10,429 results match your criteria stress age-related


[Multimodal therapeutic strategies in the treatment of cerebrovascular disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(12):112-118

Pirogov Russian National Research Medical University, Moscow, Russia.

The review presents the scientific substantiation of the relationship between age-related cerebrovascular changes and dysregulation of cerebral perfusion, blood-brain barrier (BBB) function and neurovascular units. The ischemic cascade in cerebrovascular disease (CVD) is considered, the main links of which are glutamate excitoxicosis, oxidative stress and neuroinflammation. Endothelial dysfunction and increased BBB permeability play an important role in the development of neuroinflammation. Read More

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January 2021

Progranulin as a therapeutic target in neurodegenerative diseases.

Trends Pharmacol Sci 2022 Jan 15. Epub 2022 Jan 15.

Alector, Inc., South San Francisco, CA 94080, USA. Electronic address:

Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. It regulates lysosomal biogenesis, inflammation, repair, stress response, and aging. GRN loss-of-function mutations cause neuronal ceroid lipofuscinosis or frontotemporal dementia-GRN (FTD-GRN) in a gene dosage-dependent manner. Read More

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January 2022

Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.

J Hum Genet 2022 Jan 17. Epub 2022 Jan 17.

Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Age-related hearing loss (ARHL) is a complex multifactorial disorder. Studies in animals, including mitochondria-mutator mice, and in human suggest that oxidative stress and mitochondrial disturbance play an important role in the pathoetiology of ARHL. Mitochondrial DNA (mtDNA) haplogroups are populations with genetically similar traits, and they have been reported to affect the mitochondrial function of oxidative phosphorylation. Read More

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January 2022

XENOHORMESIS UNDERLYES THE ANTI-AGING AND HEALTHY PROPERTIES OF OLIVE POLYPHENOLS.

Mech Ageing Dev 2022 Jan 13:111620. Epub 2022 Jan 13.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy. Electronic address:

The paper provides a comprehensive and foundational mechanistic framework of hormesis that establishes its centrality in medicine and public health. This hormetic framework is applied to the assessment of olive polyphenols with respect to their capacity to slow the onset and reduce the magnitude of a wide range of age-related disorders and neurodegenerative diseases, including Alzheimer's Disease and Parkinson's Disease. It is proposed that olive polyphenol-induced anti-inflammatory protective effects are mediated in large part via the activation of AMPK and the upregulation of Nrf2 pathway. Read More

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January 2022

Bone permeability and mechanotransduction: Some current insights into the function of the lacunar-canalicular network.

Tissue Cell 2022 Jan 7;75:101730. Epub 2022 Jan 7.

Institute for Globally Distributed Open Research and Education (IGDORE); Ilmajoki Health Public Dental Clinics, Social and Health Care Services in Jalasjärvi, Ilmajoki, Kurikka, Finland. Electronic address:

Lacunar-canalicular (LC) permeability involves the passage of fluids, nutrients, oxygen, ions, and signalling molecules through bone tissue, facilitating the maintenance of bone vitality and function and responses to various physiological conditions and diseases. LC permeability and fluid flow-shear stress/drag force play important roles in mechanotransduction in bone tissue by inducing mechanical stimuli in osteocytes, modulating cellular functions, and determining bone adaptation. Alterations in LC structure may therefore influence the fluid flow pattern through the LC network, thereby affecting the ability of osteocytes to sense and translate mechanical signals and possibly contributing to bone remodelling. Read More

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January 2022

3-Hydroxykynurenine as a Potential Ligand for Hsp70 Proteins and Its Effects on Drosophila Memory After Heat Shock.

Mol Neurobiol 2022 Jan 14. Epub 2022 Jan 14.

Neurogenetics Laboratory, Pavlov Institute of Physiology RAS, St. Petersburg, Russia.

Kynurenine products of tryptophan metabolism are modifiers of the nervous activity and oxidative processes in mammals and invertebrates. 3-Hydroxykynurenine (3HOK) in moderate concentrations is a lipid peroxidation inhibitor. However, its accumulation and oxidative auto-dimerization lead to oxidative stress development manifested in age-related neurodegenerative diseases (NDD) and neurological disorders provoked by acute stress. Read More

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January 2022

Mitochondrial Homeostasis in Neurodegeneration and Ageing.

Adv Exp Med Biol 2021 ;1339:381-382

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas Medical School, University of Crete, Heraklion, Crete, Greece.

Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules vital for proper cellular function. Although this process is fundamentally haphazard and uncontrollable, senescent decline and ageing is broadly influenced by genetic and extrinsic factors. Numerous gene mutations and treatments have been shown to extend the lifespan of diverse organisms ranging from the unicellular Saccharomyces cerevisiae to primates. Read More

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January 2022

The involvement of TRPM2 on the MPP-induced oxidative neurotoxicity and apoptosis in hippocampal neurons from neonatal mice: protective role of resveratrol.

