4,439 results match your criteria strictly controlled


Postresuscitation care and prognostication.

Curr Opin Crit Care 2021 Sep 15. Epub 2021 Sep 15.

Warwick Clinical Trials Unit, University of Warwick Royal United Hospital, Bath, UK Center for Resuscitation Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Most patients who are successfully resuscitated after cardiac arrest are initially comatose and require mechanical ventilation and other organ support in an ICU. Knowledge about the optimal strategy for treating these patients is evolving rapidly. This review will summarize the evidence on key aspects of postarrest care and prognostication, with a focus on actionable parameters that may impact patient survival and neurologic outcomes. Read More

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September 2021

New indices system for quantifying the nexus between economic-social development, natural resources consumption, and environmental pollution in China during 1978-2018.

Sci Total Environ 2021 Sep 8;804:150180. Epub 2021 Sep 8.

Department of Urban Planning and Design, Faculty of Architecture, the University of Hong Kong, Hong Kong 999077, China.

It is meaningful to study how China can maintain the sustainable utilization of natural resources and the continuous improvement of environmental conditions while ensuring the stable development of the economy and society. In this study, a new indices system was proposed for the analysis of nexus among social-economic-natural resource-environment complex systems following the DPSIR (Driving Force - Pressure - State - Impact - Respond) framework, CCD (Coupling Coordination Degree) analysis and VAR (Vector Auto-Regressive) model were applied for quantifying the synergy and trade-off of China in the nexus framework. Results showed that: (1) Although China's rapid development has caused big consumption of natural resources and increasing pollutants discharges during 1978-2018, China has not got into trouble of extreme resource depletion and ecosystem collapse. Read More

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September 2021

MAIT Cells Balance the Requirements for Immune Tolerance and Anti-Microbial Defense During Pregnancy.

Front Immunol 2021 9;12:718168. Epub 2021 Aug 9.

Department of Clinical Immunology and Transfusion Medicine, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset with proinflammatory and cytotoxic effector functions. During pregnancy, modulation of the maternal immune system, both at the fetal-maternal interface and systemically, is crucial for a successful outcome and manifests through controlled enhancement of innate and dampening of adaptive responses. Still, immune defenses need to efficiently protect both the mother and the fetus from infection. Read More

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Consolidation/reconsolidation therapies for the prevention and treatment of PTSD and re-experiencing: a systematic review and meta-analysis.

Transl Psychiatry 2021 Sep 3;11(1):453. Epub 2021 Sep 3.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.

Translational research highlights the potential of novel 'memory consolidation/reconsolidation therapies' to treat re-experiencing symptoms and post-traumatic stress disorder (PTSD). This systematic review and meta-analysis assessed the efficacy of so-called memory consolidation/reconsolidation therapies in randomised controlled trials (RCTs) for prevention and treatment of PTSD and symptoms of re-experiencing in children and adults (PROSPERO: CRD42020171167). RCTs were identified and rated for risk of bias. Read More

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September 2021

The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels.

PLoS Genet 2021 Sep 2;17(9):e1009726. Epub 2021 Sep 2.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a consequence, specific diseases are now prevalent in certain breeds, but whether the recent breeding practice led to an overall increase in genetic load remains unclear. Here we generate whole genome sequencing (WGS) data from 20 dogs per breed from eight breeds and document a ~10% rise in the number of derived alleles per genome at evolutionarily conserved sites in the heavily bottlenecked cavalier King Charles spaniel breed (cKCs) relative to in most breeds studied here. Read More

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September 2021

Current approaches for the purification of antibody-drug conjugates.

Authors:
Yutaka Matsuda

J Sep Sci 2021 Sep 2. Epub 2021 Sep 2.

Ajinomoto Co., Inc., Tokyo, Japan.

In the past two decades, antibody-drug conjugates have gained increasing attention because they expand the therapeutic index when compared with that of traditional chemotherapies. Antibody-drug conjugates are highly complex structures consisting of antibodies covalently conjugated with small-molecule cytotoxic drugs. The complex structure of antibody-drug conjugates makes chemistry, manufacturing, and control difficult. Read More

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September 2021

[Overview of systematic reviews on Shenmai Injection in prevention and treatment of diseases].

