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Building a bridge between patients and transplant healthcare professionals - A descriptive study.

Transpl Int 2021 Sep 15. Epub 2021 Sep 15.

Donation and Transplant Coordination Unit, Hospital Clinic, Associate Professor Surgical Department, University of Barcelona, Barcelona, Spain.

This paper describes a pathway for collaboration between transplant healthcare professionals and organ recipients. Under the umbrella of the European Society for Organ Transplantation (ESOT) a joint initiative started from three Sections and Committees of ESOT: EDTCO (European Donation and Transplant Coordination Organisation), ETHAP (European Transplant Allied Healthcare Professionals) and ELPAT (Ethical, Legal and Psycho-social Aspects of Transplantation). The formal "kick-off" of the Advisory Board Meeting of the European Transplant Patients' Organisation (ETPO) was during the ESOT congress in 2019. Read More

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September 2021

3D-Reactive printing of engineered alginate inks.

Soft Matter 2021 Sep 15;17(35):8105-8117. Epub 2021 Sep 15.

Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.

Alginate is a common component of bioinks due to its well-described ionic crosslinking mechanism and tunable viscoelastic properties. Extrusion-based 3D-printing of alginate inks requires additives, such as gelatin and Pluronic, pre- or post-printing crosslinking processes and/or coextrusion with crosslinkers. In this work, we aim to develop a different printing approach for alginate-based inks, introducing 3D-reactive printing. Read More

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September 2021

Development of a Programme Theory for Early Intervention Vocational Rehabilitation: A Realist Literature Review.

J Occup Rehabil 2021 Sep 15. Epub 2021 Sep 15.

Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.

Purpose Little is currently known about how early intervention vocational rehabilitation (EIVR) works for people with newly acquired neurological conditions such as traumatic brain injury, acquired brain injury and spinal cord injury. This study aims, from a realist framework, to identify relevant literature and develop an initial programme theory to understand how EIVR might work for people experiencing acquired neurological disability. Realist reviews are ideally placed to address the identified knowledge gap as they assist in gaining a deeper understanding of how the intervention works, for whom it works best, and the contexts that promote the activation of desired outcomes. Read More

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September 2021

Splenomegaly: Diagnosis and Management in Adults.

Am Fam Physician 2021 Sep;104(3):271-276

University of Arizona, Tucson, AZ, USA.

Splenomegaly can be due to several mechanisms but is almost always a sign of a systemic condition. Patient habits, travel, and medical conditions can increase risk of splenomegaly and suggest etiology. Symptoms can suggest infectious, malignant, hepatic, or hematologic causes. Read More

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September 2021

Multistage fractionation of pine bark by liquid and supercritical carbon dioxide.

Bioresour Technol 2021 Aug 30;341:125862. Epub 2021 Aug 30.

University of Natural Resources and Life Sciences (BOKU, Vienna), Department of Chemistry, Institute of Chemistry of Renewable Resources, Konrad-Lorenz-Straße 24, A-3430 Tulln, Austria. Electronic address:

Multistage fractionation of pine bark was performed using subcritical and supercritical CO at increasing pressures and temperatures. In total, seven fractions were collected, which demonstrated different enrichments of families of compounds. In particular, subcritical CO yielded 41% of the total extract in which unsaturated fatty acids represented the most abundant family. Read More

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Depression mediates physical activity readiness and physical activity in patients with heart failure.

ESC Heart Fail 2021 Sep 15. Epub 2021 Sep 15.

Heart Failure and Transplants Unit, Department of Cardiology, Universitary and Politecnic La Fe Hospital, Valencia, Spain.

Aims: Although physical activity (PA) and exercise are essential for patients with heart failure (HF), adherence to the recommended guidelines is low. Not much is known about the mediating effect of HF patients' mental state with their readiness for PA and reported activity levels. The purpose of this study is to investigate the mediatory effect of depression on PA readiness (physical limitation and psychological readiness) and self-reported PA in patients with HF. Read More

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September 2021

Contribution of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Videos on YouTube to the Learning Curve in COVID-19 Pandemic Process.

