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Movement asymmetries in horses presented for pre purchase or lameness examination.

Equine Vet J 2021 Apr 16. Epub 2021 Apr 16.

Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Background: The increasing popularity of objective gait analysis makes application in pre-purchase examinations (PPE) a logical next step. Therefore, there is a need to have more understanding of asymmetry during a PPE in horses described on clinical evaluation as subtly lame.

Objectives: To objectively compare asymmetry in horses raising minor vet concerns in a PPE and in horses raising major vet concerns with that found in horses presented with subtle single-limb lameness, and to investigate the effect of age/discipline on the clinicians' interpretation of asymmetry on the classification of minor vet concerns in a PPE. Read More

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Review of Approaches to Developing Intersegmental Plane during Segmentectomy.

Thorac Cardiovasc Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

In recent years, with the popularity of computed tomography (CT) scanning, early lung cancer has been found in a large number of patients, and segmentectomy has been widely used in clinical practice. The development of intersegmental plane is the most critical step in segmentectomy. At present, there are many methods to identify the intersegmental plane. Read More

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Oxygen-rich PdSnCu Nanocrystals with Particle Connection Features as Enhanced Catalysts for Ethanol Oxidation Reaction.

Nanotechnology 2021 Apr 16. Epub 2021 Apr 16.

College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, CHINA.

Most electrocatalysts show a high mass and special activity during the ethanol oxidation reaction, but those still suffer from limited stability, finite renewable capability and poor anti-poisoning durability. Furthermore, the reliable structure and appropriate composition of alloys catalysts are fairly associated with the electrocatalysis performance. Herein, we report the development of well-alloyed PdSnCunanocrystals (NCs) whose rough surfaces are rich in step atoms and coupled with abundant of SnOand CuO, which may effectively boost reaction activity and rapidly remove carbonaceous intermediate, respectively. Read More

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Dosimetric analysis of cervical cancer stage IIB patients treated with volumetric modulated arc therapy using plan uncertainty parameters module of Varian Eclipse treatment planning system.

Biomed Phys Eng Express 2021 Apr 16. Epub 2021 Apr 16.

Dr BL Kapur Memorial Hospital, Rajender Nagar, Pusa Road, New Delhi, Delhi, 110005, INDIA.

Introduction: The present study aims to investigate the dosimetric and radiobiological impact of patient setup errors (PSE) on the target and organs at risk (OAR) of the cervix carcinoma stage IIB patients treated with volumetric-modulated arc therapy (VMAT) delivery technique using plan uncertainty parameters module of Varian Eclipse treatment planning system and in-house developed DVH Analyzer program.

Materials And Methods: A total of 976 VMAT plans were generated to simulate the PSE in the base plan that varies from -10 mm to 10 mm in a step size of 1 mm in x- (lateral), y- (craniocaudal), and z- (anteroposterior) directions. The different OAR and tumor volumes were delineated in each case. Read More

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A pH-sensitive drug delivery system based on hyaluronic acid co-deliver doxorubicin and aminoferrocene for the combined application of chemotherapy and chemodynamic therapy.

Colloids Surf B Biointerfaces 2021 Apr 7;203:111750. Epub 2021 Apr 7.

School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, PR China. Electronic address:

Doxorubicin is a broad-spectrum antineoplastic drug used in tumor therapy, its clinical application is limited by side effects on normal tissues. In this article, a pH-responsive drug delivery system (NPs(DOX/AFc)) with co-delivers doxorubicin (DOX) and aminoferrocene (AFc) was prepared by a two-step synthesis method including the oxidation of hyaluronic acid and Schiff base reaction. NPs(DOX/AFc) can be used in combination therapy of chemodynamic therapy (CDT) and chemotherapy (CT), thus the dosage of the chemotherapeutic drug DOX was reduced. Read More

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Individual risk management strategy for SARS-CoV-2 infection: A step toward personalized healthcare.

Int Immunopharmacol 2021 Apr 1;96:107629. Epub 2021 Apr 1.

Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway. Electronic address:

Lethal or critical COVID-19 occurs most in infected hosts with certain risk factors such as advanced age or pre-existing disease. Host metabolic status significantly affects the clinical presentations of SARS-CoV-2 infection. Individual risk management is thus crucial for preventing severe COVID-19. Read More

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Quantitative determination of creatinine from serum of prostate cancer patients by N-doped porous carbon antimony (Sb/NPC) nanoparticles.

Bioelectrochemistry 2021 Apr 5;140:107815. Epub 2021 Apr 5.

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address:

Creatinine is an indicator of hindrance in urination and renal insufficiency. Creatinine levels are the marker of the late stages of prostate cancer. Early and sensitive detection of creatinine can reduce deaths associated with prostate cancer. Read More

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Molecular engineering of carbon nitride towards photocatalytic H evolution and dye degradation.

J Colloid Interface Sci 2021 Mar 31;597:39-47. Epub 2021 Mar 31.

Department of Chemistry, Sri Siddhartha Institute of Technology, Tumkur 572105, Karnataka, India. Electronic address:

The development of superior heterogeneous catalyst for hydrogen (H) evolution is a significant feature and challenging for determining the energy and environmental crises. However, the dumping of numerous lethal colorants (dye) as of textile manufacturing has fascinated widespread devotion-aimed water pollution anticipation and treatment. In this regard, a photocatalytic H evolution by visible light using low-dimensional semiconducting materials having pollutant degradable capacity for Rhodamine B dyes (RhB) has been anticipated as a route towards environmental aspect. Read More

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New taxonomy for assessing manual material handlers' footstep patterns.

Appl Ergon 2021 Apr 13;94:103424. Epub 2021 Apr 13.

Department of Kinesiology, Université Laval, Québec, Québec, Canada; Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale (CIRRIS), Centre Intégré Universitaire de Santé et de Services Sociaux de la Capitale-Nationale (CIUSSS-CN), Québec, Canada. Electronic address:

Current taxonomies for assessing foot strategies in manual material handling lack exhaustive classification of foot movements and foot positioning. They also fail to consider different instants of the task as checkpoints to relate foot strategies. The goal of the study was first to develop a new taxonomy to assess foot positions and motions considering those limitations. Read More

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Virtual screening of peptides with high affinity for SARS-CoV-2 main protease.

Comput Biol Med 2021 Apr 2;133:104363. Epub 2021 Apr 2.

Porto Reports, Brasília, DF, 72236-011, Brazil. Electronic address:

The current pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 2,000,000 deaths worldwide. Currently, vaccine development and drug repurposing have been the main strategies to find a COVID-19 treatment. However, the development of new drugs could be the solution if the main strategies fail. Read More

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Single step nanospray drying preparation technique of gabapentin-loaded nanoparticles-mediated brain delivery for effective treatment of PTZ-induced seizures.

Int J Pharm 2021 Apr 13:120604. Epub 2021 Apr 13.

Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6(th) of October City, Cairo, Egypt.

In the present study, gabapentin (GBP)-loaded chitosan nanosized particles were fabricated applying the nanospray drying technique. Different preparation parameters (spray mesh diameter, chitosan concentration and presence of D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) were studied while fixing other parameters (spraying rate, inlet temperature and gas flow rate). An optimized formulation with a particle size 107±13 nm was obtained upon spraying 0. Read More

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β-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery.

Int J Pharm 2021 Apr 13:120602. Epub 2021 Apr 13.

Department of Chemistry and Department of Health Sciences, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia, B1P 6L2, Canada. Electronic address:

β-Cyclodextrin (β-CD) was grafted onto hyaluronic acid (HA) in a single step to generate a supramolecular biopolymer (HA-β-CD) that was explored for targeted drug delivery applications. Along with its excellent biocompatibility, the prepared HA-β-CD exhibits not only exceptionally high loading capacity for the model drugs doxorubicin and Rhodamine B through the formation of inclusion complexes with the β-CD component, but also the capability of targeted drug delivery to cancerous cells with a high level of expression of CD44 receptors, attributable to its HA component. The polymer can release the drug under slightly acidic conditions. Read More

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Parasite community structure in sympatric Bornean primates.

