9,217 results match your criteria stimulating neutrophil


Factors for the optimal selection of granulocyte colony-stimulating factor preparations and predictors for R-CHOP dose reductions/delays among patients with non-Hodgkin B-cell lymphoma (STOP FN in NHL 2 subanalysis).

BMC Cancer 2021 Apr 6;21(1):358. Epub 2021 Apr 6.

Division of Hematology Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: A classification tree was used to analyze background factors for granulocyte colony-stimulating factor (G-CSF) preparation selection for febrile neutropenia (FN) prophylaxis in Japanese patients with non-Hodgkin B-cell lymphoma receiving the first R-CHOP cycle.

Methods: This was a subanalysis of the retrospective observational study STOP FN in NHL 2 (UMIN000029534). Patient characteristics, changes in neutrophil count, incidence and severity of neutropenia, and risk factors for dose reduction/delay of R-CHOP were assessed by G-CSF formulation. Read More

View Article and Full-Text PDF

Change in the neutrophil-to-lymphocyte ratio during chemotherapy may predict prognosis in patients with advanced or metastatic colorectal cancer.

Mol Clin Oncol 2021 May 20;14(5):107. Epub 2021 Mar 20.

Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Fukushima 969-3492, Japan.

The neutrophil-to-lymphocyte ratio (NLR) has been reported to be an independent prognostic factor of unresectable advanced or metastatic colorectal cancer (uCRC). However, few studies have documented changes in NLR during chemotherapy. The current study analyzed whether a change in NLR during chemotherapy in patients with uCRC could be used as a prognostic biomarker. Read More

View Article and Full-Text PDF

Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.

Fibrinogen is a well-known risk factor for arterial and venous thrombosis. Its function is not restricted to clot formation, however, as it partakes in a complex interplay between thrombin, soluble plasma fibrinogen, and deposited fibrin matrices. Fibrinogen, like thrombin, participates predominantly in hemostasis to maintain vascular integrity, but executes some important pleiotropic effects: firstly, as observed in thrombin generation experiments, fibrin removes thrombin from free solution by adsorption. Read More

View Article and Full-Text PDF

Infarct in the Heart: What's MMP-9 Got to Do with It?

Biomolecules 2021 Mar 25;11(4). Epub 2021 Mar 25.

Center for Heart and Vascular Research, Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68102, USA.

Over the past three decades, numerous studies have shown a strong connection between matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left ventricle remodeling and dysfunction. Despite this fact, clinical trials using MMP-9 inhibitors have been disappointing. This review focuses on the roles of MMP-9 in MI wound healing. Read More

View Article and Full-Text PDF

Inflammation-Related Markers and Thyroid Function Measures in Pediatric Patients: Is the Grade of Obesity Relevant?

Diagnostics (Basel) 2021 Mar 9;11(3). Epub 2021 Mar 9.

Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, Louis Pasteur Str., No. 6, 400349 Cluj-Napoca, Romania.

We aimed to investigate the effect of weight status on inflammation-related markers and thyroid function tests in overweight and obese pediatric patients. Children and adolescents diagnosed between January 2017 and January 2019 with overweight or obesity were included in the study. Neutrophil-to-lymphocyte ratio (NLR), platelet-to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) were calculated for the groups defined according to Body Mass Index (BMI)-for-age -score: overweight (≥1 BMI-for-age -score), obese (≥2 BMI-for-age -score) and severely obese (≥3 BMI-for-age -score). Read More

View Article and Full-Text PDF

Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining.

Front Oncol 2021 16;11:608113. Epub 2021 Mar 16.

Public Experimental Technology Center, The School of Basic Medical Science, Southwest Medical University, Luzhou, China.

Sialic acid-binding immunoglobulin-type lectin (SIGLEC) family members are involved in regulating immune-cell activation, proliferation, and apoptosis, and they play an important role in tumor development. However, their expression and correlation with immune molecules in lung adenocarcinoma (LUAD) remain unclear. We utilized Gene Expression Profiling Interactive Analysis, Kaplan-Meier analysis, the limma package in R/Bioconductor, the University of California Santa Cruz Cancer Genome Browser, cBioPortal, STRING, Cytoscape, DAVID, and the Tumor Immune Estimation Resource for gene and protein profiling and analyses. Read More

View Article and Full-Text PDF

A whole-body circulatory neutrophil model with application to predicting clinical neutropenia from in vitro studies.

