28,635 results match your criteria stress pregnancy


Apoptotic mechanism of premature ovarian failure and rescue effect of Traditional Chinese Medicine: a review.

J Tradit Chin Med 2021 Jun;41(3):492-498

Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Social and environmental factors render premature ovarian failure (POF) as a major cause of decline or loss of female fertility. The natural pregnancy rate of patients with POF is only 5%-10%. Follicular atresia is the main factor in the pathogenesis of POF. Read More

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The effects of Intimate Partner Violence and a history of Childhood Abuse on Mental Health and Stress during Pregnancy.

J Fam Violence 2021 Apr 11;36(3):337-346. Epub 2020 Mar 11.

Department of Psychiatry, University of Connecticut School of Medicine.

Purpose: Maternal adverse childhood experiences (ACEs) and intimate partner violence (IPV) are temporally distinct risk factors that negatively impact mothers and their offspring. Risk associated with ACEs and IPV begin during pregnancy, a period of increased physical and psychological demands. The current study examined a person-centered method to empirically identify profiles of pregnant women based on type and severity of ACEs and past-year IPV. Read More

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Genetic and epigenetic modifications of F1 offspring's sperm cells following in utero and lactational combined exposure to nicotine and ethanol.

Sci Rep 2021 Jun 10;11(1):12311. Epub 2021 Jun 10.

Department of Anatomical Sciences, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

It is well established that maternal lifestyle during pregnancy and lactation affects the intrauterine programming of F1 offspring. However, despite the co-use of alcohol and nicotine is a common habit, the effects of exposure to both substances on the reproductive system of F1 male offspring and the underlying mechanisms of developmental programming have not been investigated. The present study aimed to examine pre- and postnatal concurrent exposure to these substances on genetic and epigenetic alterations of sperm cells as well as testis properties of F1 offspring compared with exposure to each substance alone. Read More

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Meditation and mindfulness reduce perceived stress in women with recurrent pregnancy loss: a randomized controlled trial.

Reprod Biomed Online 2021 May 7. Epub 2021 May 7.

Recurrent Pregnancy Loss Unit, Copenhagen University Hospitals, Rigshospitalet, Fertility Clinic 4071, Copenhagen Ø, Denmark and Hvidovre Hospital, Department of Obstetrics and Gynaecology, Hvidovre, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen N, Denmark.

Research Question: Can participating in a tailored 7-week meditation and mindfulness programme with additional standard supportive care versus standard supportive care only reduce perceived stress for women with recurrent pregnancy loss (RPL)?

Design: A two-armed randomized controlled trial (RCT) with 12-month follow-up. In total 76 patients were enrolled and randomly assigned to either standard supportive care or to a 7-week meditation and mindfulness programme led by an instructor in addition to standard supportive care.

Results: At intervention completion (after 7 weeks), perceived stress decreased significantly both in the intervention group (P = 0. Read More

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Prenatal and breastfeeding exposure to low dose of diethylhexyl phthalate induces behavioral deficits and exacerbates oxidative stress in rat hippocampus.

Food Chem Toxicol 2021 Jun 7:112322. Epub 2021 Jun 7.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Diethylhexyl phthalate (DEHP) is one of the most important derivatives of phthalate that has devastating effects on nervous system function. In this study, the effects of exposure with low doses of DEHP during pregnancy and lactation periods have been evaluated in rat's puppies. DEHP at doses 5, 40, 400 μg/kg/day and 300 mg/kg/day was given to mothers by gavage during pregnancy and lactation. Read More

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Maternal Diabetes and Infant Sex Ratio.

Curr Diab Rep 2021 Jun 10;21(8):24. Epub 2021 Jun 10.

The University of Tennessee, Knoxville, 390 HPER, 1914 Andy Holt Ave, Knoxville, TN, 37996, USA.

Purpose Of Review: Evolutionary hypotheses on the ratio of males to females at birth posit that women terminate pregnancies with low likelihood of surviving and producing grandchildren. Thus, females are preferred to males under unfavorable conditions. Much of this literature has focused on catastrophic disruptions that induce maternal stress and result in fewer males. Read More

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The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome.

Expert Rev Proteomics 2021 Jun 9. Epub 2021 Jun 9.

Neonatal Intensive Care Unit, Department of Surgical Sciences, AOU and University of Cagliari. SS 554 km 4,500, 09042 Monserrato. Italy.

