75,135 results match your criteria stiffness

Resistance to thrombomodulin correlates with liver stiffness in chronic liver disease a prospective single-center cohort study.

Thromb Res 2021 Sep 14;207:40-49. Epub 2021 Sep 14.

Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland; Department for BioMedical Research, University of Bern, Switzerland. Electronic address:

Introduction: Chronic liver disease (CLD) is characterized by changes in haemostasis, embracing both hypo- and hypercoagulability. Global hemostatic tests such as thrombin generation assays evaluate the hemostatic balance, to better assess bleeding and thrombotic risks. In addition, procoagulant state in patients with CLD has been demonstrated using modified thrombin generation assays with thrombomodulin, a cofactor for protein C activation. Read More

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September 2021

The relationship between kinesiophobia and health-related quality of life in patients with rheumatoid arthritis: A controlled cross-sectional study.

Joint Bone Spine 2021 Sep 15:105275. Epub 2021 Sep 15.

Department of Physical Medicine and Rehabilitation, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Erzincan, Turkey.

Objectives: To evaluate the kinesiophobia and kinesiophobia-related factors in patients with rheumatoid arthritis (RA) and provide a better perspective on the relationship between kinesiophobia and patients' health-related quality of life (HRQoL).

Methods: A total of 88 patients (67 females, 21 males) with RA and 93 healthy volunteers (67 females, 26 males) were included in the study between March 2020 and July 2020. Kinesiophobia was evaluated using the Tampa Scale of Kinesiophobia (TSK) and HRQoL was evaluated using the 36-item Short-Form Health Survey (SF-36). Read More

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September 2021

Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study.

Int J Cardiovasc Imaging 2021 Sep 18. Epub 2021 Sep 18.

Department of Physical Therapy, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.

Sepsis is a serious organ dysfunction leading to endothelial damage in critical patients. Physiologically, there is an augment of vascular diameter in response to increased vascular blood flow and shear stress stimulus. However, the pattern of vascular response in face of passive mobilization (PM), an early mobilization physical strategy, has not yet been explored in patients with sepsis. Read More

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September 2021

Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis.

Sci Rep 2021 Sep 17;11(1):18578. Epub 2021 Sep 17.

School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.

Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikungunya arthralgia and 40 patients with RA were enrolled in a cross-sectional study. Read More

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September 2021

Single-level subject-specific finite element model can predict fracture outcomes in three-level spine segments under different loading rates.

Comput Biol Med 2021 Sep 9;137:104833. Epub 2021 Sep 9.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Osteoporosis-related vertebral compression fracture can occur under normal physiological activities. Bone metastasis is another source of vertebral fracture. Different loading rates, either high-energy traumas such as falls or low-energy traumas under normal physiological activities, can result in different fracture outcomes. Read More

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September 2021

Joint involvement in Noonan syndrome.A retrospective paediatric descriptive study.

Joint Bone Spine 2021 Sep 14:105270. Epub 2021 Sep 14.

Rheumatology Department, CHU Cavale Blanche, Center of Autoimmune Rare Diseases (CERAINO), Brest, France; UMR1227, INSERM, Université de Bretagne Occidentale, Brest, France. Electronic address:

Objectives: Noonan syndrome is a rare genetic disorder characterized mainly by congenital heart disease, occasional intellectual disability, and varied orthopaedic, rheumatological and haematologic anomalies. Despite potentially serious functional consequences, joint involvement has been rarely studied in the literature. Our objective was to perform a retrospective study evaluating the prevalence and characteristics of joint involvement in Noonan syndrome. Read More

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September 2021

Measuring the effects of postmortem time and age on mouse lens elasticity using atomic force microscopy.

Exp Eye Res 2021 Sep 14:108768. Epub 2021 Sep 14.

