4,843 results match your criteria sterility caused

Gene and histomorphology alteration analysis in spermatogenesis arrest mouse model: a probable novel approach for infertility.

Cent European J Urol 2021 31;74(1):99-108. Epub 2020 Dec 31.

Pediatric Urology and Regenerative Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Approximately 15% of couples in the reproductive age are struggling with infertility which, in nearly half of them, is caused by male factors.

Material And Methods: The present study comprised of two groups of sixteen C57BL/6 mice; each mouse received either an intraperitoneal injection of 30 mg/kg of an alkylating agent or the same amount of distilled water. Testes were harvested 30 days following the injection. Read More

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December 2020

Reproductive outcomes in individuals with chromosomal reciprocal translocations.

Genet Med 2021 May 10. Epub 2021 May 10.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Patients with reciprocal balanced translocations (RBT) have a risk for recurrent pregnancy losses (RPL), affected child, and infertility. Currently, genetic counseling is based on karyotypes found among the products of conception (POC), although factors influencing the success of assisted reproductive technologies (ART) in RBT couples are not established.

Methods: Cytogenetic results from 261 POC and offspring of the parents (113 women and 90 men) with RBT were evaluated. Read More

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Progress in the genetic studies of spermatogenesis abnormalities.

Yi Chuan 2021 May;43(5):473-486

State Key Laboratory of Reproductive Medicine, Nanjing Medical University. Nanjing 211166, China.

About 15% couples suffer from infertility, half of which are caused by male factors. Male infertility usually manifests as teratozoospermia, oligospermia and/or asthenospermia, of which the most severe form is azoospermia. In this review, we summarize the recent progress in the study of genetic factors involved in nonobstructive azoospermia and teratozoospermia, Recently, with the rapid development of high-throughput chips and sequencing technologies, many genetic factors of spermatogenesis have been discovered and analyzed. Read More

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Evaluation of mitochondria in mouse oocytes following cisplatin exposure.

J Ovarian Res 2021 May 10;14(1):65. Epub 2021 May 10.

Ovarian Biology Laboratory, Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.

Background: Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common side effect of which is depletion of the primordial follicle reserve, leading to infertility and early menopause. Read More

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Novel bi-allelic mutations in cause multiple morphological abnormalities of the sperm flagella resulting in male infertility.

Transl Androl Urol 2021 Apr;10(4):1656-1664

Center of Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

Background: Male infertility is a major health concern and approximately 10-15% of cases are caused by genetic abnormalities. Defects in the sperm flagella are closely related to male infertility, since flagellar beating allows sperm to swim. The sperm of males afflicted with multiple morphological abnormalities of the flagella (MMAF) possess severe defects of the sperm flagella, may impair sperm motility and lead to male infertility. Read More

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Effect of varicoceles on spermatogenesis.

Semin Cell Dev Biol 2021 May 6. Epub 2021 May 6.

Department of Urology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, Starr 900, New York, NY 10065, United States. Electronic address:

Varicoceles are dilated veins within the spermatic cord and a relatively common occurrence in men. Fortunately, the large majority of men are asymptomatic, however, a proportion of men with varicoceles can suffer from infertility and testosterone deficiency. Sperm and testosterone are produced within the testis, and any alteration to the testicular environment can negatively affect the cells responsible for these processes. Read More

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Stimulant-Induced Pituitary Failure and Reversible Azoospermia.

Cureus 2021 Apr 3;13(4):e14269. Epub 2021 Apr 3.

Reproductive Endocrinology and Infertility, IVFMD, Cooper City, USA.

Attention-deficit hyperactivity disorder (ADHD) is a commonly diagnosed disorder that is managed with stimulant medications, which function by increasing the levels of dopamine in the brain. Excess dopamine has been known to affect several body systems, including the endocrine system. This case presents male factor infertility caused by a negative interaction between excess dopamine and the endocrine system, inducing pituitary failure, which led to azoospermia. Read More

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Pigment epithelium-derived factor negates oxidative stress in mouse oocytes.

FASEB J 2021 Jun;35(6):e21637

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Molecular changes, caused by various environmental factors, affect the quality and developmental potential of oocytes. Oxidative stress (OS) is a major factor involved in various gynecologic disorders and/or in aging. Recent studies suggest that elevated reactive oxygen species (ROS) hamper oocyte quality and future embryonic development. Read More

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Endometriosis: New Perspective for the Diagnosis of Certain Cytokines in Women and Adolescent Girls, as Well as the Progression of Disease Outgrowth: A Systematic Review.

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia in Katowice, Markiefki 87, 40-211 Katowice, Poland.