Introduction: Pre-pregnancy overweight and obesity, depending on maternal nutrition and metabolic state, can influence fetal, neonatal and long-term offspring health, regarding cardio-metabolic, respiratory, immunological and cognitive outcomes. Thus, maternal weight can act, through mechanisms that are not full understood, on the physiology and metabolism of some fetal organs and tissues, to adapt themselves to the intrauterine environment and nutritional reserves. These effects could occur by modulating gene expression, neonatal microbiome, and through breastfeeding. Read More

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Effects of maternal mental health on prenatal movement profiles in twins and singletons.

Acta Paediatr 2021 Jun 8. Epub 2021 Jun 8.

Department of Psychology, Durham University, Durham, UK.

Aim: Prenatal experiences, including maternal stress, depression and anxiety, form crucial building blocks affecting the maturation of the foetal central nervous system. Previous research has examined foetal movements without considering effects of maternal mental health factors critical for healthy foetal development. The aim of this research is to assess the effects of maternal mental health factors on foetal twin compared with singleton movement profiles. Read More

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Inclusion of microbe-derived antioxidant during pregnancy and lactation attenuates high-fat diet-induced hepatic oxidative stress, lipid disorders, and NLRP3 inflammasome in mother rats and offspring.

Food Nutr Res 2019 23;63. Epub 2019 Aug 23.

Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Objective: This study aimed to evaluate the effects of microbe-derived antioxidant (MA) on high-fat diet (HFD)-induced hepatic lipid disorders in mother rats and offspring.

Methods: A total of 36 female rats were randomly divided into three groups at the beginning of pregnancy: the control group (CG), HFD, and HFD with 2% MA. Mother rats were slaughtered at the first and 10th day of lactation (L1 and L10) and offspring were slaughtered at L10. Read More

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Marijuana use and sleep quality during pregnancy.

J Matern Fetal Neonatal Med 2021 Jun 8:1-8. Epub 2021 Jun 8.

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.

Objective: Marijuana use among pregnant women is on the rise in part due to the perception that marijuana may improve problems related to pregnancy such as poor sleep. This study's objective was to examine associations between marijuana use and sleep quality among a sample of women during pregnancy.

Material And Methods: The sample included women seeking prenatal care at The Ohio State University Wexner Medical Center (2010-2015). Read More

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The Role of Immune Cells in Recurrent Spontaneous Abortion.

Reprod Sci 2021 Jun 8. Epub 2021 Jun 8.

Departments of Cardiovascular Medicine, First Hospital, Jilin University, Changchun, 130000, China.

Recurrent spontaneous abortion affects approximately 1-2% of women of childbearing, and describes a condition in which women suffer from three or more continuous spontaneous miscarriages. However, the origin of recurrent spontaneous abortion (RSA) remains unknown, preventing effective treatment and placing stress upon patients. It has been acknowledged that successful pregnancy necessitates balanced immune responses. Read More

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Assembly of Cytoplasmic Stress Granules in Placentas in Women with Preeclampsia.

Reprod Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics and Gynecology, Qingdao Women and Children's Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 266034, Shandong Province, China.

Inflammation is a well-recognized factor associated with preeclampsia (PE). Stress granules (SGs) have been shown to play an important role in regulating inflammation and immune responses. However, whether SGs are involved in the pathogenesis of PE has not been studied. Read More

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Intergenerational Impacts of Maternal Stress on Early Childhood Atopy in Black Americans.

J Pediatr Psychol 2021 Jun 8. Epub 2021 Jun 8.

Department of Psychology, Emory University, USA.

Objective: Black children are disproportionately affected by atopic diseases (i.e., atopic dermatitis, allergic rhinitis, asthma, and food allergies), with health disparities present in early life. Read More

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Comprehensive transcriptome mining identified the gene expression signature and differentially regulated pathways of the late-onset preeclampsia.

Pregnancy Hypertens 2021 May 28;25:91-102. Epub 2021 May 28.

Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Preeclampsia (PE) is categorized as a pregnancy-related hypertensive disorder and is a serious concern in pregnancies. Several factors, including genetic factors (placenta gene expression, and imprinting), oxidative stress, the inaccurate immune response of the mother, and the environmental factors are responsible for PE development, but still, the exact mechanism of the pathogenesis has remained unknown. The main aim of the present study is to identify the gene expression signature in placenta tissue, to unveil disease etiology mechanisms. Read More

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Maternal prenatal gut microbiota composition predicts child behaviour.

EBioMedicine 2021 Jun 4;68:103400. Epub 2021 Jun 4.

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Geelong, VIC, 3220, Australia; Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; Barwon Health, Geelong, Victoria 3220, Australia. Electronic address:

Background: Murine studies demonstrate that maternal prenatal gut microbiota influences brain development and behaviour of offspring. No human study has related maternal gut microbiota to behavioural outcomes during early life. This study aimed to evaluate relationships between the prenatal faecal microbiota, prenatal diet and childhood behaviour. Read More

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Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting.