Biomedical Atomic Force Microscopy Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, FL, USA. Electronic address:

The mouse lens is frequently used both in vivo and ex vivo in ophthalmic research to model conditions affecting the human lens, such as presbyopia. The mouse lens has a delicate structure which is prone to damage and biomechanical changes both before and after extraction from the whole globe. When not properly controlled for, these changes can confound the biomechanical analysis of mouse lenses. Read More

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September 2021

Functional outcomes and physical performance of knee osteoarthritis patients after ultrasound-guided genicular nerve radiofrequency ablation.

Pain Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthesiology, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City, Taiwan.

Objective: To elucidate the effectiveness of ultrasound-guided genicular nerve radiofrequency ablation in alleviating pain as well as its effects on functional outcomes, quality of life and physical performance in knee osteoarthritis patients.

Design: Prospective observational study.

Setting: Patients were recruited within one community hospital. Read More

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September 2021

Different Risk Factors for Early and Late Recurrence After Curative Resection of Hepatocellular Carcinoma.

World J Surg 2021 Sep 17. Epub 2021 Sep 17.

Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea.

Background: Factors of early and late recurrence after curative resection of hepatocellular carcinoma (HCC) may be different. The aim of this study was to identify clinical factors, including liver stiffness measurement (LSM), which are associated with HCC recurrence after curative resection.

Methods: Patients who underwent preoperative LSM and primary curative resection for HCC between October 2015 and May 2018 were retrospectively reviewed, with 1 year as the cut-off between early and late recurrence. Read More

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September 2021

Effects of various doses of lubabegron on calculated ammonia gas emissions, growth performance, and carcass characteristics of beef cattle during the last 56 days of the feeding period.

Transl Anim Sci 2021 Jul 21;5(3):txab137. Epub 2021 Aug 21.

Elanco, Greenfield, IN 46140, USA.

Lubabegron (LUB; Experior, Elanco, Greenfield, IN, USA) was approved by the U.S. Food and Drug Administration in 2018 and is indicated for the reduction of ammonia (NH) gas emissions·kg body weight (BW) and hot carcass weight (HCW) when fed to feedlot cattle during the final 14 to 91 d of the finishing period. Read More

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Lateral minimal approach to the terrible triad of the elbow: a treatment protocol in Beijing Jishuitan Hospital.

Ann Transl Med 2021 Aug;9(15):1232

Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Beijing, China.

Background: This study aimed to report the surgical techniques and results of treating coronoid process and radial head fracture combined with dislocation of the elbow (terrible triad of the elbow) using a single lateral incision, known as the extensor digitorum communis (EDC) split approach.

Methods: A retrospective analysis was performed of 109 patients with terrible triad of the elbow who had been treated by the authors from January 2013 to December 2019. The participants included 67 males and 42 females, with a mean age of 42. Read More

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Diagnostic prediction of ovine fracture healing outcomes via a novel multi-location direct electromagnetic coupling antenna.

Ann Transl Med 2021 Aug;9(15):1223

Orthopaedic Bioengineering Research Laboratory, Departments of Mechanical Engineering and School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.

Background: Expedient prediction of adverse bone fracture healing (delayed- or non-union) is necessary to advise secondary treatments for improving healing outcome to minimize patient suffering. Radiographic imaging, the current standard diagnostic, remains largely ineffective at predicting nonunions during the early stages of fracture healing resulting in mean nonunion diagnosis times exceeding six months. Thus, there remains a clinical deficit necessitating improved diagnostic techniques. Read More

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The Advance of Magnetic Resonance Elastography in Tumor Diagnosis.

Front Oncol 2021 31;11:722703. Epub 2021 Aug 31.

Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engneering, University of Science and Technology of China, Hefei, China.

The change in tissue stiffness caused by pathological changes in the tissue's structure could be detected earlier, prior to the manifestation of their clinical features. Magnetic resonance elastography (MRE) is a noninvasive imaging technique that uses low-frequency vibrations to quantitatively measure the elasticity or stiffness of tissues. In tumor tissue, stiffness is directly related to tumor development, invasion, metastasis, and chemoradiotherapy resistance. Read More

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Kakkonto Inhibits Cytokine Production Induced by Rhinovirus Infection in Primary Cultures of Human Nasal Epithelial Cells.

