243,620 results match your criteria stimulation therapy


Five-Session Dual-Transcranial Direct Current Stimulation With Task-Specific Training Does Not Improve Gait and Lower Limb Performance Over Training Alone in Subacute Stroke: A Pilot Randomized Controlled Trial.

Neuromodulation 2021 Sep 21. Epub 2021 Sep 21.

Neuro Electrical Stimulation laboratory (NeuE), Faculty of Physical Therapy, Mahidol University, Salaya, Nakhon Pathom, Thailand.

Objective: To determine the effect of five-session dual-transcranial direct current stimulation (dual-tDCS) combined with task-specific training on gait and lower limb motor performance in individuals with subacute stroke.

Materials And Methods: Twenty-five participants who had a stroke in the subacute phase with mild motor impairment were recruited, randomized, and allocated into two groups. The active group (n = 13) received dual-tDCS with anodal over the lesioned hemisphere M1 and cathodal over the nonlesioned hemisphere, at 2 mA for 20 min before training for five consecutive days, while the sham group (n = 12) received sham mode before training. Read More

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September 2021

Sacral Anterior Root Stimulation (SARS) and visceral function outcomes in spinal cord injury - a systematic review of literature over four decades.

World Neurosurg 2021 Sep 18. Epub 2021 Sep 18.

Centre Bouffard-Vercelli, Pôle Santé Roussillon, 66000 Perpignan, France.

Objectives: The sacral anterior root stimulator (SARS) was developed 40 years ago to restore urinary and bowel functions to individuals with spinal cord injury (SCI). Mostly used to restore lower urinary tract function, SARS implantation is coupled with sacral deafferentation to counteract the problems of chronic detrusor sphincter dyssynergia and detrusor overactivity. In this article, we systematically review 40 years of SARS implantation and assess the medical added-value of this approach in accordance with the PRISMA guidelines (Preferred Reporting Items for Systematic reviews and Meta-Analyses). Read More

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September 2021

Wearable sensor-driven responsive deep brain stimulation for essential tremor.

Brain Stimul 2021 Sep 18. Epub 2021 Sep 18.

J. Crayton Pruitt Department of Biomedical Engineering, Gainesville, FL, USA; Department of Neuroscience, Norman Fixel Institute for Neurological Diseases, Gainesville, FL, USA; Department of Neurology, Norman Fixel Institute for Neurological Diseases, Gainesville, FL, USA. Electronic address:

Background: Deep brain stimulation (DBS) is an effective surgical therapy for individuals with essential tremor (ET). However, DBS operates continuously, resulting in adverse effects such as postural instability or dysarthria. Continuous DBS (cDBS) also presents important practical issues including limited battery life of the implantable neurostimulator (INS). Read More

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September 2021

A tool for evaluating novel osteoarthritis therapies using multivariate analyses of human cartilage-synovium explant co-culture.

Osteoarthritis Cartilage 2021 Sep 18. Epub 2021 Sep 18.

Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Canada; Krembil Research Institute, University Health Network, Canada; Institute of Biomedical Engineering, University of Toronto, Canada; Division of Hematology, Department of Medicine, University of Toronto, Canada. Electronic address:

Objective: There is a need to incorporate multiple tissues into in vitro OA models to evaluate novel therapeutics. This approach is limited by inherent donor variability. We present an optimized research tool: a human OA cartilage-synovium explant co-culture model (OA-EXM) that employs donor-matched lower and upper limit response controls combined with statistical approaches to address variability. Read More

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September 2021

Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation.

J Nanobiotechnology 2021 Sep 20;19(1):280. Epub 2021 Sep 20.

Department of Surgery, University of Wisconsin-Madison, Madison, WI, 53792, USA.

Background: Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy.

Methods: We adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven ES (NG-ES) effects on human skin in vivo-an essential translational step toward clinical application of the NG-ES technique for wound healing.

Results: We show that NG-ES leads to rapid wound closure with complete restoration of normal skin architecture within 7 days compared to more than 30 days in the literature. Read More

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September 2021

Clinical trial on stimulation of suction in preterm cases using neuromotor reactions.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):450-457

Universidad CEU San Pablo, Facultad de Medicina, Departamento de Fisioterapia.