Int J Parasitol 2021 Apr 13. Epub 2021 Apr 13.

Primate Research Institute, Kyoto University, Inuyama, Japan; Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.

Parasites are important components of ecosystems, influencing trophic networks, competitive interactions and biodiversity patterns. Nonetheless, we are not nearly close to disentangling their complex roles in natural systems. Southeast Asia falls within global areas targeted as most likely to source parasites with zoonotic potential, where high rates of land conversion and fragmentation have altered the circulation of wildlife species and their parasites, potentially resulting in altered host-parasite systems. Read More

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Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis.

Lancet Oncol 2021 Apr 13. Epub 2021 Apr 13.

Service de Biostatistique et d'Epidémiologie, Gustave Roussy, Oncostat U1018, Ligue Contre le Cancer, INSERM, Université Paris-Saclay, Villejuif, France; Department of Radiation Oncology, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, F-94805 Villejuif, France; Groupe d'Oncologie Radiothérapie Tête Et Cou, Tours, France. Electronic address:

Background: Randomised, controlled trials and meta-analyses have shown the survival benefit of concomitant chemoradiotherapy or hyperfractionated radiotherapy in the treatment of locally advanced head and neck cancer. However, the relative efficacy of these treatments is unknown. We aimed to determine whether one treatment was superior to the other. Read More

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Cocaine-Induced Fos Expression in the Rat Brain: Modulation by Prior Δ-Tetrahydrocannabinol Exposure During Adolescence and Sex-Specific Effects.

Brain Res 2021 Apr 13:147480. Epub 2021 Apr 13.

Department of Psychobiology. School of Psychology, National University for Distance Learning (UNED), Madrid, Spain. Electronic address:

It has been suggested that cannabis consumption during adolescence may be an initial step to cocaine use in adulthood. Indeed, previous preclinical data show that adolescent exposure to cannabinoids (both natural and synthetic) potentiates cocaine self-administration in rats. Here we aimed at gaining a deeper understanding of the cellular activation patterns induced by cocaine as revealed by Fos imaging and how these patterns may change due to adolescent exposure to THC. Read More

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Prediction of genomic breeding values of milk traits in Brazilian Saanen goats.

J Anim Breed Genet 2021 Apr 16. Epub 2021 Apr 16.

Animal Sciences Department, Federal University of Ceará, Fortaleza, Brazil.

The study's objective was to compare the genomic prediction ability methods for the traits milk yield, milk composition and somatic cell count of Saanen Brazilian goats. Nine hundred forty goats, genotyped with an Axiom_OviCap (Caprine) panel, Affimetrix customized array with 62,557 single nucleotide polymorphisms (SNPs), were used for the genomic selection analyses. The genomic methods studied to estimate the effects of SNPs and direct genomic values (DGV) were as follows: (a) genomic BLUP (GBLUP), (b) Bayes Cπ and (c) Bayesian Lasso (BLASSO). Read More

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EmoTIC: Impact of a game-based social-emotional programme on adolescents.

PLoS One 2021 16;16(4):e0250384. Epub 2021 Apr 16.

Department of Personality, Assessment and Psychological Treatment, Faculty of Psychology, Universitat de València, Valencia, Spain.

Introduction: Technologies provide a brilliant opportunity to promote social-emotional competences, well-being and adjustment in adolescence. Game-based programmes and serious games are digital tools that pursue an educational goal in an attractive environment for adolescents. The purpose of this study was therefore to determine the effectiveness of emoTIC, a game-based social-emotional programme designed according to Mayer, Caruso, and Salovey's model of emotional intelligence. Read More

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Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.

PLoS Pathog 2021 Apr 16;17(4):e1009417. Epub 2021 Apr 16.

Immunology Catalyst, Immunology Network, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.