Environ Res 2021 Jun 4:111435. Epub 2021 Jun 4.

University of Michigan School of Public Health, Department of Environmental Health Sciences, Ann Arbor, MI, United States. Electronic address:

Background: Studies on the health effects of metal mixtures typically utilize biomarkers measured in a single biological medium, such as blood or urine. However, the ability to evaluate mixture effects are limited by the uncertainty whether a unified medium can fully capture exposure for each metal. Therefore, it is important to compare and assess metal mixtures measured in different media in epidemiology studies. Read More

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The effect of the information-motivation-behavioral skills (IMB) model variables on orthorexia nervosa behaviors of pregnant women.

Eat Weight Disord 2021 Jun 7. Epub 2021 Jun 7.

Psychiatric Nursing, Fethiye Faculty of Health Sciences, Muğla Sıtkı Kocman University, Muğla, Turkey.

Purpose: This study aims to test the effect of the components of the Information-Motivation-Behavioral Skills Model on Orthorexia Nervosa (ON) behavior of pregnant women and health outcomes using a hypothetical model.

Methods: The study is cross-sectional research and was carried out with 350 pregnant women who had the Non-Stress Test in the obstetrics outpatient clinic of a university hospital. The participants were selected using the convenience sampling method. Read More

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COVID-19 pandemic and population-level pregnancy and neonatal outcomes: a living systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2021 Jun 6. Epub 2021 Jun 6.

Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.

Introduction: Conflicting reports of increases and decreases in rates of preterm birth (PTB) and stillbirth in the general population during the COVID-19 pandemic have surfaced. The objective of our study was to conduct a living systematic review and meta-analyses of studies reporting pregnancy and neonatal outcomes by comparing the pandemic and pre-pandemic periods.

Material And Methods: We searched PubMed and Embase databases, reference lists of articles published up until May 14, 2021 and included English language studies that compared outcomes between the COVID-19 pandemic time period vs. Read More

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The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity.

Theranostics 2021 12;11(14):6983-7004. Epub 2021 May 12.

Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.

We recently demonstrated that the 'Metabesity' factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as pregnancy and pre-diabetes. HMG20A also dictates central nervous system (CNS) development via inhibition of the LSD1-CoREST complex but its expression pattern and function in adult brain remains unknown. Herein we sought to determine whether HMG20A is expressed in the adult CNS, specifically in hypothalamic astrocytes that are key in glucose homeostasis and whether similar to islets, HMG20A potentiates astrocyte function in response to environmental cues. Read More

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The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn.

Peptides 2021 Jun 3:170593. Epub 2021 Jun 3.

Department of Behavioural and Molecular Neurobiology, Regensburg Center for Neuroscience, University of Regensburg, 93053 Regensburg, Germany. Electronic address:

The bond between a mother and her child is the strongest bond in nature. Consequently, the loss of a child is one of the most stressful and traumatic life events that causes Prolonged Grief Disorder in up to 94% of bereaved parents. While both parents are affected, mothers are of higher risk to develop mental health complications; yet, very little research has been done to understand the impact of the loss of a child, stillbirth and pregnancy loss on key neurobiological systems. Read More

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Cell death mechanisms and their roles in pregnancy related disorders.

Adv Protein Chem Struct Biol 2021 27;126:195-225. Epub 2021 Feb 27.

Department of Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India. Electronic address:

Autophagy and apoptosis are catabolic pathways essential for homeostasis. They play a crucial role for normal placental and fetal development. These cell death mechanisms are exaggerated in placental disorders such as preeclampsia, intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM). Read More

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February 2021

Prenatal exposure to ambient air pollutants and early infant growth and adiposity in the Southern California Mother's Milk Study.

Environ Health 2021 Jun 5;20(1):67. Epub 2021 Jun 5.

Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.

Background: Prior epidemiological and animal work has linked in utero exposure to ambient air pollutants (AAP) with accelerated postnatal weight gain, which is predictive of increased cardiometabolic risk factors in childhood and adolescence. However, few studies have assessed changes in infant body composition or multiple pollutant exposures. Therefore, the objective of this study was to examine relationships between prenatal residential AAP exposure with infant growth and adiposity. Read More

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Fertility responses of melatonin-treated gilts before and during the follicular and early luteal phases when there are different temperatures and lighting conditions in the housing area.

Anim Reprod Sci 2021 Jul 15;230:106769. Epub 2021 May 15.