Zhongguo Zhong Yao Za Zhi 2021 Aug;46(15):3998-4007

Evidence-based Medicine Center, Lanzhou University Lanzhou 730000, China School of Basic Medical Sciences, Lanzhou University Lanzhou 730000, China Key Laboratory of Evidence-based Medicine and Knowledge Translation of Gansu Province, Lanzhou University Lanzhou 730000, China.

To summarize and evaluate the efficacy and safety of Shenmai Injection in the treatment of viral myocarditis, shock, pulmonary heart disease, coronary heart disease, neutropenia and tumor chemotherapy, so as to provide supportive evidences for clinical rational use of Shenmai Injection. By searching literatures about studies on the systematic reviews on Shenmai Injection in treatment of viral myocarditis, shock, pulmonary heart disease, coronary heart disease, neutropenia and tumor chemotherapy from the main Chinese and English databases. Primary efficacy and safety outcome measures were selected for comparative analysis and summary, and the appraisal tool of AMSTAR 2 was used to evaluate the included studies. Read More

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Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus.

Nucleic Acids Res 2021 Sep 1. Epub 2021 Sep 1.

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.

The activation of eukaryotic DNA replication origins needs to be strictly controlled at multiple steps in order to faithfully duplicate the genome and to maintain its stability. How the checkpoint recovery and adaptation protein Polo-like kinase 1 (Plk1) regulates the firing of replication origins during non-challenged S phase remained an open question. Using DNA fiber analysis, we show that immunodepletion of Plk1 in the Xenopus in vitro system decreases replication fork density and initiation frequency. Read More

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September 2021

Event-Triggered Control for Markov Jump Systems Subject to Mismatched Modes and Strict Dissipativity.

IEEE Trans Cybern 2021 Sep 1;PP. Epub 2021 Sep 1.

In order to save network resources of discrete-time Markov jump systems, an event-triggered control framework is employed in this article. The threshold parameter in the event-triggered mechanism is designed as a diagonal matrix in which all elements can be adjusted according to system performance requirements. The hidden Markov model is introduced to characterize the asynchronization between the controller and controlled system. Read More

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September 2021

[Effects of different calcium intakes on metabolism in healthy adults under strict dietary intervention].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Aug;55(8):965-972

School of Public Health, Harbin Medical University, Harbin 150081, China.

To explore the effect of different calcium intakes on metabolism in healthy adults with traditional Chinese dietary pattern. A total of 64 college students (32 males and 32 females) were recruited from the School of Public Health, Harbin Medical University from September to October 2015. A prospective, randomized, double-blind, placebo-controlled trial design (RCT trial) was used to strictly control the diet of the volunteers through meal preparation, so that the background of the experimental and the control group was exactly the same. Read More

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Simultaneous Quantification and Speciation of Trace Metals in Paired Serum and CSF Samples by Size Exclusion Chromatography-Inductively Coupled Plasma-Dynamic Reaction Cell-Mass Spectrometry (SEC-DRC-ICP-MS).

Int J Mol Sci 2021 Aug 18;22(16). Epub 2021 Aug 18.

Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, 60590 Frankfurt am Main, Germany.

Background: Transition metals play a crucial role in brain metabolism: since they exist in different oxidation states they are involved in ROS generation, but they are also co-factors of enzymes in cellular energy metabolism or oxidative defense.

Methods: Paired serum and cerebrospinal fluid (CSF) samples were analyzed for iron, zinc, copper and manganese as well as for speciation using SEC-ICP-DRC-MS. Brain extracts from Mn-exposed rats were additionally analyzed with SEC-ICP-DRC-MS. Read More

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Micro Scalable Graphene Oxide Productions Using Controlled Parameters in Bench Reactor.

Nanomaterials (Basel) 2021 Jul 31;11(8). Epub 2021 Jul 31.

Departamento de Ingeniería, Universidad de Monterrey, Av. Ignacio Morones Prieto 4500 Pte., San Pedro Garza García 66238, Mexico.