IntroducciÓn: La succión nutritiva es un hito importante para la correcta alimentación del neonato. Los prematuros no tienen desarrollada esta habilidad, por lo que se han diseñado diferentes maneras de estimular su aparición.

Objetivo: Comprobar si la estimulación de los reflejos orales innatos, a través de reacciones neuromotrices, disminuye el tiempo para adquirir la destreza de succión nutritiva. Read More

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January 2020

The Efficacy, Safety and Outcomes of Brain-responsive Neurostimulation (RNS® System) therapy in older adults.

Epilepsia Open 2021 Sep 20. Epub 2021 Sep 20.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Responsive neurostimulation is approved in patients above 18 years of age with drug resistant focal epilepsy. We aimed to investigate whether RNS outcomes and safety varied based on age. We included patients who had been implanted with RNS for >6 months (N=55), dividing them into older (N=11) and younger adults (N=44) depending on implantation age (≥50 and <50 years, respectively). Read More

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September 2021

Heparin-induced Thrombocytopenia in Patients with Coronavirus Disease 2019: Systematic Review and Meta-analysis.

Blood Adv 2021 Sep 20. Epub 2021 Sep 20.

Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red C, Jamaica Plain, Massachusetts, United States.

Heparin thromboprophylaxis is routinely administered during hospitalization for coronavirus disease 2019 (COVID-19). Due to the immune stimulation related to COVID-19, there is ongoing concern regarding a heightened incidence of heparin-induced thrombocytopenia (HIT). We performed a literature search using PubMed, EMBASE, Cochrane and, medRxiv database to identify studies that reported clinical and laboratory characteristics and/or the incidence of HIT in COVID-19 patients. Read More

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September 2021

Repetitive transcranial magnetic stimulation for fibromyalgia patients: A Systematic Review with Meta-Analysis.

Pain Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Rehabilitation, Yueyang Integrated traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of traditional Chinese Medicine, Shanghai, 200437, P. R. China.

Objective: Fibromyalgia is a poorly understood pain syndrome. Repetitive transcranial magnetic stimulation is a noninvasive brain stimulation therapy and is commonly applied for the management of fibromyalgia. However, controversy regarding its efficacy remains. Read More

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September 2021

An unusually prolonged course of late onset severe OHSS with successful outcome - a rare but avoidable complication.

JBRA Assist Reprod 2021 Sep 20. Epub 2021 Sep 20.

Department of Obstetrics & Gynecology. All India Institute of Medical Sciences, New Delhi, India.

Ovarian hyperstimulation syndrome (OHSS) is an entity associated with controlled ovarian stimulation (COS) in assisted reproduction. It presents a great challenge for clinicians concerning a timely diagnosis and intervention, because it is a life-threatening condition. We came across a rare case of late onset severe OHSS, which lasted till 19 weeks of gestation (POG) with diagnostic challenge in which the patient had hemorrhagic ascites post embryo transfer, and transaminitis. Read More

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September 2021

Treatment of upper limb spasticity with inhibitory repetitive transcranial magnetic stimulation: A randomized placebo-controlled trial.

NeuroRehabilitation 2021 Sep 13. Epub 2021 Sep 13.

BDH-Clinic Hessisch Oldendorf, Institute for Neurorehabilitation Research (InFo), Associated Institute of Hannover Medical School, Hessisch Oldendorf, Germany.

Background: Upper limb dysfunction is a frequent complication after stroke impairing outcome. Inhibitory repetitive transcranial magnetic stimulation (rTMS) applied over the contralesional hemisphere is supposed to enhance the positive effects of conventional rehabilitative treatment.

Objective: This double-blind randomized placebo-controlled trial investigated whether inhibitory rTMS as add-on to standard therapy improves upper limb spasticity. Read More

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September 2021

Intermittent Vagal Nerve Stimulation-Associated Vocal Fold Movement Impairment.

Ann Otol Rhinol Laryngol 2021 Sep 18:34894211047459. Epub 2021 Sep 18.

Pediatric Otolaryngology, Texas Children's Hospital, Houston, TX, USA.

