Search Our Scientific Publications & Authors

Open Heart 2022 May;9(1)

Department of Cardiology, University Hospital Limerick, Dooradoyle, Ireland.

Background: The clinical significance of peak troponin levels following ST-elevation myocardial infarction (STEMI) has not been definitively established. The purpose of this study was to examine the relationship between peak high-sensitivity cardiac troponin T (hs-cTnT) and all-cause mortality at 30 days and 1 year, and left ventricular ejection fraction (LVEF) in STEMI.

Methods: A single-centre retrospective observational study was conducted of all patients with STEMI between January 2015 and December 2017. Read More

J Artif Organs 2022 May 23. Epub 2022 May 23.

Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine, 1801 N. Senate Boulevard Suite 2000, Indianapolis, IN, 46202, USA.

Despite left ventricular assist device (LVAD) therapy becoming established for end-stage heart failure (HF), complications remain. Thromboembolic complications are rare with the newest iteration of LVADs. We managed a case of a continuous-flow LVAD-related thromboembolic event that presented as an acute myocardial infarction. Read More

Front Med (Lausanne) 2022 4;9:882341. Epub 2022 May 4.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: Infections are not common but important in patients with acute myocardial infarction, and are associated with worse outcomes. Infection was proved to be associated with the use of proton pump inhibitor (PPI) in several cohorts. It remains unclear whether PPI usage affects infection in patients with acute myocardial infarction. Read More

Circ Rep 2022 May 15;4(5):187-193. Epub 2022 Apr 15.

Faculty of Health Science, Osaka Aoyama University Osaka Japan.

To achieve early reperfusion therapy for ST-elevation myocardial infarction (STEMI), proper and prompt patient transportation and activation of the catheterization laboratory are required. We investigated the efficacy of prehospital 12-lead electrocardiogram (ECG) acquisition and destination hospital notification in patients with STEMI. This is a systematic review of observational studies. Read More

Ann Med Surg (Lond) 2022 Jun 10;78:103730. Epub 2022 May 10.

Division of Pharmacology and Therapy, Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine Universitas Airlangga, Jl. Mayjend Prof. Dr. Moestopo No 47, Surabaya, East Java, 60132, Indonesia.

Introduction: and importance: Protein C and S deficiency are some of the coagulation cascade disorders which may also contributes not only to venous thromboembolism (VTE), but also rarely to arterial thrombosis. Here we present a report of 3 severe coronary artery disease (CAD) cases ranging from very young to elderly patients with concomitant inherited thrombophilia.

Case Presentation: The first case was a chronic coronary syndrome from a very young male patient with history of VTE without any other risk factor of CAD. Read More

Clin Case Rep 2022 May 18;10(5):e05872. Epub 2022 May 18.

Cardiology Ward Shiraz University of Medical Sciences Shiraz Iran.

The coronavirus disease 2019 (COVID-19) pandemic originated from Wuhan, China, in late 2019. In addition to the respiratory system, COVID-19 also affects other organ systems. The disease can lead to cardiovascular complications such as myocarditis, acute myocardial infarction, acute heart failure, and venous thromboembolism; patients with COVID-19 experience more thrombotic events than non-COVID-19 patients. Read More

Am J Cardiol 2022 May 19. Epub 2022 May 19.

Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, Florida; Herbert Wertheim College of Medicine, Florida International University, Miami, Florida. Electronic address:

Cardiovascular diseases and frailty are common conditions of aging populations and often coexist. In this study, we examined the in-hospital management, outcomes, and resource use of frail patients hospitalized for ST-segment elevation myocardial infarction (STEMI). This was a retrospective analysis of the 2005-2014 data from the Nationwide Inpatient Sample. Read More

Circ J 2022 May 21. Epub 2022 May 21.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.

Background: The aim of this study was to create a risk scoring model to differentiate obstructive coronary artery (CA) from CA spasm in the etioology of acute coronary syndrome (ACS).Methods and Results: We included 753 consecutive patients with ACS without persistent ST-segment elevation (p-STE). The exclusion criteria were: (1) out-of-hospital cardiac arrest; (2) cardiogenic shock; (3) hemodialysis; (4) atrial fibrillation/flutter; (5) severe valvular disease; (6) no coronary angiography; (7) non-obstructive coronary artery without "definite" vasospastic angina definition; and/or (8) missing data. Read More

Nutr Metab Cardiovasc Dis 2022 Apr 4. Epub 2022 Apr 4.

Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

Elevated serum uric acid (SUA) levels have been associated with several cardiovascular risk factors and the progression of coronary artery disease. In the setting of acute myocardial infarction, increasing evidence suggests that high SUA levels could be related to adverse outcomes. Interestingly elevated SUA levels have been linked to endothelial dysfunction, inflammation and oxidative stress. Read More

Am J Cardiol 2022 May 18. Epub 2022 May 18.

Harrington Heart and Vascular Institute, Case Western Reserve University, Cleveland, Ohio. Electronic address:

The optimal timing of postinfarction ventricular septal defect (PI-VSD) repair is subject to debate. Patients with ventricular septal defect (VSD) and ST-elevation myocardial infarction (STEMI) were queried using appropriate International Classification of Diseases, Ninth and Tenth Revision Clinical Modification codes from the National Inpatient Sample (2003 to 2018). VSD repair was identified using appropriate International Classification of Diseases, Ninth and Tenth Revision Procedure Coding System codes. Read More

Cardiovasc Diabetol 2022 May 20;21(1):80. Epub 2022 May 20.

Fuwai Hospital, Chinese Academy of Medical Sciences, 12 Langshan Rd, Shenzhen, 518000, China.

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to be predictive of cardiovascular outcomes in stable coronary artery disease with diabetes. We aimed to assess the relationship between PCSK9 and major adverse cardiovascular events (MACEs) in ST-segment elevation myocardial infarction (STEMI) patients with or without diabetes, as well as the relationships between PCSK9 and metabolism, inflammation and platelet activation markers.

Methods: A total of 1027 patients with STEMI undergoing primary percutaneous coronary intervention (PCI) and without prior lipid-lowering therapy were consecutively enrolled and the baseline plasma PCSK9 levels were determined by ELISA. Read More

BMC Cardiovasc Disord 2022 May 20;22(1):233. Epub 2022 May 20.

Department of Radiology, Tongjiang People's Hospital, Tongjiang City, 156400, China.

Background: To evaluate the myocardial microcirculation perfusion of patients with acute ST-segment elevation myocardial infarction (STEMI) with a different index of microcirculatory resistance (IMR) after percutaneous coronary intervention (PCI) by myocardial contrast echocardiography (MCE) and analyse the value of MCE in predicting myocardial perfusion after PCI.

Methods: Fifty-six patients with acute STEMI who underwent an emergency PCI were selected from October 2018 to October 2019 in our hospital. According to the IMR values measured during PCI treatment, the patients were divided into three groups. Read More

Air Med J 2022 May-Jun;41(3):326-327. Epub 2022 Mar 9.

Department of Emergency Medicine, University of Cincinnati College of Medicine; UC Health Air Care & Mobile Care, Cincinnati, Ohio.

Objective: The aim of this study was to evaluate the feasibility of statin administration by a critical care transport medicine (CCTM) team during rotor wing transport for ST-elevation myocardial infarction patients to a percutaneous intervention-capable center.

Methods: We conducted a retrospective study at a single CCTM program after an intervention focused on statin administration for ST-elevation myocardial infarction that included a formulary change and a single brief educational presentation to flight physicians. A comparison group of flight nurse practitioners underwent training after the study period and were used as a control. Read More

Diabetes Care 2022 May 20. Epub 2022 May 20.

During the conduction of a recent analysis, an error in the coding of the rule-in path of the ESC 0/3-h algorithm in the main database was discovered. This coding error affected the diagnostic measures for the positive predictive value and the specificity to detect acute myocardial infarction. In summary, the coding error resulted in an incorrect high relative increase of troponin comparing the baseline and 3-h value, while all other analyses were not affected. Read More

Eur Heart J Acute Cardiovasc Care 2022 May 20. Epub 2022 May 20.

Hospital Rudolfstiftung, Vienna, Austria.

Aims: To determine the current state of the use of reperfusion and adjunctive therapies and in-hospital outcomes in European Society of Cardiology (ESC) member and affiliated countries for patients with ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS).

