3,102 results match your criteria straightforward cases

The molecular and phenotypic spectrum of CLCN4-related epilepsy.

Epilepsia 2021 May 5. Epub 2021 May 5.

Institute of Chemistry and Biochemistry, Berlin Free University, Berlin, Germany.

Objective: This study was undertaken to expand the phenotypic and genetic spectrum of CLCN4-related epilepsy and to investigate genotype-phenotype correlations.

Methods: We systematically reviewed the phenotypic and genetic spectrum of newly diagnosed and previously reported patients with CLCN4-related epilepsy. Three novel variants identified in four patients reported in this study were evaluated through in silico prediction and functional analysis by Western blot, immunofluorescence, and electrophysiological measurements. Read More

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Calculation of ocular magnification in phakic and pseudophakic eyes based on anterior segment OCT data.

Ophthalmic Physiol Opt 2021 May 4. Epub 2021 May 4.

Department of Ophthalmology, Vienna University, Vienna, Austria.

Purpose: The purpose of this study is to develop a straightforward mathematical concept for determination of object to image magnification in both phakic and pseudophakic eyes, based on biometric measures, refractometry and data from an anterior segment optical coherence tomography (OCT).

Methods: We have developed a strategy for calculating ocular magnification based on axial length measurement, phakic anterior chamber and lens thickness, keratometry and crystalline lens front and back surface curvatures for the phakic eye, and axial length measurement, anterior chamber and lens thickness, keratometry and intraocular lens power, refractive index and shape factor for the pseudophakic eye. Comparing the magnification of both eyes of one individual yields aniseikonia, while comparing the preoperative and postoperative situation of one eye provides the gain or loss in ocular magnification. Read More

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When the law influences medical practice: Potential impact of the Bouchard-Lebrun ruling on the forensic unit of the Malartic Psychiatric Hospital in Northern Quebec, Canada.

Int J Law Psychiatry 2021 Apr 28;76:101686. Epub 2021 Apr 28.

Forensic Psychiatrist, Hôpital Psychiatrique de Malartic, 1141 Rue Royale, Malartic, QC J0Y 1Z0, Canada.

The attribution of criminal responsibility in the context of substance intoxication is a matter of controversy in forensic psychiatry. In 2011, the Supreme Court of Canada ruled that Tommy Bouchard-Lebrun was guilty in the straightforward case of a crime committed while in a state of substance-induced psychosis by an individual without a history of mental disorder. However, the ruling may since have served as a precedent also for settling cases where an offence is committed while in a certain state of intoxication and where there is much more diagnostic uncertainty. Read More

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Assessments of Physicians' Electrocardiogram Interpretation Skill: A Systematic Review.

Acad Med 2021 Apr 27. Epub 2021 Apr 27.

D.A. Cook is professor of medicine and medical education, director of education science, Office of Applied Scholarship and Education Science, research chair, Mayo Clinic Rochester Multidisciplinary Simulation Center, and consultant, Division of General Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. S.Y. Oh is program manager for digital learning, Institute for Innovations in Medical Education, NYU Grossman School of Medicine, NYU Langone Health, New York, New York. M.V. Pusic is associate professor of emergency medicine and pediatrics, Department of Emergency Medicine, NYU Grossman School of Medicine, New York, New York.

Purpose: To identify features of instruments, test procedures, study design, and validity evidence in published studies of electrocardiogram (ECG) skill assessments.

Method: The authors conducted a systematic review, searching MEDLINE, Embase, Cochrane CENTRAL, PsycINFO, CINAHL, ERIC, and Web of Science databases in February 2020 for studies that assessed the ECG interpretation skill of physicians or medical students. Two authors independently screened articles for inclusion and extracted information on test features, study design, risk of bias, and validity evidence. Read More

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Proximal femoral replacement: A salvage treatment of cephalomedullary nails' mechanical failures in the elderly population.

Injury 2021 Apr 16. Epub 2021 Apr 16.