Cureus 2021 Aug 2;13(8):e16820. Epub 2021 Aug 2.

General Surgery, Ankara City Hospital, Ankara, TUR.

Introduction: YouTube is a free video-sharing platform, which is watched by residents or specialists in order to catch up on their skills, see new techniques, and have information. In this study, our purpose is to evaluate whether or not these videos are an appropriate educational source for surgeons by analyzing their quality and content, in an environment of reduced elective operations due to the COVID-19 pandemic.

Methods: YouTube video search was performed by entering keywords such as CRS and HIPEC, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, cytoreductive surgery, and HIPEC. Read More

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The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background.

BMC Genom Data 2021 Sep 14;22(1):33. Epub 2021 Sep 14.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.

Background: The lymphatic and the blood vasculature are closely related systems that collaborate to ensure the organism's physiological function. Despite their common developmental origin, they present distinct functional fates in adulthood that rely on robust lineage-specific regulatory programs. The recent technological boost in sequencing approaches unveiled long noncoding RNAs (lncRNAs) as prominent regulatory players of various gene expression levels in a cell-type-specific manner. Read More

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September 2021

Construction and validation of conceptual and operational definitions of the defining characteristics of the nursing diagnosis "Ineffective health self-management" in people living with HIV/AIDS.

Int J Nurs Knowl 2021 Sep 14. Epub 2021 Sep 14.

Federal University of Rio Grande do Norte, Nursing Department, Natal, Rio Grande do Norte, Brazil.

Purpose: Build and validate the content of conceptual and operational definitions of the defining characteristics of the nursing diagnosis of NANDA-I "Ineffective health self-management" in people living with HIV/AIDS.

Methods: Methodological study, with a quantitative approach. The validation was performed by 26 specialist nurses selected through the Lattes do Brazil platform. Read More

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September 2021

Deciphering the inflection points to achieve proficiency for each procedure step during training in laparoscopic appendicectomy.

BJS Open 2021 Sep;5(5)

Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway.

Background: Laparoscopic appendicectomy is a common procedure early in surgical training. A minimum number is usually required for certification in general surgery. However, data on proficiency are scarce. Read More

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September 2021

Teaching Basic Life Support to 5- to 8-Year-Old Children: A Cluster Randomized Trial.

Pediatrics 2021 Sep 13. Epub 2021 Sep 13.

Department of Anaesthesiology and Pain Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.

Objective: We aimed to compare traditional basic life support (BLS) education with specific and innovative educative didactic material that has been previously designed and validated.

Methods: Fifteen classes of schoolchildren aged 5 to 8 years ( = 237) were randomly assigned to 4 groups in which different didactic and complementary materials were used: (1) the tool with a cuddly toy ( = 61), (2) the tool with a cuddly toy ( = 74), (3) traditional teaching with a cuddly toy ( = 46), and (4) traditional teaching with a manikin ( = 55). The BLS sequence was assessed at baseline (T0). Read More

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September 2021

Acceptability and usability of HIV self-tests in two European countries: findings from surveys of clients at non-governmental organisations in Lithuania and Italy.

BMC Infect Dis 2021 Sep 13;21(Suppl 2):844. Epub 2021 Sep 13.

Blood Safety, Hepatitis, STI and HIV division, National Infection Service, Public Health England, London, UK.

Background: Uptake of HIV self-tests (HIVST) remains low in Europe. We conducted two separate surveys to understand facilitators and barriers to the use of HIVST in two European countries, as part of the EU INTEGRATE Joint Action. In both countries, HIV has been legal since 2016. Read More

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September 2021

Early Experience of a Robotic Foregut Surgery Program at a Cancer Center: Video of Shared Steps in Robotic Pancreatoduodenectomy and Gastrectomy.

