84,971 results match your criteria stimulating hormone

The relationship between urinary phthalate metabolites and polycystic ovary syndrome in women undergoing in vitro fertilization: Nested case-control study.

Iman Al-Saleh

Chemosphere 2021 Jul 14;286(Pt 1):131495. Epub 2021 Jul 14.

Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, PO Box: 3354, Riyadh, 11211, Saudi Arabia. Electronic address:

Certain endocrine disruptor chemicals are involved in the pathogenesis of polycystic ovary syndrome (PCOS), a hormonal disease related to infertility in women. Phthalates are the most common plasticizers found in several consumer products. Experimental and epidemiologic evidence suggests that some phthalates disrupt endocrine functions in reproductive mechanisms and development. Read More

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Vitamin D improves oxidative stress and histopathological damage in rat ovaries caused by hyperthyroidism.

J Obstet Gynaecol Res 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, Adıyaman University School of Medicine, Adıyaman, Turkey.

Objective: The aim of this study is to investigate the histopathological and biochemical efficacy of vitamin D on oxidative damage and fibrosis in rat ovaries induced by experimental hyperthyroidism.

Methods: This study is a comparative, prospective experimental rat study. Sprague-Dawley female rats were divided into four groups. Read More

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How to use thionamide anti-thyroid drug in the young- what's new?

Tim Cheetham

Thyroid Res 2021 Jul 21;14(1):18. Epub 2021 Jul 21.

Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

The excess thyroid hormone secretion that characterises Graves' disease (GD) is generated when stimulatory antibodies bind to the thyroid stimulating hormone receptor on the follicular cell of the thyroid gland.This underlying mechanism cannot easily be abolished and the mainstay of Graves' disease (GD) management in the young remains thionamide anti-thyroid drug (ATD). Unfortunately, GD will usually recur after a 2 or 3 year course of ATD, even when the stimulatory antibody titres have fallen. Read More

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High Iodine Nutrition May Be a Risk Factor for Cervical Lymph Node Metastasis in Papillary Thyroid Cancer Patients.

Ann Nutr Metab 2021 Jul 21:1-10. Epub 2021 Jul 21.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.

Purpose: The aim of this study was to retrospectively identify the effect of iodine on the papillary thyroid cancer (PTC) process and investigate the risk clinicopathologic characteristics of cervical lymph node metastasis (CLNM) for achieving a better preventive strategy of PTC.

Methods: Totally 187 patients with CLNM and 279 without CLNM (NCLNM) were enrolled, and their urinary iodine concentration (UIC) and serum iodine concentration (SIC) were measured. Logistic regressions were used to reveal the effects of iodine nutrition on the CLNM status of PTC. Read More

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C-reactive protein and thyroid-stimulating hormone levels as risk factors for hypothyroidism in patients with subacute thyroiditis.

Endocr Connect 2021 Jul 1. Epub 2021 Jul 1.

N Zhang, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, 310016, China.

Objective: This study was designed to explore the relationships between the clinical characteristics and outcomes of patients with subacute thyroiditis (SAT).

Design: This is a single-center retrospective study.

Patients: Eighty-nine patients with SAT who were hospitalized in the Sir Run Run Shaw Hospital in Zhejiang, China, from October 2014 to September 2020 were included. Read More

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Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment.

Clin Exp Pharmacol Physiol 2021 Jul 21. Epub 2021 Jul 21.

Department of Dermatology and Andrology, Al-Azhar University (Assuit), Egypt.

Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible changes in thyroid-stimulating hormone (TSH), free thyroxin (fT4) and free triiodothyronine (fT3) levels during isotretinoin treatment and analyzing the possible factors which may contribute to such changes. In the present study, forty-seven patients received (0. Read More

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Laboratory characteristics analysis of the efficacy of levothyroxine on subclinical hypothyroidism during pregnancy: a single-center retrospective study.

Bioengineered 2021 Dec;12(1):4183-4190

Department of Obstetrics, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.

To reassess the efficacy of levothyroxine on subclinical hypothyroidism (SCH, 4.0 mIU/L ≤ TSH (thyroid stimulating hormone) <10 mIU/L with normal free T4) during pregnancy. 165 levothyroxine-treated pregnant women experiencing SCH were screened. Read More

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December 2021

Prediction of ovarian response in IVF/ICSI cycles.

JBRA Assist Reprod 2021 Jul 21;25(3):422-427. Epub 2021 Jul 21.

Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.

Objective: Our study aims to evaluate the various correlations between demographic, biochemical, ultrasound, and ovarian stimulation parameters with the percentage of mature oocytes in conventional stimulation for IVF/ICSI cycles in order to develop a predictive model to improve our understanding of the oocyte maturation process.

