237,075 results match your criteria strategy study


Pilates improves physical performance and decreases risk of falls in older adults: a systematic review and meta-analysis.

Physiotherapy 2021 Jun 7;112:163-177. Epub 2021 Jun 7.

Universidad de Castilla La-Mancha, Health and Social Research Center, Cuenca, Spain; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile.

Background: Falls are the leading cause of injury-related deaths in older adults. Physical exercise is a suitable strategy to reduce the risk of falls, but there is little research on the effectiveness of specific exercise modalities.

Objectives: To estimate the effectiveness of Pilates compared to habitual or non-exercise on physical performance and the risk of falls in older adults. Read More

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Investigation into the impact of aged microplastics on oil behavior in shoreline environments.

J Hazard Mater 2021 Jul 21;421:126711. Epub 2021 Jul 21.

Department of Building, Civil and Environmental Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.

Understanding the interactions between oil and other particles in shoreline can help determine the environmental risk and cleanup strategy after oil spill. Nevertheless, far less has been known regarding the impact of aged MPs on oil behavior in the shoreline environment. In this study, the aging course of polyethylene (PE) in shaking seawater and ultraviolet (UV) radiation conditions was investigated. Read More

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Calcium hypochlorite enhances the digestibility of and the phosphorus recovery from waste activated sludge.

Bioresour Technol 2021 Jul 26;340:125658. Epub 2021 Jul 26.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada. Electronic address:

Waste activated sludge (WAS) can be treated using anaerobic digestion (AD) for biogas recovery and volume reduction. However, the poor digestibility and hydrolysis of WAS limit AD applications. The current study investigated the feasibility of applying calcium hypochlorite as a WAS pretreatment strategy to improve AD treatment efficiency using laboratory reactors. Read More

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A fed-batch feeding with succinic acid strategy for astaxanthin and lipid hyper-production in Haematococcus pluviualis.

Bioresour Technol 2021 Jul 26;340:125648. Epub 2021 Jul 26.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address:

Effects of succinic acid (SA) in fed-batch feeding mode on astaxanthin and lipids biopoduction of Haematococcus pluvialis against abiotic stresses were explored. By comparison with the control, the initial addition of SA on day 0 increased the production of astaxanthin by 71.61%. Read More

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Unique ternary Ni-MOF-74/NiP/MoS composite for efficient photocatalytic hydrogen production: Role of NiP for accelerating separation of photogenerated carriers.

J Colloid Interface Sci 2021 Jul 24;605:385-397. Epub 2021 Jul 24.

School of Chemistry and Chemical Engineering, Ningxia Key Laboratory of Solar Chemical Conversion Technology, Key Laboratory for Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, PR China. Electronic address:

A reasonable introduction of MOFs-derived NiP with high dispersity is a valid way to reduce the recombination rate of photogenerated electron-holes, thus for more effective visible-light-driven water splitting. In this study, Ni-MOF-74/NiP precursor was obtained by low-temperature phosphating method. A ternary heterojunction Ni-MOF-74/NiP/MoS with a unique structure is obtained by a solution-based mixing method. Read More

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Computational identification of repurposed drugs against viruses causing epidemics and pandemics via drug-target network analysis.

Comput Biol Med 2021 Jul 23;136:104677. Epub 2021 Jul 23.

Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39-A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address:

Viral epidemics and pandemics are considered public health emergencies. However, traditional and novel antiviral discovery approaches are unable to mitigate them in a timely manner. Notably, drug repurposing emerged as an alternative strategy to provide antiviral solutions in a timely and cost-effective manner. Read More

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Sleep-related problems and eating habits during COVID-19 lockdown in a southern Brazilian youth sample.

Sleep Med 2021 Jul 7;85:150-156. Epub 2021 Jul 7.