Ann Surg Oncol 2021 Sep 13. Epub 2021 Sep 13.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Over the past few decades, robotic surgery techniques required to resect gastric and pancreatic malignancies have evolved remarkably; however, the safety and generalizability of robotic pancreatoduodenectomy remain unknown. At our cancer center, gastrectomies and pancreatectomies are performed in a combined foregut minimally-invasive surgery program; this effectively increases the composite case volume and shortens the learning curve for any individual surgeon. In this video, we demonstrate the shared steps in pancreatoduodenectomy and gastrectomy and explain how the skills gained through robotic gastrectomy can be used during robotic pancreatoduodenectomy. Read More

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September 2021

Droplet contact-based spheroid transfer technique as a multi-step assay tool for spheroid arrays.

Lab Chip 2021 Sep 13. Epub 2021 Sep 13.

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

Hanging drop plates and low-attachment well plates are suitable for a high throughput screening model of a spheroid, because each drop (or well) contains a single spheroid and the spheroid environment are separated from each other. However, uniform spheroid culture on these devices is difficult as the liquid around the spheroid is replaced by direct pipetting, which can cause spheroid damage or loss, and well-to-well variation. If spheroids need to be cultured for a long time or analyzed through chemical treatment of immunostaining, it becomes a more considerable problem as the number of pipetting action increases. Read More

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September 2021

Usefulness of a stepwise training program for laparoscopic gastrectomy.

Asian J Endosc Surg 2021 Sep 12. Epub 2021 Sep 12.

Department of Surgery, University of Tokushima Graduate School, Tokushima, Japan.

Introduction: Laparoscopic gastrectomy (LG) is a complicated procedure with a long learning curve. This study was performed to investigate the usefulness of our stepwise training program for LG for improving the quality of the surgery.

Methods: The stepwise training method comprised the following four steps: (1) basic training using a dry box and checking by mentors; (2) advanced training, including the use of animals and cadavers; (3) clinical experience, including standardization and preoperative three-dimensional simulation; and (4) self-assessment and feedback. Read More

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September 2021

Integrative Network Analysis Revealed Genetic Impact of Pyruvate Kinase L/R on Hepatocyte Proliferation and Graft Survival after Liver Transplantation.

Oxid Med Cell Longev 2021 2;2021:7182914. Epub 2021 Sep 2.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Background: Pyruvate kinase L/R (PKLR) has been suggested to affect the proliferation of hepatocytes via regulation of the cell cycle and lipid metabolism. However, its impact on the global metabolome and its clinical implications remain unclear.

Aims: We aimed to clarify the genetic impact of PKLR on the metabolomic profiles of hepatoma cells and its potential effects on grafts for liver transplantation (LT). Read More

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September 2021

Evaluation of the Bond Strength of Densely Sintered Ceramics Subjected to Extended Firing.

Clin Cosmet Investig Dent 2021 1;13:371-377. Epub 2021 Sep 1.

Post-Graduation Program in Dentistry, University of Tuiuti of Paraná, Curitiba, 82010-330, Brazil.

Introduction: Critical failures in ceramic materials can be caused by the processing mode, which includes all steps taken in the manufacture of a ceramic part, from molding to firing.

Purpose: To evaluate the effect of extended firing on bond strength in densely sintered ceramics of the zirconium reinforced lithium silicate, lithium disilicate, and feldspathic ceramic.

Materials And Methods: Three types of ceramics were evaluated: zirconium reinforced lithium silicate, lithium disilicate, feldspathic ceramic. Read More

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September 2021

Percutaneous Drainage in Hepatic Hydatidosis-The PAIR Technique: Concept, Technique, and Results.

J Clin Exp Hepatol 2021 Sep-Oct;11(5):592-602. Epub 2021 May 26.

Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.

Over decades, surgery has been the only accepted mode of treatment for liver hydatid cysts. It had been a surgical dogma for a long that hydatid disease is an absolute contraindication for needle puncture/aspiration as it can cause anaphylaxis, death, and dissemination. We envisaged prospectively perform percutaneous drainage as a primary form of treatment for hepatic hydatidosis. Read More

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An individualized decision aid for physicians and patients for total knee replacement in osteoarthritis (Value-based TKR study): study protocol for a multi-center, stepped wedge, cluster randomized controlled trial.