Front Pharmacol 2021 31;12:687818. Epub 2021 Aug 31.

Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, Japan.

Rhinovirus (RV) is a primary etiologic agent of common cold that can subsequently acutely exacerbate bronchial asthma or chronic obstructive pulmonary disease. Kakkonto (Ge-gen-tang in Chinese), one of the most frequently prescribed traditional Japanese (Kampo) medicines, is used for treating common cold, shoulder stiffness, or inflammatory diseases of the upper body. Previous experimental studies have indicated that kakkonto exerts antiviral and anti-inflammatory effects on the influenza virus and the human respiratory syncytial virus. Read More

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Neural network-based left ventricle geometry prediction from CMR images with application in biomechanics.

Artif Intell Med 2021 Sep 11;119:102140. Epub 2021 Aug 11.

School of Mathematics and Statistics, Univeristy of Glasgow, Glasgow, UK. Electronic address:

Combining biomechanical modelling of left ventricular (LV) function and dysfunction with cardiac magnetic resonance (CMR) imaging has the potential to improve the prognosis of patient-specific cardiovascular disease risks. Biomechanical studies of LV function in three dimensions usually rely on a computerized representation of the LV geometry based on finite element discretization, which is essential for numerically simulating in vivo cardiac dynamics. Detailed knowledge of the LV geometry is also relevant for various other clinical applications, such as assessing the LV cavity volume and wall thickness. Read More

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September 2021

Passive elastography of the esophagus: from model to preliminaryexperiments using diameter measurements.

Biomed Phys Eng Express 2021 Sep 16. Epub 2021 Sep 16.

LabTAU, 151 cours albert thomas, Lyon, 69424 cedex03, FRANCE.

Numerous diseases alter the esophagus elasticity, such as eosinophilic esophagitis and esophageal motility disorders like achalasia. The possibility to measure these modifications using minimally invasive techniques is a key issue for the diagnosis of such pathologies. The commercially available EndoflipTM (endoluminal functional lumen imaging probe) can be used to measure the luminal cross-sectional diameter of the esophagus at different points and over time, and is used in clinical routine to assess esophageal distensibility. Read More

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September 2021

Characterization of the vascular system using overnight wearable-based pulse arrival time and ambulatory blood pressure: A pilot study.

Comput Biol Med 2021 Sep 9;137:104861. Epub 2021 Sep 9.

GMed IT Ltd., Hong Kong, China.

Pulse arrival time (PAT) has been broadly investigated for its potential for cuffless blood pressure (BP) estimation and ease of measurement by wearable devices. It is also of great significance to explore whether PAT conveys complementary information to BP for vascular health assessment. In this paper, the differences between the 24-h ambulatory BP and wearable-based PAT were compared among 12 young normotensives and 15 elderly hypertensives in terms of the mean and coefficients of variation (CoVs). Read More

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September 2021

Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4.

Cell Calcium 2021 Aug 31;99:102467. Epub 2021 Aug 31.

Biomedical Engineering, University of Delaware, Newark, DE, United States; Biomechanics and Movement Science Program, University of Delaware, Newark, DE, United States; Department of Biological Sciences, University of Delaware, Newark, DE, United States; Department of Biology, University of Michigan-Flint, Flint, MI, United States. Electronic address:

Both mechanical and biochemical stimulation are required for maintaining the integrity of articular cartilage. However, chondrocytes respond differently to mechanical stimuli in osteoarthritic cartilage when biochemical signaling pathways, such as Insulin-like Growth Factor-1 (IGF-1), are altered. The Transient Receptor Potential Vanilloid 4 (TRPV4) channel is central to chondrocyte mechanotransduction and regulation of cartilage homeostasis. Read More

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A taper-fit junction to improve long bone reconstruction: A parametric In Silico model.