Department of Sports and Computer Science, Universidad Pablo de Olavide (UPO), 41013 Seville, Spain; PDU EFISAL, Centro Universitario Regional Noreste, Universidad de la República (UDELAR), 40000 Rivera, Uruguay. Electronic address:

The pandemic has affected children's behaviors and this fact has an effect on their healthy habits, such as sleep and diet. The aim of the current study was to determinate the prevalence of sleep-related problems and its relationship with eating habits in children from the south of Brazil during the pandemic. Parents/legal guardians of 3-17 years old participants responded to a online survey distributed using the snowball sampling strategy in Brazil. Read More

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A five-dimensional data collection strategy for multicomponent discovery and characterization in Traditional Chinese Medicine: Gastrodia Rhizoma as a case study.

J Chromatogr A 2021 Jul 14;1653:462405. Epub 2021 Jul 14.

Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:

Establishing the identity of bioactive compounds to control the quality of Traditional Chinese Medicines is made more challenging by the complexity of the metabolite matrix, the existence of isomers, and the range of compound concentration and polarity observed between individual samples of the same plant in a multicomponent preparation. In addition, LC-MS analysis has limited capability for the separation and analysis of potentially important trace compounds and isomers, which hinders the comprehensive metabolite characterization of functional foods and Traditional Natural Medicine. To facilitate and improve the chemical composition characterization and enhance metabolite discernment, a comprehensive strategy was developed which integrates ion mobility mass spectrometry (IMS) with offline two-dimensional liquid chromatography based on hydrophilic interaction chromatography (HILIC) and conventional reversed phase (RP) C18 chromatography. Read More

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FaHSP17.8-CII orchestrates lead tolerance and accumulation in shoots via enhancing antioxidant enzymatic response and PSII activity in tall fescue.

Ecotoxicol Environ Saf 2021 Jul 28;223:112568. Epub 2021 Jul 28.

College of Agriculture, Henan University of Science and Technology, Luoyang, China. Electronic address:

Tall fescue (Festuca arundinacea Schreb.) shows huge potential for lead (Pb) phytoremediation, while little is known on the molecular mechanisms involved in Pb tolerance and accumulation. Here, genetic engineering strategy was firstly used to investigate Pb tolerance and accumulation in tall fescue. Read More

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Direct Reprogramming Induces Vascular Regeneration Post Muscle Ischemic Injury.

Mol Ther 2021 Jul 28. Epub 2021 Jul 28.

Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA, 10029; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA, 10029; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA, 10029. Electronic address:

Reprogramming non-cardiomyocytes (non-CMs) into cardiomyocyte (CM)-like cells is a promising strategy for cardiac regeneration in conditions such as ischemic heart disease. Here, we used a modified mRNA (modRNA) gene delivery platform to deliver a cocktail of four cardiac-reprogramming genes (Gata4 (G), Mef2c (M), Tbx5 (T) and Hand2 (H)) together with three reprogramming-helper genes (Dominant Negative (DN)-TGFβ, DN-Wnt8a and Acid ceramidase (AC)), termed 7G-modRNA, to induce CM-like cells. We showed that 7G-modRNA reprogrammed 57% of CM-like cells in vitro. Read More

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Immunometabolism in human brucellosis: An emerging field of investigation.

Microb Pathog 2021 Jul 28:105115. Epub 2021 Jul 28.

Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

In recent years, extreme attention has been focused on the role of immunometabolism in the regulation of immune cell responses in healthy individuals during infection, autoimmunity, and cancer. In the infection biology area, it has been shown that there is a close relationship between the immune system and the host metabolic changes. Brucella species is an intracellular coccobacillus that infects humans and mammals, which led to brucellosis. Read More

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The discovery and characterization of a novel chitinase with dual catalytic domains from a Qinghai-Tibetan Plateau wetland soil metagenome.

Int J Biol Macromol 2021 Jul 28. Epub 2021 Jul 28.

College of Life Sciences, Sichuan Normal University, Chengdu 610101, PR China.

A novel chitinase (P1724) was discovered from a Qinghai-Tibetan plateau microbial metagenome. P1724 contains two GH18 family catalytic domains and is phylogenetically distant from any of the chitinases studied. P1724 and its truncated versions, P1724(∆cGH18) and P1724(∆nGH18), were produced in Escherichia coli and characterized. Read More

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Vorinostat targets UBE2C to reverse epithelial-mesenchymal transition and control cervical cancer growth through the ubiquitination pathway.