CPT Pharmacometrics Syst Pharmacol 2021 Apr 1. Epub 2021 Apr 1.

Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.

A circulatory model of granulopoiesis and its regulation is presented that includes neutrophil trafficking in lung, liver, spleen, bone marrow, lymph node and blood. In each organ, neutrophils undergo transendothelial migration from vascular to interstitial space, clearance due to apoptosis, and recycling via the lymphatic flow. The model includes cell cycling of progenitor cells in the bone marrow, granulocyte-colony stimulating factor (G-CSF) kinetics and its neutrophil regulatory action, as well as neutrophil margination in the blood. Read More

View Article and Full-Text PDF

Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP.

Cell Rep 2021 Mar;34(13):108919

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, AB T2N 4N1, Canada; Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona 08036, Spain. Electronic address:

Neutrophils with immunoregulatory properties, also referred to as type-2 neutrophils (N2), myeloid-derived suppressor cells (MDSCs), or tumor-associated neutrophils (TANs), comprise a heterogeneous subset of cells that arise from unknown precursors in response to poorly understood cues. Here, we find that, in several models of liver autoimmunity, pharmacologically induced, autoantigen-specific T regulatory type-1 (TR1) cells and TR1-cell-induced B regulatory (B) cells use five immunoregulatory cytokines to coordinately recruit neutrophils into the liver and program their transcriptome to generate regulatory neutrophils. The liver-associated neutrophils from the treated mice, unlike their circulating counterparts or the liver neutrophils of sick mice lacking antigen-specific TR1 cells, are proliferative, can transfer disease protection to immunocompromised hosts engrafted with pathogenic effectors, and blunt antigen-presentation and local autoimmune responses via cathelin-related anti-microbial peptide (CRAMP), a cathelicidin, in a CRAMP-receptor-dependent manner. Read More

View Article and Full-Text PDF

G-CSF reduces loss of dopaminergic neurons by inhibiting TNF-α and IL-1β in mouse model of Parkinson's disease.

Int J Neurosci 2021 Mar 29:1-12. Epub 2021 Mar 29.

Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.

granulocyte-colony stimulating factor (G-CSF) is a hematopoietic growth factor existing in neutrophils, glial cells and neurons. Increasing researches discovered that G-CSF improved cell survival in neurodegenerative diseases by its anti-inflammatory effect. However, the effect of G-CSF in suppressing inflammation in Parkinson's disease (PD) remains unclear. Read More

View Article and Full-Text PDF

Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease.

Alzheimers Dement (N Y) 2021 24;7(1):e12158. Epub 2021 Mar 24.

Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.

Introduction: Inflammatory markers have long been observed in the brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients, suggesting that inflammation contributes to AD and might be a therapeutic target. However, non-steroidal anti-inflammatory drug trials in AD and mild cognitive impairment (MCI) failed to show benefit. Our previous work seeking to understand why people with the inflammatory disease rheumatoid arthritis are protected from AD found that short-term treatment of transgenic AD mice with the pro-inflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) led to an increase in activated microglia, a 50% reduction in amyloid load, an increase in synaptic area, and improvement in spatial memory to normal. Read More

View Article and Full-Text PDF

Chronic infection by nontypeable fuels airway inflammation.

ERJ Open Res 2021 Jan 22;7(1). Epub 2021 Mar 22.

IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Emerging bacterial pathogens Unit, Milan, Italy.

Nontypeable (NTHi) is commonly isolated from airways of patients suffering from chronic respiratory diseases, such as COPD or cystic fibrosis (CF). However, to what extent NTHi long-term infection contributes to the lung inflammatory burden during chronic airway disease is still controversial. Here, we exploited human respiratory samples from a small cohort of CF patients and found that patients chronically infected with NTHi had significantly higher levels of interleukin (IL)-8 and CXCL1 than those who were not infected. Read More

View Article and Full-Text PDF
January 2021

Lung Functioning and Inflammation in a Mouse Model of Systemic Juvenile Idiopathic Arthritis.

Front Immunol 2021 12;12:642778. Epub 2021 Mar 12.

