167 results match your criteria strains sysu


Cysteiniphilum marinum sp. nov., isolated from coastal seawater.

Antonie Van Leeuwenhoek 2021 Apr 24. Epub 2021 Apr 24.

State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

Six aerobic Gram-negative bacteria were isolated from seawater in Guangdong Province, P.R. China. Read More

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In vitro anti-bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection.

Chin Med 2021 Apr 17;16(1):33. Epub 2021 Apr 17.

School of Pharmaceutical Science (Shenzhen), Sun Yat-Sen University, Guangzhou, 510006, China.

Background: Helicobacter pylori (H. pylori) infection has become an international public health problem, and antibiotic-based triple or quadruple therapy is currently the mainstay of treatment. However, the effectiveness of these therapies decreases due to resistance to multiple commonly used antibiotics. Read More

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A LysR family transcriptional regulator modulates biofilm formation and protease production in .

Appl Environ Microbiol 2021 Apr 2. Epub 2021 Apr 2.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China

Quorum sensing (QS) signals are widely employed by bacteria to regulate biological functions in response to cell densities. Previous studies showed that mostly utilizes two types of QS systems, including the -acylhomoserine lactone (AHL) and -2-dodecenoic acid (BDSF) systems, to regulate biological functions. We demonstrated here that a LysR family transcriptional regulator Bcal3178 controls the QS-regulated phenotypes, including biofilm formation and protease production, in H111. Read More

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ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.

Nat Commun 2021 03 3;12(1):1401. Epub 2021 Mar 3.

Medical Research Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Rd. 2, Guangzhou, China.

Effective treatments for patients suffering from heat hypersensitivity are lacking, mostly due to our limited understanding of the pathogenic mechanisms underlying this disorder. In the nervous system, activating transcription factor 4 (ATF4) is involved in the regulation of synaptic plasticity and memory formation. Here, we show that ATF4 plays an important role in heat nociception. Read More

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Recruitment of γδ T cells to the lesion via the CCL2/CCR2 signaling after spinal cord injury.

J Neuroinflammation 2021 Mar 2;18(1):64. Epub 2021 Mar 2.

Department of Orthopedics, The First Affiliated Hospital of Jinan University, 601 West Whampoa Avenue, Guangzhou, 510000, China.

Background: Immune cell infiltration and neuroinflammation are heavily associated with spinal cord injury (SCI). C-C motif chemokine ligand 2/C-C chemokine receptor type 2 (CCL2/CCR2) axis has been identified as a critical role player during the invasion of immune cells to lesions in many diseases. γδ T cells, a subgroup of T cells, manage the course of inflammation response in various diseases; however, it remains unknown whether γδ T cells are recruited to injury site through CCL2/CCR2 signaling and exert the regulation effect on neuroinflammation after SCI. Read More

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Profiling of alternative polyadenylation and gene expression in PEDV-infected IPEC-J2 cells.

Virus Genes 2021 Apr 23;57(2):181-193. Epub 2021 Feb 23.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.

Since 2010, porcine epidemic diarrhea virus (PEDV) has received global attention with the emergence of variant strains characterized with high pathogenicity. The pathogen-host interaction after PEDV infection is still unclear. To investigate this issue, high-throughput-based sequencing technology is one of the optimal choices. Read More

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Thermaurantiacus tibetensis gen. nov., sp. nov., a novel moderately thermophilic bacterium isolated from hot spring microbial mat in Tibet.

Antonie Van Leeuwenhoek 2021 Apr 23;114(4):445-455. Epub 2021 Feb 23.

State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

Two bacterial strains SYSU G02173 and SYSU G03142 were isolated from hot springs in Tibet, China. Based on the results of nearly full-length 16S rRNA gene sequences and phylogenetic analyses, strains SYSU G02173 and SYSU G03142 were assigned to the family Sphingosinicellaceae, and were closest to Sandaracinobacter sibiricus RB16-17 (96.04% and 96. Read More

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CRISPR/Cas9-mediated knockout of the NlCSAD gene results in darker cuticle pigmentation and a reduction in female fecundity in Nilaparvata lugens (Hemiptera: Delphacidae).

Comp Biochem Physiol A Mol Integr Physiol 2021 Jun 19;256:110921. Epub 2021 Feb 19.

State Key Laboratory of Biocontrol and School of Life Sciences, Sun Yat-sen University, Guangzhou, China. Electronic address:

In insects, cuticular pigmentation genes have been exploited as potential visible markers for constructing genetic manipulation systems. Here, we cloned cysteine sulfinic acid decarboxylase (CSAD), an orthologue of melanin metabolism pathway genes, and performed RNAi experiments in the brown planthopper Nilaparvata lugens (Hemiptera: Delphacidae). The results showed that a decrease in the level of transcription of NlCSAD increased melanin deposition in the body compared to the control group, resulting in darker cuticle pigmentation. Read More

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Siccirubricoccus phaeus sp. nov., isolated from oil reservoir water and emended description of the genus Siccirubricoccus.