Eur J Pharmacol 2021 Jul 28:174399. Epub 2021 Jul 28.

Foshan Maternal and Child Health Research Institute, South Medical University Affiliated Maternal & Child Health Hospital of Foshan, Foshan, 528000, China; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Vorinostat is a histone deacetylase inhibitor (HDACi) that was demonstrated in our previous study to inhibit the proliferation, migration, and invasion of cervical cancer cells by regulating the PI3K/Akt signaling pathway. However, the molecular mechanism of vorinostat in cervical cancer treatment remains to be further elucidated. A nude mouse xenograft model was established to analyze the antitumor effect of vorinostat in vivo. Read More

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Oral vaccination with attenuated Salmonella encoding the Trichinella spiralis 43-kDa protein elicits protective immunity in BALB/c mice.

Acta Trop 2021 Jul 28:106071. Epub 2021 Jul 28.

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China; Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Agricultural University, Changchun, China; Key Laboratory of animal production and product quality safety of Ministry of Education, Jilin Agricultural University, Changchun, China. Electronic address:

A vaccine against Trichinella spiralis infection is urgently needed to interrupt its transmission from domestic animals to humans. However, no vaccine against T. spiralis is currently available. Read More

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A semi-Markov model comparing the lifetime cost-effectiveness of mesh prophylaxis to prevent parastomal hernia in patients undergoing end colostomy creation for rectal cancer.

Colorectal Dis 2021 Jul 31. Epub 2021 Jul 31.

The CIPHER study group investigators.

Aim: Parastomal hernia (PSH) is a common problem following colostomy. Using prophylactic mesh during end colostomy creation may reduce PSH incidence, but concerns exist regarding the optimal type of mesh, potential long-term complications, and cost-effectiveness of its use. We evaluated the cost-effectiveness of mesh prophylaxis to prevent PSH in patients undergoing end colostomy for rectal cancer. Read More

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Improving systems of antenatal and postpartum care for hyperglycemia in pregnancy: A process evaluation.

Int J Gynaecol Obstet 2021 Jul 31. Epub 2021 Jul 31.

Menzies School of Health Research, Charles Darwin University, Darwin, Australia.

Objective: To identify successes to date and opportunities for improvement in the implementation of a complex health systems intervention aiming to improve antenatal and postpartum care and health outcomes for women with hyperglycemia in pregnancy in regional and remote Australia.

Methods: A qualitative evaluation, underpinned by the RE-AIM framework (reach, effectiveness, adoption, implementation, maintenance), was conducted mid-intervention. Semi-structured interviews were conducted with 45 participants, including clinicians; regional policymakers and managers; and study implementation staff. Read More

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Impact of probiotics supplement on the gut microbiota in neonates with antibiotic exposure: an open-label single-center randomized parallel controlled study.

World J Pediatr 2021 Jul 31. Epub 2021 Jul 31.

Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai, China.

Background: Antibiotics, a common strategy used for neonatal infection, show consistent effect on the gut microbiota of neonates. Supplementation with probiotics has become increasingly popular in mitigating the loss of the gut microbiota. However, no clear consensus recommending the use of probiotics in the infection of neonates currently exists. Read More

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In silico screening of neurokinin receptor antagonists as a therapeutic strategy for neuroinflammation in Alzheimer's disease.

Mol Divers 2021 Jul 31. Epub 2021 Jul 31.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Neuroinflammation is one of the detrimental factors leading to neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative disorders. The activation of microglial neurokinin 1 receptor (NK1R) by substance P (SP) enhances neuroinflammation which is mediated through pro-inflammatory pathways involving NFkB, ERK1/2, and P38 and thus projects the scope and importance of NK1R inhibitors. Emphasizing the inhibitory role of N Acetyl L Tryptophan (L-NAT) on NK1R, this is the first in silico screening of L-NAT mediated NK1R antagonism. Read More

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Study on ecological adaptability construction characteristics of residential buildings in Kangba area, Tibet, China.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

College of Enviromental Science and Engineering, Ocean University of China, Qingdao, 266100, China.

