45,902 results match your criteria stress liver

Polystyrene microplastics induce microbial dysbiosis and dysfunction in surrounding seawater.

Environ Int 2021 Jun 20;156:106724. Epub 2021 Jun 20.

Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China. Electronic address:

Microplastics are ubiquitously present in the environment, accumulate in aquaculture water, and cause toxicological effects on aquatic organisms. Besides, microplastics provide ecological niches for microorganisms in aquatic environments. However, the effects of microplastics on microbial balance and function in surrounding water are still unclear, especially for aquaculture water. Read More

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Firefighters' occupational exposure: Contribution from biomarkers of effect to assess health risks.

Environ Int 2021 Jun 20;156:106704. Epub 2021 Jun 20.

REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto. Electronic address:

Firefighting is physically and physiologically exhausting besides encompassing exposure to toxic fire emissions. Biomonitoring studies from the past five years have been significantly contributing to characterize the occupational-related health effects in this group of professionals and to improve risk assessment. Therefore, this study gathers and critically discusses the most characterized biomarkers of effect (oxidative stress, DNA and protein damage, stress hormones, inflammation, and vascular, lung, and liver injury), including those potentially more promising to be explored in future studies, and their relation with health outcomes. Read More

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Potential Hepatoprotective Effect of Cheatomorpha gracilis extract against High Fat Diet (HFD)-Induced Liver Damage, and its characterization by HPLC.

Braz J Biol 2021 21;82:e247102. Epub 2021 Jun 21.

University of Sfax, Faculty of Sciences of Sfax, Laboratory of Animal Physiology, Sfax, Tunisia.

The current investigation was carried out to estimate the protective effect of aqueous extract of Cheatomorpha gracilis (AEC) against High fat Diet (HFD) induced liver damage in mice. The results of the in vitro study showed that AEC have higher antioxidant capacities in the DPPH and hydroxyl radical-scavenging assays. Indeed, many phenolic compounds (gallic acid, quercetin, naringenin, apigenin, kaempferol and rutin) were identified in the AEC. Read More

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Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes.

PLoS One 2021 23;16(6):e0253475. Epub 2021 Jun 23.

Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Medicine, McGill University, Montreal, Quebec, Canada.

Hepcidin is a peptide hormone that targets the iron exporter ferroportin, thereby limiting iron entry into the bloodstream. It is generated in hepatocytes mainly in response to increased body iron stores or inflammatory cues. Iron stimulates expression of bone morphogenetic protein 6 (BMP6) from liver sinusoidal endothelial cells, which in turn binds to BMP receptors on hepatocytes and induces the SMAD signaling cascade for transcriptional activation of the hepcidin-encoding HAMP mRNA. Read More

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Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism.

Phytother Res 2021 Jun 22. Epub 2021 Jun 22.

State Key Laboratory of Southwestern Chinese Medicine Resources, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Quercetin is the major representative of the flavonoid subgroup of flavones, with good pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty hepatitis, liver fibrosis, and liver cancer. It can significantly influence the development of liver diseases via multiple targets and multiple pathways via antifat accumulation, anti-inflammatory, and antioxidant activity, as well as the inhibition of cellular apoptosis and proliferation. Despite extensive research on understanding the mechanism of quercetin in the treatment of liver diseases, there are still no targeted therapies available. Read More

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Hepatoprotective effect of Saccharomyces Cervisciae Cell Wall Extract against thioacetamide-induced liver fibrosis in rats.

Heliyon 2021 Jun 27;7(6):e07159. Epub 2021 May 27.

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Fibrosis represents a common outcome of almost all chronic liver diseases and leads to an impairment of liver function that requires medical intervention. The current study aimed to evaluate the potential anti-fibrotic effect of cell wall extract (SCCWE) against thioacetamide (TAA)-induced liver fibrosis in rats (200mg/kg b.w. Read More

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Hepatobiliary Surg Nutr 2021 Jun;10(3):364-366

Department of Hepatobiliary and Digestive Surgery, University Hospital, Rennes 1 University, Rennes, France.

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Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease.

Evid Based Complement Alternat Med 2021 1;2021:9931542. Epub 2021 Jun 1.

Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

Alcoholic liver disease (ALD) is a liver disease caused by long-term alcohol consumption. ROS-mediated oxidative stress is the leading cause of ALD. Pien-Tze-Huang (PZH), a traditional formula, is famous in China. Read More

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Resveratrol suppresses cholestasis-induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers.

Clin Exp Pharmacol Physiol 2021 Jun 22. Epub 2021 Jun 22.

Departments of Physiology Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.