Antonie Van Leeuwenhoek 2021 Apr 6;114(4):355-364. Epub 2021 Feb 6.

State Key Laboratory of Agrobiotechnology, Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, 100193, People's Republic of China.

A Gram-staining-negative, non-motile, aerobic bacterium, designated 1-3, was isolated from oil reservoir water collected from Liaohe oilfield, north-east of China. Growth was observed at 15-40 °C (optimum 37 °C) and pH 6-10 (optimum 7). The strain can grow under nitrogen-limiting condition. Read More

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Neobacillus sedimentimangrovi sp. nov., a Thermophilic Bacterium Isolated from Mangrove Sediment.

Curr Microbiol 2021 Mar 4;78(3):1039-1044. Epub 2021 Feb 4.

Fujian Agricultural and Forestry University, Fuzhou, 350002, Fujian, China.

Two Gram-stain positive, rod-shaped, endospore-forming, aerobic, thermophilic strains, designated FJAT-2464 and FJAT-52740, were isolated from the sediment collected from Zhangjiang Estuary Mangrove National Nature Reserve in Fujian Province, China. The 16S rRNA gene sequence similarity between strains FJAT-2464 and FJAT-52740 was 100%. The result suggests that strains FJAT-2464 and FJAT-52740 belong to the same genome species, hence only FJAT-2464 was considered for further analysis. Read More

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Zafaria cholistanensis gen. nov. sp. nov., a moderately thermotolerant and halotolerant actinobacterium isolated from Cholistan desert soil of Pakistan.

Arch Microbiol 2021 May 18;203(4):1717-1729. Epub 2021 Jan 18.

State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences,, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

A Gram-staining positive, non-spore forming, non-pigmented and non-motile bacterium, designated strain NCCP-1664, was isolated from Cholistan desert, Pakistan. Cells of strain NCCP-1664 were strictly aerobic, catalase positive and oxidase negative with a rod to coccus growth cycle and can grow at pH 6.0-9. Read More

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Complete Genome Sequences of Allofrancisella inopinata SYSU YG23 and Allofrancisella frigidaquae SYSU 10HL1970, Isolated from Water from Cooling Systems in China.

Microbiol Resour Announc 2020 Nov 25;9(48). Epub 2020 Nov 25.

Swedish Defence Research Agency, CBRN Defence and Security, Umeå, Sweden

Near neighbors to the causative agent of tularemia, , isolated from diverse sources, have been reported in recent years. In this announcement, we present the complete sequences of circular chromosomes of one of the closest neighboring genera of (i.e. Read More

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November 2020

A highly pathogenic recombinant infectious bronchitis virus with adaptability in cultured cells.

Virus Res 2021 01 15;292:198229. Epub 2020 Nov 15.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:

Infectious bronchitis virus (IBV) of GI-19 (QX), GI-7 (TW), GI-13 (4/91) and GI-1 (Mass) lineages have been frequently detected in China in recent years. Here, An IBV strain, referred as GD17/04, was isolated from the dead yellow feather chicken vaccinated with H52 and 4/91 vaccines, whose genome sequence was obtained through high-throughput sequencing. Then it has been confirmed by the RDP and SimPlot analysis that GD17/04 is a recombinant strain deriving from YX10, 4/91, TW 2575/98 and H52 strains. Read More

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January 2021

Na-NQR Confers Aminoglycoside Resistance via the Regulation of l-Alanine Metabolism.

mBio 2020 11 17;11(6). Epub 2020 Nov 17.

The Third Affiliated Hospital, Sun Yat-sen University, University City, Guangzhou, People's Republic of China

Sodium-translocating NADH:quinone oxidoreductase (Na-NQR) functions as a unique redox-driven sodium pump, generating membrane potential, which is related to aminoglycoside antibiotic resistance. However, whether it modulates other metabolisms to confer antibiotic resistance is unknown. The present study showed that loss of or led to differential metabolomes with elevated resistance to aminoglycoside antibiotics. Read More

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November 2020

Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions.

J Mater Chem B 2020 12;8(46):10549-10558

School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China.

Conductive hydrogel-based epidermal strain sensors can generate repeatable electrical changes upon mechanical deformations for indication of the skin's physiological condition. However, this remains challenging for many conductive hydrogel sensors due to biomechanical mismatch with skin tissues and an unstable resistance variation response, resulting in non-conformable deformations with the epidermis and dermis, and consequently generating inaccurate monitoring of human movements. Herein, a conductive hydrogel that highly matches the skin is fabricated from dynamically hydrogen-bonded nanocrystallites of polydopamine-modified reduced graphene oxide (PDA-rGO) nanosheets composited with polyvinyl alcohol, namely the PDA-rGO/PVA hydrogel. Read More

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December 2020

sp. nov. and sp. nov., two new species of bacteria belonging to the family .