Methods: This is a retrospective cohort study; patients underwent conventional antagonist ovarian stimulation protocols for fresh IVF/ICSI cycles. A total of 256 IVF/ICSI cycles were included. Read More

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Burnout and metabolic syndrome among healthcare workers: Is subclinical hypothyroidism a mediator?

J Occup Health 2021 Jan;63(1):e12252

Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taiwan.

Objectives: Evidence suggests that subclinical hypothyroidism (SCH) is associated with burnout and metabolic syndrome (MetS). We examined the relationship between burnout and MetS among healthcare workers (HCWs) and investigated the potential mediation of SCH.

Methods: This cross-sectional study included HCWs from a tertiary medical center; demographic data were obtained using a questionnaire. Read More

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January 2021

Interpretative commenting in clinical chemistry with worked examples for thyroid function test reports.

Pract Lab Med 2021 Aug 9;26:e00243. Epub 2021 Jul 9.

Department of Laboratory Medicine, National University Hospital, Singapore.

Correct interpretation of pathology results is a requirement for accurate diagnosis and appropriate patient management. Clinical Pathologists and Scientists are increasingly focusing on providing quality interpretative comments on their reports and these comments are appreciated by clinicians who receive them. Interpretative comments may improve patient outcomes by helping reduce errors in application of the results in patient management. Read More

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A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy.

Biomed Res Int 2021 3;2021:6624101. Epub 2021 Jul 3.

Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Aims: Although several studies have indicated that valproate (VPA) and oxcarbazepine (OXC) cause reproductive endocrine disorders and sexual dysfunction, there remains some controversy regarding these issues in males with epilepsy. This study is aimed at evaluating the effects of VPA and OXC on sexual function, sperm quality, and sex hormones in young males with epilepsy.

Methods: Males with newly diagnosed epilepsy treated with VPA and OXC were recruited, and sexual function questionnaires (International Index of Erectile Function-5 (IIEF-5)), sperm quality, and sex hormone levels were assessed before treatment and at 6 months after treatment with VPA or OXC monotherapy. Read More

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Giant plurihormonal pituitary adenoma in a child - case study.

J Pediatr Endocrinol Metab 2021 Jul 21. Epub 2021 Jul 21.

Department of Endocrinology and Diabetology, Children's Memorial Health Institute, Warsaw, Poland.

Objectives: To describe the case of a 12-year-old girl with a rare plurihormonal pituitary macroadenoma secreting prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), and alpha subunit (α-SU).

Case Presentation: The patient experienced recurrent headaches and progressing loss of vision in one eye. During the examination, abnormalities such as tall stature, coarse facial features, enlarged feet and hands, tachycardia, hand tremor, hyperhidrosis, galactorrhea, and goiter were observed. Read More

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Biochemical transition during triphasic postpartum thyroiditis: confusion with central hypothyroidism.

Endocrinol Diabetes Metab Case Rep 2021 Jul 19;2021(21-0069). Epub 2021 Jul 19.

Department of Diabetes and Endocrinology, Peterborough City Hospital, Peterborough, UK.

Summary: Hypothyroidism occurring in the postpartum period can be due to pituitary or hypothalamic disease as in Sheehan's syndrome and postpartum autoimmune hypophysitis or due to a primary thyroid disease as in postpartum thyroiditis. It is important that the correct diagnosis is ascertained because hypothalamic or pituitary disorders are often associated with other pituitary hormone deficiencies, especially life-threatening adrenal insufficiency or adrenal crisis. A combination of various symptoms and biochemical markers, especially serum thyroid-stimulating hormone levels dictate the initial diagnostic pathway. Read More

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Over-the-counter protein supplement resulting in impaired thyroxine absorption in a hypothyroid patient.

Endocrinol Diabetes Metab Case Rep 2021 Jul 19;2021(21-0070). Epub 2021 Jul 19.

Diabetes and Endocrinology Unit, National Hospital Kandy, Kandy, Sri Lanka.

Summary: Whey protein is a popular dietary supplement that is claimed to provide multiple health benefits. It has been shown to delay gastric emptying and impair ileal nutrient absorption. Additionally, some of the other additives like papain enzyme, soy lecithin in these protein supplements could interfere with L-thyroxine absorption. Read More

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Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice.

Toxicology 2021 Jul 16;459:152860. Epub 2021 Jul 16.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu, 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu, 210093, China. Electronic address:

Di-n-butyl phthalate (DBP) is considered as a potential modifier of puberty. However, different results indicate that DBP plays an accelerated, delayed, or neutral role in the initiation of puberty. Furthermore, whether the effect of DBP on puberty will disrupt the function of reproductive system in the adults is still ambiguous. Read More

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Impacts of microplastics on reproductive performance of male tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis.

