4,394 results match your criteria stepwise selection


Predicting clinically significant response to primary care treatment for depression from electronic health records of veterans.

J Affect Disord 2021 Jul 16;294:337-345. Epub 2021 Jul 16.

VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Objective: To reduce delays in referral to specialty mental health care, we evaluated clinical prediction models estimating the likelihood of response to primary care treatment of depression in the VA healthcare system.

Methods: We included patients with a primary care depression diagnosis between October 1, 2015 and December 31, 2017, an initial PHQ-9 score ≥ 10 within 30 days, a follow-up PHQ-9 score within 2-8 months, and no specialty mental health care within three months prior to depression diagnosis. We evaluated eight ordinary least squares regression models, each with a different procedure for selecting predictors of percentage change in PHQ-9 score from baseline to follow-up. Read More

View Article and Full-Text PDF

Use of multivariate analysis as a tool in the morphological characterization of the main indigenous bovine ecotypes in northeastern Algeria.

PLoS One 2021 26;16(7):e0255153. Epub 2021 Jul 26.

Research Institute of Animal Science, HAO-DEMETER, Paralimni Giannitsa, Greece.

Sustainability in livestock farming requires monitoring of autochthonous breeds which are well adapted to the local environment. The morphometric measurements seem to be the first approach which can provide useful information on the suitability of animal genetic resources for selection. In this work, thirteen morphometric variables were used for the phenotypic characterization of 130 adult autochthones cattle randomly selected from 30 local farms in Guelma. Read More

View Article and Full-Text PDF

Variations in length of stay of inpatients with COVID-19: A nationwide test of the new model of care under vision 2030 in Saudi Arabia.

Saudi J Biol Sci 2021 Jul 20. Epub 2021 Jul 20.

Jazan Health Affairs, Jazan City, Jazan, Saudi Arabia.

Objective: The coronavirus disease 2019 (COVID-19) has impacted the Kingdom of Saudi Arabia (KSA) as it has other nations. However, length of stay (LOS), as a healthcare quality indicator, has not been examined across the healthcare regions in the KSA. Therefore, this study aimed to examine factors associated with LOS to better understand the Saudi Health System's performance in response to the COVID-19 pandemic in the newly suggested five Saudi regional business units (BUs). Read More

View Article and Full-Text PDF

Relevant factors of self-care in children and adolescents with spastic cerebral palsy.

PLoS One 2021 21;16(7):e0254899. Epub 2021 Jul 21.

Faculty of Health Sciences, Department of Physical Therapy, Tokyo Metropolitan University, Arakawa-ku, Tokyo, JP.

Objective: Manual ability is considered one of the factors that can predict functional independence in activities of daily living. For evaluating personal tasks such as self-care, the Pediatric Evaluation of Disability Inventory (PEDI) comprises/introduces/offers a set of useful measures that assist in enhancing the capability for self-care among children and adolescents with cerebral palsy (CP). The aim of this study was to investigate the relevant factors of self-care capability and performance in children and adolescents with spastic CP. Read More

View Article and Full-Text PDF

Nomogram and a predictive model for postoperative hemorrhage in preoperative patients of laparoscopic pancreaticoduodectomy.

Sci Rep 2021 Jul 20;11(1):14822. Epub 2021 Jul 20.

Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang, 050000, Hebei, China.

To develop a predictive model and a nomogram for predicting postoperative hemorrhage in preoperative patients undergoing laparoscopic pancreaticoduodenectomy (LPD). A total of 409 LPD patients that underwent LPD by the same surgical team between January 2014 and December 2020 were included as the training cohort. The preoperative data of patients were statistically compared and analyzed for exploring factors correlated with postoperative hemorrhage. Read More

View Article and Full-Text PDF

Interventions for treating cavitated or dentine carious lesions.

Cochrane Database Syst Rev 2021 Jul 19;7:CD013039. Epub 2021 Jul 19.

School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.

Background: Traditionally, cavitated carious lesions and those extending into dentine have been treated by 'complete' removal of carious tissue, i.e. non-selective removal and conventional restoration (CR). Read More

View Article and Full-Text PDF

Screening and prognostic value of potential biomarkers for ovarian cancer.

Ann Transl Med 2021 Jun;9(12):1007

Department of Surgery, Changshu Affiliated Hospital of Nanjing University of Chinese Medicine, Changshu Traditional Chinese Medicine Hospital, Changshu, China.