BMC Musculoskelet Disord 2021 Sep 12;22(1):783. Epub 2021 Sep 12.

University Center of Orthopedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

Background: Total knee replacement (TKR) is one of the most commonly performed routine procedures in the world. Prognostic studies indicate that the number of TKR will further increase constituting growing burden on healthcare systems. There is also substantial regional heterogeneity in TKR rates within and between countries. Read More

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September 2021

Advanced data preprocessing for comprehensive two-dimensional gas chromatography with vacuum ultraviolet spectroscopy detection.

J Sep Sci 2021 Sep 12. Epub 2021 Sep 12.

IFP Energies nouvelles, Rond-point de l'échangeur de Solaize BP 3, Solaize, 69360, France.

Comprehensive two-dimensional gas chromatography with vacuum ultraviolet detection results in sizable data for which noise and baseline drift ought to be corrected. As the data is acquired from multiple channels, preprocessing steps have to be applied to the data from all channels while being robust and rather fast with respect to the significant size of the data. In this study, we have described advanced data preprocessing techniques for such data which were not available in the existing commercial software solutions and which were dedicated primarily to noise and baseline correction. Read More

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September 2021

The revolution of cosmeceuticals delivery by using nanotechnology: A narrative review of advantages and side effects.

J Cosmet Dermatol 2021 Sep 12. Epub 2021 Sep 12.

Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Scotland, UK.

Background: The qualified and paradigm jump in the formulation and production of cosmeceuticals refer in some way to the great revolution in nanotechnology. Nowadays, the industry of nano-formulated cosmeceuticals plays a significant and essential role in the evolution and growth of the pharmaceutical industries. This review manuscript focuses on the use of nanocarriers in delivering the cosmetic agents into the target area such as skin, hair, and nails. Read More

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September 2021

Assessment of land use and land cover change detection and prediction using remote sensing and CA Markov in the northern coastal districts of Tamil Nadu, India.

Environ Sci Pollut Res Int 2021 Sep 12. Epub 2021 Sep 12.

Department of Civil Engineering, National Institute of Technology, Tiruchirappalli, Tamil Nadu, India.

The study on land use and land cover (LULC) changes assists in analyzing the change and regulates environment sustainability. Hence, this research analyzes the Northern TN coast, which is under both natural and anthropogenic stress. The analysis of LULC changes and LULC projections for the region between 2009-2019 and 2019-2030 was performed utilizing Google Earth Engine (GEE), TerrSet, and Geographical Information System (GIS) tools. Read More

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September 2021

Validation of the Italian spine youth quality of life (ISYQOL) in Korean population.

J Clin Neurosci 2021 Oct 23;92:165-168. Epub 2021 Aug 23.

Department of Orthopaedic Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea. Electronic address:

We aimed to evaluate the reliability and validity of the adapted Korean version of the Italian Spine Youth Quality of Life (ISYQOL) questionnaire. Translation/retranslation of the English version of ISYQOL was conducted, and all steps of the cross-cultural adaptation process were performed. The Korean version of the ISYQOL and the previously validated Scoliosis Research Society-22 (SRS-22) questionnaire were mailed to 120 consecutive idiopathic scoliosis patients wearing brace. Read More

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October 2021

Effectiveness of community-based cardiovascular disease prevention interventions to improve physical activity: A systematic review and meta-regression.

Prev Med 2021 Sep 8;153:106797. Epub 2021 Sep 8.

Department of Primary and Interdisciplinary Care, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp 2610, Belgium; Global Health Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp 2610, Belgium.

Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally. Despite preventive community-based interventions (CBIs) seem efficacious in reducing CVD risks, a comprehensive up-to-date synthesis on the effectiveness of such interventions in improving physical activity (PA) is lacking. We performed a systematic review and meta-analysis of community-based CVD preventive interventions aimed at improving PA level. Read More

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September 2021

Pharmacological Treatment for the Management of COVID 19: A Narrative Review.