Laboratory of Immunobiology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

Systemic juvenile idiopathic arthritis (sJIA) is an immune disorder characterized by fever, skin rash, arthritis and splenomegaly. Recently, increasing number of sJIA patients were reported having lung disease. Here, we explored lung abnormalities in a mouse model for sJIA relying on injection of IFN-γ deficient (IFN-γ KO) mice with complete Freund's adjuvant (CFA). Read More

View Article and Full-Text PDF

In-Depth Analysis of the Hidradenitis Suppurativa Serum Proteome Identifies Distinct Inflammatory Subtypes.

J Invest Dermatol 2021 Mar 22. Epub 2021 Mar 22.

Laboratory of Investigative Dermatology, The Rockefeller University, New York, NY, USA. Electronic address:

Hidradenitis Suppurativa (HS) is a chronic inflammatory dermatosis with presentations ranging from painful nodules and abscesses to draining tunnels. Using an unbiased proteomics approach, we assessed 368 cardiovascular, cardiometabolic and inflammation-related biomarkers in serum of moderate to severe HS patients. HS serum clustered separately from healthy controls and had an up-regulation of neutrophil-related markers (Cathepsin D, IL-17A, CXCL1). Read More

View Article and Full-Text PDF

Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival.

J Immunol Res 2021 1;2021:6613247. Epub 2021 Mar 1.

Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Neutrophils are prominent components of gastric cancer (GC) tumors and exhibit distinct phenotypes in GC environment. However, the phenotype, regulation, and clinical relevance of neutrophils in human GC are presently unknown. Here, immunohistochemistry, real-time PCR, and flow cytometry analyses were performed to examine levels and phenotype of neutrophils in samples from 41 patients with GC, and also isolated, stimulated, and/or cultured neutrophils for regulation assays. Read More

View Article and Full-Text PDF

Toll-Like Receptor 4 Protects Against Infection in Mice.

Front Cell Infect Microbiol 2021 8;11:633440. Epub 2021 Mar 8.

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Japan.

Toll-like receptor 4 (TLR4) has been reported to protect against Gram-negative bacteria by acting as a pathogen recognition receptor that senses mainly lipopolysaccharide (LPS) from Gram-negative bacteria. However, the role of TLR4 in Gram-positive bacterial infection is less well understood. type A is a Gram-positive bacterium that causes gas gangrene characterized by severe myonecrosis. Read More

View Article and Full-Text PDF

Rare case of pancrelipase therapy-induced neutropaenia.

BMJ Case Rep 2021 Mar 22;14(3). Epub 2021 Mar 22.

Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.

A 61-year-old man was transferred to our facility from an outside hospital due to refractory neutropaenia of unknown aetiology. The patient presented to the referring hospital with a 5-day history of worsening diarrhoea and abdominal pain. Initial lab results at presentation showed severe neutropaenia with an absolute neutrophil count of 0. Read More

View Article and Full-Text PDF

Primary prophylaxis with pegfilgrastim during the first cycle of R-CHOP to avoid reduction of dose intensity in elderly patients.

Int J Hematol 2021 Mar 18. Epub 2021 Mar 18.

Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

The long-term effects of pegfilgrastim administered in the first cycle of chemotherapy in day-to-day practice remain unclear. We retrospectively identified 114 patients aged ≥ 70 years with diffuse large B-cell lymphoma who received a rituximab-cyclophosphamide-doxorubicin-vincristine-prednisolone (R-CHOP) regimen in our institution. Twenty-six patients received pegfilgrastim (pegfilgrastim group); of the 88 patients scheduled to receive conventional granulocyte-colony stimulating factor (G-CSF) when their neutrophil count decreased (neut-adjusted-G group), conventional G-CSF was ultimately administered to 57. Read More

View Article and Full-Text PDF

Effect of smoking cessation on chronic waterpipe smoke inhalation-induced airway hyperresponsiveness, inflammation and oxidative stress.

Am J Physiol Lung Cell Mol Physiol 2021 Mar 10. Epub 2021 Mar 10.

Sultan Qaboos University‎.

Waterpipe smoking (WPS) prevalence is increasing globally. Clinical and laboratory investigations reported that WPS triggers impairment of pulmonary function, inflammation and oxidative stress. However, little is known if smoking cessation (SC) would reverse the adverse pulmonary effects induced by WPS. Read More

View Article and Full-Text PDF

Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, , in Patients With Cirrhosis.

