January 2013 to 30 September 2015 was conducted using five insurance claims databases. Read More

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The Association Between Mild Cognitive Impairment Diagnosis and Patient Treatment Preferences: a Survey of Older Adults.

J Gen Intern Med 2021 May 7. Epub 2021 May 7.

Department of Internal Medicine and Cognitive Health Services Research Program, University of Michigan (U-M), Ann Arbor, MI, USA.

Background: Older patients (65+) with mild cognitive impairment (MCI) receive less guideline-concordant care for cardiovascular disease (CVD) and other conditions than patients with normal cognition (NC). One potential explanation is that patients with MCI want less treatment than patients with NC; however, the treatment preferences of patients with MCI have not been studied.

Objective: To determine whether patients with MCI have different treatment preferences than patients with NC. Read More

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Safety of intravenous thrombolysis in stroke of unknown time of onset: A systematic review and meta-analysis.

J Thromb Thrombolysis 2021 May 7. Epub 2021 May 7.

Cerebrovascular Disease Center, Department of Neurology, People's Hospital, China Medical University. Address, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People's Republic of China.

The safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke of unknown time of onset (SUTO) was unclear and mostly concerned. We sought to investigate the safety in terms of symptomatic intracranial hemorrhage (sICH) and death in SUTO patients treated with IV-tPA. We searched PubMed and EMBASE from inception to 2 December 2020 for eligible studies reporting IV-tPA in SUTO patients compared to conservative medical therapy, or to stroke of known onset time (SKOT) treated with IV-tPA within standard time window. Read More

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Application of Near-Infrared Spectroscopy for the Detection of Delayed Cerebral Ischemia in Poor-Grade Subarachnoid Hemorrhage.

Neurocrit Care 2021 May 7. Epub 2021 May 7.

Genetic and Research Inc., Chuncheon, Republic of Korea.

Background: The objective of this study was to investigate the clinical feasibility of near-infrared spectroscopy (NIRS) for the detection of delayed cerebral ischemia (DCI) in patients with poor-grade subarachnoid hemorrhage (SAH) treated with coil embolization.

Methods: Cerebral regional oxygen saturation (rSO) was continuously monitored via two-channel NIRS for 14 days following SAH. The rSO levels according to DCI were analyzed by using the Mann-Whitney U-test. Read More

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Rapid Assessment of Acute Ischemic Stroke by Computed Tomography Using Deep Convolutional Neural Networks.

J Digit Imaging 2021 May 7. Epub 2021 May 7.

Department of Computer Science and Information Engineering, National Taipei University, 151 University Rd., Taipei, 237, Sanshia, Taiwan.

Acute stroke is one of the leading causes of disability and death worldwide. Regarding clinical diagnoses, a rapid and accurate procedure is necessary for patients suffering from acute stroke. This study proposes an automatic identification scheme for acute ischemic stroke using deep convolutional neural networks (DCNNs) based on non-contrast computed tomographic (NCCT) images. Read More

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Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants.

Eur Heart J 2021 May 8. Epub 2021 May 8.

The Population Health Research Institute, Hamilton Health Sciences, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada.

Aims: Rosuvastatin (10 mg per day) compared with placebo reduced major adverse cardiovascular (CV) events by 24% in 12 705 participants at intermediate CV risk after 5.6 years. There was no benefit of blood pressure (BP) lowering treatment in the overall group, but a reduction in events in the third of participants with elevated systolic BP. Read More

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Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes.

Nat Methods 2021 May 7;18(5):507-519. Epub 2021 May 7.

Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.

RNA-binding proteins (RBPs) are critical regulators of gene expression and RNA processing that are required for gene function. Yet the dynamics of RBP regulation in single cells is unknown. To address this gap in understanding, we developed STAMP (Surveying Targets by APOBEC-Mediated Profiling), which efficiently detects RBP-RNA interactions. Read More

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Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor.

Mol Psychiatry 2021 May 7. Epub 2021 May 7.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has been a crucial breakthrough in mood disorder research. (R,S)-ketamine is a racemic mixture of equal amounts of (R)-ketamine (arketamine) and (S)-ketamine (esketamine). In 2019, an esketamine nasal spray from Johnson & Johnson was approved in the United States of America and Europe for treatment-resistant depression. Read More

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Clinical studies on pharmacological treatment of hypertension in Japan.

J Hum Hypertens 2021 May 7. Epub 2021 May 7.

Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Differences in the epidemiology and phenotypes of hypertension in Japan compared with Western countries mean that optimal approaches to the pharmacological management of hypertension should be based on local data. Fortunately, there is a large body of evidence from studies conducted in Japanese populations to inform guidelines and treatment decisions. This article highlights treatment recommendations and BP targets for Japanese patients with hypertension, and summarizes key literature supporting these recommendations. Read More

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Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.

Nat Commun 2021 May 7;12(1):2558. Epub 2021 May 7.

Department of Pediatric Neurophysiology AP-HP, Necker Enfants Malades Hospital, Paris University, Paris, France.

GEMIN5, an RNA-binding protein is essential for assembly of the survival motor neuron (SMN) protein complex and facilitates the formation of small nuclear ribonucleoproteins (snRNPs), the building blocks of spliceosomes. Here, we have identified 30 affected individuals from 22 unrelated families presenting with developmental delay, hypotonia, and cerebellar ataxia harboring biallelic variants in the GEMIN5 gene. Mutations in GEMIN5 perturb the subcellular distribution, stability, and expression of GEMIN5 protein and its interacting partners in patient iPSC-derived neurons, suggesting a potential loss-of-function mechanism. Read More

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Incremental prognostic value of visually estimated coronary artery calcium in patients undergoing positron emission tomography imaging.

Open Heart 2021 May;8(1)

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Objective: Visually estimated coronary artery calcium (VECAC) from chest CT or attenuation correction (AC)/CT obtained during positron emission tomography (PET)-myocardial perfusion imaging (MPI) is feasible. Our aim was to determine the prognostic value of VECAC beyond conventional risk factors and PET imaging parameters, including coronary flow reserve (CFR).

Methods: We analysed 608 patients without known coronary artery disease who underwent PET-MPI between 2012 and 2016 and had AC/CT and/or chest CT images. Read More

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A way to a woman's heart might be through her bones.

Heart 2021 May 7. Epub 2021 May 7.

Deep Medicine, Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.

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