Cholestasis caused by slowing or blockage of bile flow is a serious liver disease that can lead to liver fibrosis and cirrhosis. The link between transforming growth factor beta 1 (TGFβ1), Smad family member 3 (Smad3), and microRNA 21 (miR21) in bile duct ligation (BDL)-induced liver fibrosis in the presence and absence of the anti-inflammatory and antioxidant compound, resveratrol (RSV) has not been previously studied. Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. Read More

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A Decreased Response to Resistin in Mononuclear Leukocytes Contributes to Oxidative Stress in Nonalcoholic Fatty Liver Disease.

Dig Dis Sci 2021 Jun 22. Epub 2021 Jun 22.

Facultad de Farmacia Y Bioquímica, Instituto de Inmunología, Genética Y Metabolismo (INIGEM), CONICET-Universidad de Buenos Aires, Hospital de Clínicas José de San Martín, Avda. Córdoba 2351 (1120) CABA, Buenos Aires, Argentina.

Background: Deregulation of immune response and oxidative stress contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. Resistin is a physiological modulator of inflammation and redox homeostasis of different cell types. Increased resistin serum concentration and the direct association between resistin hepatic expression and NAFLD severity suggest that resistin participates in NAFLD pathogenesis. Read More

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Carvacrol hinders the progression of hepatic fibrosis via targeting autotaxin and thioredoxin in thioacetamide-induced liver fibrosis in rat.

Hum Exp Toxicol 2021 Jun 22:9603271211026729. Epub 2021 Jun 22.

Department of Pharmacology, Faculty of Veterinary Medicine, 63526Cairo University, Cairo, Egypt.

Fibrosis is a common outcome of nearly all chronic diseases of liver that results in changes of its functions which requires medical attention. The current research aims to investigate the potential anti-fibrotic efficacy of Carvacrol against thioacetamide (TAA)-induced liver fibrosis in male rats using Ursodeoxycholic acid (UDCA) as a reference anti-fibrotic product. Carvacrol (25 and 50 mg/kg) markedly declined TAA-increased serum liver enzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) as well as total bilirubin (TB) and direct bilirubin (DB) levels as well as increased levels of total protein (TP) and albumin. Read More

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Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.

J Cell Mol Med 2021 Jun 21. Epub 2021 Jun 21.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.

Procyanidin B2 (PB2), a naturally occurring flavonoid abundant in a wide range of fruits, has been shown to exert antioxidant, anti-inflammatory and anticancer properties. However, the role of PB2 in the prevention of cold stimulation (CS)-induced liver injury. The present study was undertaken to determine the effects of PB2 on liver injury induced by cold stimulation and its potential molecular mechanisms. Read More

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Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice.

J Food Biochem 2021 Jun 21:e13816. Epub 2021 Jun 21.

College of Food science and Engineering, Jilin Agricultural University, Changchun, China.

With the development of technology, drugs are being developed for different purposes. Thus, the rate of drug injury considerably increased worldwide. Liver is the largest detoxification organ in the human body, but it is also the organ most vulnerable to drug damage. Read More

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Lagerstroemia speciosa (L.) Pers., ethanolic extract attenuates simultaneously administered isoniazid- and dapsone-induced hepatotoxicity in rats.

J Food Biochem 2021 Jun 21:e13830. Epub 2021 Jun 21.

Department of Pharmacology, The Blue Lab, Molecular Medicine and Toxicology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, India.

Herbal tea of Lagerstroemia speciosa Pers., commonly known as banaba, has been traditionally used to treat various ailments including diabetes and obesity due to its antioxidant and anti-inflammatory efficacies. Drug-induced liver injury is a common cause of acute liver failure. Read More

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High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats.

Sci Rep 2021 Jun 21;11(1):12924. Epub 2021 Jun 21.

Centre for Molecular Biology, Central University of Jammu, Jammu, UT of Jammu and Kashmir, 184311, India.

Metabolic disorders are becoming more common in young population due to increased consumption of carbohydrate rich diet, lack of physical activity and stress. Fructose is used as a sweetener in many carbonated beverages and is a known inducer of oxidative stress and hypertension. Up-regulation of the double-stranded RNA-dependent protein kinase (PKR) causes impairment in insulin signaling pathway and metabolic dysfunctions in type 2 diabetes mellitus. Read More

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Comprehensive analysis of metabolic changes in rats exposed to acrylamide.

Environ Pollut 2021 Jun 16;287:117591. Epub 2021 Jun 16.

Jining First People's Hospital, Jining Medical University, Jining, 272000, China; Department of Clinical & Translational Medicine, Jining Life Science Center, Jining, 272000, China. Electronic address:

Acrylamide (ACR) is a widely used environmentally hazardous compound that is known to be neurotoxic, genotoxic, carcinogenic, and reproductive toxicity. It is widely present in soil, water, agents used in chemical industries, and food. It can be distributed to all organs and tissues, and can cause damage to various human systems and those of other animals. Read More

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Characterization of the liver proteome in dairy cows experiencing negative energy balance at early lactation.