University of Florence, Orthopaedic Clinic CTO, Largo Palagi 1 50139 Florence, Italy. Electronic address:

Background: The use of proximal femoral replacements (PFR) has been recently described for catastrophic internal fixation failures. PFR is an attractive treatment option because it is technically straightforward and allows for immediate mobilization of the patient. The aim of the study was to determine the survivorship, functional outcome and complications' rate in a group of elderly patients who underwent proximal femoral replacement as a salvage treatment after femur cephalomedullary nails' mechanical failures. Read More

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Deploying Mass Spectrometric Data Analysis in the Amazon AWS Cloud Computing Environment.

Jonathan E Katz

Methods Mol Biol 2021 ;2271:375-397

Lawrence J. Ellison Institute for Transformative Medicine of USC, Los Angeles, CA, USA.

There are many advantages for deploying a mass spectrometry workflow to the cloud. While "cloud computing" can have many meanings, in this case, I am simply referring to a virtual computer that is remotely accessible over the Internet. This "computer" can have as many or few resources (CPU, RAM, disk space, etc. Read More

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January 2021

A New Active Osseointegrated Implant System in Patients with Single-Sided Deafness.

Audiol Neurootol 2021 Apr 26:1-9. Epub 2021 Apr 26.

Department of Otorhinolaryngology, Medical University Hannover, Hannover, Germany.

Objective: The Cochlear™ Osia® System (Osia) is an active transcutaneous bone conduction implant system intended for patients with conductive and mixed hearing loss but can also be used in cases of single-sided deafness (SSD) for the contralateral routing of signal (CROS). The Osia implant is placed subcutaneously under the intact skin behind the ear with the piezoelectric actuator connected to an osseointegrated BI300 implant - a titanium screw used for a 2-stage Baha surgery - on the mastoid. The external processor is magnetically attached to the subcutaneous implant receiver coil. Read More

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One-Piece Titanium Implants: Retrospective Case Series.

Case Rep Dent 2021 8;2021:6688355. Epub 2021 Apr 8.

Dental Practice, 37213 Witzenhausen, Germany.

Purpose: One-piece titanium implants are not routinely used for reconstruction after tooth loss. Several limitations seemed to be apparent although the concept provides a straightforward approach for different clinical situations. A clinical documentation of five prosthetic restorations with one-piece titanium implants serving as a relevant treatment option in dental surgery is pursued. Read More

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Clinical analysis of Pseudomonas aeruginosa-positive and -negative green nail syndrome cases: A single center retrospective analysis.

J Dermatol 2021 Apr 23. Epub 2021 Apr 23.

Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Green nail syndrome (GNS) is a paronychial infection mainly due to Pseudomonas aeruginosa, characterized by green discoloration of the nail plate. Although the diagnosis of GNS may be straightforward with its distinctive color change, the clinical management of the disease can be sometimes confusing, especially when the bacterial culture result is inconsistent. There is, however, a paucity of comprehensive reviews regarding the treatment of GNS in the actual clinical setting. Read More

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[Treatment of a Patient with a Pronounced Cytokine Storm in Severe COVID-19 Pneumonia using a Hemoadsorption in Combination with the Administration of tocilizumab].

Pneumologie 2021 Apr 21. Epub 2021 Apr 21.

Klinikum Würzburg Mitte gGmbH, Standort Missioklinik, Medizinische Klinik mit Schwerpunkt Pneumologie & Beatmungsmedizin.

Despite growing experience due to increasing patient numbers, the intensive care treatment of patients with severe COVID-19 pneumonia continues to be a particular challenge in individual cases, which may also therefore legitimize individualized therapeutic attempts. In this context, the so-called hyperinflammation syndrome characterized by a cytokine storm accompanied by a massive increase in inflammatory markers such as interleukin(IL)-6, represents such a situation. This case report describes the therapeutic approach of using the IL-6-specific antibody tocilizumab in combination with hemoadsorption therapy (CytoSorb) in a 58-year-old male patient with severe COVID-19 pneumonia. Read More

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Augmented Reality in Medical Practice: From Spine Surgery to Remote Assistance.

Front Surg 2021 30;8:657901. Epub 2021 Mar 30.

Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy.