Methods And Results: ESC EurObservational Research Programme prospective international cohort study of admissions with STEMI within 24 h of symptom onset (196 centres; 26 ESC member and 3 affiliated countries). Of 11 462 patients enrolled, 448 (3. Read More

Sensors (Basel) 2022 May 7;22(9). Epub 2022 May 7.

Faculty of Medicine, University of Medicine and Pharmacy "Grigore T Popa", 700115 Iasi, Romania.

Background: Heart rate variability (HRV) could have independent and critical prognostic values in patients admitted for ST segment elevation myocardial infarction (STEMI). There are limited data in the literature regarding HRV assessment in STEMI setting. Thus, we aim to investigate the potential correlations between HRV and adverse outcomes in a contemporary cohort of patients presenting with STEMI undergoing primary percutaneous coronary intervention (PCI). Read More

Zhonghua Xin Xue Guan Bing Za Zhi 2022 May;50(5):443-449

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To assess the prevalence, pattern and outcome of multimorbidity in elderly patients with acute coronary syndrome (ACS). Secondary analysis was performed based on the data from the BleeMACS registry, which was conducted between 2003 and 2014. We stratified elderly patients (≥65 years) according to their multimorbidity. Read More

Wilderness Environ Med 2022 May 16. Epub 2022 May 16.

Department of Emergency Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Mushroom poisoning and subsequently the number of patients visiting emergency rooms are increasing, as well as the proportion of fatal mushroom poisonings. Myocytic mushroom poisoning is one of the new clinical classifications. This report documents the course of a family with Russula subnigricans poisoning complicated by severe rhabdomyolysis, including a case that was misdiagnosed as myocardial infarction. Read More

JACC Cardiovasc Interv 2022 May;15(10):1074-1084

King's College Hospital NHS Foundation Trust, London, United Kingdom; School of Cardiovascular Medicine & Sciences, British Heart Foundation Centre of Excellence, King's College London, London, United Kingdom.

Objectives: The purpose of this study was to evaluate the impact of performing immediate coronary angiography (CAG) after out-of-hospital cardiac arrest (OHCA) with stratification of predicted neurologic injury and cardiogenic shock on arrival to a center.

Background: The role of immediate CAG for patients with OHCA is unclear, which may in part be explained by the majority of patients dying of hypoxic brain injury.

Methods: Between May 2012 and July 2020, patients from 5 European centers were included in the EUCAR (European Cardiac Arrest Registry). Read More

Glob Heart 2022 30;17(1):24. Epub 2022 Mar 30.

National Institute of Cardiovascular Diseases (NICVD), Karachi, PK.

Background: Stent thrombosis (ST) remains the most feared complication of percutaneous coronary intervention (PCI). Therefore, this study aimed to determine acute and sub-acute ST incidence, predictors, and outcomes after primary PCI.

Methods: This prospective observational study included patients who had undergone primary PCI at a tertiary care cardiac center. Read More

Glob Heart 2022 29;17(1):23. Epub 2022 Mar 29.

Cardiovascular department, Tanta University, EG.

Background: Stress hyperglycemia is a common finding during acute myocardial infarction and associated with poor prognosis. To reduce the occurrence of no-reflow, prognostic factors must be identified before primary percutaneous coronary intervention (PPCI). Our objective was to investigate the impact of stress hyperglycemia in non-diabetic and diabetic patients on no-reflow phenomenon after PPCI. Read More

World J Cardiol 2022 Apr;14(4):260-265

Department of Cardiology, Military Hospital Avicenne, University Cadi Ayyad, Marrakech 40000, Morocco.

Background: Mechanical complications are a rare presentation in chronic coronary syndromes, which have significantly decreased in the primary coronary intervention era. Incomplete rupture may occur, resulting in pseudoaneurysms (PANs). Early reperfusion decreases the risk of this complication. Read More

Cardiorenal Med 2022 May 17. Epub 2022 May 17.

Objective: The systemic immune-inflammation index (SII), derived from counts of neutrophil, platelet and lymphocyte, have been developed to predict clinical outcomes in several cancers and cardiovascular diseases. The aim of this study was to evaluate the utility of SII to predict contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).