J Mech Behav Biomed Mater 2021 Aug 26;124:104790. Epub 2021 Aug 26.

Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, IT, Italy.

Purpose: Critical size long bone defects represent a clinical challenge in orthopaedic surgery. Various grafting techniques have been developed through the years, but they all present several downsides. A key requirement of all grafting techniques is the achievement of a continuous interface between host bone and graft to enhance both biological processes and mechanical stability. Read More

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Transluminal compression increases mechanical stability, stiffness and endothelialization capacity of fibrin-based bioartificial blood vessels.

J Mech Behav Biomed Mater 2021 Sep 10;124:104835. Epub 2021 Sep 10.

Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), Hannover Medical School, Hannover, Germany, Stadtfelddamm 34, 30625, Hannover, Germany; Department of Vascular- and Endovascular Surgery, St. Bernward Hospital, Hildesheim, Germany.

Fibrin is used successfully as a biological matrix in various bioengineering approaches. Its unique combination of autologous availability, hemocompatibility and biological activity makes it an almost ideal matrix material for vascular tissue engineering. However, clinical application of fibrin-based bioartificial blood vessels is still limited due to insufficient mechanical stability and stiffness of fibrin matrices. Read More

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September 2021

Molecular dynamics investigation of structural and mechanical properties of silica nanorod reinforced dental resin composites.

J Mech Behav Biomed Mater 2021 Sep 9;124:104830. Epub 2021 Sep 9.

State Key Laboratory of Materials Processing and Die & Mould Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

In this work, molecular dynamics simulations are conducted to investigate the structural and mechanical properties of dental materials, i.e., the silica nanorod reinforced Bis-GMA/TEGDMA resin composite. Read More

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September 2021

The Effect of Denosumab and Alendronate on Trabecular Plate and Rod Microstructure at the Distal Tibia and Radius: A Post-hoc HR-pQCT Study.

Bone 2021 Sep 13:116187. Epub 2021 Sep 13.

Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address:

Background: Age-related trabecular microstructural deterioration and conversion from plate-like trabeculae to rod-like trabeculae occur because of unbalanced rapid remodeling. As denosumab achieves greater remodeling suppression and lower cortical porosity than alendronate, we hypothesized that denosumab might also preserve trabecular plate microstructure, bone stiffness and strength more effectively than alendronate.

Methods: In this post hoc analysis of a phase 2 study, postmenopausal women randomized to placebo (P, n=74), denosumab (D, n=72), or alendronate (A, n=68). Read More

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September 2021

The biological regulation of sea urchin larval skeletogenesis - From genes to biomineralized tissue.

J Struct Biol 2021 Sep 13:107797. Epub 2021 Sep 13.

Marine Biology Department, Charney School of Marine Sciences, the University of Haifa, Haifa, Israel. Electronic address:

Biomineralization is the process in which soft organic tissues use minerals to produce shells, skeletons and teeth for various functions such as protection and physical support. The ability of the cells to control the time and place of crystal nucleation as well as crystal orientation and stiffness is far beyond the state-of-the art of human technologies. Thus, understanding the biological control of biomineralization will promote our understanding of embryo development as well as provide novel approaches for material engineering. Read More

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September 2021

The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study.

PLoS One 2021 16;16(9):e0257269. Epub 2021 Sep 16.

Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Familial hypercholesterolemia, a common genetic metabolic disorder characterized by high cholesterol levels, is involved in the development of atherosclerosis and other preventable diseases. Familial hypercholesterolemia can also cause tendinous abnormalities, such as thickening and xanthoma (tendon lipid accumulation) in the Achilles, which may impede tendon biomechanics. The objective of this study was to investigate the effect of cholesterol accumulation on the biomechanical performance of Achilles tendons, in vivo. Read More

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September 2021

Hemodynamic response and pulse wave analysis after upper- and lower-body resistance exercise with and without blood flow restriction.

Eur J Sport Sci 2021 Sep 16:1-22. Epub 2021 Sep 16.

