414 results match your criteria stem barks

Dilignans with a Chromanol Motif Discovered by Molecular Networking from the Stem Barks of and Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activity.

Biomolecules 2021 Mar 19;11(3). Epub 2021 Mar 19.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.

Natural products have been fundamental materials in drug discovery. Traditional strategies for observing natural products with novel structure and/or biological activity are challenging due to large cost and time consumption. Implementation of the MS/MS-based molecular networking strategy with the in silico annotation tool is expected to expedite the dereplication of secondary metabolites. Read More

View Article and Full-Text PDF

Identification of Bioactive Natural Product from the Stems and Stem Barks of : Benzyl Salicylate Shows Potential Anti-Inflammatory Activity in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

Pharmaceutics 2021 Mar 25;13(4). Epub 2021 Mar 25.

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.

(Cornaceae), known as Walter's dogwood, has been used to treat dermatologic inflammation and diarrheal disease in traditional oriental medicine. As part of an ongoing research project to discover natural products with biological activities, the anti-inflammatory potential of compounds from in lipopolysaccharide (LPS)-stimulated mouse RAW 264.7 macrophages were explored. Read More

View Article and Full-Text PDF

The effect of S.reticulata, S.cumini, A.heterophyllus, and C.auriculata on controlling the rapid formation of advanced glycation end-products.

J Ayurveda Integr Med 2021 Mar 14. Epub 2021 Mar 14.

Herbal Technology Section (HTS), Industrial Technology Institute (ITI), 363, Bauddhaloka Mawatha, Colombo, 07, Sri Lanka.

Background: The excessive formation of Advanced Glycation End-products (AGEs) by non-enzymatic glycation mediates many health complications in the human body and the formation of AGEs largely accelerated under the hyperglycaemic condition.

Objective: The prospect of the study to assess the strength of inhibiting the rapid AGE formations in four Ayurvedic medicinal plants, namely; Salacia reticulata (stems), Syzygium cumini (barks), Artocarpus heterophyllus (mature leaves) and, Cassia auriculata (flowers).

Materials And Methods: Herbal decoctions of four medicinal plant materials were prepared by simmering with hot water as prescribed by the Ayurvedic medicine. Read More

View Article and Full-Text PDF

Phytochemical characterization, and antioxidant and antibacterial activities of the hydroethanolic extract of Anadenanthera peregrina stem bark.

Braz J Biol 2021 5;82:e234476. Epub 2021 Mar 5.

Pontifícia Universidade Católica de Goiás - PUCGO, Programa de Pós-graduação em Ciências Ambientas e Saúde, Goiânia, GO, Brasil.

The Brazilian Cerrado biome consists of a great variety of endemic species with several bioactive compounds, and Anadenanthera peregrina (L.) Speg is a promising species. In this study, we aimed to perform phytochemical characterization and evaluate the antioxidant and antibacterial activities against Staphylococcus aureus and Escherichia coli of the hydroethanolic extract of A. Read More

View Article and Full-Text PDF

Response of photosynthetic characteristics and non-structural carbohydrate accumulation of seedlings to drought stress.

Ying Yong Sheng Tai Xue Bao 2021 Feb;32(2):513-520

Key Laboratory of Forest Ecology and Management, Institute of Applied Ecology, Chinese Academy of Sciences, Shen-yang 110016, China.

We explored the effects of drought stress on photosynthetic characteristics and non-structural carbohydrate (NSC) accumulation of the timberline tree species in Changbai Mountain with a drought control experiment. The results showed that drought significantly reduced the net photosynthetic rate and stomatal conductance, but increased water use efficiency (WUE) of seedlings. Drought dramatically improved the contents of soluble sugar and total NSC in leaves, barks, stems, and roots of seedlings, but significantly reduced their starch content. Read More

View Article and Full-Text PDF
February 2021

Antimicrobial and cytotoxic activities of indole alkaloids and other constituents from the stem barks of Sond (Apocynaceae).

Nat Prod Res 2021 Mar 1:1-9. Epub 2021 Mar 1.

Department of Chemie, Universität of Fribourg, Fribourg, Switzerland.