Methods: A total of 632 patients with STEMI who underwent primary PCI were retrospectively included. Read More

J Cardiovasc Pharmacol 2022 May 13. Epub 2022 May 13.

Pharmacy Department, Buffalo General Medical Center 100 High Street, Buffalo, New York 14203.

Abstract: Regardless of early invasive or ischemia guided approaches to non-ST segment elevation myocardial infarction (NSTEMI) management, P2Y12 inhibitors remain the backbone in therapy. The ideal timing of administration remains unclear. The purpose of this study was to determine the safety and effectiveness of early versus late administration of P2Y12 inhibitors in patients presenting with an NSTEMI who go to the catheterization laboratory beyond 24 hours from presentation. Read More

Circ Cardiovasc Interv 2022 May 17;15(5):e011336. Epub 2022 May 17.

Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Canada (M.A., M.K., C.K., V.D.).

Background: It is unclear whether more effective forms of thrombus removal than current aspiration catheters would lead to improved outcomes. We sought to evaluate the prognostic role of residual thrombus burden (rTB), after manual thrombectomy, in patients undergoing primary percutaneous coronary intervention with routine manual thrombectomy in the TOTAL trial (Thrombectomy Versus PCI Alone).

Methods: This is a single-arm analysis of patients from the TOTAL trial who underwent routine manual aspiration thrombectomy. Read More

Cardiol J 2022 May 17. Epub 2022 May 17.

Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: It remains controversial whether contrast-associated acute kidney injury (CA-AKI) is associated with long-term major adverse kidney events (MAKE) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).

Methods: By the Acute Kidney Injury Network (AKIN) criteria, CA-AKI was defined as an increase in serum creatinine ≥ 0.3 mg/dL or 50% from baseline within 48 h after PCI; or an increase in serum creatinine ≥ 0. Read More

Sci Rep 2022 May 16;12(1):8030. Epub 2022 May 16.

Department of Laboratory Medicine, Sun Yat-sen University Affiliated Zhongshan Hospital, Zhongshan, 528403, Guangdong Province, China.

Atherosclerosis is the primary origin of acute coronary syndrome (ACS) diseases. Previous studies have shown that lncRNA plaque-enriched long noncoding RNA in atherosclerotic macrophage regulation (lncRNA PELATON) is a specific lncRNA in macrophage nuclei. This study aims to identify serum lncRNA PELATON as a biomarker for assessing the incidence and prognosis of ACS. Read More

Int J Cardiol 2022 May 13. Epub 2022 May 13.

Department of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Background: Atrial fibrillation (AF) is the most common arrythmia following ST-segment elevation myocardial infarction (STEMI) and can lead to stroke and other heart-related diseases. This study aimed to determine the prognostic value of left atrial (LA) strain, obtained by speckle tracking echocardiography (STE), in predicting incident AF outcomes following STEMI treated with primary percutaneous coronary intervention (pPCI).

Methods And Results: This prospective study comprised of 392 STEMI patients treated with pPCI. Read More

Int J Cardiol 2022 May 13. Epub 2022 May 13.

Department of Cardiology, GB, Pant Institute of Postgraduate Medical Education and Research, New Delhi, India. Electronic address:

Background: Risk prediction following ST-Elevation Myocardial Infarction (STEMI) in resource limited countries is critical to identify patients at an increased risk of mortality who might benefit from intensive management.

Methods: North India ST-Elevation Myocardial Infarction (NORIN-STEMI) is an ongoing registry that has prospectively enrolled 3,635 STEMI patients. Of these, 3191 patients with first STEMI were included. Read More

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):288-294

National Institute of Cardiovascular Diseases, Karachi, Pakistan.

Background: Aim of this study was to perform quantitative evaluation of high thrombus burden (Grade ≥4) as an independent predictor of slow/no reflow phenomenon during primary percutaneous coronary interventions (PCI) of patients with ST-segment elevation myocardial infarction (STEMI).

Methods: In this analytical cross-sectional study we included consecutive patients who have undergone primary PCI for STEMI at a tertiary care cardiac center of the Pakistan. High thrombus burden was defined as angiographic thrombus grade ≥4. Read More