Background: Ovarian cancer is a common gynecological malignant tumor that greatly threatens women's health, so we screened potential biomarkers of ovarian cancer and analyzed their prognostic value.

Methods: The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were used to analyze the ovarian cancer-related genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to analyze the function of ovarian cancer-related genes. Read More

View Article and Full-Text PDF

Radiomic assessment as a method for predicting tumor mutation burden (TMB) of bladder cancer patients: a feasibility study.

BMC Cancer 2021 Jul 16;21(1):823. Epub 2021 Jul 16.

Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Background: Tumor mutation burden (TMB) is an emerging prognostic biomarker of immunotherapy for bladder cancer (BLCA). We aim at investigating radiomic features' value in predicting the TMB status of BLCA patients.

Methods: Totally, 75 patients with BLCA were enrolled. Read More

View Article and Full-Text PDF

Anther Culture in Coconut (Cocos nucifera L.).

Methods Mol Biol 2021 ;2289:167-178

Tissue Culture Division, Coconut Research Institute, Lunuwila, Sri Lanka.

Doubled haploids have a high impact on the improvement of heterozygous crops through hybridization. Anther culture is a doubled haploid technique for producing homozygous lines. In coconut, a tree species reported to be recalcitrant for tissue culture, a successful doubled haploid protocol was established through anther culture. Read More

View Article and Full-Text PDF
January 2021

[Pharmacotherapy of allergic rhinitis: position of a clinical pharmacologist].

Vestn Otorinolaringol 2021 ;86(3):118-126

Sechenov First Moscow State Medical University, Moscow, Russia.

Pharmacotherapy for allergic rhinitis is based on different categories of drugs used either in monotherapy or in combination regimens. The current clinical guidelines suggest a stepwise approach to pharmacotherapy for allergic rhinitis. The use of intranasal corticosteroids is considered as the preferred second-stage pharmacotherapy. Read More

View Article and Full-Text PDF

Association of Outcomes with Model-Based Indices of Cerebral Autoregulation After Pediatric Traumatic Brain Injury.

Neurocrit Care 2021 Jul 15. Epub 2021 Jul 15.

Department of Neurosciences, Barrow Neurological Institute at Phoenix Children's Hospital, 1919 E. Thomas Road, Ambulatory Building B, 4th Floor, Phoenix, AZ, USA.

Background: We investigated whether model-based indices of cerebral autoregulation (CA) are associated with outcomes after pediatric traumatic brain injury.

Methods: This was a retrospective analysis of a prospective clinical database of 56 pediatric patients with traumatic brain injury undergoing intracranial pressure monitoring. CA indices were calculated, including pressure reactivity index (PRx), wavelet pressure reactivity index (wPRx), pulse amplitude index (PAx), and correlation coefficient between intracranial pressure pulse amplitude and cerebral perfusion pressure (RAC). Read More

View Article and Full-Text PDF

Effects of lncRNA ANRIL-knockdown on the proliferation, apoptosis and cell cycle of gastric cancer cells.

Oncol Lett 2021 Aug 28;22(2):621. Epub 2021 Jun 28.

Department of Oncology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang 315000, P.R. China.

Gastric cancer is one of the most common types of malignant tumor of the gastrointestinal tract worldwide. Cisplatin (DDP) is a commonly used chemotherapeutic drug in the clinic; however, the resistance of gastric cancer cells to DDP limits its efficacy. In the present study, drug-resistant gastric cancer cell lines were constructed using the stepwise continuous selection method, and the relative expression levels of long non-coding RNA (lncRNA) CDKN2B antisense RNA 1 (ANRIL) and microRNA (miR)-181a-5p were detected using reverse transcription-quantitative PCR. Read More

View Article and Full-Text PDF

Cisplatin Ototoxicity: Examination of the Impact of Dosing, Infusion Times, and Schedules In Pediatric Cancer Patients.

Front Oncol 2021 28;11:673080. Epub 2021 Jun 28.

Division of Pediatric Hematology/Oncology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, United States.

Background: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss.

Methods: A retrospective review of 993 pediatric patients' medical and audiological charts from August 1990 to March 2015 was conducted using stringent inclusion criteria to characterize patients with hearing loss. Read More

View Article and Full-Text PDF

Evaluating the association of social needs assessment data with cardiometabolic health status in a federally qualified community health center patient population.

