72,779 results match your criteria stiffness injectable

Arterial stiffness and COVID-19: A bidirectional cause-effect relationship.

J Clin Hypertens (Greenwich) 2021 May 5. Epub 2021 May 5.

University of Milano-Bicocca, Milano and Policlinico di Monza, Monza, Italy.

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Animal experimental research assessing urogynecologic surgical mesh implants: Outcome measures describing the host response, a systematic review and meta-analysis.

Neurourol Urodyn 2021 May 5. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Amsterdam Reproduction and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Aim: Before the introduction of new biomaterials for prolapse surgery, animal studies on the host response are required. Unfortunately, large variation in study design hampers obtaining an overview of the safety and efficacy, and translation to clinical practice. Our aim is to systematically review the literature on all outcome measures describing the host response in animal studies assessing the biocompatibility of urogynecologic surgical mesh implants for prolapse surgery. Read More

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Association between Sarcopenic Obesity and Nonalcoholic Fatty Liver Disease and Fibrosis detected by Fibroscan.

J Gastrointestin Liver Dis 2021 May 3. Epub 2021 May 3.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA.

Background And Aims: Nonalcoholic fatty liver disease (NAFLD) and sarcopenic obesity share several pathophysiologic backgrounds. No prior studies have determined a plausible association between sarcopenic obesity and NAFLD and NAFLD-associated fibrosis. We aim to investigate the association between sarcopenic obesity and NAFLD, and NAFLD-associated fibrosis detected by transient elastography. Read More

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Clinical significance of central systolic blood pressure in LV diastolic dysfunction and CV mortality.

PLoS One 2021 5;16(5):e0250653. Epub 2021 May 5.

Division of Cardiology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.

Background And Aims: Cardiovascular (CV) disease is the major cause of death in patients with end-stage kidney disease (ESKD). Left ventricular (LV) diastolic dysfunction reflects LV pressure overload and is common in patients with ESKD. Recently, there have been studies on the usefulness of central blood pressure (BP); however, the relationship between central BP and LV diastolic dysfunction is not clear in dialysis patients with preserved systolic function. Read More

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Is the Anterior Injection Approach Without Ultrasound Guidance Superior to the Posterior Approach for Adhesive Capsulitis of the Shoulder? A Sequential, Prospective Trial.

Clin Orthop Relat Res 2021 May 5. Epub 2021 May 5.

Z. Rijs, Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, the Netherlands.

Background: Shoulder injections for conditions such as adhesive capsulitis are commonly performed and can be administered through image-based or landmark-based injection approaches. Ultrasound-guided injections are widely used and accurate because ultrasound allows real-time visualization of the needle and injected contrast. Landmark-based injections would be advantageous, if they were accurate, because they would save the time and expense associated with ultrasound. Read More

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Pulse wave imaging coupled with vector flow mapping: A phantom, simulation and in vivo study.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 5;PP. Epub 2021 May 5.

Pulse wave imaging (PWI) is an ultrasound imaging modality that estimates the wall stiffness of an imaged arterial segment by tracking the pulse wave propagation. The aim of the present study is to integrate PWI with vector flow imaging, enabling simultaneous and co-localized mapping of vessel wall mechanical properties and 2-D flow patterns. Two vector flow imaging techniques were implemented using the PWI acquisition sequence: 1) multi-angle vector Doppler, and 2) a cross correlation based vector flow imaging (CC VFI) method. Read More

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Kidney graft function and arterial stiffness in renal transplant recipients.

Acta Biochim Pol 2021 May 5. Epub 2021 May 5.

Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin Charité - Universitätsmedizin Berlin, Berlin, Germany.

Introduction: In renal transplant recipients (RTRs), cardiovascular (CV) complications are associated with non-traditional risk factors, such as a decline in graft function, immunosuppressive therapy, time of dialysis before transplantation, inflammation and anemia. Higher value of arterial stiffness is the consequence of risk factors and it can lead to CV events. The aim of this study was the assessment of the arterial stiffness in RTRs with different value of estimated glomerular filtration rate (eGFR) and its correlation with classical and non-classical CV risk factors. Read More

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Impaired bone microarchitecture and strength in patients with tumor-induced osteomalacia.

J Bone Miner Res 2021 May 5. Epub 2021 May 5.

IDIM, Universidad del Salvador, Buenos Aires, Argentina.

Some studies based on bone biopsy have demonstrated that in patients with tumor-induced osteomalacia (TIO) the mineralization process of the bone matrix is profoundly disturbed. However, the interrelationship between clinical and biochemical features and bone microarchitecture in this disease needs further analysis. With this purpose in mind, we set out three objectives: i) to determine bone microarchitecture and estimated bone strength in a group of patients with tumor-induced osteomalacia using high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA), ii) to investigate correlations between duration of disease, biochemical features, bone density, HR-pQCT and FEA parameters, and iii) to compare HR-pQCT and FEA parameters with a healthy control group. Read More

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Molecular rotors as intracellular probes of red blood cell stiffness.