Twenty indole alkaloids, among which two undescribed ones named rauvolfianoids A () and B (), were isolated from the stem barks of Sond along with eight other compounds from other biosynthetic pathways. The structures were elucidated by analysis of spectroscopic data, including 1 D and 2 D NMR; absolute configurations of and were determined by CD exciton chirality method. Compounds and were evaluated for antimicrobial and anticancer activities against three bacterial strains (, and ) and CRC-related opportunistic pathogens. Read More

View Article and Full-Text PDF

Antiplasmodial Activity and Phytochemical Constituents of Selected Antimalarial Plants Used by Native People in West Timor Indonesia.

Turk J Pharm Sci 2021 Feb;18(1):80-90

Airlangga University Faculty of Pharmacy, Department of Pharmacognosy and Phytochemistry, Surabaya, Indonesia.

Objectives: To document traditional antimalarial plants used by Tetun ethnic people in West Timor Indonesia and evaluate the antiplasmodial activity and phytochemicals of several plants that are widely used as oral medicine.

Materials And Methods: A field study to document antimalarial plants followed by laboratory works to test antiplasmodial activity and identify the phytochemical constituents of some selected plants extract were applied. The inhibitory potency of ethanolic extracts of wood, roots of , , and , whole plant of and , stem barks of , , and , and leaves of on the 3D7 strain were tested. Read More

View Article and Full-Text PDF
February 2021

A new isoquinoline and ceramide from the stem barks of (Pax) Prain (Euphorbiaceae) with antiproteinase and cytotoxic activities.

Nat Prod Res 2021 Feb 24:1-9. Epub 2021 Feb 24.

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.

Two new compounds, an isoquinoline () and caloneuramide (), a ceramide were isolated from the stem bark of together with seven known compounds namely aurantiamide acetate (), acetylaleuritolic acid (), 3-hydroxylaleuritolic acid 2-p-hydroxybenzoate (), mixture of stigmasterol () and -sitosterol (), mixture of 7-oxo-stigmasterol () and 7-oxo--sitosterol (). Their structures were determined based on data from literature and spectroscopic methods. Derivatization reactions on the isoquinoline led to two new compounds, the methylated () and acetylated () derivatives. Read More

View Article and Full-Text PDF
February 2021

Structural characterization of anticoagulant and antithrombotic polysaccharides isolated from Caesalpinia ferrea stem barks.

Int J Biol Macromol 2021 Apr 30;175:147-155. Epub 2021 Jan 30.

Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, 60740-000 Fortaleza, CE, Brazil; Faculdade de Educação, Ciências e Letras do Sertão Central, Universidade Estadual do Ceará, Rua José de Queiroz 2554, 63900-000 Quixadá, CE, Brazil. Electronic address:

This study aimed to isolate, characterize chemical-structurally and evaluate the effects of polysaccharides from Caesalpinia (Libidibia) ferrea stem barks in the haemostatic system. The deproteinated-polysaccharide extract (PE-Cf) after being fractionated by ion exchange chromatography-DEAE-cellulose resulted in three fractions (FI, FII, FIII) containing total carbohydrates (14.3-38%), including uronic acid (5-16%), and polyphenols (0. Read More

View Article and Full-Text PDF

Bioactivity assays, chemical characterization, ADMET predictions and network analysis of Khaya senegalensis A. Juss (Meliaceae) extracts.

Food Res Int 2021 Jan 8;139:109970. Epub 2020 Dec 8.

Department of Analytical Chemistry, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain; Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda. Del Conocimiento s/n., Edificio BioRegion, 18016 Granada, Spain.

Khaya senegalensis A. Juss (Meliaceae) is a popular medicinal plant, widely used in the management of various ailments in the African traditional medicine. This study attempts to investigate into the different extraction methods (homogenizer-assisted extraction (HAE), maceration (MAC), infusion and Soxhlet (SE) extraction) on the pharmacological properties and chemical profiles of K. Read More

View Article and Full-Text PDF
January 2021

The First Report of Parasitizing Pomegranate () in Georgia.

Plant Dis 2020 Dec 29. Epub 2020 Dec 29.