BMC Cardiovasc Disord 2021 Jul 14;21(1):342. Epub 2021 Jul 14.

Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Dr, Chapel Hill, NC, 27519, USA.

Background: Health systems are increasingly using standardized social needs screening and response protocols including the Protocol for Responding to and Assessing Patients' Risks, Assets, and Experiences (PRAPARE) to improve population health and equity; despite established relationships between the social determinants of health and health outcomes, little is known about the associations between standardized social needs assessment information and patients' clinical condition.

Methods: In this cross-sectional study, we examined the relationship between social needs screening assessment data and measures of cardiometabolic clinical health from electronic health records data using two modelling approaches: a backward stepwise logistic regression and a least absolute selection and shrinkage operation (LASSO) logistic regression. Primary outcomes were dichotomized cardiometabolic measures related to obesity, hypertension, and atherosclerotic cardiovascular disease (ASCVD) 10-year risk. Read More

View Article and Full-Text PDF

A methodology for supplier selection under the curse of dimensionality problem based on fuzzy quality function deployment and interval data envelopment analysis.

Authors:
Xi Bao Fenfen Li

PLoS One 2021 14;16(7):e0253917. Epub 2021 Jul 14.

School of Public Administration, Hunan University of Finance and Economics, Changsha, P. R. China.

Supplier selection is an important decision-making problem, which involves many quantitative and qualitative factors incorporating vagueness and imprecision. This study proposes a novel fuzzy multi-criteria decision-making framework for supplier selection, which integrates quality function deployment (QFD) and interval data envelopment analysis (DEA). The proposed methodology allows for considering the relationships among the product features and supplier evaluation criteria (SEs) and the impacts of inner dependence among SEs by constructing a house of quality (HOQ). Read More

View Article and Full-Text PDF

Predictive Risk Models for Wound Infection-Related Hospitalization or ED Visits in Home Health Care Using Machine-Learning Algorithms.

Adv Skin Wound Care 2021 Aug;34(8):1-12

Jiyoun Song, PhD, RN, AGACNP-BC, is Postdoctoral Fellow, Columbia University School of Nursing, New York, NY. Kyungmi Woo, PhD, RN, is Assistant Professor, The Research Institute of Nursing Science, Seoul National University College of Nursing, Republic of Korea. Jingjing Shang, PhD, RN, is Associate Professor, Columbia University School of Nursing, New York, NY. Marietta Ojo, MPH, is Research Assistant, Columbia University Mailman School of Public Health, New York, NY. Maxim Topaz, PhD, RN, is Associate Professor, Columbia University School of Nursing, New York, NY. Acknowledgments: This study is funded by the Eugenie and Joseph Doyle Research Partnership Fund from Visiting Nurses Service of New York and the Intramural Pilot Grant from Columbia University School of Nursing. At the time of data analysis and manuscript development, Jiyoun Song was supported in part by the Agency for Healthcare Research and Quality (R01HS024915), Nursing Intensity of Patient Care Needs and Rates of Healthcare-Associated Infections, and The Jonas Center for Nursing and Veterans Healthcare. Kyungmi Woo was supported by the Comparative and Cost-Effectiveness Research (T32 NR014205) grant through the National Institute of Nursing Research. The authors have disclosed no other financial relationships related to this article. Submitted August 28, 2020; accepted in revised form December 8, 2020.

Objective: Wound infection is prevalent in home healthcare (HHC) and often leads to hospitalizations. However, none of the previous studies of wounds in HHC have used data from clinical notes. Therefore, the authors created a more accurate description of a patient's condition by extracting risk factors from clinical notes to build predictive models to identify a patient's risk of wound infection in HHC. Read More

View Article and Full-Text PDF

Automated Processing of Head CT Perfusion Imaging for Ischemic Stroke Triage: A Practical Guide to Quality Assurance and Interpretation.

AJR Am J Roentgenol 2021 Jul 14. Epub 2021 Jul 14.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, 30322.

Recent successful trials of thrombectomy launched a shift to imaging-based patient selection for stroke intervention. Many centers have adopted CT perfusion imaging (CTP) as a routine part of stroke workflow, and the demand for emergent CTP interpretation is growing. Fully automated CTP postprocessing software that rapidly generates standardized color-coded CTP summary maps with minimal user input and with easy accessibility of the software output is increasingly being adopted. Read More

View Article and Full-Text PDF

Hepatocellular uptake index obtained with gadoxetate disodium-enhanced magnetic resonance imaging in the assessment future liver remnant function after major hepatectomy for biliary malignancy.