Neurol Res 2022 Jan 12:1-9. Epub 2022 Jan 12.

Department of Neuroscience, Health Science Institute, Suleyman Demirel University, Isparta, Turkey.

Parkinson's disease (PD) is an age-related chronic neurodegenerative disease. Although PD is known to be a result of damage to hippocampal neurons, its molecular mechanism has yet to be completely clarified. The neurodegeneration in hippocampal neurons has been suggested to include excessive production of reactive oxygen species (ROS). Read More

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January 2022

Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.

Nat Commun 2022 Jan 11;13(1):177. Epub 2022 Jan 11.

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.

Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the roles of a recently discovered enzyme at the heart of metabolism in mammalian cells, glycerol-3-phosphate phosphatase (G3PP) (gene name Pgp) that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol. Read More

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January 2022

Evaluation of lifespan promoting effects of biofortified wheat in Drosophila melanogaster.

Exp Gerontol 2022 Jan 8:111697. Epub 2022 Jan 8.

RNA Biology Laboratory, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad 121001, Haryana, India. Electronic address:

Evaluation of nutritionally enhanced biofortified dietary interventions that increase lifespan may uncover cost-effective and sustainable approaches for treatment of age-related morbidities and increasing healthy life expectancy. In this study, we report that anthocyanin rich, high yielding crossbred blue wheat prolongs lifespan of Drosophila melanogaster in different dietary contexts. In addition to functioning as an antioxidant rich intervention, the biofortified blue wheat also works through modulating expression of DR pathway genes including AMPK alpha, SREBP, PEPCK and Cry. Read More

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January 2022

Therapeutic opportunities for senolysis in cardiovascular disease.

FEBS J 2022 Jan 11. Epub 2022 Jan 11.

MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.

Cellular senescence within the cardiovascular system has, until recently, been understudied and unappreciated as a factor in the development of age-related cardiovascular diseases such as heart failure, myocardial infarction and atherosclerosis. This is in part due to challenges with defining senescence within post-mitotic cells such as cardiomyocytes. However, recent evidence has demonstrated senescent-like changes, including a senescence-associated secretory phenotype, in cardiomyocytes in response to ageing and cell stress. Read More

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January 2022

Targeting Cellular Senescence with Senotherapeutics: Senolytics and Senomorphics.

FEBS J 2022 Jan 11. Epub 2022 Jan 11.

Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis.

The concept of Geroscience is that since aging is the greatest risk factor for many diseases and conditions, targeting the aging process itself will have the greatest impact on human health. Of the hallmarks of aging, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is a cell state of irreversible proliferative arrest driven by different types of stress, including oncogene-induced stress. Read More

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January 2022

Insights into the multifaceted role of circular RNAs: implications for Parkinson's disease pathogenesis and diagnosis.

NPJ Parkinsons Dis 2022 Jan 10;8(1). Epub 2022 Jan 10.

Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece.

Parkinson's disease (PD) is a complex, age-related, neurodegenerative disease whose etiology, pathology, and clinical manifestations remain incompletely understood. As a result, care focuses primarily on symptoms relief. Circular RNAs (circRNAs) are a large class of mostly noncoding RNAs that accumulate with aging in the brain and are increasingly shown to regulate all aspects of neuronal and glial development and function. Read More

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January 2022

Autophagy facilitates age-related cell apoptosis-a new insight from senile cataract.

Cell Death Dis 2022 01 10;13(1):37. Epub 2022 Jan 10.

Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, PR China.

Age-related cell loss underpins many senescence-associated diseases. Apoptosis of lens epithelial cells (LECs) is the important cellular basis of senile cataract resulted from prolonged exposure to oxidative stress, although the specific mechanisms remain elusive. Our data indicated the concomitance of high autophagy activity, low SQSTM1/p62 protein level and apoptosis in the same LEC from senile cataract patients. Read More

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January 2022

Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation.

mBio 2022 Jan 11:e0339421. Epub 2022 Jan 11.

Department of Pathology, School of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA.

Denham Harman's oxidative damage theory identifies superoxide (O) radicals as central agents of aging and radiation injury, with Mn-dependent superoxide dismutase (MnSOD) as the principal O-scavenger. However, in the radiation-resistant nematode Caenorhabditis elegans, the mitochondrial antioxidant enzyme MnSOD is dispensable for longevity, and in the model bacterium Deinococcus radiodurans, it is dispensable for radiation resistance. Many radiation-resistant organisms accumulate small-molecule Mn-antioxidant complexes well-known for their catalytic ability to scavenge O, along with MnSOD, as exemplified by D. Read More

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January 2022

High-Content Screen Identifies Natural Compounds Impacting Mitochondria-Lipid Homeostasis and Promoting Healthspan.