Hepatol Commun 2021 Mar 5;5(3):502-515. Epub 2021 Jan 5.

Department of Medicine Massachusetts General Hospital Boston MA USA.

Neutrophils are the most abundant white blood cell in the body and are key participants in the defense against fungal infections. Fungal infections occur often in patients with cirrhosis and are associated with increased 30-day and 90-day mortality. Previous studies have shown that specific neutrophil functions are abnormal in patients with cirrhosis, although the extent of neutrophil dysfunction is not well understood. Read More

View Article and Full-Text PDF

Inhibition of Colony Stimulating Factor 1 Receptor Suppresses Neuroinflammation and Neonatal Hypoxic-Ischemic Brain Injury.

Front Neurol 2021 18;12:607370. Epub 2021 Feb 18.

Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Hypoxic-ischemic (HI) brain injury is a major cause of neonatal death or lifetime disability without widely accepted effective pharmacological treatments. It has been shown that the survival of microglia requires colony-stimulating factor 1 receptor (CSF1R) signaling and microglia participate in neonatal HI brain injury. We therefore hypothesize that microglia depletion during a HI insult period could reduce immature brain injury. Read More

View Article and Full-Text PDF
February 2021

[Analysis of the efficacy and safety of plerixafor combined with G-CSF in plasma cell disease mobilization].

Zhonghua Xue Ye Xue Za Zhi 2021 Jan;42(1):21-26

Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematology Disease, Beijing 100044, China Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215123, China.

To analyze the effect and safety of plerixafor combined with G-CSF mobilization in plasma cell disease. The clinical baseline data, success rate of collection, and adverse reactions of consecutive cases of plasma cell disease were analyzed retrospectively, where the patients received plerixafor combined with G-CSF for autologous hematopoietic stem cell mobilization in Peking University People's Hospital from January 2018 to December 2019. Forty-nine patients with plasma disease were included, of which 39 (79. Read More

View Article and Full-Text PDF
January 2021

G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation.

Cytokine 2021 Mar 4;142:155479. Epub 2021 Mar 4.

Division of Gastroenterology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, United States. Electronic address:

Granulocyte colony-stimulating factor (G-CSF) is a cytokine most well-known for maturation and mobilization of bone marrow neutrophils. Although it is used therapeutically to treat chemotherapy induced neutropenia, it is also highly expressed in some tumors. Case reports suggest that tumors expressing high levels of G-CSF are aggressive, more difficult to treat, and present with poor prognosis and high mortality rates. Read More

View Article and Full-Text PDF

Janus kinase signaling as risk factor and therapeutic target for severe SARS-CoV-2 infection.

Eur J Immunol 2021 Mar 5. Epub 2021 Mar 5.

Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Cytokine signaling, especially interferon (IFN) signaling is closely linked to several aspects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During initial SARS-CoV-2 infection, symptomatic patients present with impaired type I/III IFN-mediated antiviral responses. Interestingly, IFNs regulate the cellular entry receptor for SARS-CoV-2 on epithelial and endothelial cells. Read More

View Article and Full-Text PDF

A neutrophil activation signature predicts critical illness and mortality in COVID-19.

Blood Adv 2021 03;5(5):1164-1177

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and.

Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling of plasma from cross-sectional and longitudinal cohorts of hospitalized patients with COVID-19 and analyzed clinical data from our health system database of more than 3300 patients. Using a machine learning algorithm, we identified a prominent signature of neutrophil activation, including resistin, lipocalin-2, hepatocyte growth factor, interleukin-8, and granulocyte colony-stimulating factor, which were the strongest predictors of critical illness. Read More

View Article and Full-Text PDF

[Clinical and molecular inflammatory alterations in chronic granulomatous disease].

Rev Alerg Mex 2020 Oct-Dec;67(4):370-380

Secretaría de Salud, Instituto Nacional de Pediatría, Unidad de Investigación en Inmunodeficiencias, Ciudad de México, México.

Chronic granulomatous disease (CGD) is an inborn error of immunity. CGD is characterized by a deficiency in the function of the NADPH oxidase complex. CGD has been an opportunity to study the function of reactive oxygen species (ROS) in the innate immune system. Read More

View Article and Full-Text PDF
February 2021

Neonatal Encephalopathy Is Associated With Altered IL-8 and GM-CSF Which Correlates With Outcomes.