BJS Open 2021 Jul;5(4)

Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Paediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

Background: Functional assessment of the future liver remnant (FLR) after major hepatectomy is essential but often difficult in patients with biliary malignancy, owing to obstructive jaundice and portal vein embolization. This study evaluated whether a novel index using gadoxetate disodium-enhanced MRI (EOB-MRI) could predict posthepatectomy liver failure (PHLF) after major hepatectomy for biliary malignancy.

Methods: The remnant hepatocellular uptake index (rHUI) was calculated in patients undergoing EOB-MRI before major hepatectomy for biliary malignancy. Read More

View Article and Full-Text PDF

Financial toxicity in sarcoma patients and survivors in Germany: results from the multicenter PROSa study.

Support Care Cancer 2021 Jul 11. Epub 2021 Jul 11.

National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.

Purpose: Cancer patients have been shown to frequently suffer from financial burden before, during, and after treatment. However, the financial toxicity of patients with sarcoma has seldom been assessed. Therefore, the aim of this study was to evaluate whether financial toxicity is a problem for sarcoma patients in Germany and identify associated risk factors. Read More

View Article and Full-Text PDF

Impact of viewing conditions on the performance assessment of different computer monitors used for dental diagnostics.

Imaging Sci Dent 2021 Jun 9;51(2):137-148. Epub 2021 Feb 9.

School of Oral Hygiene, Artevelde University of Applied Sciences, Gent, Belgium.

Purpose: This study aimed to assess the computer monitors used for analysis and interpretation of digital radiographs within the clinics of the Oral Health Centre of Western Australia.

Materials And Methods: In total, 135 computer monitors (3 brands, 6 models) were assessed by analysing the same radiographic image of a combined 13-step aluminium step wedge and the Artinis CDDent 1.0® (Artinis Medical Systems B. Read More

View Article and Full-Text PDF

Distinct Extracellular RNA Profiles in Different Plasma Components.

Front Genet 2021 21;12:564780. Epub 2021 Jun 21.

Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States.

Circulating extracellular RNAs (exRNAs) have great potential to serve as biomarkers for a wide range of diagnostic, therapeutic, and prognostic applications. So far, knowledge of the difference among different sources of exRNAs is limited. To address this issue, we performed a sequential physical and biochemical precipitation to collect four fractions (platelets and cell debris, the thrombin-induced precipitates, extracellular vesicles, and supernatant) from each of 10 plasma samples. Read More

View Article and Full-Text PDF

Risk Factors Associated With Progression to Surgical Release After Injection of Trigger Digits.

J Am Acad Orthop Surg Glob Res Rev 2021 07 7;5(7). Epub 2021 Jul 7.

From the Department of Orthopaedic Surgery, University of Southern California, Los Angeles, CA.

Introduction: The mainstay of trigger finger treatment is a corticosteroid injection of the affected digits and is associated with a very high success rate. However, some patients do not respond to nonsurgical management and undergo subsequent surgical release. The purpose of this study is to investigate the comorbidities that predispose patients to progressing from injection to surgical release. Read More

View Article and Full-Text PDF

Bedside clinical data subphenotypes of critically ill COVID-19 patients: a cohort study.

Rev Bras Ter Intensiva 2021 Apr-Jun;33(2):196-205

Departamento de Emergência, Unidade de Terapia Intensiva, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brasil.

Objective: To identify more severe COVID-19 presentations.

Methods: Consecutive intensive care unit-admitted patients were subjected to a stepwise clustering method.

Results: Data from 147 patients who were on average 56 ± 16 years old with a Simplified Acute Physiological Score 3 of 72 ± 18, of which 103 (70%) needed mechanical ventilation and 46 (31%) died in the intensive care unit, were analyzed. Read More

View Article and Full-Text PDF

Five-Minute Power-Based Test to Predict Maximal Oxygen Consumption in Road Cycling.

Int J Sports Physiol Perform 2021 Jul 5:1-7. Epub 2021 Jul 5.

Purpose: To examine the ability of a multivariate model to predict maximal oxygen consumption (VO2max) using performance data from a 5-minute maximal test (5MT).