Endometriosis is a common chronic gynecological disorder that undoubtedly impacts on quality of life, and is one of the more complex and mysterious illnesses of our century, which is associated with the improper growth of endometrial tissue outside of the uterine cavity. This pathologically implanted tissue can be found most frequently in the minor pelvis, but also in the peritoneal cavity, and can affect many organs, leading to chronic pelvic pain syndrome, infertility, and dysmenorrhea. Endometrial tissue is a particularly dynamic tissue that has a direct impact on the progression of the disease, with altered immunity, as well as cytokine storms within the metaplastic endometriotic site, as possible key factors. Read More

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Severe Acute Respiratory Syndrome Coronavirus 2 and Male Reproduction: Relationship, Explanations, and Clinical Remedies.

Front Physiol 2021 14;12:651408. Epub 2021 Apr 14.

Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Coronavirus disease 2019 (COVID-2019) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been an ongoing pandemic and worldwide public health emergency, having drawn a lot of attention around the world. The pathogenesis of COVID-19 is characterized by infecting angiotensin-converting enzyme 2 (ACE2)-expressing cells, including testis-specific cells, namely, Leydig, Sertoli, and spermatogenic cells, which are closely related to male reproduction. This leads to aberrant hyperactivation of the immune system generating damage to the infected organs. Read More

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Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity.

Int J Obes (Lond) 2021 May 1. Epub 2021 May 1.

Department of Comparative Medicine, University of Washington, Seattle, WA, USA.

Background: Retinoic acid (RA) controls diverse physiological functions including weight regulation and energy metabolism. It has been reported that mice lacking ALDH1A1, one of the aldehyde dehydrogenases (ALDH) that synthesize RA, are healthy and resistant to weight gain, raising the possibility that inhibiting this enzyme might treat obesity. We previously demonstrated that treatment with a pan-ALDH1A enzyme inhibitor, WIN18446, suppressed weight gain in mice fed a high-fat diet (HFD), but caused increased hepatic lipidosis and reversible male infertility. Read More

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Maternal Heat Stress Alters Expression of Genes Associated with Nutrient Transport Activity and Metabolism in Female Placentae from Mid-Gestating Pigs.

Int J Mol Sci 2021 Apr 16;22(8). Epub 2021 Apr 16.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC 3010, Australia.

Placental insufficiency is a known consequence of maternal heat stress during gestation in farm animals. The molecular regulation of placentae during the stress response is little known in pigs. This study aims to identify differential gene expression in pig placentae caused by maternal heat exposure during early to mid-gestation. Read More

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Small and Large Intestine (I): Malabsorption of Nutrients.

Nutrients 2021 Apr 11;13(4). Epub 2021 Apr 11.

Unidad de Gastroenterología, Hepatología y Nutrición, Hospital Universitario San Jorge de Huesca, 22004 Huesca, Spain.

Numerous disorders can alter the physiological mechanisms that guarantee proper digestion and absorption of nutrients (macro- and micronutrients), leading to a wide variety of symptoms and nutritional consequences. Malabsorption can be caused by many diseases of the small intestine, as well as by diseases of the pancreas, liver, biliary tract, and stomach. This article provides an overview of pathophysiologic mechanisms that lead to symptoms or complications of maldigestion (defined as the defective intraluminal hydrolysis of nutrients) or malabsorption (defined as defective mucosal absorption), as well as its clinical consequences, including both gastrointestinal symptoms and extraintestinal manifestations and/or laboratory abnormalities. Read More

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Association between the Effects of High Temperature on Fertility and Sleep in Female Intra-Specific Hybrids of .

Insects 2021 Apr 9;12(4). Epub 2021 Apr 9.

Laboratory of Sleep/Wake Neurobiology, The Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, 119991 Moscow, Russia.

Humans and fruit flies demonstrate similarity in sleep-wake behavior, e.g., in the pattern of sleep disturbances caused by an exposure to high temperature. Read More

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Association of novel Stop Gained Leukemia Inhibitory Factor Receptor Gene (rs121912501)Variant, Leukemia Inhibitory Factor and Ovarian Steroids with Unexplained Infertility among Pakistani women.

Int J Clin Pract 2021 Apr 29:e14245. Epub 2021 Apr 29.

Department of Physiology, University of Karachi, Karachi, Pakistan.

Aims And Objectives: Embryo implantation is a complex process that requires sequential steps at the interface of embryo interaction with decidual endometrium. Many women after experiencing multiple attempts of Assisted Reproductive Techniques fail to get implantation due to instability of Leukemia Inhibitory factor and Leukemia Inhibitory Factor Receptor-Signal Transducer and Activator of Transcription Factor 3 (LIF-LIFR STAT3) signaling cascade. Therefore, this study explores the association of ovarian steroids, LIF and LIFR stop gained variant using the Tetra Primer Amplification Refractory Mutation System-Polymerase Chain Reaction (TARMS-PCR) with unexplained infertility (UEX-IF) among Pakistani women MATERIALS AND METHODS: This is a case-control study, a total of 81 unexplained infertile women and 162 fertile controls (with age and BMI matched) were inducted. Read More

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Effectiveness of acupuncture for asthenozoospermia: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(17):e25711

Nanchang Reproductive Hospital, Nanchang, PR China.