Jagiellonian University, 37799, Institute of Botany, Krakow, Małopolska, Poland;

Orobanche laxissima Uhlich & Rätzel (Orobanchaceae) is a polyphagous root parasitic plant distributed in the Caucasus Mountains and Transcaucasia; especially Russia, Georgia, Armenia, Azerbaijan, N.E. Turkey (Piwowarczyk et al. Read More

View Article and Full-Text PDF
December 2020

Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique.

Heliyon 2020 Dec 18;6(12):e05746. Epub 2020 Dec 18.

CFE, Centre for Functional Ecology - Science for People & the Planet, Department of Life Sciences, University of Coimbra, Portugal.

Introduction: Malaria is an important parasitic disease that affects mostly the African continent. Traditional medicine is very important in Mozambique and traditional healers play a key role in the primary health care services, particularly in rural areas. We aim to report the results of an ethnobotanical survey undertaken in Mogovolas district, northern region of Mozambique. Read More

View Article and Full-Text PDF
December 2020

Antibacterial Activities of against Selected Animal Pathogenic Bacterial Strains.

Getachew Mulatu

Adv Pharmacol Pharm Sci 2020 17;2020:8840468. Epub 2020 Nov 17.

Department Veterinary Laboratory Technology, College of Agriculture and Veterinary Sciences, Ambo University, P.O. Box 19, Ambo, Ethiopia.

The study aimed to determine the phytochemicals and to assess the antibacterial activities of crude extracts of different parts of against , , , O157 H:7, , and The fresh and healthy leaves, barks, stems, and roots of the plant parts were collected, herbarium, dried, and grounded, and bioactive compounds were extracted by ethanol (99%) and water. Mass of crude extracts was determined by using the Whatman No. 1 filter paper and rotary evaporator. Read More

View Article and Full-Text PDF
November 2020

Sesquiterpene Polygodial from (Winteraceae) Down-Regulates Implant-Induced Inflammation and Fibrogenesis in Mice.

J Nat Prod 2020 12 24;83(12):3698-3705. Epub 2020 Nov 24.

Departamento de Ciências Fisiológicas, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia (UFU), Uberlândia, MG 38408-100, Brazil.

(Winteraceae) has been investigated in traditional medicine for its anti-inflammatory properties to treat gastric ulcers and allergic and respiratory system diseases as well as for cancer treatment. In this work, we investigate the ability of the sesquiterpene polygodial, isolated from stem barks, to modulate the chronic inflammatory response induced by polyester-polyurethane sponge implants in C57BL/6J mice. Daily treatment with polygodial inhibited the macrophage content in the implants as determined by the activity of the -acetyl-β-d-glucosaminidase enzyme as well as decreased the levels of CXCL1/KC and CCL2/JE/MCP-1 pro-inflammatory chemokines and the presence of mast cells along the formed fibrovascular tissue. Read More

View Article and Full-Text PDF
December 2020

Polysaccaride-rich extract of Caesalpina ferrea stem barks attenuates mice acute inflammation induced by zymosan: Oxidative stress modulation.

J Ethnopharmacol 2021 Mar 27;267:113501. Epub 2020 Oct 27.

Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Ethnopharmacological Relevance: Stem barks of Caesalpinia ferrea Mart. Ex Tul. (Caesalpiniaceae), also known as pau-ferro jucá or jucaína, are popularly used to treat contusions, diabetes, rheumatism and other inflammatory conditions in the form of tea, lick or decoction. Read More

View Article and Full-Text PDF

In vitro Effects of Ellagitannins on Adult Worms of .

Res Rep Trop Med 2020 5;11:73-80. Epub 2020 Oct 5.

Department of Microbiology and Biotechnology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.

Schistosomiasis ranks second behind malaria in terms of overall morbidity and mortality. We evaluated the lethal effect of ellagitannins, extracted from the fruit rind, placenta and barks of the root and stem, on adult worms of . All four ellagitannins were lethal to adult worms. Read More

View Article and Full-Text PDF
October 2020

Cytotoxic activity of phytochemicals from L. and (Planch. & Triana) Pipoly against breast cancer cells.