Located in the southwest of the Qinghai-Tibet Plateau, Tibet is characterized by high cold, high radiation, and large differences in temperature between day and night. Tibetan residential buildings are famous for adapting to the harsh ecological environment and maintaining durability. Based on the residential buildings in Tibet, this paper extracts the technical process and color decoration culture in the construction process in order to adapt to the harsh natural environment. Read More

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Predictive model of global tilt (GT) determined by individual thoracic kyphosis, lumbar lordosis and pelvic incidence in the human degenerative spine.

Eur Spine J 2021 Jul 31. Epub 2021 Jul 31.

Department of Spine Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, People's Republic of China.

Purpose: Previous studies only investigated the simple linear relationships of global tilt (GT) with thoracic kyphosis (TK), lumbar lordosis (LL) and pelvic incidence (PI). This study aimed to establish multiple linear regressions of GT based on individual TK, LL and PI in patients with degenerative spines.

Methods: Four hundred sixty-nine adult patients aged older than 35 years with various degenerative spinal diseases were enrolled in this two-centre study between January 2017 and December 2020. Read More

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Invasive tree cover covaries with environmental factors to explain the functional composition of riparian plant communities.

Oecologia 2021 Jul 31. Epub 2021 Jul 31.

Department of Biological Sciences, University of Denver, Denver, CO, USA.

Invasive species are a major cause of biodiversity loss worldwide, but their impact on communities and the mechanisms driving those impacts are varied and not well understood. This study employs functional diversity metrics and guilds-suites of species with similar traits-to assess the influence of an invasive tree (Tamarix spp.) on riparian plant communities in the southwestern United States. Read More

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Simultaneous LC-MS/MS bioanalysis of alkaloids, terpenoids, and flavonoids in rat plasma through salting-out-assisted liquid-liquid extraction after oral administration of extract from Tetradium ruticarpum and Glycyrrhiza uralensis: a sample preparation strategy to broaden analyte coverage of herbal medicines.

Anal Bioanal Chem 2021 Jul 31. Epub 2021 Jul 31.

Institute of Chinese Materia Medica, The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.

Herbal medicines have historically been practiced in combinatorial way, which achieves therapeutic efficacy by integrative effects of multi-components. Thus, the accurate and precise measurement of multi bioactive components in matrices is inalienable to understanding the metabolism and disposition of herbal medicines. In this study, aiming to provide a strategy that improves analyte coverage, evaluation of six protocols employing sample pretreatment methods- protein precipitation (PPT), liquid-liquid extraction (LLE), sugaring-out-assisted liquid-liquid extraction (SULLE), and salting-out-assisted liquid-liquid extraction (SALLE)- was performed by LC-MS/MS using rat plasma and a mixture of alkaloid (evodiamine, rutaecarpine, dehydroevodiamine), terpenoid (limonin, rutaevin, obacunone), and flavonoid (liquiritin, isoliquiritin, liquiritigenin) standards isolated from Tetradium ruticarpum and Glycyrrhiza uralensis. Read More

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Field evaluation of specific mycobacterial protein-based skin test for the differentiation of Mycobacterium bovis-infected and bacillus calmette guerin-vaccinated crossbred cattle in ethiopia.

Transbound Emerg Dis 2021 Jul 31. Epub 2021 Jul 31.

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.

Bovine tuberculosis (bTB) challenges intensive dairy production in Ethiopia and implementation of the test and slaughter control strategy is not economically acceptable in the country. Vaccination of cattle with Bacillus Calmette-Guerin (BCG) could be an important adjunct to control, which would require a diagnostic test to differentiate Mycobacterium bovis (M. bovis)-infected and BCG-vaccinated animals (DIVA role). Read More

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Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.

Pediatr Blood Cancer 2021 Jul 31:e29237. Epub 2021 Jul 31.

University Hospital Southampton NHS Foundation Trust, Southampton, UK.

There is increasing recognition that contralateral metachronous tumor may occur following treatment of unilateral mature ovarian teratoma. We aimed to define this risk to guide appropriate surveillance strategies. We undertook a systematic review of three large medical databases (Ovid Medline, Embase, and Cochrane Controlled Trials Register) to April 2020 using a defined search strategy. Read More

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FALL PREVENTION EDUCATION TO REDUCE FALL RISK AMONG COMMUNITY-DWELLING OLDER PERSONS: A SYSTEMATIC REVIEW.