Cells 2021 Dec 29;11(1). Epub 2021 Dec 29.

IUF-Leibniz Research Institute for Environmental Medicine, 40225 Duesseldorf, Germany.

The aging process is concurrently shaped by genetic and extrinsic factors. In this work, we screened a small library of natural compounds, many of marine origin, to identify novel possible anti-aging interventions in , a powerful model organism for aging studies. To this aim, we exploited a high-content microscopy platform to search for interventions able to induce phenotypes associated with mild mitochondrial stress, which is known to promote animal's health- and lifespan. Read More

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December 2021

Molecular Insights into the Antistress Potentials of Brazilian Green Propolis Extract and Its Constituent Artepillin C.

Molecules 2021 Dec 23;27(1). Epub 2021 Dec 23.

AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305-8565, Japan.

Propolis, also known as bee-glue, is a resinous substance produced by honeybees from materials collected from plants they visit. It contains mixtures of wax and bee enzymes and is used by bees as a building material in their hives and by humans for different purposes in traditional healthcare practices. Although the composition of propolis has been shown to depend on its geographic location, climatic zone, and local flora; two largely studied types of propolis: (i) New Zealand and (ii) Brazilian green propolis have been shown to possess Caffeic Acid Phenethyl Ester (CAPE) and Artepillin C (ARC) as the main bioactive constituents, respectively. Read More

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December 2021

Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake.

Int J Mol Sci 2021 Dec 24;23(1). Epub 2021 Dec 24.

Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 113 Żeromskiego Street, 90-549 Lodz, Poland.

Ageing, in a natural way, leads to the gradual worsening of the functional capacity of all systems and, eventually, to death. This process is strongly associated with higher metabolic and oxidative stress, low-grade inflammation, accumulation of DNA mutations and increased levels of related damage. Detrimental changes that accumulate in body cells and tissues with time raise the vulnerability to environmental challenges and enhance the risk of major chronic diseases and mortality. Read More

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December 2021

ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation.

Int J Mol Sci 2021 Dec 24;23(1). Epub 2021 Dec 24.

Institute of Physiological Chemistry and Pathobiochemistry, Waldeyerstraße 15, 48149 Muenster, Germany.

Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum (ER) of chondrocytes. This condition is called ER stress and leads to induction of the unfolded protein response (UPR), which, depending on the stress level, restores normal cell function or initiates apoptotic cell death. Here the role of ER stress in knee osteoarthritis (OA) was evaluated. Read More

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December 2021

STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway.

Life Sci 2022 Jan 7:120089. Epub 2022 Jan 7.

Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Aim: Aging-related dysfunction of retinal pigment epithelium (RPE) is the main pathogenic factors for pathological angiogenesis due to dysregulated vascular endothelial growth factor (VEGF) in retinal vascular diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR). However, the molecular mechanism behind the up-regulation of VEGF in senescent RPE is still blurred.

Materials And Methods: As oxidative damage is the key cause of RPE dysfunction, we employed a model of oxidative stress-induced premature senescence of ARPE-19 to explore the effect of senescent RPE on VEGF. Read More

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January 2022

Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy.

Genes Dis 2022 Jan 27;9(1):62-79. Epub 2021 Feb 27.

The Key Laboratory for Human Disease Gene Study of Sichuan Province, Department of Clinical Laboratory, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, PR China.

Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). Read More

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January 2022

Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases.

Front Cardiovasc Med 2021 23;8:778674. Epub 2021 Dec 23.

Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

Forkhead box O3 (FOXO3) has been proposed as a homeostasis regulator, capable of integrating multiple upstream signaling pathways that are sensitive to environmental changes and counteracting their adverse effects due to external changes, such as oxidative stress, metabolic stress and growth factor deprivation. FOXO3 polymorphisms are associated with extreme human longevity. Intriguingly, longevity-associated single nucleotide polymorphisms (SNPs) in human correlate with lower-than-average morbidity from cardiovascular diseases in long-lived people. Read More

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December 2021

Addressing the biological embedding of early life adversities (ELA) among adults through mindfulness: Proposed mechanisms and review of converging evidence.

Neurosci Biobehav Rev 2022 Jan 5;134:104526. Epub 2022 Jan 5.

Department of Behavioral and Social Sciences, Brown University School of Public Health, United States; Mindfulness Center at Brown University, United States.

Early life adversities (ELA) are prevalent and have a profound and adverse impact across the lifespan, including on age-related health outcomes, yet interventions to remediate its adverse impact are scarce. This paper presents evidence for mindfulness training to reduce the elevated mental and physical health risks linked to ELA among adults by targeting biological mechanisms of ELA leading to these adverse health outcomes. We first provide a brief overview of ELA, its adverse health impacts, and mechanisms that might be responsible. Read More

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January 2022

Dec1 deficiency restores the age-related dysfunctions of submandibular glands.