Nat Prod Res 2020 Oct 23:1-6. Epub 2020 Oct 23.

School of Biosciences, Taylor's University, Lakeside Campus, Subang Jaya, Selangor, Malaysia.

Four xanthones, α-mangostin (), β-mangostin (), mangostenol (), mangaxanthone B (), three benzophenones, mangaphenone (), benthamianone (), congestiflorone () and one sterol, stigmasterol () were isolated from the stem barks of L. and (Planch. & Triana) Pipoly. Read More

View Article and Full-Text PDF
October 2020

Traditional Herbal Medicines Against CNS Disorders from Bangladesh.

Nat Prod Bioprospect 2020 Dec 14;10(6):377-410. Epub 2020 Oct 14.

Pharmazeutisches Institut, Abteilung Pharmazeutische Biologie, Christian-Albrechts-Universität zu Kiel, Gutenbergstraße 76, 24118, Kiel, Germany.

The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. Read More

View Article and Full-Text PDF
December 2020

Richness of non-timber forest products in Himalayan communities-diversity, distribution, use pattern and conservation status.

J Ethnobiol Ethnomed 2020 Sep 23;16(1):56. Epub 2020 Sep 23.

G.B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Almora, Uttarakhand, 263643, India.

Background: Non-timber forest products (NTFPs) are important resources for sustenance of rural communities; a systematic planning to manage diverse NTFPs may immensely contribute to food and livelihood security of forest dwellers. Considering this, the present study has been undertaken in the Himachal Pradesh state in north India. It aims to provide detailed information on diversity, distribution, use pattern, and conservation status of selected NTFPs that have market potential, and suggest a possible way for their sustained management and possible role in livelihood upgradation of dependent communities. Read More

View Article and Full-Text PDF
September 2020

Metals in Traditional Chinese medicinal materials (TCMM): A systematic review.

Ecotoxicol Environ Saf 2021 Jan 15;207:111311. Epub 2020 Sep 15.

Department of Environmental Science and Engineering, Sichuan University, Chengdu, 610065, China. Electronic address:

Traditional Chinese medicine has become an important pillar of "Healthy China" and the national medical system in recent years. Due to the wide range of raw materials in traditional Chinese medicinal materials (TCMM), the issue of metals has attracted more and more attention. In this paper, a comprehensive review of public reports on metals in TCMM in recent decades was conducted. Read More

View Article and Full-Text PDF
January 2021

De novo assembly of transcriptome and genome-wide identification reveal GA stress-responsive WRKY transcription factors involved in fiber formation in jute (Corchorus capsularis).

BMC Plant Biol 2020 Sep 1;20(1):403. Epub 2020 Sep 1.

Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops / Fujian Key Laboratory for Crop Breeding by Design / College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

Background: WRKY is a group of transcription factors (TFs) that play a vital role in plant growth, development, and stress tolerance. To date, none of jute WRKY (CcWRKY) genes have been identified, even if jute (Corchorus capsularis) is one of the most important natural fiber crops in the world. Little information about the WRKY genes in jute is far from sufficient to understand the molecular mechanism of bast fiber biosynthesis. Read More

View Article and Full-Text PDF
September 2020

Bioguided chemical study of Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle.

Nat Prod Res 2020 Jul 30:1-10. Epub 2020 Jul 30.

Chemistry Department, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany.

Stem barks of are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CHCl (1/1, v/v) stem barks extract led to the isolation of fourteen compounds , identified based on spectroscopic data. Dalzienoside ( is reported here for the first time. Read More

View Article and Full-Text PDF

In vitro antioxidant and antityrosinase activities of Manilkara kauki.

Acta Pharm 2021 Mar;71(1):153-162

Institute of Biotechnology and Genetic Engineering, Chulalongkorn University Bangkok 10330, Thailand.

Manilkara kauki L. Dubard is a tropical plant in the genus Manilkara of family Sapotaceae. This study investigated the total phenolic and flavonoid contents, and antioxidant and antityrosinase activities in different parts of M. Read More

View Article and Full-Text PDF

Decumbic anhydride from the stem barks of (Anacardiaceae).