J Nurs Manag 2021 Jul 31. Epub 2021 Jul 31.

Department of Sport Studies, Faculty of Educational Studies, Universiti Putra, Malaysia, Serdang, Selangor.

Objectives: This review aims to identify types of the existing fall prevention education and their effectiveness in promoting fall risk awareness, knowledge and preventive fall behaviour change among community-dwelling older people.

Background: Fall prevention education is a cost-effective and helpful tool for reducing fall occurrences.

Evaluation: This is a systematic review study using electronic searches via EBSCOHost® platform, ScienceDirect, Scopus and Google Scholar in March 2021. Read More

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Validation of the Orlando Protocol for endoscopic management of pancreatic fluid collections in the era of lumen-apposing metal stents.

Dig Endosc 2021 Jul 31. Epub 2021 Jul 31.

Digestive Health Institute, Orlando Health, Orlando, Florida, USA.

Objectives: Although lumen-apposing metal stents (LAMS) are being increasingly used in lieu of plastic stents, clinical approach to endoscopic management of pancreatic fluid collections (PFCs) is poorly standardized. We compared outcomes of approaches over two time intervals, initially using plastic stents and later integrating LAMS.

Methods: This was a retrospective, observational, before-after study of prospectively collected data on consecutive patients with symptomatic PFCs managed over two time periods. Read More

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Statin use and survival in 16 098 patients with non-Hodgkin lymphoma or chronic lymphocytic leukaemia treated in the rituximab era.

Br J Haematol 2021 Jul 31. Epub 2021 Jul 31.

Department of Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.

Statin use has been associated with reduced mortality from several cancers but also suggested, in vitro, to diminish the effectiveness of lymphoma treatments including rituximab. The present study aimed to assess the association of statin use with mortality in patients with non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). We identified all incident NHLs and CLLs in Sweden from 2007 to 2013 with subtype information in the Swedish Lymphoma and Cancer Registers. Read More

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A Novel Stimuli-Responsive Injectable Antibacterial Hydrogel to Achieve Synergetic Photothermal/Gene-Targeted Therapy towards Uveal Melanoma.

Adv Sci (Weinh) 2021 Jul 31:e2004721. Epub 2021 Jul 31.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, P. R. China.

Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high lethal rate. Patients who undergo conventional enucleation treatments consistently suffer permanent blindness, facial defects, and mental disorders, therefore, novel therapeutic modalities are urgently required. Herein, an injectable and stimuli-responsive drug delivery antibacterial hydrogel ([email protected]@DC_AC50) is constructed via a facile grinding method that is inspired by the preparation process of traditional Chinese medicine. Read More

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Prevalence of fatigue and associated factors among clinically stable patients with chronic obstructive pulmonary disease in Guizhou, China:A Cross-Sectional Study.

Clin Respir J 2021 Jul 31. Epub 2021 Jul 31.

Affiliated Hospital of Zunyi Medical University, ZunYi, Guizhou.

Introduction: Fatigue is important, but ignored symptom among COPD patients. At present there is very limited data are available for the prevalence of fatigue and its risk factors among COPD patients in China.

Objective: The purpose of this study is to determine the prevalence of fatigue and to investigate the factors associated with fatigue among clinically stable patients with COPD in China. Read More

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Improving Safety for Day Case Adenotonsillectomy in Paediatric Obstructive Sleep Apnoea.

Clin Otolaryngol 2021 Jul 31. Epub 2021 Jul 31.

Paediatric Anaesthetic Department, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Outcomes following adenotonsillectomy for paediatric obstructive sleep apnoea from our centre support the paediatric national safety strategy recommendations published in 2019 Age and significant comorbidities are key factors in determining post-operative complication risk following adenotonsillectomy in paediatric patients with obstructive sleep apnoea Day case surgery is safe for children aged 2 and over who do not have comorbidities There is no significant difference in post-operative bleeding rates for intracapsular coblation verses extracapsular dissection tonsillectomy techniques in our study. Read More

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