Int J Syst Evol Microbiol 2020 Dec;70(12):6266-6283

Laboratory of Microbiology, Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung City 811, No. 142, Hai-Chuan Rd. Nan-Tzu, Kaohsiung City 811, Taiwan, ROC.

Two Gram-stain-negative, aerobic, non-motile bacteria, designated KMS-5 and CYK-10, were isolated from freshwater environments. 16S rRNA gene sequence similarity results indicated that these two novel strains belong to the family . Strain KMS-5 is closely related to species within the genus (96. Read More

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December 2020

Nesterenkonia haasae sp. nov., an alkaliphilic actinobacterium isolated from a degraded pasture in Songnen Plain.

Arch Microbiol 2021 Apr 26;203(3):959-966. Epub 2020 Oct 26.

State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

An alkaliphilic actinobacterial strain, designated Hz 6-5, was isolated from saline-alkaline soil from Songnen Plain in north-eastern China. The isolate formed light yellow-colored colonies and its cells were Gram-staining positive, non-motile, and non-spore-forming short rods. The strain was aerobic with optimal growth at 33 °C, pH 9. Read More

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Structure-guided optimization and mechanistic study of a class of quinazolinone-threonine hybrids as antibacterial ThrRS inhibitors.

Eur J Med Chem 2020 Dec 19;207:112848. Epub 2020 Sep 19.

Research Center for Drug Discovery and Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address:

Aminoacyl-tRNA synthetases (aaRSs) are an attractive class of antibacterial drug targets due to their essential roles in protein translation. While most traditional aaRS inhibitors target the binding pockets of substrate amino acids and/or ATP, we recently developed a class of novel tRNA-amino acid dual-site inhibitors including inhibitor 3 ((2S,3R)-2-amino-N-((E)-4-(6,7-dichloro-4-oxoquinazolin-3(4H)-yl)but-2-en-1-yl)-3-hydroxybutanamide) against threonyl-tRNA synthetase (ThrRS). Here, the binding modes and structure-activity relationships (SARs) of these inhibitors were analyzed by the crystal structures of Salmonella enterica ThrRS (SeThrRS) in complex with three of them. Read More

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December 2020

gen. nov., sp. nov., a novel cellulose- and xylan-degrading member of the family isolated from a hot spring.

Int J Syst Evol Microbiol 2020 Nov;70(11):5717-5724

State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, PR China.

Two anaerobic bacteria, designated strains SYSU GA16112 and SYSU GA16107, were isolated from a hot spring in Tengchong County, Yunnan Province, south-west PR China. Phylogenetic analyses based on 16S rRNA gene sequences showed that strains SYSU GA16112 and SYSU GA16107 belong to the family . Cells of strains SYSU GA16112 and SYSU GA16107 were Gram-stain-negative, rod-shaped and non-motile. Read More

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November 2020

The enhancing antibiofilm activity of curcumin on Streptococcus mutans strains from severe early childhood caries.

BMC Microbiol 2020 09 16;20(1):286. Epub 2020 Sep 16.

Department of Preventive Dentistry, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, 56 Ling Yuan Road West, Guangzhou, 510055, China.

Background: Streptococcus mutans (S. mutans) is one of the main cariogenic bacteria for caries. It was found that the clinical strains of S. Read More

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September 2020

Efficient arsenate reduction in As-hyperaccumulator Pteris vittata are mediated by novel arsenate reductases PvHAC1 and PvHAC2.

J Hazard Mater 2020 11 15;399:122895. Epub 2020 May 15.

Institute of Soil and Water Resources and Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Arsenic-hyperaccumulator Pteris vittata is efficient in As absorption, reduction, and translocation. But the molecular mechanisms and locations of arsenate (AsV) reduction in P. vittata are still unclear. Read More

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November 2020

Isolation of Clostridium from Yunnan-Tibet hot springs and description of Clostridium thermarum sp. nov. with lignocellulosic ethanol production.

Syst Appl Microbiol 2020 Sep 21;43(5):126104. Epub 2020 Jun 21.

State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address:

Lignocellulose is considered a major source of renewable energy that serve as an alternative to the fossil fuels. Members of the genus Clostridium are some of the many microorganisms that have the ability to degrade lignocellulose efficiently to sugar, which can be further converted to biofuel. In this study, we isolated twelve Clostridium strains from hot spring samples of Yunnan and Tibet, of which isolates SYSU GA15002 and SYSU GA17076 showed low 16S rRNA gene sequence identity profiles to any of the validly named Clostridium strains (<94. Read More

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September 2020

Quantitative secretome analysis of polymyxin B resistance in Escherichia coli.