While performing surgeries in the OR, surgeons and assistants often need to access several information regarding surgical planning and/or procedures related to the surgery itself, or the accessory equipment to perform certain operations. The accessibility of this information often relies on the physical presence of technical and medical specialists in the OR, which is increasingly difficult due to the number of limitations imposed by the COVID emergency to avoid overcrowded environments or external personnel. Here, we analyze several scenarios where we equipped OR personnel with augmented reality (AR) glasses, allowing a remote specialist to guide OR operations through voice and visuals, superimposed to the field of view of the operator wearing them. Read More

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The Making of Long-Lasting Memories: A Fruit Fly Perspective.

Front Behav Neurosci 2021 30;15:662129. Epub 2021 Mar 30.

Department of Biology, Georgetown University, Washington, DC, United States.

Understanding the nature of the molecular mechanisms underlying memory formation, consolidation, and forgetting are some of the fascinating questions in modern neuroscience. The encoding, stabilization and elimination of memories, rely on the structural reorganization of synapses. These changes will enable the facilitation or depression of neural activity in response to the acquisition of new information. Read More

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Tyrosinemia type 1 in pediatric nephrology: Not always straightforward.

Arch Pediatr 2021 May 12;28(4):338-341. Epub 2021 Apr 12.

Centre de Référence des Maladies Rénales Rares, Filières de santé maladies rares ORKID et ERK-Net, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Faculté de Médecine Lyon Est, Université Claude Bernard Lyon 1, Lyon, France; INSERM, UMR 1033, Faculté de Medecine Lyon Est, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

The main clinical features of tyrosinemia type 1 usually appear in the first months of life, including fever, diarrhea, vomiting, liver involvement, growth failure, and renal proximal tubulopathy with subsequent hypophosphatemic rickets. An early diagnosis is crucial in order to provide specific management and to prevent complications. Here, we report on two cases referred primarily to pediatric nephrologists for the diagnosis of "neonatal tubulopathy" and management of "X-linked hypophosphatemia (XLH)," respectively. Read More

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Current Concepts in Fluid Therapy in Horses.

Front Vet Sci 2021 29;8:648774. Epub 2021 Mar 29.

Department of Large Animal Medicine, University of Georgia College of Veterinary Medicine, Athens, GA, United States.

Despite the frequent inclusion of fluid therapy in the treatment of many conditions in horses, there are limited studies available to provide evidenced-based, species-specific recommendations. Thus, equine fluid therapy is based on the application of physiology and extrapolation from evidence in other veterinary species and human medicine. The physiologic principles that underly the use of fluids in medicine are, at first glance, straightforward and simple to understand. Read More

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Unusual Clinical Presentation of Giant Extragenital Condyloma.

Acta Dermatovenerol Croat 2020 Dec;28(7):240-241

Andrija Jovic, MD, Clinical Center of Nis, Clinic of Dermatovenereology , Bulevar Zorana Djindjica 48, Nis, Serbia;

Dear editor, Condylomata accuminatum (CA) is a human papillomavirus (HPV) related sexually transmitted infection (STI), clinically characterized by solitary or even clustered dark red or pink lesions solely affecting the anogenital area (1). CA involving the extragenital, non-mucosal skin has been sporadically reported (2-4). Diagnosis of CA is usually straightforward when the lesions are located on the anogenital area. Read More

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December 2020

A filter-assisted culture method for isolation of spp. from bovine digital dermatitis and their identification by MALDI-TOF MS.

J Vet Diagn Invest 2021 Apr 9:10406387211008511. Epub 2021 Apr 9.

Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Digital dermatitis (DD) is a major infectious foot disease of cattle worldwide. Some DD stages are associated with lameness, and the disease has significant economic and animal welfare consequences. The pathogenesis of the disease is not yet fully understood, but spp. Read More

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Transanal fistulectomy for postoperative persistent rectourethral fistula in patients with ARM: is simple resection enough?

BMC Surg 2021 Apr 2;21(1):179. Epub 2021 Apr 2.

Department of General Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Beijing, 100045, China.

Background: Postoperative rectourethral fistula (RUF) in patients with congenital anorectal malformation (ARM) remains a challenge for paediatric surgeons, among them persistent fistula is the most common. Various techniques have been proposed, only a few reports based on different causes are available, and there is no consensus so far. This study is to evaluate the application, advantages and limitations of transanal fistulectomy approach in repairing persistent RUF in ARM patients. Read More

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Balancing Heterogeneous Image Quality for Improved Cross-Spectral Face Recognition.

