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The associations between smart device use and psychological distress among secondary and high school students in Kuwait.

PLoS One 2021 15;16(6):e0251479. Epub 2021 Jun 15.

Department of Physical Education, College of Basic Education, The Public Authority for Applied Education and Training, Kuwait.

Background: Smart devices (SDs) are widely used among adolescents. Numerous studies have recommended further research on this topic to find out the prevalence of SD overuse among school students and to what extent this is associated with psychological distress. The present study aimed to investigate the pattern of SD use among secondary and high school students in the state of Kuwait, as well as the possible associations with psychological problems, weight, physical activity, and school performance. Read More

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Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma.

Pediatr Blood Cancer 2021 Jun 14:e29172. Epub 2021 Jun 14.

Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.

Background: Central nervous system (CNS) germinomas are treatment-sensitive tumors with excellent survival outcomes. Current treatment strategies combine chemotherapy with radiotherapy (RT) in order to reduce the field and dose of RT. Germinomas originating in the basal ganglia/thalamus (BGTGs) have proven challenging to treat given their rarity and poorly defined imaging characteristics. Read More

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Liposomal Form of L-Dopa and SH-Sy5y Cell-Derived Exosomes Modulate the Tyrosine Hydroxylase/Dopamine Receptor D2 Signaling Pathway in Parkinson's Rat Models.

J Mol Neurosci 2021 Jun 14. Epub 2021 Jun 14.

Biology Department, Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.

Parkinson's disease is a progressive neurodegenerative disorder in which dopaminergic neurons located in the substantia nigra are gradually lost. Currently, combined treatment strategies are receiving increasing attention as potential therapeutic approaches for Parkinson's disease. This study aimed to evaluate the potential effects of exosomes released from SH-Sy5y cells and the liposomal form of L-dopa on Parkinson's rat models. Read More

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Effectiveness of Perioperative Opioid Educational Initiatives: A Systematic Review and Meta-Analysis.

Anesth Analg 2021 Jun 11. Epub 2021 Jun 11.

Department of Anesthesiology, Hospital for Special Surgery, New York, New York.

Background: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid education on postoperative opioid consumption patterns including opioid cessation, number of pills consumed, and opioid prescription refills. Read More

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Uncovering transmission patterns of COVID-19 outbreaks: A region-wide comprehensive retrospective study in Hong Kong.

EClinicalMedicine 2021 Jun 6:100929. Epub 2021 Jun 6.

Department of Computer Science, Hong Kong Baptist University, Hong Kong Special Administrative Region, People's Republic of China.

Background: Given the dynamism and heterogeneity of COVID-19 transmission patterns, determining the most effective yet timely strategies for specific regions remains a severe challenge for public health decision-makers.

Methods: In this work, we proposed a spatiotemporal connectivity analysis method for discovering transmission patterns across geographic locations and age-groups throughout different COVID-19 outbreak phases. First, we constructed the transmission networks of the confirmed cases during different phases by considering the spatiotemporal connectivity of any two cases. Read More

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A Patient-Controlled Intravenous Analgesia With Tramadol Ameliorates Postpartum Depression in High-Risk Woman After Cesarean Section: A Randomized Controlled Trial.

Front Med (Lausanne) 2021 27;8:679159. Epub 2021 May 27.

Department of Anesthesiology, Second Affiliated Hospital of Army Medical University, People's Liberation Army of China (PLA), Chongqing, China.

Postpartum depression (PPD) is a severe psychiatric disorder. Its risk is associated with the cesarean section (CS). Currently, there are few early intervention strategies for these women with PPD who underwent CS. Read More

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Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study.

Front Oncol 2021 26;11:676683. Epub 2021 May 26.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Objective: Atypical meningioma is a non-benign tumor, and its prognostic factors and treatment strategies are unclear.

Methods: Patients with atypical meningioma, between 2004 and 2016, were collected from the Surveillance, Epidemiology, and End Results database. Then, we randomly divided patients into a training set and a validation set at a ratio of 8:2. Read More

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The Effectiveness of Psychosocial Interventions for Elder Abuse in Community Settings: A Systematic Review and Meta-Analysis.

Front Psychol 2021 26;12:679541. Epub 2021 May 26.

Graduate School of Social Work, University of Denver, Denver, CO, United States.

As a global public health concern, elder abuse negatively affects health, psychosocial wellbeing, and mortality among elders. Research and practice efforts made to explore effective prevention and intervention strategies are growing. Despite the growing number of intervention studies on elder abuse, research synthesis on the empirical literature seems lacking. Read More

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A ten-year review of childhood obesity in a teaching hospital, South West Nigeria.