Methods: Forty-six road cyclists (age 38 [9] y, height 177 [9] cm, weight 71.4 [8. Read More

View Article and Full-Text PDF

Pediatric Invasive Fungal Risk Score in Cancer and Hematopoietic Stem Cell Transplantation Patients With Febrile Neutropenia.

J Pediatr Hematol Oncol 2021 Jul 1. Epub 2021 Jul 1.

Departments of Pediatrics Medicine, Division of Infectious Diseases Department of Pediatrics, University of Chicago Medicine Center for Health and the Social Sciences, University of Chicago, Chicago, IL.

Background: Invasive fungal diseases (IFDs) are opportunistic infections that result in significant morbidity and mortality in pediatric oncology patients. Predictive risk tools for IFD in pediatric cancer are not available.

Methods: We conducted a 7-year retrospective study of pediatric oncology patients with a diagnosis of febrile neutropenia at UCM Comer Children's Hospitals. Read More

View Article and Full-Text PDF

In vitro evolution of cefepime/zidebactam (WCK 5222) resistance in Pseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact on in vivo efficacy.

J Antimicrob Chemother 2021 Jul 5. Epub 2021 Jul 5.

Servicio de Microbiología and Unidad de Investigación, Hospital Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.

Objectives: To study the dynamics, mechanisms and fitness cost of resistance selection to cefepime, zidebactam and cefepime/zidebactam in Pseudomonas aeruginosa.

Methods: WT P. aeruginosa PAO1 and its ΔmutS derivative (PAOMS) were exposed to stepwise increasing concentrations of cefepime, zidebactam and cefepime/zidebactam. Read More

View Article and Full-Text PDF

Episiotomy practice and associated factors among mothers who gave birth at public health facilities in Metema district, northwest Ethiopia.

Reprod Health 2021 Jul 2;18(1):142. Epub 2021 Jul 2.

Department of Public Health, Debre Markos University, Debre Markos, Ethiopia.

Background: Episiotomy is a surgical incision of the perineum to hasten the delivery. There is a scarce of information related to episiotomy practice, and its associated factors, in developing countries, including Ethiopia. Thus, this study was aimed to determine the level of episiotomy practice and to identify its determinants at public health facilities of Metema district, northwest, Ethiopia. Read More

View Article and Full-Text PDF

Risk prediction models based on hematological/body parameters for chemotherapy-induced adverse effects in Chinese colorectal cancer patients.

Support Care Cancer 2021 Jul 2. Epub 2021 Jul 2.

Department of Pharmacy, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.

Purpose: To determine risk factors and develop novel prediction models for chemotherapy-induced adverse effects (CIAEs) in Chinese colorectal cancer (CRC) patients receiving capecitabine.

Methods: A total of 233 Chinese CRC patients receiving post-operative chemotherapy with capecitabine were randomly divided into a training set (70%) and a validation set (30%). CIAE-related hematological/body parameters were screened by univariate logistic regression. Read More

View Article and Full-Text PDF

Radiomics Is Effective for Distinguishing Coronavirus Disease 2019 Pneumonia From Influenza Virus Pneumonia.

Front Public Health 2021 15;9:663965. Epub 2021 Jun 15.

Department of General Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

To develop and validate a radiomics model for distinguishing coronavirus disease 2019 (COVID-19) pneumonia from influenza virus pneumonia. A radiomics model was developed on the basis of 56 patients with COVID-19 pneumonia and 90 patients with influenza virus pneumonia in this retrospective study. Radiomics features were extracted from CT images. Read More

View Article and Full-Text PDF

Crop Classification Based on Red Edge Features Analysis of GF-6 WFV Data.

Sensors (Basel) 2021 Jun 24;21(13). Epub 2021 Jun 24.

Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100101, China.

A red edge band is a sensitive spectral band of crops, which helps to improve the accuracy of crop classification. In view of the characteristics of GF-6 WFV data with multiple red edge bands, this paper took Hengshui City, Hebei Province, China, as the study area to carry out red edge feature analysis and crop classification, and analyzed the influence of different red edge features on crop classification. On the basis of GF-6 WFV red edge band spectral analysis, different red edge feature extraction and red edge indices feature importance evaluation, 12 classification schemes were designed based on GF-6 WFV of four bands (only including red, green, blue and near-infrared bands), stepwise discriminant analysis (SDA) and random forest (RF) method were used for feature selection and importance evaluation, and RF classification algorithm was used for crop classification. Read More

View Article and Full-Text PDF