Sensors (Basel) 2021 Mar 26;21(7). Epub 2021 Mar 26.

Molecular and Neuroimaging Engineering Research Center of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710071, China.

Matching infrared (IR) facial probes against a gallery of visible light faces remains a challenge, especially when combined with cross-distance due to deteriorated quality of the IR data. In this paper, we study the scenario where visible light faces are acquired at a short standoff, while IR faces are long-range data. To address the issue of quality imbalance between the heterogeneous imagery, we propose to compensate it by upgrading the lower-quality IR faces. Read More

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Food Traceability: A Consumer-Centric Supply Chain Approach on Sustainable Tomato.

Foods 2021 Mar 5;10(3). Epub 2021 Mar 5.

Deptartment of Agricultural Economics, School of Agriculture, Aristotle University of Thessaloniki, 541-24 Thessaloniki, Greece.

Technological advances result in new traceability configurations that, however, cannot always secure transparency and food safety. Even in cases where a system guarantees transparency, the actual consumer involvement and a real consumer-based perspective cannot always be ensured. The importance of such consumer centricity is vital, since it is strongly associated with effective supply chains that properly fulfil their end-users' needs and requests. Read More

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Characterisation of Fat Crystal Polymorphism in Cocoa Butter by Time-Domain NMR and DSC Deconvolution.

Foods 2021 Mar 2;10(3). Epub 2021 Mar 2.

Particle and Interfacial Technology, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium.

The polymorphic state of edible fats is an important quality parameter in fat research as well as in industrial applications. Nowadays, X-ray diffraction (XRD) is the most commonly used method to determine the polymorphic state. However, quantification of the different polymorphic forms present in a sample is not straightforward. Read More

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Optimization-Based Resource Management Algorithms with Considerations of Client Satisfaction and High Availability in Elastic 5G Network Slices.

Sensors (Basel) 2021 Mar 8;21(5). Epub 2021 Mar 8.

Research Center for Information Technology Innovation, Academia Sinica, Taipei 115, Taiwan.

A combined edge and core cloud computing environment is a novel solution in 5G network slices. The clients' high availability requirement is a challenge because it limits the possible admission control in front of the edge cloud. This work proposes an orchestrator with a mathematical programming model in a global viewpoint to solve resource management problems and satisfying the clients' high availability requirements. Read More

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A 12-point recommendation framework to support advancement of the multidisciplinary care of psoriatic arthritis: A call to action.

Joint Bone Spine 2021 05 23;88(3):105175. Epub 2021 Mar 23.

Service de Rhumatologie, Hôpital Lariboisiere Centre Viggo Petersen, Université de Paris, 2, Rue Ambroise-Pare, 75010 Paris, France; Inserm UMR1132 Bioscar, Universite Paris Diderot UFR de Medecine, Paris, France. Electronic address:

Objective: Making a differential diagnosis of psoriatic arthritis (PsA) is not straightforward. This is partly because of its heterogeneous presentation and partly because many patients with PsA are initially diagnosed with psoriasis and treated in primary care or by dermatologists, with referral to rheumatologists being delayed. Once diagnosed, optimal disease control requires frequent specialist monitoring, adjustment or switching of therapies, and management of comorbidities and concomitant diseases, as well as attention to patients' overall well-being. Read More

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Guidelines on reporting treatment conditions for emerging technologies in food processing.

Crit Rev Food Sci Nutr 2021 Mar 25:1-25. Epub 2021 Mar 25.

Dept. Química y Tecnología de Alimentos, ETSIAAB, Universidad Politécnica de Madrid, Madrid, Spain.

In the last decades, different non-thermal and thermal technologies have been developed for food processing. However, in many cases, it is not clear which experimental parameters must be reported to guarantee the experiments' reproducibility and provide the food industry a straightforward way to scale-up these technologies. Since reproducibility is one of the most important science features, the current work aims to improve the reproducibility of studies on emerging technologies for food processing by providing guidelines on reporting treatment conditions of thermal and non-thermal technologies. Read More

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The gray zone of thyroid nodules: Using a nomogram to provide malignancy risk assessment and guide patient management.