Objectives: Implanted vagal nerve stimulators (VNS) are an accepted therapy for refractory seizures. However, VNS have been shown to affect vocal fold function, leading to voice complaints of hoarseness. We present a case of intermittent VNS-related vocal fold paralysis leading to dysphonia and dysphagia with aspiration in a pediatric patient. Read More

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September 2021

The role of immunotherapy for management of advanced thymic epithelial tumors: a narrative review.

Mediastinum 2021 Sep 25;5. Epub 2021 Sep 25.

Thoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

The emergence of immunotherapy as a modern pillar of cancer treatment has changed the treatment landscape for various cancers. Immune checkpoint inhibitors directed at programed death-1 (PD-1) or its ligand (PD-L1), in particular, have found widespread clinical applications and have resulted in durable responses and an improvement in survival of patients with advanced or metastatic disease. Tumor cell PD-L1 expression and tumor mutation burden (TMB) are biomarkers of response and efforts are underway to identify other biomarkers that might predict benefit with these drugs. Read More

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September 2021

Synthetic Antigen-Presenting Cells for Adoptive T Cell Therapy.

Adv Ther (Weinh) 2021 Aug 18;4(8). Epub 2021 Mar 18.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA 30332, USA.

Adoptive T cell therapies are transforming the treatment of solid and liquid tumors, yet their widespread adoption is limited in part by the challenge of generating functional cells. T cell activation and expansion using conventional antigen-presenting cells (APCs) is unreliable due to the variable quality of donor-derived APCs. As a result, engineered approaches using nanomaterials presenting T cell activation signals are a promising alternative due to their ability to be robustly manufactured with precise control over stimulation cues. Read More

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A Comprehensive Update of the Current Understanding of Chronic Fatigue Syndrome.

Anesth Pain Med 2021 Jun 26;11(3):e113629. Epub 2021 Jun 26.

Louisiana State University Health Shreveport, Department of Anesthesiology, Shreveport, LA, USA.

This is a comprehensive literature review of chronic fatigue syndrome (CFS). We provide a description of the background, etiology, pathogenesis, diagnosis, and management regarding CFS. CFS is a multifaceted illness that has many symptoms and a wide array of clinical presentations. Read More

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High Frequency 10 kHz Spinal Cord Stimulation as a First Line Programming Option for Patients With Chronic Pain: A Retrospective Study and Review of the Current Evidence.

Cureus 2021 Aug 16;13(8):e17220. Epub 2021 Aug 16.

Department of Neurosurgery, Rutgers New Jersey Medical School, Newark, USA.

Introduction Neuromodulation is an evolving and increasingly popular therapy for chronic pain management. Recent data suggest that novel waveforms have demonstrated greater benefit over traditional spinal cord stimulation (SCS). The authors conducted a retrospective review of patients undergoing high-frequency 10 kHz SCS at a single tertiary medical center for the purpose of contributing further evidence to this growing body of data. Read More

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Programmed Cell Death Protein 1/Programmed Cell Death Ligand-1 Axis activates Intracellular ERK Signaling in Tumor Cells to Mediate Poor Prognosis in T-cell Lymphoma.

J Cancer 2021 25;12(20):6126-6134. Epub 2021 Aug 25.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

To investigate the prognostic significance of programmed cell death ligand-1 (PD-L1) and phosphorylated ERK (p-ERK) and their interactions in T-cell lymphoma (TCL). The mRNA levels of PD-L1 and ERK in TCL samples were analyzed. Formalin-fixed paraffin-embedded tissues from 69 TCL patients were collected to detect the expression of PD-L1 and p-ERK by multiplexed immunofluorescence staining. Read More

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Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells.

Oncol Lett 2021 Nov 27;22(5):749. Epub 2021 Aug 27.

Beijing Key Laboratory of Therapeutic Gene Engineering Antibody, Beijing 100850, P.R. China.

The receptor tyrosine kinase, anexelekto (Axl) is involved in tumor cell growth, migration and invasion, and has been associated with chemotherapy resistance, which makes it an attractive target for cancer therapy. In total, six Axl-targeted monoclonal antibodies (mAbs) and two antibody-drug conjugates have been reported in the last 10 years, which have been shown to have bioactivity in inhibiting tumor cell proliferation and migration. The Axl external cell domain (Axl), consisting of 426 amino acids, has always been used as an antigen in the screening process for all six of these Axl-targeted mAbs. Read More

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November 2021

Fatigue in patients with acquired brain damage.