Front Pediatr 2020 8;8:556216. Epub 2021 Feb 8.

National Children's Research Centre, Dublin, Ireland.

To investigate the relationship between cytokines associated with innate immune cell activation and brain injury and outcome in infants with NE compared to neonatal controls. Serum and CSF biomarkers associated with activated neutrophils and monocytes [Interleukin-8 (IL-8) and Granulocyte-Macrophage-Colony-Stimulating-Factor (GM-CSF)] were serially measured using duplex immunoassays on days 1, 3 and 7 in term newborns with NE and controls. Results were compared to grade of encephalopathy, seizures, MRI brain imaging, mortality and Bayley Score of Infant and Toddler Development (Bayley-III) at 2 years of age. Read More

View Article and Full-Text PDF
February 2021

Safety of fluoroscopically guided pain procedures in patients receiving cytotoxic chemotherapy: a retrospective analysis.

Support Care Cancer 2021 Feb 24. Epub 2021 Feb 24.

Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI, USA.

Purpose: To examine the incidence of bleeding and infectious adverse events (AEs) in patients undergoing interventional, fluoroscopic-guided axial spine procedures to modulate pain.

Methods: Retrospective data of patients undergoing fluoroscopically guided axial spine injections at a single tertiary care medical center Cancer Rehabilitation program in the USA were reviewed. AEs, type of chemotherapy, type of tumor, age, platelet and absolute neutrophil counts (ANC) prior to the procedure, and relevant past medical history were collected. Read More

View Article and Full-Text PDF
February 2021

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status.

J Neuroinflammation 2021 Feb 21;18(1):55. Epub 2021 Feb 21.

Department of Pediatrics, Zhujiang Hospital of Southern Medical University, Guangzhou, 510282, People's Republic of China.

Hypoxic-ischemic encephalopathy (HIE) is an important cause of permanent damage to central nervous system (CNS) that may result in neonatal death or manifest later as mental retardation, epilepsy, cerebral palsy, or developmental delay. The primary cause of this condition is systemic hypoxemia and/or reduced cerebral blood flow with long-lasting neurological disabilities and neurodevelopmental impairment in neonates. About 20 to 25% of infants with HIE die in the neonatal period, and 25-30% of survivors are left with permanent neurodevelopmental abnormalities. Read More

View Article and Full-Text PDF
February 2021

Neutropenia Prevention in the Treatment of Post-docetaxel Metastatic, Castration-resistant Prostate Cancer With Cabazitaxel and Prednisone: A Multicenter, Open-label, Single-arm Phase IV Study.

Clin Genitourin Cancer 2021 Jan 7. Epub 2021 Jan 7.

CEPHO - Center for Studies and Research in Hematology and Oncology, Medicine Faculty of ABC, Santo André, Brazil.

Introduction: Severe neutropenia is a dose-limiting factor that occurs in up to 82% of patients with metastatic castration-resistant prostate cancer (mCRPC) treated with cabazitaxel. This study evaluated the effectiveness of granulocyte colony-stimulating factor (G-CSF) plus ciprofloxacin as prophylaxis in post-docetaxel patients with mCRPC treated with cabazitaxel and at high risk for neutropenia.

Patients And Methods: This was a phase IV, multicenter, open-label, single-arm interventional study with men aged ≥ 65 years (or < 65 years and ≥ 25% irradiated bone marrow), presenting with mCRPC after docetaxel failure, performance status ≤ 1, and life expectancy > 12 weeks. Read More

View Article and Full-Text PDF
January 2021

G-CSFR antagonism reduces mucosal injury and airways fibrosis in a virus-dependent model of severe asthma.

Br J Pharmacol 2021 Apr;178(8):1869-1885

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.

Background And Purpose: Asthma is a chronic disease that displays heterogeneous clinical and molecular features. A phenotypic subset of late-onset severe asthmatics has debilitating fixed airflow obstruction, increased neutrophilic inflammation and a history of pneumonia. Influenza A virus (IAV) is an important viral cause of pneumonia and asthmatics are frequently hospitalised during IAV epidemics. Read More

View Article and Full-Text PDF