Environ Sci Pollut Res Int 2021 Jul 19. Epub 2021 Jul 19.

Zoology Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

This study examines the potential defending effects of the diatom, Amphora coffeaeformis, as a feed additive versus the deleterious effects (mainly on gonads) caused by microplastics (MPs) in Nile tilapia, Oreochromes niloticus. Groups of male tilapia were pre-fed diets with four different supplementation levels of A. coffeaeformis (0%, 2. Read More

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A deeper understanding of the causal relationships between thyroid function and atrial fibrillation.

J Clin Endocrinol Metab 2021 Jul 19. Epub 2021 Jul 19.

Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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Poorly differentiated thyroid carcinoma coexisting with Graves' disease involving T3 thyrotoxicosis due to increased D1 and D2 activities.

Thyroid 2021 Jul 18. Epub 2021 Jul 18.

Kansai Medical University, Department of Internal Medicine II, 2-3-1 Shinmachi, Hirakata, Osaka, Japan, 573-1191;

Background Poorly differentiated thyroid carcinoma is rare and typically euthyroid. We report a novel rarer case of poorly differentiated thyroid carcinoma involving T3 thyrotoxicosis. Patients' Findings A 77-year-old man visited Kuma Hospital due to a neck tumor. Read More

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Aptasensing luteinizing hormone to determine gynecological endocrine complications on graphene oxide layered sensor.

Biotechnol Appl Biochem 2021 Jul 18. Epub 2021 Jul 18.

Faculty of Chemical Engineering Technology, Universiti Malaysia Perlis, Perlis, Malaysia.

Luteinizing hormone (LH)/Lutropin is an interstitial cell stimulating hormone playing a predominant role in the reproductive system, and highly correlated with the infertility treatment in both men and women. This research was concentrated to quantify LH level by using interdigitated electrode sensor. To improve the electric current flow, sensing electrode was modified with graphene oxide (GO) and the aptamer probe was attached on GO through biotin-streptavidin linker. Read More

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Association of bioavailable inhibin B and oocyte yield in controlled ovarian stimulation.

F S Rep 2021 Jun 31;2(2):189-194. Epub 2021 Mar 31.

Departments of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California.

Objective: To determine if the biologically active or bioavailable inhibin B (bio-inhB) correlated with the oocyte yield in controlled ovarian stimulation (COS).

Design: Cross-sectional study.

Setting: Academic center. Read More

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The relationships of sex hormone-binding globulin, total testosterone, androstenedione and free testosterone with metabolic and reproductive features of polycystic ovary syndrome.

Endocrinol Diabetes Metab 2021 Jul 24;4(3):e00267. Epub 2021 May 24.

Division of Endocrinology and Metabolic Diseases Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands.

Objective: A recent Mendelian randomization study has suggested a causal role for sex hormone-binding globulin (SHBG), total testosterone and free testosterone in the pathogenesis of polycystic ovary syndrome (PCOS). The aim of this study was to assess the relationships of SHBG, androstenedione, total and free testosterone with the individual metabolic and reproductive features of PCOS.

Design: Cross-sectional data in PCOS patients (n=96) prospectively collected in a secondary/tertiary clinic for menstrual cycle disorders. Read More

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The Effect of ThyroidߚStimulating Hormone on Stage of Differentiated Thyroid Carcinoma.

Endocrinol Diabetes Metab 2021 Jul 7;4(3):e00266. Epub 2021 Jun 7.

Endocrine and Metabolism Research Center Institute of Basic and Clinical Physiology Sciences Kerman University of Medical Sciences Kerman Iran.

Introduction: Thyroid cancer is the most common endocrine malignancy, and it has the fastest increase rate in incidence in both sexes, with a yearly increase of 3% over the last decade. Thyroid-stimulating hormone (TSH) is the main driver for the thyroid gland to produce thyroid hormone. The main purpose of this study was to assess the relationship between serum TSH level and the stage of malignancy in patients with differentiated thyroid cancer. Read More

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Pre-Transplantation Serum Parathyroid Hormone Influences the Number of Mobilized CD34+ Hematopoietic Stem Cells in Autologous Hematopoietic Stem Cell Transplantation.

Rep Biochem Mol Biol 2021 Apr;10(1):76-83

Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Parathyroid hormone (PTH) is a calcium homeostasis regulator and can affect bone marrow niche. PTH leads to the bone marrow stem cell niche expansion as well as the induction of stem cell mobilization from the bone marrow into peripheral blood. In this study, we evaluated the association between pre- transplantation serum PTH levels and the number of circulating CD34+ cells along with the platelets/white blood cells (Plt/WBC) engraftment in patients who underwent autologous Hematopoietic Stem Cell Transplantation. Read More

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Efficacy and safety of pulsatile gonadotropin-releasing hormone therapy in patients with congenital hypogonadotropic hypogonadism: a multicentre clinical study.