Neurologia 2021 Sep 15. Epub 2021 Sep 15.

Unidad Avanzada de Neurorrehabilitación, Hospital Los Madroños, Madrid, España; Servicio de Neurofisiología, Hospital Los Madroños, Madrid, España; Grupo FENNSI, Hospital Nacional de Parapléjicos, SESCAM, Toledo, España.

Fatigue is a complex, multidimensional syndrome that is prevalent in patients with acquired brain damage and has a negative impact on the neurorehabilitation process. It presents from early stages after the injury, and may persist over time, regardless of whether sequelae have resolved. Fatigue is conditioned by upper neuronal circuits, and is defined as an abnormal perception of overexertion. Read More

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September 2021

Shape and volume changes of the superior lateral ventricle after electroconvulsive therapy measured with ultra-high field MRI.

Psychiatry Res Neuroimaging 2021 Sep 3;317:111384. Epub 2021 Sep 3.

University Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells and Systems, Groningen, the Netherlands.

The subventricular zone (SVZ) of the lateral ventricles harbors neuronal stem cells in adult mammals. Rodent studies report neurogenic effects in the SVZ of electroconvulsive stimulation. We hypothesize that if this finding translates to depressed patients undergoing electroconvulsive therapy (ECT), this would be reflected in shape changes at the SVZ. Read More

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September 2021

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system.

J Neuroinflammation 2021 Sep 18;18(1):213. Epub 2021 Sep 18.

Cyclerion Therapeutics, 245 First St., Riverview II, 18th Floor, Cambridge, MA, 02142, USA.

Background: Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling plays an essential role in modulating neuroinflammation. CYR119 is a CNS-penetrant sGC stimulator that amplifies endogenous NO-sGC-cGMP signaling. Read More

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September 2021

HLA-DRB1 risk alleles for RA are associated with differential clinical responsiveness to abatacept and adalimumab: data from a head-to-head, randomized, single-blind study in autoantibody-positive early RA.

Arthritis Res Ther 2021 Sep 18;23(1):245. Epub 2021 Sep 18.

Division of Rheumatology, Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021, USA.

Background: Certain risk alleles associated with autoantibody-positive rheumatoid arthritis (RA) have been linked to poorer prognoses. In patients with autoantibody-positive RA, abatacept shows differential efficacy to tumor necrosis factor inhibitors. Our aim was to investigate the relationship between clinical response to abatacept and to adalimumab and presence of risk alleles encoding human leukocyte antigen (HLA)-DRB1 shared epitope (SE) in RA. Read More

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September 2021

Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma.

Biomed Pharmacother 2021 Sep 15;143:112168. Epub 2021 Sep 15.

Department of Histology and Embryology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.

We investigated the anticancer effect of disulfiram and metformin combination on fibrosarcoma in hamsters. Hamsters of both sexes (~ 70 g) were randomly allocated to control and experimental groups (8 animals per group). In all 10 groups, 2 × 10 BHK-21/C13 cells in 1 ml were injected subcutaneously into the animals' backs. Read More

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September 2021

Non-pharmacological Treatment for Children With Functional Constipation: A Systematic Review and Meta-analysis.

J Pediatr 2021 Sep 15. Epub 2021 Sep 15.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Gastroenterology and Nutrition, Amsterdam, The Netherlands.

Objective: To evaluate the effectiveness and safety of non-pharmacological interventions for the treatment of childhood functional constipation functional constipation.

Study Design: Randomized controlled trials (RCTs) evaluating non-pharmacological treatments in children with functional constipation which reported at least one outcome of the core outcome set for children with functional constipation.

Results: 52 RCTs were included with 4668 children, aged between 2 weeks and 18 years, of whom 47% were females. Read More

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September 2021

PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism: Drp1-dependent mechanism.

Mol Oncol 2021 Sep 17. Epub 2021 Sep 17.

Department of Biology, University of Rome Tor Vergata, 00133, Rome, Italy.