Macrophages are important drivers of pathogenesis and progression to AIDS in HIV infection. The virus in the later phases of the infection is often predominantly macrophage-tropic and this tropism contributes to a chronic inflammatory and immune activation state that is observed in HIV patients. Pattern recognition receptors of the innate immune system are the key molecules that recognise HIV and mount the inflammatory responses in macrophages. Read More

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An integrated approach of Ecological Footprint (EF) and Analytical Hierarchy Process (AHP) in human ecology: A base for planning toward sustainability.

PLoS One 2021 16;16(4):e0250167. Epub 2021 Apr 16.

Global Footprint Network, Oakland, California, United States of America.

Environmental challenges to natural resources have been attributed to human behavior and traditional agricultural production techniques. Natural resource degradation in agriculture has always been a prime concern in agro ecological research and sustainability analysis. There are many techniques for assessing environmental performance; one of which, ecological footprint (EF), assesses human pressure on the environment and natural resources. Read More

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A new model for simultaneous dimensionality reduction and time-varying functional connectivity estimation.

Diego Vidaurre

PLoS Comput Biol 2021 Apr 16;17(4):e1008580. Epub 2021 Apr 16.

Center for Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

An important question in neuroscience is whether or not we can interpret spontaneous variations in the pattern of correlation between brain areas, which we refer to as functional connectivity or FC, as an index of dynamic neuronal communication in fMRI. That is, can we measure time-varying FC reliably? And, if so, can FC reflect information transfer between brain regions at relatively fast-time scales? Answering these questions in practice requires dealing with the statistical challenge of having high-dimensional data and a comparatively lower number of time points or volumes. A common strategy is to use PCA to reduce the dimensionality of the data, and then apply some model, such as the hidden Markov model (HMM) or a mixture model of Gaussian distributions, to find a set of distinct FC patterns or states. Read More

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Physical activity correlates in children and adolescents, adults, and older adults with an intellectual disability: a systematic review.

Disabil Rehabil 2021 Apr 16:1-12. Epub 2021 Apr 16.

Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.

Purpose: Understanding enablers of and barriers for physical activity (PA) participation in people with intellectual disability (ID) is an essential first step to develop effective interventions. This systematic review examined correlates of PA across the socio-ecological model (i.e. Read More

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Gold Nanostar Spatial Distribution Impacts the Surface-Enhanced Raman Scattering Detection of Uranyl on Amidoximated Polymers.

Langmuir 2021 Apr 16. Epub 2021 Apr 16.

Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States.

The plasmonic properties of carboxylated gold nanostars distributed on amidoximated polyacrylonitrile (AO PAN) electrospun polymer films scale with surface-enhanced Raman scattering (SERS) intensities for coordinated uranium(VI) oxide (uranyl) species. This two-step plasmonic sensor first isolates uranyl from solution using functionalized polymers; then carboxylated gold nanostars are subsequently deposited for SERS. Spatially resolved localized surface plasmon resonance (LSPR) and SERS facilitate correlated nanostar optical density and uranyl quantification. Read More

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Polyazido-methyl Derivatives of Prominent Oxadiazole and Isoxazole Scaffolds: Synthesis, Explosive Properties, and Evaluation.

J Org Chem 2021 Apr 16. Epub 2021 Apr 16.

Department of Chemistry, Ludwig-Maximilian University of Munich, Butenandtstr. 5-13(D), D-81377 Munich, Germany.

Recently, different nitrato-methyl-substituted oxadiazoles have been described as potential melt-cast explosives. In this work, corresponding N-O heterocyclic-based compounds with azido-methyl functionalities were synthesized. In each case, the explosophoric azide group is inserted by chlorine-azide exchange during the last synthetic step. Read More

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Interactive Regulation between Aliphatic Hydroxylation and Aromatic Hydroxylation of Thaxtomin D in TxtC: A Theoretical Investigation.

Inorg Chem 2021 Apr 16. Epub 2021 Apr 16.

Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, Beijing Normal University, Beijing 100875, China.