JNMA J Nepal Med Assoc 2021 Jul 1;59(238):614-621. Epub 2021 Jul 1.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is alarming worldwide incurring tremendous loss of life and possession. Individuals are facing a terrible pandemic condition in the absence of appropriate medicines and vaccines to combat SARS-CoV-2 infection. This review aimed to provide details on potential treatment steps that can be taken in the current pandemic-fighting situation in Nepal. Read More

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Comparison of surface topography and roughness in different yttrium oxide compositions of dental zirconia after grinding and polishing.

J Adv Prosthodont 2021 Aug 26;13(4):258-267. Epub 2021 Aug 26.

Department of Prosthodontics, College of Dentistry, Dankook University, Cheonan, Republic of Korea.

Purpose: The purpose of this study was to compare the surface roughness, phase transformation, and surface topography of dental zirconia with three different yttrium oxide compositions under same grinding and polishing conditions.

Materials And Methods: Three zirconia disks (IPS e.max ZirCAD LT, MT, MT multi, Ivoclar Vivadent AG, Schaan, Liechtenstein) were selected for experimental materials. Read More

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Targeting CA-125 Transcription by Development of a Conditionally Replicative Adenovirus for Ovarian Cancer Treatment.

Cancers (Basel) 2021 Aug 24;13(17). Epub 2021 Aug 24.

Department of Medical Oncology and Therapeutics Research, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

CA-125, encoded by the gene, is highly expressed in most ovarian cancer cells and thus serves as a tumor marker for monitoring disease progression or treatment response in ovarian cancer patients. However, targeting /CA-125 for ovarian cancer treatment has not been successful to date. In the current study, we performed multiple steps of high-fidelity PCR and obtained a 5 kb DNA fragment upstream of the human gene. Read More

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Valorization of Aquatic Weed and Agricultural Residues for Innovative Biopolymer Production and Their Biodegradation.

Polymers (Basel) 2021 Aug 24;13(17). Epub 2021 Aug 24.

Research Center for Environmental and Hazardous Substance Management (EHSM), Faculty of Engineering, Khon Kaen University, Khon Kaen 40002, Thailand.

In this work, water hyacinths, bagasse and rice straw were valorized to produce an innovative biopolymer. Serial steps of extraction, bleaching and conversion of cellulose to be carboxymethylcellulose (CMC) as well as the last steps of blending and molding were performed. The CMC was mixed with tapioca starch solution by a ratio of 9:18, and a plastic sizer of glycerol was varied at 2%, 4% and 6% by volume. Read More

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Water-Airborne-Particle Abrasion as a Pre-Treatment to Improve Bioadhesion and Bond Strength of Glass-Ceramic Restorations: From In Vitro Study to 15-Year Survival Rate.

Materials (Basel) 2021 Aug 31;14(17). Epub 2021 Aug 31.

Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.

The purposes of this study were to evaluate the efficacy of water-airborne-particle abrasion (WAPA) as pre-etching procedure for tooth surfaces to increase bond strength, and to compare the survival rate of WAPA vs. non-WAPA glass-ceramic restorations with a 15-year follow-up. The occlusal surfaces of 20 human molars were sectioned and flattened. Read More

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Evaluation of the In Vitro Cytotoxic Activity of Ursolic Acid PLGA Nanoparticles against Pancreatic Ductal Adenocarcinoma Cell Lines.

Materials (Basel) 2021 Aug 29;14(17). Epub 2021 Aug 29.

Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland.

Among all the types of cancer, Pancreatic Ductal Adenocarcinoma remains one of the deadliest and hardest to fight and there is a critical unmet need for new drugs and therapies for its treatment. Naturally derived compounds, such as pentacyclic triterpenoids, have gathered attention because of their high cytotoxic potential towards pancreatic cancer cells, with a wide biological activity spectrum, with ursolic acid (UA) being one of the most interesting. However, due to its minimal water solubility, it is necessary to prepare a nanocarrier vehicle to aid in the delivery of this compound. Read More

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