Programmed cell death-1 (PD-1) signaling downregulates the T cell response, promoting an exhausted state in tumor-infiltrating T cells, through mostly unveiled molecular mechanisms. Dynamin-related protein-1 (Drp1)-dependent mitochondrial fission plays a crucial role in sustaining T cell motility, proliferation, survival, and glycolytic engagement. Interestingly, such processes are exactly those inhibited by PD-1 in tumor-infiltrating T cells. Read More

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September 2021

Comparative efficacy of non-invasive neurostimulation therapies for poststroke dysphagia: A systematic review and meta-analysis.

Neurophysiol Clin 2021 Sep 15. Epub 2021 Sep 15.

Department of Physical Medicine and Rehabilitation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, 266000, PR China. Electronic address:

Objective: To explore the effect of non-invasive neurostimulation therapies on dysphagia patients after stroke.

Methods: We searched MEDLINE (Ovid), PubMed, Embase, Web of Science, ScienceDirect, and Cochrane library databases until April 22, 2020. All published and unpublished randomized controlled trials (RCT) were included. Read More

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September 2021

"Pityriasis Rosea-like cutaneous eruption as a possible dermatological manifestation after Oxford-AstraZeneca vaccine: case report and brief literature review."

Dermatol Ther 2021 Sep 17:e15129. Epub 2021 Sep 17.

Infectious Disease Specialist - Department of Infectiology Diagnosis - State Program - STI/AIDS Reference and Training Center of São Paulo, São Paulo, São Paulo, Brazil.

Pityriasis Rosea (PR) has been manifested in patients suffering from COVID-19 as well as after vaccine protocols against SARS-CoV-2. It has a possible association with the HHV-6B virus (roseola infantum) and can be controlled by antivirals such as acyclovir as well as by the amino acid L-Lysine that showed a positive result in reducing the number of lesions and healing time. The aim of this study was to report a case of PR after a second dose of Oxford-AstraZeneca, the adopted therapy and a brief literature review. Read More

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September 2021

Relevance of the Kappa Dynorphin System to Schizophrenia and Its Therapeutics.

J Psychiatr Brain Sci 2021 24;6. Epub 2021 Aug 24.

Stony Brook University, 100 Nicolls rd, Stony Brook, 11794 NY, USA.

Multiple lines of evidence suggest a potential role for the kappa dynorphin system in schizophrenia and its therapeutics. Kappa stimulation acutely and chronically modulates dopamine in opposite ways, where acutely it decreases dopamine transmission and chronically it increases it and it can induce D2 sensitization. In addition, pharmacological evidence from studies using agonist and antagonists at KOR have indicated a therapeutic potential of KOR antagonists for psychosis. Read More

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Effects of N-Methyl-D-aspartate receptor (NMDAR) and Ca/calmodulin-dependent protein kinase IIα (CaMKIIα) on learning and memory impairment in depressed rats with different charge by modified electroconvulsive shock.

Ann Transl Med 2021 Aug;9(16):1320

Department of Anesthesiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: With the development of modified electroshock therapy (MECT), it has become necessary to increase the electric quantity in order to achieve a good antidepressant effect, but this increase will lead to more serious learning and memory impairment. The purpose of this study was to investigate the intrinsic mechanism of cognitive impairment induced by high-energy electroconvulsive shock (MECS, an animal model of MECT).

Methods: Rats were randomly divided into 6 groups: control (C, n=6), M0, M60, M120, M180, and M240 groups (MECS at 0, 60, 120, 180, and 240 mC stimulation intensity after 80 mg/kg propofol, with 12 rats in each group). Read More

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Hemodynamic Responses in Carotid Bifurcation Induced by Enhanced External Counterpulsation Stimulation in Healthy Controls and Patients With Neurological Disorders.

Front Physiol 2021 31;12:717080. Epub 2021 Aug 31.

Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.

Enhanced external counterpulsation is a Food and Drug Administration-approved, non-invasive, assisted circulation therapy for ischemic cardiovascular and cerebrovascular diseases. Previous studies have confirmed that EECP stimulation induces largely different cerebral hemodynamic responses in patients with ischemic stroke and healthy controls. However, the underlying mechanisms remain uncertain. Read More

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