J Physiol Pharmacol 2021 Aug 31;72(4). Epub 2021 Dec 31.

Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, India.

Age-related organ and tissue-specific cell kinetic and morphological alterations are associated with the incidence of numerous diseases in old age. Salivary dysfunction frequently appears in a wide range of older people and thus is a physiological and biological aspect of aging. The transcription factor Dec1 (differentiated embryo chondrocyte expressed gene 1) is essential for the regulation of cellular senescence. Read More

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Neuroinflammation and Behavioral Deficit in Rotenone-Induced Neurotoxicity in Rats and the Possible Effects of Butanolic Extract of Centaurea Africana.

Recent Adv Inflamm Allergy Drug Discov 2022 Jan 5. Epub 2022 Jan 5.

Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri Constantine1, Algérie.

Background: Many studies have used rotenone (ROT) to create an experimental animal model of Parkinson's disease (PD) because of its ability to induce similar behavioral and motor deficits. PD is the most common age-related motoric neurodegenerative disorder. Neuroinflammation and apoptosis play an important role in the pathogenesis of this disease. Read More

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January 2022

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category.

Geriatr Gerontol Int 2022 Jan 5. Epub 2022 Jan 5.

Department of Diabetes, Metabolism and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

Although the lifespan of people with diabetes has increased in many countries, the age-related increase in comorbidities (sarcopenia, frailty and disabilities) and diabetic complications has become a major issue. Diabetes accelerates the aging of skeletal muscles and blood vessels through mechanisms, such as increased oxidative stress, chronic inflammation, insulin resistance, mitochondrial dysfunction, genetic polymorphism (fat mass and obesity-associated genes) and accumulation of advanced glycation end-products. Diabetes is associated with early onset, and progression of muscle weakness and sarcopenia, thus resulting in diminished daily life function. Read More

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January 2022

Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD.

Exp Eye Res 2022 Jan 2:108918. Epub 2022 Jan 2.

The Stephen J. Ryan Initiative for Macular Research (RIMR), Doheny Eye Institute, Los Angeles, CA, 90033, USA; Stein Eye Institute, Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. Electronic address:

Oxidative stress in the retinal pigment epithelium (RPE) can cause mitochondrial dysfunction and is likely a causative factor in the pathogenesis of age-related macular degeneration (AMD). Under oxidative stress conditions, some of the RPE cells become senescent and a contributory role for RPE senescence in AMD pathology has been proposed. The purpose of this study is to 1) characterize senescence in human RPE; 2) investigate the effect of an αB Crystallin chaperone peptide (mini Cry) in controlling senescence, in particular by regulating mitochondrial function and senescence-associated secretory phenotype (SASP) production and 3) develop mouse models for studying the role of RPE senescence in dry and nAMD. Read More

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January 2022

Benefits, mechanisms, and risks of intermittent fasting in metabolic syndrome and type 2 diabetes.

J Physiol Biochem 2022 Jan 5. Epub 2022 Jan 5.

Instituto Politécnico de Coimbra, Coimbra Health School (ESTeSC), Coimbra, Portugal.

One of the emergent nutritional strategies for improving multiple features of cardiometabolic diseases is the practice of intermittent fasting (IF), which consists of alternating periods of eating and fasting. IF can reduce circulating glucose and insulin levels, fat mass, and the risk of developing age-related pathologies. IF appears to upregulate evolution-conserved adaptive cellular responses, such as stress-response pathways, autophagy, and mitochondrial function. Read More

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January 2022

Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities.

Authors:
Rohit Sharma

Probiotics Antimicrob Proteins 2022 Jan 5. Epub 2022 Jan 5.

Faculty of Applied Sciences & Biotechnology, Shoolini University, Solan, 173229, India.

The significance of diversity, composition, and functional attributes of the gut microbiota in shaping human health is well recognized. Studies have shown that gut microbiota is closely linked to human aging, and changes in the gut microbiome can predict human survival and longevity. In addition, a causal relationship between gut microbiota dysbiosis and chronic age-related disorders is also becoming apparent. Read More

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January 2022

Preliminary evidence of differential expression of myogenic and stress factors in skeletal muscle of older adults with low muscle strength.

J Gerontol A Biol Sci Med Sci 2022 Jan 4. Epub 2022 Jan 4.

Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Belgium.

The age-related loss of muscle strength and mass, or sarcopenia, is a growing concern in the ageing population. Yet, it is not fully understood which molecular mechanisms underlie sarcopenia. Therefore, the present study compared the protein expression profile, such as catabolic, oxidative, stress-related and myogenic pathways, between older adults with preserved (8 ♀ and 5 ♂; 71. Read More

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January 2022