Department of Animal Science, University of Illinois, Urbana, IL, 61801, United States. Electronic address:

This study was conducted to determine whether exogenous melatonin affected gilt fertility when there were different housing temperature and lighting conditions. Prepubertal gilts (n = 72) were fed (MEL, 5 mg/day) or not fed (CON) melatonin while housed in rooms where temperatures (31.0 ± 1 °C) and daily lighting (240 lx) duration differed: 8 (8 H); 16 (16 H); or 24 (24 H) h in winter and summer replicates. Read More

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The relationship between serum thiol levels and thiol/disulfide homeostasis in women with tubal ectopic pregnancy.

J Gynecol Obstet Hum Reprod 2021 Jun 2:102175. Epub 2021 Jun 2.

Department of Obstetrics and Gynecology, Bezmialem Vakıf University, Istanbul, Turkey.

Objective: The aim of this study was to investigate the thiol/disulfide homeostasis in tubal ectopic pregnancies in terms of early diagnosis of the disease.

Design: A prospective case-control study was carried out between June 2017-February 2018 in the Gynaecology Department of Umraniye Medical and Research Hospital.

Materials And Methods: A total of 42 women with ectopic pregnancy were compared with 44 healthy women who have intrauterine first trimester pregnancies. Read More

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Proteomic dissection of the impact of environmental exposures on mouse seminal vesicle function.

Mol Cell Proteomics 2021 Jun 2:100107. Epub 2021 Jun 2.

Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, Discipline of Biological Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, Pregnancy and Reproduction Program, New Lambton Heights, NSW 2305, Australia. Electronic address:

Seminal vesicles are an integral part of the male reproductive accessory gland system. They produce a complex array of secretions containing bioactive constituents that support gamete function and promote reproductive success, with emerging evidence suggesting these secretions are influenced by our environment. Despite their significance, the biology of seminal vesicles remains poorly defined. Read More

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Antenatal and postnatal assessment of pelvic floor muscles in continent and incontinent primigravida women.

Int Urogynecol J 2021 Jun 5. Epub 2021 Jun 5.

Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction And Hypothesis: Reduced pelvic floor muscle (PFM) strength and thickness are considered critical factors in pregnancy-related stress urinary incontinence. Various methods have been evaluated for the measurement of these two factors, but validity needs to be well established. The objective was to assess the strength and thickness of pelvic floor muscles of continent and incontinent primigravida women using the digital method and transperineal ultrasound, and to study the correlation between the two methods. Read More

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Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells.

Geroscience 2021 Jun 5. Epub 2021 Jun 5.

Barshop Institute for Longevity and Aging Studies and Department of Molecular Medicine, The University of Texas Health Science Center At San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA.

Aging is associated with progressive loss of cellular homeostasis resulting from intrinsic and extrinsic challenges. Lack of a carefully designed, well-characterized, precise, translational experimental model is a major limitation to understanding the cellular perturbations that characterize aging. Here, we tested the feasibility of primary fibroblasts isolated from nonhuman primates (baboons) as a model of cellular resilience in response to homeostatic challenge. Read More

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Depression and anxiety among pregnant mothers in the initial stage of the Coronavirus Disease (COVID-19) pandemic in the southwest of Iran.

Reprod Health 2021 Jun 4;18(1):111. Epub 2021 Jun 4.

Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

‌BACKGROUND: Women are at a higher risk for depression progression, especially during pregnancy. The current study purposed to investigate depression, anxiety, and stress levels of pregnant mothers in the initial stage of the COVID-19 infection in the southwest of Iran.

Methods: This cross-sectional study was conducted during March and April, 2020, in Shiraz, Iran. Read More

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Association between Physiological Equivalent Temperature (PET) with adverse pregnancy outcomes in Ahvaz, southwest of Iran.

BMC Pregnancy Childbirth 2021 Jun 4;21(1):415. Epub 2021 Jun 4.

Department of Epidemiology and Biostatistics, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: There are few epidemiological studies on the relation between temperature changes and adverse pregnancy outcomes. The purpose of this study was to determine the relation between Physiological Equivalent Temperature (PET) with adverse pregnancy outcomes including stillbirth, low birth weight (LBW), preterm labor (PTL), spontaneous abortion (SA), preeclampsia and hypertension in Ahvaz, Iran.

Methods: Distributed Lag Non-linear Models (DLNM) combined with quasi-Poisson regression were used to investigate the effect of PET on adverse pregnancy outcomes. Read More

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Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

PLoS One 2021 4;16(6):e0252642. Epub 2021 Jun 4.

Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California, United States of America.

Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1+/-) mothers, fetuses, and offspring. Read More

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