Background: According to the World Health Organization, the global incidence of infertility is about 15%, and more than 50% of infertility cases are caused by male infertility. Asthenozoospermia is caused by male fertility decline and male infertility. Due to work pressure, environmental pollution, sexual diseases, and other factors, the number of patients with asthenozoospermia has increased in recent years. Read More

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The status and comparison of ovarian reserve between fertile and infertile healthy Chinese women of reproductive age.

Medicine (Baltimore) 2021 Apr;100(17):e25361

Reproductive Medicine Center, Department of Gynecology and Obstetrics.

Abstract: We aimed to investigate ovarian reserve status, and explore differences in ovarian reserve between fertile and infertile healthy Chinese women of reproductive age.We recruited 442 fertile women aged 23 to 49 years (mean: 35.22 ± 4. Read More

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Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2).

Bioengineered 2021 Dec;12(1):1351-1359

Department of Pathology and Pathophysiology, College of Basic Medical Science, Guizhou Medical University, Guiyang, Guizhou, China.

RNA interference (RNAi) was used to investigate the role of epididymal vascular endothelial growth factor (VEGF) gene expression on sperm hyaluronidase (HYD) in a rat model of arsenic poisoning and to identify a new gene therapy target for male infertility caused by arsenic poisoning. The Rat model of chronic arsenic poisoning was established. And we found that positive expression of VEGF and VEGF receptor 2 (VEGFR2) was observed by Immunohistochemical staining in the epididymal tissues of arsenic-exposed rats. Read More

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December 2021

Fibroids and natural fertility: a systematic review and meta-analysis.

Reprod Biomed Online 2021 Mar 23. Epub 2021 Mar 23.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via M. Fanti, 6, Milan 20122, Italy.

Available evidence from IVF studies supports a detrimental effect of submucosal and intramural fibroids on embryo implantation. It is misleading, however, to infer evidence obtained in IVF settings to natural fertility. Therefore, a systematic review and meta-analysis was conducted on the effect of fibroids on natural fertility. Read More

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Current markers for infertility in men.

JBRA Assist Reprod 2020 Nov 5. Epub 2020 Nov 5.

Laboratory of Translational Research, Christus University (UNICHRISTUS), Fortaleza, CE, Brazil.

Male infertility accounts for about 30% of the causes of couple infertility and has become a public health concern. Male infertility may be caused by several factors occurring in isolation or association with several complex syndromes. Despite the importance of semen analysis in the initial investigation of infertility, it has been estimated that 15% of infertile men present normal sperm, a proportion that calls for additional tests to further investigate cases of infertility and accurately determine the factors that alter ejaculate quality. Read More

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November 2020

Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis, inflammation and oxidative stress.

J Ethnopharmacol 2021 Apr 22;275:114139. Epub 2021 Apr 22.

Department of Radiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Ethnopharmacological Relevance: Diabetes mellitus (DM), as a multiorgan syndrome, is an endocrine and metabolic disorder that is associated with male reproductive system dysfunction and infertility. Safflower (Carthamus tinctorius L.) as an herbal remedy improves DM and infertility-related disorders. Read More

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A homozygous variant in TBPL2 was identified in women with oocyte maturation defects and infertility.

Hum Reprod 2021 Apr 24. Epub 2021 Apr 24.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, China.

Study Question: What are the genetic causes of oocyte maturation defects?

Summary Answer: A homozygous splicing variant (c.788 + 3A>G) in TATA-box binding protein like 2 (TBPL2) was identified as a contributory genetic factor in oocyte maturation defects.

What Is Known Already: TBPL2, a vertebrate oocyte-specific general transcription factor, is essential for oocyte development. Read More

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Pollen-Specific Protein PSP231 Activates Callose Synthesis to Govern Male Gametogenesis and Pollen Germination.

Plant Physiol 2020 Oct;184(2):1024-1041

Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei 430079, China.

Spatiotemporally regulated callose deposition is an essential, genetically programmed phenomenon that promotes pollen development and functionality. Severe male infertility is associated with deficient callose biosynthesis, highlighting the significance of intact callose deposition in male gametogenesis. The molecular mechanism that regulates the crucial role of callose in production of functional male gametophytes remains completely unexplored. Read More

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October 2020

Tauroursodeoxycholic acid/TGR5 signaling promotes survival and early development of glucose-stressed porcine embryos.