Soft Matter 2021 May;17(17):4525-4537

Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS - Université de Paris, 75013 Paris, France.

The deformability of red blood cells is an essential parameter that controls the rheology of blood as well as its circulation in the body. Characterizing the rigidity of the cells and their heterogeneity in a blood sample is thus a key point in the understanding of occlusive phenomena, particularly in the case of erythrocytic diseases in which healthy cells coexist with pathological cells. However, measuring intracellular rheology in small biological compartments requires the development of specific techniques. Read More

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Metamaterial-like aerogels for broadband vibration mitigation.

Soft Matter 2021 May;17(17):4496-4503

Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA.

We report a mechanical metamaterial-like behavior as a function of the micro/nanostructure of otherwise chemically identical aliphatic polyurea aerogels. Transmissibility varies dramatically with frequency in these aerogels. Broadband vibration mitigation is provided at low frequencies (500-1000 Hz) through self-assembly of locally resonant metastructures wherein polyurea microspheres are embedded in a polyurea web-like network. Read More

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Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response.

Lab Chip 2021 May;21(9):1738-1751

Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, USA. and Department of Cardiovascular Sciences, Houston Methodist Institute for Academic Medicine, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, Texas 77030, USA. and Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Bryan, TX 77807, USA.

Endothelial mechanobiology is a key consideration in the progression of vascular dysfunction, including atherosclerosis. However mechanistic connections between the clinically associated physical stimuli, vessel stiffness and shear stress, and how they interact to modulate plaque progression remain incompletely characterized. Vessel-chip systems are excellent candidates for modeling vascular mechanobiology as they may be engineered from the ground up, guided by the mechanical parameters present in human arteries and veins, to recapitulate key features of the vasculature. Read More

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Arterial structure and function in Africans with HIV for > 5 years: longitudinal relationship with endothelial activation and cardiovascular risk markers.

HIV Med 2021 May 5. Epub 2021 May 5.

Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.

Objectives: We aimed to determine whether people with human immunodeficiency virus (PWHIV) have increased measures of arterial injury [carotid intima-media thickness (cIMT)] and large artery stiffness [carotid-femoral pulse wave velocity (cfPWV)] when compared with their counterparts without HIV, and whether baseline markers of endothelial activation and cardiovascular risk are associated with cIMT and cfPWV after 5 years.

Methods: We matched 126 PWHIV from North West Province, South Africa, to 126 without HIV according to age, sex and locality. Cardiovascular risk and endothelial function markers [soluble intracellular adhesion molecule (ICAM-1) and soluble vascular cell adhesion molecule (VCAM-1)] were measured at baseline and cIMT and cfPWV at follow-up. Read More

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Proximal muscle strength as a predictor of vitamin D insufficiency in elderly.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):84-90. Epub 2021 Mar 4.

Department of Physical Medicine and Rehabilitation, Çukurova University Faculty of Medicine, Adana, Turkey.

Objectives: This study aims to evaluate the association of serum vitamin D level with proximal muscle strength, tone, elasticity, and stiffness in elderly.

Patients And Methods: Between September 2017 and January 2018, a total of 109 participants (21 males, 88 females; mean age: 71.2±4. Read More

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Mechanotransduction assays for neural regeneration strategies: A focus on glial cells.

APL Bioeng 2021 Jun 30;5(2):021505. Epub 2021 Apr 30.

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459.

Glial cells are mechanosensitive, and thus, engineered systems have taken a step forward to design mechanotransduction platforms in order to impart diverse mechanical stresses to cells. Mechanical strain encountered in the central nervous system can arise from diverse mechanisms, such as tissue reorganization, fluid flow, and axon growth, as well as pathological events including axon swelling or mechanical trauma. Biomechanical relevance of the mechanical testing requires to be placed in line with the physiological and mechanical changes in central nervous tissues that occur during the progression of neurodegenerative diseases. Read More

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Cryptococcal meningitis presenting with acute hearing loss.

BMJ Case Rep 2021 May 4;14(5). Epub 2021 May 4.

Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.

Reversible sensorineural hearing loss is a recognised complication of cryptococcal meningitis. Cryptococcal meningitis typically presents with usual symptoms of fever, headache and neck stiffness. This case highlights acute, profound, bilateral hearing loss as the initial symptom and presentation of cryptococcal meningitis in a young woman, who was later diagnosed with AIDS. Read More

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A thermo-responsive collagen-nanocellulose hydrogel for the growth of intestinal organoids.

Mater Sci Eng C Mater Biol Appl 2021 May 24;124:112051. Epub 2021 Mar 24.