Niger J Clin Pract 2021 Jun;24(6):841-846

Department of Paediatrics, Faculty of Clinical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.

Background: Obesity is an important cosmopolitan cause of morbidity in children and adolescence age groups. Information on obesity in this age group in Nigeria is scant.

Aim: To determine the prevalence of obesity and the associated morbidities seen at the Paediatric Endocrinology clinic of Ekiti State University Teaching Hospital, South West, Nigeria. Read More

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Exploring the associations among occupational balance and health of adults with and without inflammatory arthritis.

Arthritis Care Res (Hoboken) 2021 Jun 13. Epub 2021 Jun 13.

Department of Occupational Science & Occupational Therapy, The University of British Columbia, Vancouver, BC, Canada.

Objective: Occupational balance is a person's subjective perception of the amount and variation of their everyday activities. Evidence suggests an association between occupational balance and health. However, the impact of arthritis on occupational balance and its association with health is unclear. Read More

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Analysis of mental health symptoms and insomnia levels of intensive care nurses during the COVID-19 pandemic with a structural equation model.

J Clin Nurs 2021 Jun 13. Epub 2021 Jun 13.

Faculty of Health Sciences, Nursing Department, Artvin Coruh University, Artvin, Turkey.

Background: Faced with this critical situation and directly involved in the treatment and care of COVID-19 patients, front-line healthcare workers are at high risk in terms of mental health symptoms.

Aims And Objectives: To determine the stress, anxiety, depression, and insomnia levels of intensive care nurses during the pandemic with a structural equation model.

Design: A multi-site survey study. Read More

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Umbrella review of 42 systematic reviews with meta-analyses: the safety of proton pump inhibitors.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.

Background: Proton pump inhibitors (PPIs) are widely used to treat and prevent acid-related disorders. Despite high efficacy, PPI safety has been increasingly scrutinised. However, no comprehensive review summarising investigations of various adverse events is available. Read More

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Students' Perceptions and Attitudes After Exposure to Three Different Instructional Strategies in Applied Anatomy.

Adv Med Educ Pract 2021 4;12:607-612. Epub 2021 Jun 4.

Anatomy Department, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Background: The advancements of technologies have developed anatomical education into a new era. The study aims to assess medical students' performance and overall satisfaction who used the anatomage table and plastinated specimens for the teaching and learning anatomy courses.

Methods: A cross-sectional study was conducted on students of the first-year college of medicine at Imam Mohammad Ibn Saud Islamic University (IMSIU). Read More

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Differential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors.

Sci Rep 2021 Jun 10;11(1):12303. Epub 2021 Jun 10.

Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112-5550, USA.

Neuroendocrine tumors (NETs) of the small intestine undergo large chromosomal and methylation changes. The objective of this study was to identify methylation differences in NETs and consider how the differentially methylated genes may impact patient survival. Genome-wide methylation and chromosomal copy number variation (CNV) of NETs from the small intestine and appendix were measured. Read More

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On anesthesia and race.

J Natl Med Assoc 2021 Jun 7. Epub 2021 Jun 7.

Boston University School of Medicine, Boston, MA, USA.

Racial tensions continue to ignite social unrest in the United States. Structural racism is increasingly recognized as a public health issue. It is therefore necessary to continue addressing the interaction of race and medicine, including anesthesiology. Read More

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Schema modes and their associations with emotion regulation, mindfulness, and self-compassion among patients with personality disorders.

Borderline Personal Disord Emot Dysregul 2021 Jun 10;8(1):19. Epub 2021 Jun 10.

Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.

Background: The current study's goal was to examine the multivariate patterns of associations between schema modes and emotion regulation mechanisms in personality disorders. Schema modes are either integrated or dissociative states of mind, including intense emotional states, efforts to regulate emotions, or self-reflective evaluative thought processes. Exploring the multivariate patterns of a shared relationship between schema modes and emotion regulation strategies may lead to a better understanding of their associations and a deeper understanding of the latent personality profiles that organize their associations in a mixed personality disorder sample. Read More

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Additively manufactured titanium scaffolds and osteointegration - meta-analyses and moderator-analyses of in vivo biomechanical testing.

Biomater Res 2021 Jun 10;25(1):18. Epub 2021 Jun 10.

European Face Centre, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 1090, Brussels, Belgium.