Ann Transl Med 2021 Jun;9(12):962

NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital; Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: Pulsatile gonadotropin-releasing hormone (GnRH) therapy may restore function of the hypothalamus-pituitary-gonad axis and induce spermatogenesis in male patients with congenital hypogonadotropic hypogonadism (CHH). The study sought to test the reliability of a newly developed Innopump hormone pump, and to confirm the efficacy and safety of pulsatile GnRH therapy (by Innopump hormone pump) in CHH patients.

Methods: From November 2017 to November 2018, 28 male patients with CHH were treated with pulsatile GnRH at Peking Union Medical College Hospital, Beijing Chaoyang Hospital, and Shandong Provincial Hospital. Read More

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Past, Present, and Future of Gonadotropin Use in Controlled Ovarian Stimulation During Assisted Reproductive Techniques.

Cureus 2021 Jun 15;13(6):e15663. Epub 2021 Jun 15.

1st Department of Obstetrics and Gynecology, "Alexandra" General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, GRC.

A variety of protocols have evaluated the use of several forms of gonadotropins in controlled ovarian stimulation (COS). We aim to review the evolving trends on the use of gonadotropins human chorionic gonadotropin (hCG), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) over time and their combinations in COS for patients who undergo assisted reproductive techniques (ART) protocols. A meticulous search of three electronic databases was performed for articles published in the field up to September 2020. Read More

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Strength Performance Across the Oral Contraceptive Cycle of Team Sport Athletes: A Cross-Sectional Study.

Front Physiol 2021 1;12:658994. Epub 2021 Jul 1.

Subunit Sports Medicine, Exercise Physiology and Prevention, Centre for Sport Science and University Sports, Institute of Sport Science, University of Vienna, Vienna, Austria.

Oral contraceptive pills (OCP) are very popular in female athletes not only for contraceptive effects but also due to the possibility of cycle manipulation. Moreover, it is debatable whether the manipulation of the menstrual cycle has a beneficial effect on exercise performance. Therefore, the aim of this study was to investigate potential differences in knee-extensor and flexor strength performance of first division team sport athletes between phases of the oral contraceptive cycle. Read More

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Quercetin and vitamin E attenuate diabetes-induced testicular anomaly in Wistar rats via the mitochondrial-mediated apoptotic pathway.

Andrologia 2021 Jul 18:e14185. Epub 2021 Jul 18.

Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

The role of quercetin and vitamin E treatment against streptozotocin (STZ)-induced testicular abnormalities in diabetic rats and the possible mechanism of action they use for protection were investigated. Diabetes was induced by STZ (45 mg/kg i.p. Read More

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The changes of essential trace elements in residents from an e-waste site and the relationships between elements and hormones of the hypothalamic-pituitary-thyroid (HPT) axis.

Ecotoxicol Environ Saf 2021 Jul 15;222:112513. Epub 2021 Jul 15.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

The heavy metals pollution and related health issues were widely reported in e-waste sites, while the impacts of e-waste exposure on the essential trace elements have been neglected. The aim of this study was focused on the internal Cu, Fe, Mn and Zn levels in the residents from an e-waste site and the potential endocrine disrupting effects of these essential trace elements on the hypothalamic-pituitary-thyroid (HPT) axis. This was a cross-sectional study that 87 subjects were recruited from the e-waste site and 81 from the reference site. Read More

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Thyroid hormones in persons with schizophrenia: A systematic review and meta-analysis.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Jul 15;111:110402. Epub 2021 Jul 15.

Department of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, Poland.

There is accumulating evidence that individuals with schizophrenia show altered levels of thyroid hormones. However, a qualitative and quantitative synthesis of findings in this field has not been performed so far. Therefore, we aimed to perform a systematic review and meta-analysis of studies investigating the levels of thyroid-stimulating hormone (TSH), free thyroxine (fT4), total thyroxine (tT4), free triiodothyronine (fT3) and total triiodothyronine (tT3) in multiple-episode schizophrenia (MES) and first-episode psychosis (FEP). Read More

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Corticosterone's roles in avian migration: Assessment of three hypotheses.

Horm Behav 2021 Jul 14;135:105033. Epub 2021 Jul 14.

School of Biological Sciences, Washington State University, Pullman, WA, USA; Center for Reproductive Biology, Washington State University, Pullman, WA, USA.

While corticosterone (CORT) is often suggested to be an important hormone regulating processes necessary for avian migration, there has been no systematic assessment of CORT's role in migration. Prior to migration, birds increase fat stores and flight muscle size to prepare for the high energetic costs associated with long-distance flight. After attaining sufficient energetic stores, birds then make the actual decision to depart from their origin site. Read More

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