Bioresource Processing Research Institute of Australia (BioPRIA), Department of Chemical Engineering, Monash University, Australia. Electronic address:

Three-dimensional (3D) cell culture systems include bioengineered microenvironments that mimic the complexity of human tissues and organs in vitro. Robust biological models, like organoids and spheroids, rely on biomaterials to emulate the biochemical and biomechanical properties found in the extracellular matrix (ECM). Collagen (COL) is the main protein component of the ECM and has been used to generate fibrous matrices for 3D cell culture. Read More

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The impact of multimodal pore size considered independently from porosity on mechanical performance and osteogenic behaviour of titanium scaffolds.

Mater Sci Eng C Mater Biol Appl 2021 May 10;124:112026. Epub 2021 Mar 10.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leics LE11 3TU, UK.

Titanium porous scaffolds comprising multimodal pore ranges (i.e., uni-, bi-, tri-modal and random) were studied to evaluate the effect of pore size on osteoblastogenesis. Read More

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Stable osteosynthesis of cage in cage technique for surgical treatment of proximal humeral fractures.

BMC Surg 2021 May 4;21(1):233. Epub 2021 May 4.

Department of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing, 100853, China.

Background: The treatment of a displaced proximal humeral fracture is still a matter of controversy. The purpose of this study was to report outcomes at a long-term follow-up after fixation augmentation using peek (polyether-ether-ketone) cage and locking compression plate (LCP).

Methods: A total of 27 patients (average age 53. Read More

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Extracellular Polymeric Substance Protects Some Cells in an Biofilm from the Biomechanical Consequences of Treatment with Magainin 2.

Microorganisms 2021 Apr 30;9(5). Epub 2021 Apr 30.

Departments of Biology and Chemistry, Cornell College, Mount Vernon, IA 52314, USA.

Bacterial biofilms have long been recognized as a source of persistent infections and industrial contamination with their intransigence generally attributed to their protective layer of extracellular polymeric substances (EPS). EPS, consisting of secreted nucleic acids, proteins, and polysaccharides, make it difficult to fully eliminate biofilms by conventional chemical or physical means. Since most bacteria are capable of forming biofilms, understanding how biofilms respond to new antibiotic compounds and components of the immune system has important ramifications. Read More

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Polymer-coated microparticle scaffolds engineered for potential use in musculoskeletal tissue regeneration.

Biomed Mater 2021 May 4. Epub 2021 May 4.

Department of Oral and Craniofacial Sciences, University of Missouri Kansas City School of Dentistry, 650 E 25th St, Kansas City, Missouri, 64108-2716, UNITED STATES.

Biomaterials constructed exclusively of sintered microspheres have great potential in tissue engineering scaffold applications, offering the ability to create shape-specific scaffolds with precise controlled release yet to be matched by traditional additive manufacturing methods. The problem is that these microsphere-based scaffolds are limited in their stiffness for applications such as bone regeneration. Our vision to solve this problem was borne from a hierarchical structure perspective, focusing on the individual unit of the structure: the microsphere itself. Read More

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Inhomogeneity of stiffness and density of the extracellular matrix within the leukoplakia of human oral mucosa as potential physicochemical factors leading to carcinogenesis.

Transl Oncol 2021 May 1;14(7):101105. Epub 2021 May 1.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland; Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University in Kielce, PL-25317 Kielce, Poland. Electronic address:

Oral leukoplakia is a clinical term relating to various morphological lesions, including squamous cell hyperplasia, dysplasia and carcinoma. Leukoplakia morphologically manifested as hyperplasia with epithelial dysplasia is clinically treated as precancerous condition. Nevertheless, there is a lack of good markers indicating the transformation of premalignancies towards cancer. Read More

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Assessment of the Rigidity Changes of Corpus Cavernosum Penis in Vasculary Erectile Dysfunction (ED) Subtypes by Shear Wave Elastography (SWE).

J Ultrasound Med 2021 May 4. Epub 2021 May 4.

Radiology Department, Mehmet Akif Ersoy Training and Research Hospital, Istanbul, Turkey.

Introduction: Erectile dysfunction (ED) is a condition that is very common all over the world, concerns about men and causes very important social problems. The aim of this study is to perform quantitative penile corpus cavernosum (CC) stiffness measurements by using SWE for patients with both types of vascular ED.

Methods: In our study, we handled the data of 101 participants in total. Read More

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Size-related increase in inducible mechanical variability of major ampullate silk in a huntsman spider (Araneae: Sparassidae).

Naturwissenschaften 2021 May 4;108(3):22. Epub 2021 May 4.

Department of Life Science, Tunghai University, Taichung, 407224, Taiwan.