TxtC is an unusual bifunctional cytochrome P450 that is able to perform sequential aliphatic and aromatic hydroxylation of the diketopiperazine substrate thaxtomin D in two distinct sites to produce thaxtomin A. Though the X-ray structure of TxtC complexed with thaxtomin D revealed a binding mode for its aromatic hydroxylation, the preferential hydroxylation site is aliphatic C. It is thus intriguing to unravel how TxtC accomplishes such two-step catalytic hydroxylation on distinct aliphatic and aromatic carbons and why the aliphatic site is preferred in the hydroxylation step. Read More

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Ink Engineering for Blade Coating FA-Dominated Perovskites in Ambient Air for Efficient Solar Cells and Modules.

ACS Appl Mater Interfaces 2021 Apr 16. Epub 2021 Apr 16.

Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Foshan 528216, Guangdong, P. R. China.

To accelerate the commercial application of organic-inorganic hybrid perovskite solar cells (PSCs), it is necessary to develop simple and low-cost methods to prepare pinhole-free large-area perovskite films with high quality. A one-step blade coating method is regarded as a scalable technique. It is demonstrated that with the addition of ,'-dimethylpropyleneurea (DMPU) in an FA-dominated perovskite precursor, a large-area high-quality perovskite film can be obtained by blade coating, achieving improved photovoltaic performance, thermal stability, and storage stability. Read More

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Simultaneous Small/Medium Umbilical Hernia Repair With Laparoscopic Sleeve Gastrectomy (LSG): Results of a Retrospective Case-matched Study.

Surg Laparosc Endosc Percutan Tech 2021 Feb 2. Epub 2021 Feb 2.

Advanced Biomedical Sciences Department, Naples "Federico II" University, AOU "Federico II", Naples, Italy.

Purpose: Periumbilical hernias are a common finding in morbidly obese patients undergoing bariatric surgery; however, the timing of repair is still debated. The aim of this paper is to compare the outcomes of simultaneous versus delayed mesh repair of umbilical hernia in patients undergoing laparoscopic sleeve gastrectomy (LSG).

Methods: We retrospectively compared 2 groups of morbidly obese patients with small/medium periumbilical hernia (up to 4 cm) in a case-matched study: the first group underwent LSG with simultaneous periumbilical hernia repair; in the second, hernioplasty was performed after weight loss induced by LSG. Read More

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February 2021

Study of health information needs among adolescents in Croatia shows distinct gender differences in information seeking behaviour.

Health Info Libr J 2021 Apr 16. Epub 2021 Apr 16.

Department of Information Sciences, Faculty of Humanities and Social Sciences, University of Josip Juraj Strossmayer in Osijek, Osijek, Croatia.

Background: Understanding the health information needs of adolescents is the first step towards providing them with relevant information to aid them in their decision making regarding health issues.

Objective: The goal of this study is to assess adolescents' needs, perceptions and sources of health information.

Methods: Four hundred sixty-nine high school students in Osijek, Croatia, participated in this study by answering a questionnaire. Read More

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Zinc(II)-Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process.

Macromol Biosci 2021 Apr 16:e2100048. Epub 2021 Apr 16.

Key Laboratory, of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Zinc ion complexes of dipicolylamine analogs, due to the strong synergistic effect between the Zn complex of containing polypyridine derivatives and polycations in each key step of pDNA transport, have been used as the third component to mediate polyethyleneimine with molecular weight 1.8 kDa (PEI1.8k)/DNA gene delivery system. Read More

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Spreader-CDR system for efficient, reproducible and frugal western blot.

Electrophoresis 2021 Apr 16. Epub 2021 Apr 16.

Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.

Efficient antibody incubation is a vital step for successful western blot. During the incubation, a thin antibody-depleted layer is created around the blotting membrane which limits antibody binding. Although the conventional batch shaking method is ineffective against it, this layer can be easily disrupted by cyclic draining and replenishing (CDR) of the antibody solution during membrane incubation. Read More

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Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect.

Eur Child Adolesc Psychiatry 2021 Apr 16. Epub 2021 Apr 16.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.

Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14. Read More

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