Exercise Physiology, Kent State University, Kent, OH, 44242, USA.

Resistance exercise (RE) has been shown to elevate hemodynamics and pulse wave reflection. However, the effects of acute RE with blood flow restriction (BFR) on hemodynamics and pulse wave reflection are unclear. The purpose of this study was to evaluate the differences between upper- and lower-body RE with and without BFR on hemodynamics and pulse wave reflection. Read More

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September 2021

Performance of the Enhanced Liver Fibrosis Test to Estimate Advanced Fibrosis Among Patients With Nonalcoholic Fatty Liver Disease.

JAMA Netw Open 2021 Sep 1;4(9):e2123923. Epub 2021 Sep 1.

Center for Outcomes Research in Liver Diseases, Washington, District of Columbia.

Importance: The most important surrogate for increased risk of adverse clinical outcomes among patients with nonalcoholic fatty liver disease (NAFLD) is the patient's stage of liver fibrosis. There is a significant barrier to risk-stratifying patients in clinical practice owing to the need for liver biopsy.

Objective: To determine the performance of the enhanced liver fibrosis (ELF) test as a noninvasive test for assessment of liver fibrosis among patients with NAFLD. Read More

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September 2021

Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), versus placebo in patients with non-alcoholic fatty liver disease.

Aliment Pharmacol Ther 2021 Sep 16. Epub 2021 Sep 16.

NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, USA.

Background: Pemafibrate is a novel, selective peroxisome proliferator-activated receptor α modulator (SPPARMα). In mice, Pemafibrate improved the histological features of non-alcoholic steatohepatitis (NASH). In patients with dyslipidaemia, it improved serum alanine aminotransferase (ALT). Read More

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September 2021

Predicting critical closing pressure in children with obstructive sleep apnea using fluid structure interaction simulations.

J Appl Physiol (1985) 2021 Sep 16. Epub 2021 Sep 16.

Division of Pulmonary Medicine, grid.239573.9Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Surgical treatment of obstructive sleep apnea (OSA) in children requires knowledge of upper airway dynamics, including the closing pressure (Pcrit), a measure of airway collapsibility. We applied a Flow-Structure Interaction (FSI) computational model to estimate Pcrit in patient-specific upper airway models obtained from magnetic resonance imaging (MRI) scans. We sought to examine the agreement between measured and estimated Pcrit from FSI models in children with Down syndrome. Read More

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September 2021

[Long fingers proximal interphalangeal joint trauma].

Rev Med Suisse 2021 Sep;17(750):1576-1581

Unité de chirurgie de la main, Département d'orthopédie et de traumatologie, HUG, 1211 Genève 14.

Sprains and dislocations of the proximal interphalangeal joint (PIP) are very common but are, nevertheless, often missed. They require an appropriate treatment to prevent stiffness and deformities. Initial assessment should include anteroposterior and true lateral radiographs. Read More

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September 2021

Exploring remission concept in axial spondyloarthritis through the perception of rheumatologists using vignettes and priority ratings.

Rheumatology (Oxford) 2021 Sep 16. Epub 2021 Sep 16.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.

Objectives: The optimal treatment target in axial spondyloarthritis (axSpA) is remission; however, a consensual definition of remission is lacking. Our objective was to explore rheumatologists' perception of remission using vignette cases and a priority exercise.

Methods: A cross-sectional survey of rheumatologists' perceptions of remission in axSpA was performed in 2020 using (a) 36 vignette cases, with a single clinical picture and 3 varying parameters (axial pain [ranging from 2 to 5 on a 0-10 scale], fatigue [2-8], and morning stiffness [<15 min, 30 min or 1 h], assessed as remission yes/no; (b) prioritization of elements to consider for remission from a list of 12 items: BASDAI, ASDAS, elements of BASDAI and ASDAS including CRP, NSAIDs use, extra-articular manifestations (EAMs), and other explanations of symptoms e. Read More

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September 2021