Z Naturforsch C J Biosci 2021 Jan 16;76(1-2):49-53. Epub 2020 Jul 16.

Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.

From an EtOAc-soluble fraction of the stem barks of (Anacardiaceae), decumbic anhydride () and four known compounds - were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of C NMR chemical shifts was carried out to clarify the structure of . Read More

View Article and Full-Text PDF
January 2021

Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities.

Chem Pharm Bull (Tokyo) 2020 ;68(7):671-674

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University.

Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC values of 36.7 and 33. Read More

View Article and Full-Text PDF
February 2021

A New Scoring System for Prediction of Underlying Vascular Pathology in Patients with Intracerebral Hemorrhage: The Modified Secondary Intracerebral Hemorrhage Score.

World Neurosurg 2020 10 25;142:e126-e132. Epub 2020 Jun 25.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Neurosurgery, Stony Brook University, Stony Brook, New York, USA.

Background: Secondary intracerebral hemorrhage (SICH) score is used to predict risk of intracranial hemorrhage (ICH) associated vascular lesions. However, it has low clinical utility in identifying patients without need for neurovascular imaging. This study aims to develop a modified scoring system to capture patients with low risk of underlying vascular pathology, thereby decreasing need for vascular imaging and its associated morbidity. Read More

View Article and Full-Text PDF
October 2020

Apoprunellelactone (APL), an antiprotozoal lactone from the stem barks of Hutch. & Dalziel (Annonaceae).

Nat Prod Res 2020 Jun 19:1-8. Epub 2020 Jun 19.

Chimie des Substances Naturelles, CNRS UMR 8076 BioCIS, Faculté de Pharmacie, Univ. Paris-Sud, Châtenay-Malabry Cedex, France.

Bioassay guided fractionation of the stem barks of led to the isolation of a new lactone, apoprunellelactone (APL, ), and two known compounds, 5-[1-hydroxyhexyl]-2H-furan-2-one () and oleic acid (). Their structures were elucidated by spectral analysis including MS, UV, IR, 1D and 2D-NMR spectroscopy. Evaluated for its antiprotozoal activities, APL () was found to be the most active on and promastigotes with EC values of 16. Read More

View Article and Full-Text PDF

Chemical Diversity and Biological Activities of Essential Oils from , and Species (Lauraceae) with Occurrence in Brazilian Biomes.

Biomolecules 2020 06 5;10(6). Epub 2020 Jun 5.

Programa de Pós-Graduação em Química, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém 66075-900, Brazil.

Lauraceae species are known as excellent essential oil (EO) producers, and their taxa are distributed throughout the territory of Brazil. This study presents a systematic review of chemical composition, seasonal studies, occurrence of chemical profiles, and biological activities to EOs of species of , , and genera collected in different Brazilian biomes. Based on our survey, 39 species were studied, with a total of 86 oils extracted from seeds, leaves, stem barks, and twigs. Read More

View Article and Full-Text PDF

Highly potent cholinesterase inhibition of geranylated xanthones from Garcinia fusca and molecular docking studies.

Fitoterapia 2020 Oct 27;146:104637. Epub 2020 May 27.

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand. Electronic address:

Three new oxygenated xanthones, fuscaxanthones L-N (1-3), and 14 known xanthones 4-17, together with the other known metabolites 18-20 were isolated from the stem barks of Garcinia fusca Pierre. Their chemical structures were determined based on NMR and MS spectroscopic data analysis, as well as single X-ray crystallography. The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC 0. Read More

View Article and Full-Text PDF
October 2020

Comparative Assessment of the Methanol Extracts of the Leaf, Stem, and Root Barks of on Lung and Breast Cancer Cell Lines.

Turk J Pharm Sci 2019 Dec 11;16(4):375-379. Epub 2019 Nov 11.

University of Karachi, International Centre for Chemical and Biological Sciences, Dr. Panjwani Center for Molecular Medicine and Drug Research, Karachi, Pakistan.

Objectives: Mill. I.M. Read More

View Article and Full-Text PDF
December 2019