The detailed study of graphene oxide (GO) synthesis by changing the graphite/oxidizing reagents mass ratios (mG/mROxi), provided GO nanosheets production with good yield, structural quality, and process savings. Three initial samples containing different amounts of graphite (3.0 g, 4. Read More

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Chirality affects cholesterol-oxysterol association in water, a computational study.

Comput Struct Biotechnol J 2021 26;19:4319-4335. Epub 2021 Jul 26.

Department of Computational Biophysics and Bioinformatics, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.

Cholesterol (Chol) is the most prevalent sterol in the animal kingdom and an indispensable component of mammalian cell membranes. Chol content in the membrane is strictly controlled, although the oxidation of phospholipids may change the relative content of membrane Chol. An excess of it results in the formation of pure Chol microdomains in the membrane. Read More

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Social Evolution in African Mole-Rats - A Comparative Overview.

Adv Exp Med Biol 2021 ;1319:1-33

Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, South Africa.

The African mole-rat superfamily are a unique group of subterranean rodents that are remarkable for their adaptations to a subterranean lifestyle and their range in sociality, spanning strictly solitary species to the naked mole-rat, the most social of all rodents. Widely distributed through sub-Saharan Africa their occurrence is associated with the presence of food resources in the form of underground roots, bulbs and tubers, which form their staple diet. African mole-rats have an ancient Oligocene/Eocene origin, with the naked mole-rat, the extant species with the earliest divergence from the common ancestor of the clade. Read More

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Long Distance Effects of H-NS Binding in the Control of Expression in the SPI1 Locus.

J Bacteriol 2021 Aug 23:JB0030821. Epub 2021 Aug 23.

Department of Microbiology, University of Illinois at Urbana-Champaign, 601 S Goodwin Avenue Urbana Illinois, 61801.

Typhimurium utilizes a type three secretion system (T3SS) encoded on the pathogenicity island 1 (SPI1) to invade intestinal epithelial cells and induce inflammatory diarrhea. HilA activates expression of the T3SS structural genes. Expression of is controlled by the transcription factors HilD, HilC and RtsA, which act in a complex feed-forward regulatory loop. Read More

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Comparative efficacy and cognitive function of magnetic seizure therapy vs. electroconvulsive therapy for major depressive disorder: a systematic review and meta-analysis.

Transl Psychiatry 2021 Aug 21;11(1):437. Epub 2021 Aug 21.

Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, 030001, Taiyuan, China.

Magnetic seizure therapy (MST) has established efficacy in the treatment of depression and a growing evidence base in the treatment of depression. We conducted the first systematic review and meta-analysis of the efficacy of MST in anti-depressive treatment and its impact on cognitive function (INPLASY registration number: INPLASY202170061). We searched for controlled trials published in English between 1 January 2001 to 31 December 2020 in PubMed, EMBASE, Cochrane Library, Web of Science, and PsycINFO databases. Read More

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Lessons Learned Using Real-World Data to Emulate Randomized Trials: A Case Study of Treatment Effectiveness for Newly Diagnosed Immune Thrombocytopenia.

Clin Pharmacol Ther 2021 Aug 20. Epub 2021 Aug 20.

NoviSci, Inc, Durham, North Carolina, USA.

Regulatory agencies are increasingly considering real-world evidence (RWE) to support label expansions of approved medicines. We conducted a comparative effectiveness study to emulate a proposed randomized trial of romiplostim vs. standard-of-care (SOC) therapy among patients with recently diagnosed (≤12 months) immune thrombocytopenia (ITP), that could support expansion of the romiplostim label. Read More

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Basilar dolichoectasia with intermural hematoma accompanied by cerebral microbleeds and white matter hyperintensities: A case report.

Medicine (Baltimore) 2021 Aug;100(33):e27022

Department of Neurology, The First Hospital of Shanxi Medical University, Taiyuan, China.

Rationale: The clinical manifestations of basilar dolichoectasia (BD) are variable. The diagnosis is based on imaging measurements. Digital subtraction angiography displays only the dilated vascular lumen and lacks visualization of the arterial wall. Read More

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Longitudinal variations in the gastrointestinal microbiome of the white shrimp, .

PeerJ 2021 2;9:e11827. Epub 2021 Aug 2.