Cancer Med 2021 Apr 24;10(8):2723-2731. Epub 2021 Mar 24.

Department of Pathology, LSU Health Sciences Center, New Orleans, LA, USA.

Background: Thyroid nodules have a low prevalence of malignancy and most proven cancers do not behave aggressively. Thus, risk-stratification of nodules is a critical step to avoid surgical overtreatment. We hypothesized that a risk management system superior to those currently in use could be created to reduce the number of clinically indeterminate nodules (i. Read More

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Qualification of translational safety biomarkers.

Exp Biol Med (Maywood) 2021 Mar 23:15353702211002153. Epub 2021 Mar 23.

Biomarkers Program, Predictive Safety Testing Consortium, Critical Path Institute Tucson, AZ 85718, USA.

Safety biomarkers are important drug development tools, both preclinically and clinically. It is a straightforward process to correlate the performance of nonclinical safety biomarkers with histopathology, and ideally, the biomarker is useful in all species commonly used in safety assessment. In clinical validation studies, where histopathology is not feasible, safety biomarkers are compared to the response of standard biomarkers and/or to clinical adjudication. Read More

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Rerouting anomalous coronary artery origin in aortopulmonary window in newborn.

J Card Surg 2021 Mar 19. Epub 2021 Mar 19.

Department of Cardiovascular Surgery, Hacettepe University School of Medicine, Ankara, Turkey.

Coronary artery anomalies may accompany the aortopulmonary window and, if not noticed, may cause catastrophic consequences. The repair of the aortopulmonary window is quite straightforward; however, establishing a normal coronary pattern may challenge the repair. When the anomalous origin of the coronary artery is on the defect rim, right at the location where sutures are to be placed, it may interfere with proper suture placement. Read More

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Current results of left gonadal vein transposition to treat nutcracker syndrome.

J Vasc Surg Venous Lymphat Disord 2021 Mar 15. Epub 2021 Mar 15.

Department of Vascular and Endovascular Surgery, University Hospital of Besançon, Besançon, France.

Objective: Nutcracker syndrome can cause disabling chronic pain requiring surgical intervention. At present, data describing a straightforward management approach are lacking. Transposition of the left gonadal vein is one of the surgical therapeutic alternatives. Read More

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A Comparison of Artificial Intelligence and Human Doctors for the Purpose of Triage and Diagnosis.

Front Artif Intell 2020 30;3:543405. Epub 2020 Nov 30.

Babylon Health, London, United Kingdom.

AI virtual assistants have significant potential to alleviate the pressure on overly burdened healthcare systems by enabling patients to self-assess their symptoms and to seek further care when appropriate. For these systems to make a meaningful contribution to healthcare globally, they must be trusted by patients and healthcare professionals alike, and service the needs of patients in diverse regions and segments of the population. We developed an AI virtual assistant which provides patients with triage and diagnostic information. Read More

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November 2020

A new therapeutic protocol for the treatment of keloid scars: a retrospective study.

J Wound Care 2021 Mar;30(3):184-190

Saint-Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France.

Objective: There are few means to treat large keloid scars, as exeresis-even if partial-impedes direct closure without tension in the absence of a flap or a skin graft. This study evaluates the efficacy, indications for use and limitations of a new therapeutic protocol, combining an extralesional keloid excision left to heal by secondary intention with a paraffin dressing and glucocorticoid ointment, followed by monthly intrascar injections of corticosteroids upon full re-epithelialisation.

Method: A retrospective study of patients treated for keloid scars by using the new therapeutic protocol. Read More

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Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom.

J Biomed Opt 2021 Mar;26(3)

University of Twente, Multi-Modality Medical Imaging, Techmed Centre, Enschede, The Netherlands.

Significance: Recovering accurate oxygenation estimations in the breast with quantitative photoacoustic tomography (QPAT) is not straightforward. Accurate light fluence models are required, but the unknown ground truth of the breast makes it difficult to validate them. Phantoms are often used for the validation, but most reported phantoms have a simple architecture. Read More

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