Biol Reprod 2021 Apr 22. Epub 2021 Apr 22.

Department of Animal Science, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.

Conditions of impaired energy and nutrient homeostasis, such as diabetes and obesity, are associated with infertility. Hyperglycemia increases endoplasmic reticulum (ER) stress as well as oxidative stress, and reduces the quality and development of embryos. Oxidative stress also causes DNA damage, which impairs embryo quality and development. Read More

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Men's Health: Scrotal and Testicular Conditions.

FP Essent 2021 Apr;503:23-27

University of Michigan Medical School Department of Family Medicine, 300 North Ingalls St NI4C06, Ann Arbor, Michigan 48109-5435.

Scrotal and testicular conditions include benign masses, infections, testicular torsion, and testicular cancer. Common palpable benign scrotal masses include spermatocele, varicocele, and hydrocele. Most patients with these masses require no treatment. Read More

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Short-term effects of COVID-19 on semen parameters: A multicenter study of 69 cases.

Andrology 2021 Apr 13. Epub 2021 Apr 13.

Department of Urology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, Turkey.

Objective: COVID-19, which is known to be caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health problem that can cause multiorgan damage because of its use of the angiotensin-converting enzyme 2 (ACE2) receptor in its pathophysiology. We aimed to investigate whether SARS-CoV-2 had a short-term effect on spermatogenesis, which plays an important role in male reproductive health as it has abundant ACE2 expression in testicular tissue.

Material And Methods: This multicenter study included 69 patients aged 20-45 years, who admitted to our hospitals between April 2020 and October 2020 with a history of a positive test result for SARS-CoV-2 based on the nasopharyngeal or oropharyngeal swab samples and had recovered from the disease at least three months earlier and who had undergone a spermiogram test in the hospital database within the last year before the onset of disease. Read More

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16S rRNA long-read nanopore sequencing is feasible and reliable for endometrial microbiome analysis.

Reprod Biomed Online 2021 Mar 27. Epub 2021 Mar 27.

Wunschbaby Institut Feichtinger, Lainzerstrasse 6, Vienna 1130, Austria; Department of Oncology - Pathology, Karolinska Institutet, Karolinska vägen, A2:07171 64 Solna Stockholm, Sweden. Electronic address:

Research Question: Full-length 16S rRNA gene sequencing using nanopore technology is a fast alternative to conventional short-read 16S rRNA gene sequencing with low initial investment costs that has been used for various microbiome studies but has not yet been investigated as an alternative approach for endometrial microbiome analysis. Is in-situ 16S rRNA gene long-read sequencing using portable nanopore sequencing technology feasible and reliable for endometrial microbiome analysis?

Design: A prospective experimental study based on 33 patients seeking infertility treatment between January and October 2019. A 16S rRNA gene long-read nanopore sequencing protocol for analysing endometrial microbiome samples was established, including negative controls for contamination evaluation and positive controls for bias evaluation. Read More

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Pathogenesis of acephalic spermatozoa syndrome caused by SUN5 variant.

Mol Hum Reprod 2021 May;27(5)

Laboratory of Basic Medicine, Dongfang Hospital (900th Hospital of the Joint Logistics Team), Xiamen University, Fuzhou, China.

Acephalic spermatozoa syndrome (ASS) is a rare teratozoospermia that leads to male infertility. Previous work suggested a genetic origin. Variants of Sad1 and UNC84 domain containing 5 (SUN5) are the main genetic cause of ASS; however, its pathogenesis remains unclear. Read More

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Cellular fate of intersex differentiation.

Cell Death Dis 2021 Apr 12;12(4):388. Epub 2021 Apr 12.

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan, China.

Infertile ovotestis (mixture of ovary and testis) often occurs in intersex individuals under certain pathological and physiological conditions. However, how ovotestis is formed remains largely unknown. Here, we report the first comprehensive single-cell developmental atlas of the model ovotestis. Read More

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Impaired spermatogenesis caused by busulfan is partially ameliorated by treatment with conditioned medium of adipose tissue derived mesenchymal stem cells.

Biotech Histochem 2021 Apr 11:1-11. Epub 2021 Apr 11.

Student Research Committee, and Faculty of Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Busulfan (BSU) is a chemotherapeutic drug that can cause subfertility or sterility in males. We investigated the effects of adipose tissue-derived mesenchymal stem cells (AT-MSC) conditioned medium (CM) (AT-MSC-CM) on histopathological and molecular characteristics of mouse testes exposed to BSU using stereology. We used adult male mice divided randomly into five groups: control, Dulbecco's modified Eagle's medium (DMEM), dimethyl sulfoxide (DMSO), BSU, and BSU + CM. Read More

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