Most spiders use major ampullate silk (MAS) to perform many functions across their lifetimes, including prey capture, vibratory signal detection, and safety/dragline. To accommodate their various needs, adult spiders can use inducible variability to tailor MAS with specific mechanical properties. However, it is currently unknown whether this inducible mechanical variability develops gradually or remains consistent across spider size. Read More

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Hydrodynamic Mixing Tunes the Stiffness of Proteoglycan-Mimicking Physical Hydrogels.

Adv Healthc Mater 2021 May 4:e2001998. Epub 2021 May 4.

School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.

Self-assembling hydrogels are promising materials for regenerative medicine and tissue engineering. However, designing hydrogels that replicate the 3-4 order of magnitude variation in soft tissue mechanics remains a major challenge. Here hybrid hydrogels are investigated formed from short self-assembling β-fibril peptides, and the glycosaminoglycan chondroitin sulfate (CS), chosen to replicate physical aspects of proteoglycans, specifically natural aggrecan, which provides structural mechanics to soft tissues. Read More

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Liver Fibrosis is Independently Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus.

J Diabetes Investig 2021 May 4. Epub 2021 May 4.

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12 Wulumuqi Road, Shanghai, 200040, China.

Aims: Non-alcoholic fatty liver disease and type 2 diabetes mellitus are closely related and often occur simultaneously in patients. Type 2 diabetes increases the risk of diabetic peripheral neuropathy, resulting in intolerable pain and extremity amputation that reduces the quality of life. However, the role of non-alcoholic fatty liver disease in the pathogenesis of diabetic peripheral neuropathy remains unclear. Read More

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Bipolar Fractional Radiofrequency Treatment of Suprapatellar Skin Assessment Using Non-Invasive Devices and Microbiopsy.

Aesthet Surg J 2021 May 4. Epub 2021 May 4.

Department of Plastic Surgery, UT Southwestern Medical Center, Dallas, TX.

Background: Non-invasive treatments for skin tightening are gaining popularity. However, there are no studies assessing bipolar fractional radiofrequency on suprapatellar skin.

Objectives: The purpose of this study is to evaluate the efficacy of bipolar fractional radiofrequency on suprapatellar skin. Read More

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Microfluidic valvular chips and a numerical lymphatic vessel model for the study of lymph transport characteristics.

Lab Chip 2021 May 4. Epub 2021 May 4.

Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, South Korea.

Lymph transport inside lymphatic vessels is highly complex and not yet fully understood. So far, a consensus has not been reached among existing analytical models on how spatiotemporal coordination of contracting adjacent lymphangions affects lymph transport. To understand complex lymph transport, we created a novel microfluidic valvular chip with flexible bicuspid valves and segmental pneumatic pumps based on a microfluidic device with an inside 3D structure made of hydrogels. Read More

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Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling.

Proc Natl Acad Sci U S A 2021 May;118(19)

Alexander Grass Center for Bioengineering, Hebrew University of Jerusalem, 9190401 Jerusalem, Israel;

Mesenchymal stromal/stem cells (MSCs) form a heterogeneous population of multipotent progenitors that contribute to tissue regeneration and homeostasis. MSCs assess extracellular elasticity by probing resistance to applied forces via adhesion, cytoskeletal, and nuclear mechanotransducers that direct differentiation toward soft or stiff tissue lineages. Even under controlled culture conditions, MSC differentiation exhibits substantial cell-to-cell variation that remains poorly characterized. Read More

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Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease.

Ren Fail 2021 Dec;43(1):796-802

School of Medicine, Tzu Chi University, Hualien, Taiwan.

Background: The role of indoxyl sulfate (IS), an important protein-bound uremic toxin, in arterial stiffness (AS) in patients with chronic kidney disease (CKD) is unclear.

Materials And Methods: We investigated the association between serum IS levels and AS in a cross-sectional study of 155 patients with CKD. Patients in the AS group was defined as carotid-femoral pulse wave velocity (cfPWV) value >10 m/s measured by a validated tonometry system (SphygmoCor), while values ≤10 m/s were regarded as without AS group Serum IS was measured by liquid chromatography-mass spectrometry analysis. Read More

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December 2021

Vocal fold kinematics and relative fundamental frequency as a function of obstruent type and speaker age.

J Acoust Soc Am 2021 Apr;149(4):2189

Department of Speech, Language, and Hearing Sciences, Boston University, 635 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

The acoustic measure, relative fundamental frequency (RFF), has been proposed as an objective metric for assessing vocal hyperfunction; however, its underlying physiological mechanisms have not yet been fully characterized. This study aimed to characterize the relationship between RFF and vocal fold kinematics. Simultaneous acoustic and high-speed videoendoscopic (HSV) recordings were collected as younger and older speakers repeated the utterances /ifi/ and /iti/. Read More

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