Departamento de Investigaciones Científicas y Tecnológicas de la Universidad de Sonora, Universidad de Sonora, Hermosillo, Sonora, Mexico.

The shrimp gut is a long digestive structure that includes the Foregut (stomach), Midgut (hepatopancreas) and Hindgut (intestine). Each component has different structural, immunity and digestion roles. Given these three gut digestive tract components' significance, we examined the bacterial compositions of the Foregut, Hindgut, and Midgut digestive fractions. Read More

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Herd immunity: challenges and the way forward in the Republic of Korea.

Epidemiol Health 2021 Aug 18:e2021054. Epub 2021 Aug 18.

Division of Risk Assessment, Korea Disease Control and Prevention Agency, Cheongju-si, Korea, Cheongju-si, Chungcheongbuk-do, Korea.

Vaccination is considered to be the most effective in preventing the spread of COVID-19. Many countries, including Republic of Korea, are focusing on achieving herd immunity with the goal of achieving a vaccination rate of 70~80%, however, achieving herd immunity does not mean eradicating COVID-19, and the following challenges can occur in the process of achieving herd immunity. First, as the vaccination rate is likely to slow down over time, it is necessary to promote benefits of getting the vaccine through risk communication strategies and provide incentives for those who have been vaccinated. Read More

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Cohesive communities in dynamic brain functional networks.

Phys Rev E 2021 Jul;104(1-1):014302

State Key Laboratory for Strength and Vibration of Mechanical Structures and School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China.

In large-scale brain network dynamics, brain nodes switching between modules has been found to correlate with cognition. However, how the brain nodes engage in this kind of reorganization of modules is unclear. Based on a functional magnetic resonance imaging dataset, we construct dynamic brain functional networks and investigate nodal module temporal dynamic behavior by applying the multilayer network analysis approach. Read More

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The APC10 subunit of the anaphase-promoting complex/cyclosome orchestrates NLRP3 inflammasome activation during the cell cycle.

FEBS Lett 2021 Aug 18. Epub 2021 Aug 18.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, China.

The activation of the NLRP3 inflammasome plays a crucial role in the innate immune response. During cell division, NLRP3 inflammasome activation must be strictly controlled. In this study, we discover that the anaphase-promoting complex subunit 10 (APC10), a substrate recognition protein of the anaphase-promoting complex/cyclosome (APC/C), is a critical mediator of NLRP3 inflammasome activation. Read More

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The Bradyrhizobium diazoefficiens type III effector NopE modulates the regulation of plant hormones towards nodulation in Vigna radiata.

Sci Rep 2021 Aug 16;11(1):16604. Epub 2021 Aug 16.

School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.

Host-specific legume-rhizobium symbiosis is strictly controlled by rhizobial type III effectors (T3Es) in some cases. Here, we demonstrated that the symbiosis of Vigna radiata (mung bean) with Bradyrhizobium diazoefficiens USDA110 is determined by NopE, and this symbiosis is highly dependent on host genotype. NopE specifically triggered incompatibility with V. Read More

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Finite-time stabilization and H∞ control of Port-controlled Hamiltonian systems with disturbances and saturation.

PLoS One 2021 16;16(8):e0255797. Epub 2021 Aug 16.

College of Mathematics and Systems Science, Shandong University of Science and Technology, Qingdao, Shandong Province, China.

The finite-time stabilization and finite-time H∞ control problems of Port-controlled Hamiltonian (PCH) systems with disturbances and input saturation (IS) are studied in this paper. First, by designing an appropriate output feedback, a strictly dissipative PCH system is obtained and finite-time stabilization result for nominal system is given. Second, with the help of the Hamilton function method and truncation inequality technique, a novel output feedback controller is developed to make the PCH system finite-time stable when IS occurs. Read More

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Efficacy and safety of pembrolizumab/carrelizumab, alone or in combination with chemotherapy in treatment of patients with non-small cell lung cancer: A protocol for evidence-based systematic review and Bayesian network meta-analysis.

Medicine (Baltimore) 2021 Jul;100(29):e26672

Department of Respiratory and Critical Care Medicine, Bozhou City People's Hospital, Bozhou Hospital affiliated to Anhui University of Technology, Anhui, China.