Introduction: Maximizing osteointegration potential of three-dimensionally-printed porous titanium (3DPPT) is an ongoing focus in biomaterial research. Many strategies are proposed and tested but there is no weighted comparison of results.

Methods: We systematically searched Pubmed and Embase to obtain two pools of 3DPPT studies that performed mechanical implant-removal testing in animal models and whose characteristics were sufficiently similar to compare the outcomes in meta-analyses (MAs). Read More

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Impact of Physician Training Level on Neonatal Tracheal Intubation Success Rates and Adverse Events: A Report from National Emergency Airway Registry for Neonates (NEAR4NEOS).

Neonatology 2021 Jun 10:1-9. Epub 2021 Jun 10.

Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Introduction: Neonatal tracheal intubation (TI) outcomes have been assessed by role, but training level may impact TI success and safety. Effect of physician training level (PTL) on the first-attempt success, adverse TI-associated events (TIAEs), and oxygen desaturation was assessed.

Methods: Prospective cohort study in 11 international NEAR4NEOS sites between October 2014 and December 2017. Read More

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Undergraduate nursing students' resilience, challenges, and supports during corona virus pandemic.

Int J Ment Health Nurs 2021 Jun 9. Epub 2021 Jun 9.

Faculty of Health, Arts and Design, Swinburne University of Technology, Melbourne, VIC, Australia.

The coronavirus global pandemic interrupted teaching at Australian universities. Face-to-face teaching was replaced by online delivery. This presented challenges for nursing programmes due to the hands-on teaching requirements and clinical placements. Read More

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The Coordination Toolkit and Coaching Project: Cluster-Randomized Quality Improvement Initiative to Improve Patient Experience of Care Coordination.

J Gen Intern Med 2021 Jun 9. Epub 2021 Jun 9.

HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Sepulveda, CA, USA.

Background: Given persistent gaps in coordination of care for medically complex primary care patients, efficient strategies are needed to promote better care coordination.

Objective: The Coordination Toolkit and Coaching project compared two toolkit-based strategies of differing intensity to improve care coordination at VA primary care clinics.

Design: Multi-site, cluster-randomized QI initiative. Read More

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The associations between coping strategies, psychological health, and career indecision among medical students: a cross-sectional study in China.

BMC Med Educ 2021 Jun 9;21(1):334. Epub 2021 Jun 9.

Institute for International Health Professions Education and Research, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, P.R. China, 110122.

Background: Medical students experience difficulties in the process of making decisions about their careers, which is referred to as career indecision. This study aimed to examine the difficulties in the career decision-making processes of medical students and to explore the association of coping strategies and psychological health with career indecision. The findings may provide a reference for designing interventions to advance satisfying career decisions for medical students. Read More

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The use of coping strategies "shift-persist" mediates associations between physical activity and mental health problems in adolescents: a cross-sectional study.

BMC Public Health 2021 Jun 10;21(1):1104. Epub 2021 Jun 10.

School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Self-perceived mental health problems among adolescents has had an upward trend. Concurrently, adolescents' physical activity (PA) has been falling whilst sedentary time (SED) has increased. There is a lack of research using accelerometer measured PA and SED to study their relationships to perceived stress and psychosomatic symptoms, both frequently observed mental health problems among adolescents. Read More

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Effectiveness of multipoint cardiac resynchronizing therapy in heart failure: a systematic review and meta-analysis of randomized controlled trials.

Expert Rev Cardiovasc Ther 2021 Jun 16:1-11. Epub 2021 Jun 16.

School of Medical, Pharmaceutical and Biomedical Sciences, Pontifical Catholic University of Goiás, Goiânia, GO, Brazil.

: Cardiac resynchronization therapy is an important validated technique for patients with dyssynchrony and heart failure. However, the response rate to conventional resynchronization is approximately 50%; therefore, new techniques and schedules have emerged. This study aimed to evaluate the different clinical and echocardiographic variables of conventional versus multipoint cardiac resynchronization therapy. Read More

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Evaluation of group education strategies and telephone intervention for type 2 diabetes.

Rev Esc Enferm USP 2021 2;55:e03746. Epub 2021 Jun 2.

Universidade Federal de Minas Gerais, Escola de Enfermagem, Departamento de Enfermagem Aplicada, Belo Horizonte, MG, Brasil.

Objective: To evaluate group education strategies and telephone intervention regarding the variables empowerment, self-care practices, and glycemic control of people with diabetes.