J Proteomics 2021 Jun 18:104308. Epub 2021 Jun 18.

Department of Ruminant Sciences, Institute of Animal Science, ARO Volcani Center, Rishon Lezion 7505101, Israel. Electronic address:

Negative energy balance (NEB) is associated with metabolic disorders in early lactation dairy cows. Therefore, our objective was to characterize the liver proteome in cows experiencing either NEB or positive energy balance (PEB). Forty-two multiparous Holstein dairy cows were milked either 2 or 3 times daily for the first 30 days in milk (DIM) to alter EB, and were classified retrospectively as NEB (n = 18) or PEB (n = 22). Read More

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Biomarkers for assessing chronic toxicity of carbamazepine, an anticonvulsants drug on Pangasianodon hypophthalmus (Sauvage, 1878).

Environ Toxicol Pharmacol 2021 Jun 18:103691. Epub 2021 Jun 18.

Aquatic Environment and Health Management Division, ICAR- Central Institute of Fisheries Education, Mumbai, 400 061, India.

In recent times, carbamazepine (CBZ) as an anticonvulsants drug has raised attention because of its safety concern in the aquatic environment. The present study aimed to evaluate the sub-lethal effects of CBZ (1%, 0.1 % and 0. Read More

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Soluble resistance-related calcium-binding protein participates in multiple diseases via protein-protein interactions.

Biochimie 2021 Jun 18. Epub 2021 Jun 18.

Department of Blood Transfusion, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan Province 410008, China; NHC Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan Province 410008, China. Electronic address:

Soluble resistance-related calcium-binding protein (sorcin), a 22 kDa penta-EF-hand protein, has been intensively studied in cancers and multidrug resistance over a prolonged period. Sorcin is widely distributed in tissues and participates in the regulation of Ca homeostasis and Ca-dependent signaling. Protein-protein interactions (PPIs) are essential for regulating protein functions in almost all biological processes. Read More

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Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.

Toxicology 2021 Jun 18:152838. Epub 2021 Jun 18.

Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

N,N-dimethylformamide (DMF) is an organic compound widely used in industrial production processes as a solvent with a low evaporation rate. Excessive exposure to DMF may lead to liver damage. Oxidative stress has been reported as one of the main causes of DMF-induced hepatotoxicity. Read More

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Dietary Ursolic Acid Prevents Alcohol-Induced Liver Injury via Gut-Liver Axis Homeostasis Modulation: The Key Role of Microbiome Manipulation.

J Agric Food Chem 2021 Jun 21. Epub 2021 Jun 21.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, People's Republic of China.

Ursolic acid (UA), a natural triterpenoid widely distributed within fruits and edible plants, has been proven to relieve alcoholic liver disease (ALD). However, the mechanisms involved largely remain unclear. This study investigated whether the beneficial effects of UA on ALD could be related to gut-liver axis (GLA) modulation. Read More

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FGF21 prevents low protein diet-induced renal inflammation in aged mice.

Am J Physiol Renal Physiol 2021 06 21. Epub 2021 Jun 21.

Oxidative Stress and Disease Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.

Low protein diets extend lifespan through a comprehensive improvement in metabolic health across multiple tissues and organs. Many of these metabolic responses to protein restriction are secondary to transcriptional activation and release of FGF21 from the liver. However, the effects of a low protein (LP) diet on the kidney in the context of aging has not been examined. Read More

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Hepatocyte proteomes reveal the role of protein disulfide isomerase 4 in alpha 1-antitrypsin deficiency.

JHEP Rep 2021 Aug 24;3(4):100297. Epub 2021 Apr 24.

University of Bordeaux, CNRS, INSERM, BaRITOn, U1053, Bordeaux, France.

Background & Aims: A single point mutation in the Z-variant of alpha 1-antitrypsin (Z-AAT) alone can lead to both a protein folding and trafficking defect, preventing its exit from the endoplasmic reticulum (ER), and the formation of aggregates that are retained as inclusions within the ER of hepatocytes. These defects result in a systemic AAT deficiency (AATD) that causes lung disease, whereas the ER-retained aggregates can induce severe liver injury in patients with ZZ-AATD. Unfortunately, therapeutic approaches are still limited and represents the option To overcome this limitation, a better understanding of the molecular basis of ER aggregate formation could provide new strategies for therapeutic intervention. Read More

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Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure.

iScience 2021 Jun 19;24(6):102552. Epub 2021 May 19.

Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.

Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. Read More

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Pt-Coated Au Nanoparticle Toxicity Is Preferentially Triggered Via Mitochondrial Nitric Oxide/Reactive Oxygen Species in Human Liver Cancer (HepG2) Cells.

ACS Omega 2021 Jun 28;6(23):15431-15441. Epub 2021 May 28.

Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Reactive nitrogen species (RNS) that are formed from the reaction of versatile nitric oxide (NO) with reactive oxygen species (ROS) have been less explored in potential cancer therapy. This may be partly due to the fewer available agents that could induce NO in cells. Here, we report platinum-coated gold nanoparticles (Pt-coated Au NPs; 27 ± 20 nm) as a strong inducer of NO (assessed by live-cell imaging under NO-specific DAR-1 probe labeling and indirectly using a Griess reagent) in human liver carcinoma (HepG2) cells. Read More

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Enhanced Immune Response Improves Resistance to Cadmium Stress in Triploid Crucian Carp.

Front Physiol 2021 4;12:666363. Epub 2021 Jun 4.

State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, China.

Previous research has indicated that triploid crucian carp (3n fish) have preferential resistance to cadmium (Cd) compared to . (2n fish). In this article, comparative research is further conducted between the 2n and 3n fish in terms of the immune response to Cd-induced stress. Read More

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Sinapic Acid Reduces Oxidative Stress and Pyroptosis via Inhibition of BRD4 in Alcoholic Liver Disease.

Front Pharmacol 2021 4;12:668708. Epub 2021 Jun 4.

Department of Pharmacy, The Second Hospital of Dalian Medical University, Dalian, China.

Alcoholic liver disease (ALD) is one of the main causes of death in chronic liver disease. Oxidative stress and pyroptosis are important factors leading to ALD. Bromodomain-containing protein 4 (BRD4) is a factor that we have confirmed to regulate ALD. Read More

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Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats.

Nucl Med Commun 2021 Jun 18. Epub 2021 Jun 18.

Department of Endocrinology and Metabolism Department of Nuclear Medicine, University of Health Sciences, Ankara Training and Research Hospital, Ankara Department of Pathology, Harran University Faculty of Veterinary Medicine, Sanliurfa Department of Biochemistry, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.

Objective: The present study was aimed to explore the potential ameliorating effects of N-acetyl cysteine (NAC) against radioiodine (RAI)-induced early liver damage.

Methods: Thirty Wistar Albino male rats were arbitrarily allocated into three groups each containing 10 rats: the control group (group 1); the RAI group (group 2), oral 111 MBq/kg radioiodine was administered to rats; the RAI + NAC group (group 3), 150 mg/kg/day intraperitoneal NAC treatment was initiated 3 days prior to the RAI administration and continued for 10 days. Liver samples were obtained 24 h after the last dose of NAC therapy for biochemical and histopathologic evaluation. Read More

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Moderate-intensity aerobic training reduces cardiac damage due to experimental iron overload in rats.

Exp Physiol 2021 Jun 19. Epub 2021 Jun 19.

Department of Physiological Sciences, University of Espirito Santo, Brazil.

New Findings: What is the central question of this study? The current literature indicates the oxidative stress as playing a major role in the iron-overload. Although exercise is a well-established approach to treat/prevent cardiovascular diseases, its effects on iron-overload are not known. What is the main finding and its importance? Moderate-intensity aerobic training had benefits on a rodent model of iron-overload cardiomyopathy by improving the heart antioxidant capacity. Read More

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Cardiac-induced liver deformation as a measure of liver stiffness using dynamic imaging without magnetization tagging-preclinical proof-of-concept, clinical translation, reproducibility and feasibility in patients with cirrhosis.

Abdom Radiol (NY) 2021 Jun 20. Epub 2021 Jun 20.

Division of Medicine, Centre for Medical Imaging, University College London (UCL), London, UK.

Purpose: MR elastography and magnetization-tagging use liver stiffness (LS) measurements to diagnose fibrosis but require physical drivers, specialist sequences and post-processing. Here we evaluate non-rigid registration of dynamic two-dimensional cine MRI images to measure cardiac-induced liver deformation (LD) as a measure of LS by (i) assessing preclinical proof-of-concept, (ii) clinical reproducibility and inter-reader variability, (iii) the effects of hepatic hemodynamic changes and (iv) feasibility in patients with cirrhosis.

Methods: Sprague-Dawley rats (n = 21 bile duct ligated (BDL), n = 17 sham-operated controls) and fasted patients with liver cirrhosis (n = 11) and healthy volunteers (HVs, n = 10) underwent spoiled gradient-echo short-axis cardiac cine MRI studies at 9. Read More

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