Biochem Biophys Res Commun 2020 09 6;530(1):307-313. Epub 2020 Aug 6.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China. Electronic address:

Bacterial resistance has become a serious threat to human health. In particular, the gradual development of resistance to polymyxins, the last line of defense for human infections, is a major issue. Secreted proteins contribute to the interactions between bacteria and the environment. Read More

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September 2020

Biofilm for leaching precious metals from waste printed circuit boards using biocyanidation technology.

J Hazard Mater 2021 02 4;403:123586. Epub 2020 Aug 4.

School of Environmental Science and Engineering, Sun Yat-Sen University, 135 Xingang Xi Road, Guangzhou, 510275, People's Republic of China. Electronic address:

Presently, biocyanidation technology is being usually adopted to recover precious metals from an increasing quantity of waste printed circuit boards. The main aim of this work was to investigate the biofilm formation of Pseudomonas and its ability to leach precious metals. Based on batch experiments, strain 113 showed the highest biofilm-forming activity in optimal culture conditions of pH 7. Read More

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February 2021

Sphingobacterium endophyticum sp. nov., a novel endophyte isolated from halophyte.

Arch Microbiol 2020 Dec 31;202(10):2771-2778. Epub 2020 Jul 31.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

A bacterial strain designated NYYP31 was isolated from the leaves of an annual halophytes, Suaeda corniculata Bunge, collected from the southern edge of the Gurbantunggut desert, north-west China. Strain NYYP31 was Gram-staining negative, strictly aerobic, rod-shaped, non-motile, and non-spore-forming. Growth was observed at 4-42 °C, at pH 5. Read More

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December 2020

Comparative metabolic profiling of Ophiocordyceps sinensis and its cultured mycelia using GC-MS.

Food Res Int 2020 08 13;134:109241. Epub 2020 Apr 13.

Food and Health Engineering Research Center of State Education Ministry, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:

Ophiocordyceps sinensis, one of the well-known traditional Chinese medicine, has multiple health-promoting effects. It is used as herbal remedy and health food in Asian countries, together with its cultured mycelia used as a substitute of natural O. sinensis. Read More

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Distinct Expression of the Two NO-Forming Nitrite Reductases in Thermus antranikianii DSM 12462 Improved Environmental Adaptability.

Microb Ecol 2020 Oct 30;80(3):614-626. Epub 2020 May 30.

State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

Hot spring ecosystems are analogous to some thermal environments on the early Earth and represent ideal models to understand life forms and element cycling on the early Earth. Denitrification, an important component of biogeochemical nitrogen cycle, is highly active in hot springs. Nitrite (NO) reduction to nitric oxide (NO) is the significant and rate-limiting pathway in denitrification and is catalyzed by two types of nitrite reductases, encoded by nirS and nirK genes. Read More

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October 2020

sp. nov. and sp. nov., isolated from a saline lake.

Int J Syst Evol Microbiol 2020 Jun 28;70(6):3785-3793. Epub 2020 May 28.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, PR China.

Two novel strains, designated SYSU L10167 and SYSU L10180, were isolated from sediment sampled at Dabancheng saline lake in Xinjiang, PR China. A polyphasic approach was used to clarify the taxonomic positions of the two strains. Cells of the isolates were curved ring-like, horseshoe-shaped or rod-shaped, non-motile and non-spore-forming. Read More

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Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial.

Eur J Nutr 2021 Mar 21;60(2):747-758. Epub 2020 May 21.

Department of Nutrition, School of Public Health, Sun Yat-sen University, 74 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

Purpose: To explore whether probiotic supplementation could attenuate serum trimethylamine-N-oxide (TMAO) level and impact the intestinal microbiome composition.

Design: Forty healthy males (20-25 years old) were randomized into the probiotic group (1.32 × 10 CFU live bacteria including strains of Lactobacillus acidophilus, Lactobacillus rhamnosus GG, Bifidobacterium animalis, and Bifidobacterium longum daily) or the control group for 4 weeks. Read More

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sp. nov., isolated from coastal seawater.

Int J Syst Evol Microbiol 2020 May;70(5):3264-3272

Department of Clinical Laboratory, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510006, PR China.

Four strains (SYSU SYW-1, SYW-2, SYW-3 and XLW-1) were isolated from seawater near the shore in Guangdong Province, China. Cells were Gram-stain-negative, aerobic, non-motile and non-spore-forming. Growth was observed at a temperature range of 16-40 °C (optimum, 32 °C), a pH range of 4-8 (optimum, pH 7) and in the presence of up to 10 % (w/v) NaCl. Read More

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