Background: To date, there have been no reported trials that directly compare pembrolizumab/carrelizumab monotherapy versus pembrolizumab/carrelizumab and chemotherapy in the first-line treatment setting of advanced/metastatic non-small cell lung cancer (NSCLC). We performed a Bayesian network meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of pembrolizumab/carrelizumab versus pembrolizumab/carrelizumab and chemotherapy in previously treated patients with NSCLC.

Methods: The following search terms would be used in PUBMED, Scopus, EMBASE, and Cochrane Library databases on July 20, 2021, as the search algorithm: (pembrolizumab) OR (carrelizumab) OR (programmed death-1) AND (non-small cell lung cancer) OR (NSCLC). Read More

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Effects of Design Aesthetics on the Perceived Value of a Product.

Front Psychol 2021 29;12:670800. Epub 2021 Jul 29.

Pan Tianshou College of Architecture, Arts and Design, Ningbo University, Ningbo, China.

Design aesthetics play a crucial role in product design. Stakeholders expect to develop highly valuable premium products by improving the design aesthetics of products. Nevertheless, the question of how to evaluate the value of design aesthetics has not been fully addressed. Read More

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Assessment of reporting quality in randomised controlled clinical trial abstracts of dental implantology published from 2014 to 2016.

BMJ Open 2021 Aug 13;11(8):e045372. Epub 2021 Aug 13.

Institute for Medical Biometry and Epidemiology, University Witten Herdecke Faculty of Health, Witten, Nordrhein-Westfalen, Germany.

Objectives: Access to full texts of randomised controlled clinical trials (RCTs) is often limited, so brief summaries of studies play a pivotal role. In 2008, a checklist was provided to ensure the transparency and completeness of abstracts. The aim of this investigation was to estimate adherence to the reporting guidelines of the Consolidated Standards of Reporting Trials (CONSORT) criteria for abstracts (CONSORT-A) in RCT publications. Read More

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Impact of a Geriatric Intervention to Improve Screening and Management of Undernutrition in Older Patients Undergoing Surgery for Colorectal Cancer: Results of the ANC Stepped-Wedge Trial.

Nutrients 2021 Jul 9;13(7). Epub 2021 Jul 9.

Geriatric Medicine Department, Hospices Civils de Lyon, Groupement Hospitalier Sud, CEDEX, 69495 Pierre-Bénite, France.

Almost two in three patients who are aged 75 years and older and scheduled for surgery for colorectal cancer (CRC) are undernourished. Despite evidence that perioperative nutritional management can improve patients outcomes, international guidelines are still insufficiently applied in current practice. In this stepped-wedge cluster-randomized study of five surgical hospitals, we included 147 patients aged 70 years or older with scheduled abdominal surgery for CRC between October 2013 and December 2016. Read More

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Emerging Electrochemical Sensors for Real-Time Detection of Tetracyclines in Milk.

Biosensors (Basel) 2021 Jul 9;11(7). Epub 2021 Jul 9.

Civil and Environmental Engineering, University of Strathclyde, Glasgow G1 1XJ, UK.

Antimicrobial drug residues in food are strictly controlled and monitored by national laws in most territories. Tetracyclines are a major broad-spectrum antibiotic class, active against a wide range of Gram-positive and Gram-negative bacteria, and they are the leading choice for the treatment of many conditions in veterinary medicine in recent years. In dairy farms, milk from cows being treated with antibiotic drugs, such as tetracyclines, is considered unfit for human consumption. Read More

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Differential impacts of natural L2 immersion and intensive classroom L2 training on cognitive control.

Q J Exp Psychol (Hove) 2021 Aug 19:17470218211040813. Epub 2021 Aug 19.

City University of New York, New York, NY, USA.

The relationship between bilingualism and cognitive control has been controversial. We believe that the discrepant findings are likely driven by the complexities of the bilingual experience, which is consistent with the Adaptive Control Hypothesis. The current study investigates whether the natural language immersion experience and the classroom intensive language training experience have differential impacts on cognitive control. Read More

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