Method: Clinical trial with eight randomized clusters, conducted between 2015 and 2016, with 208 users with type 2 diabetes mellitus allocated for group education, telephone intervention, or control group. Sociodemographic data, glycated hemoglobin, empowerment, and self-care practices were collected. Read More

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The Childhood Arthritis & Rheumatology Research Alliance Start Time Optimization of Biologics in Polyarticular Juvenile Idiopathic Arthritis Study (STOP-JIA): A Comparative Effectiveness Study of CARRA Consensus Treatment Plans for Untreated Polyarticular JIA.

Arthritis Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Seattle Children's Hospital, Seattle, WA, USA.

Background: The optimal time to start biologics for polyarticular JIA (pJIA) remains uncertain. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed 3 consensus treatment plans (CTPs) for untreated pJIA to compare strategies for starting biologics.

Methods: Start Time Optimization of biologics in PJIA (STOP-JIA) was a prospective, observational, CARRA Registry study comparing the effectiveness of: 1) Step Up (SU)- initial non-biologic disease modifying anti-rheumatic drug (DMARD) monotherapy, adding biologic if needed; 2) Early Combination (EC)- DMARD and biologic started together; 3) Biologic First (BF)- biologic monotherapy. Read More

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The GEnetic Syntax Score: a genetic risk assessment implementation tool grading the complexity of coronary artery disease-rationale and design of the GESS study.

BMC Cardiovasc Disord 2021 Jun 8;21(1):284. Epub 2021 Jun 8.

Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636, Thessaloniki, Greece.

Background: Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide and is associated with multiple inherited and environmental risk factors. This study is designed to identify, design, and develop a panel of genetic markers that combined with clinical and angiographic information, will facilitate the creation of a personalized risk prediction algorithm (GEnetic Syntax Score-GESS). GESS score could be a reliable tool for predicting cardiovascular risk for future adverse events and for guiding therapeutic strategies. Read More

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[Case-based learning can improve the teaching quality in trauma surgery education : A survey analysis among medical students].

Unfallchirurg 2021 Jun 8. Epub 2021 Jun 8.

Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66421, Homburg/Saar, Deutschland.

Background: Medical education has always been challenging for students and teachers. Of growing importance is the promotion of knowledge of correlations and knowledge transfer from theoretical aspects into clinical practice. In order to achieve this aim, student-centered teaching concepts are increasingly being employed in the literature. Read More

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Association between limiting the number of open records in a tele-critical care setting and retract-reorder errors.

J Am Med Inform Assoc 2021 Jun 8. Epub 2021 Jun 8.

Department of Hospital Medicine, Quality and Patient Safety Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Wrong patient selection errors may be tracked by retract-reorder (RAR) events. The aim of this quality improvement study was to assess the impact of reducing the number of concurrently open electronic health records from 4 to 2 on RAR errors generated by a tele-critical care service.

Methods: The study encompassed 32 months before and 21 months after restriction. Read More

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Tumor grade estımatıon of clear cell and papıllary renal cell carcınomas usıng contrast-enhanced MDCT and FSE T2 weıghted MR ımagıng: radıology-pathology correlatıon.

Radiol Med 2021 Jun 7. Epub 2021 Jun 7.

Department of Radiology and Pathology, 34371, Sisli, Istanbul, Turkey.

Background: Discrimination of low grade (grade 1-2) renal tumors from high grade (grade 3-4) ones carries crucial importance in terms of the management of these patients and also in the decision-making of appropriate treatment strategies. Our aim was to investigate whether contrast-enhanced multidetector computed tomography (MDCT) and T2 weighted fast spin echo (FSE) magnetic resonance imaging (MRI) could play a specific role in the discrimination of low grade versus high grade tumors in clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC) patients.

Methods: In this study, we retrospectively evaluated 66 RCC patients based on histopathologic findings who had underwent either partial or total nephrectomies. Read More

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Antithrombotic therapy with or without aspirin after percutaneous coronary intervention or acute coronary syndrome in patients taking oral anticoagulation: A meta-analysis and network analysis of randomized controlled trials.

Cardiovasc Revasc Med 2021 May 19. Epub 2021 May 19.

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Introduction: Trials investigating aspirin omission in patients taking oral anticoagulation (OAC) after percutaneous coronary intervention (PCI) or acute coronary syndrome (ACS) were not powered to assess rates of major bleeding or ischemic events.

Methods: We performed an updated meta-analysis and network analysis of randomized trials comparing treatment with or without aspirin in patients taking OAC and a P2Y12-inhibitor after PCI or ACS. The primary outcome was TIMI major bleeding. Read More

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