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Intermediate vs Standard-dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to ICU: Ninety-day Results from the INSPIRATION Trial.

Thromb Haemost 2021 Apr 17. Epub 2021 Apr 17.

Rajaie Cardiovascular Medical and Research Center, Tehran, Iran (the Islamic Republic of).

Background: Thrombotic complications are considered among the main extrapulmonary manifestations of COVID-19. The optimal type and duration of prophylactic antithrombotic therapy in these patients remain unknown.

Methods: This manuscript reports the final (90-day) results of the Intermediate versus Standard-dose Prophylactic anticoagulation In cRitically-ill pATIents with COVID-19: An opeN label randomized controlled trial (INSPIRATION) study. Read More

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Stunting, IQ, and final school attainment in the Cebu Longitudinal Health and Nutrition Survey birth cohort.

Econ Hum Biol 2021 Apr 7;42:100999. Epub 2021 Apr 7.

USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.

School attainment is an important aspect of human capital, and a key determinant of long-term health and well-being. Early life deprivation and poor nutritional status are well known predictors of school entry and progression. We examine the persistence of early life influences and subsequent socioeconomic disadvantage (SED) across the multiple school continuation decisions that lead to final school attainment. Read More

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Characteristics of clinically node negative breast cancer patients needing preoperative MRI.

Surg Oncol 2021 Mar 31;38:101552. Epub 2021 Mar 31.

Department of Oncology, Turku University Hospital, Finland; University of Turku, Turku, Finland; Finnish Nuclear and Radiation Safety, Helsinki, Finland.

Background: International guidelines do not recommend magnetic resonance imaging (MRI) for all breast cancer patients at primary diagnostics. This study aimed to understand which patient or tumor characteristics are associated with the use of MRI. The role of MRI among other preoperative imaging methods in clinically node negative breast cancer was studied. Read More

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Determinants of health-related quality of life among homeless individuals during the COVID-19 pandemic.

Public Health 2021 Mar 6;194:60-66. Epub 2021 Mar 6.

Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objective: To clarify which variables are associated with the health-related quality of life (HRQoL) among homeless individuals during the COVID-19 pandemic.

Study Design: Cross-sectional research.

Methods: Data were taken from the Hamburg survey of homeless individuals (n = 151). Read More

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Influence of sedimentary organic matter sources on the distribution characteristics and preservation status of organic carbon, nitrogen, phosphorus, and biogenic silica in the Daya Bay, northern South China Sea.

Sci Total Environ 2021 Apr 5;783:146899. Epub 2021 Apr 5.

Research Center for Coastal Environment Engineering Technology of Shandong Province, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

Surface sediment samples were collected from Daya Bay in October 2018, and analyzed for total organic carbon (OC), total nitrogen (TN) and their stable isotopes (δC and δN), total phosphorus (TP), biogenic silica (BSi), sediment textures and specific surface area (SSA). The primary objective was to evaluate the influence of mariculture/aquaculture on the distribution characteristics of organic matter (OM), and preservation status of OC, TN, TP, and BSi in sediments. The average δC and δN values, and OC/TN ratios were -21. Read More

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Serum untargeted metabolomics delineates the metabolic status in different subtypes of non-alcoholic fatty liver disease.

J Pharm Biomed Anal 2021 Apr 1;200:114058. Epub 2021 Apr 1.

National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China. Electronic address:

Aims: The aim of this study was to identify novel serum metabolites associated with non-alcoholic fatty liver disease (NAFLD), and to explore the metabolic discrepancies between Lean-NAFLD and Obese-NAFLD.

Methods: Serum samples from patients with NAFLD (n = 161) and healthy participants (n = 149) were collected, and metabolites were analyzed with UPLC-Q-TOF MS/MS. Subgroup analyses were performed to explore the metabolic differences among Lean-NAFLD, Obese-NAFLD and healthy controls RESULTS: A total of 24 differentially present metabolites were found between patients with NAFLD and healthy controls. Read More

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Physical activity status and quality of life in patients with epilepsy - Survey from level four epilepsy monitoring units.

Epilepsy Res 2021 Apr 9;173:106639. Epub 2021 Apr 9.

Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX, 75390, USA. Electronic address:

Purpose: People with epilepsy (PWE) tend to have sedentary lifestyles which may predispose them to a lower perceived quality of life (QOL). Moreover, the relationship between physical activity (PA) and QOL in populations of PWE with high disease burden has been under-studied. The goal of this study was to evaluate PA level and its impact on health-related QOL in PWE who were admitted to Level-4 epilepsy monitoring units (EMU). Read More

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Utilizing benthic foraminifera to explore the environmental condition of the Laizhou Bay (Bohai Sea, China).

Mar Pollut Bull 2021 Apr 14;167:112323. Epub 2021 Apr 14.

National Research Council, Institute of Geosciences and Earth Resources, Via Gradenigo, 6, 35131 Padova, Italy.

Through the analysis of benthic foraminifera in the soft bottom sediments of the Laizhou Bay - Yellow River Delta system, this study characterized the foraminiferal biotopes and explored the possibility of obtaining an index of ecological quality comparable with other estuarine and coastal environments of the world. Five foraminiferal biotopes have been identified and their distribution patterns highlight the ecological stress from the marine-fluvial water mixing and pollution. The foraminiferal species were analyzed as a function of organic carbon gradients, and the main species were assigned to four ecological groups based on their sensitivity/tolerance towards an increasing stress gradient. Read More

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Methane in wastewater treatment plants: status, characteristics, and bioconversion feasibility by methane oxidizing bacteria for high value-added chemicals production and wastewater treatment.

Water Res 2021 Apr 6;198:117122. Epub 2021 Apr 6.

Department of Civil and Environmental Engineering, Virginia Tech, Manassas, VA 20110, USA. Electronic address:

Methane is a type of renewable fuel that can generate many types of high value-added chemicals, however, besides heat and power production, there is little methane utilization in most of the wastewater treatment plants (WWTPs) all round the world currently. In this review, the status of methane production performance from WWTPs was firstly investigated. Subsequently, based on the identification and classification of methane oxidizing bacteria (MOB), the key enzymes and metabolic pathway of MOB were presented in depth. Read More

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Profile of Patients Hospitalized for Heart Failure Who Leave Against Medical Advice.

J Card Fail 2021 Apr 14. Epub 2021 Apr 14.

David Geffen School of Medicine - University of California, Los Angeles, CA.

Background: There is a paucity of information on patients hospitalized with heart failure [HF] who leave against medical advice [AMA].

Objectives: We sought to identify patient and hospital characteristics and outcomes of patients with HF who left AMA compared to those conventionally discharged to home [CDH].

Methods: Using the Get With The Guidelines-Heart Failure registry, data were analyzed from January 2010 to June 2019. Read More

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Effect of vitamin E on periodontitis: Evidence and proposed mechanisms of action.

J Oral Biosci 2021 Apr 14. Epub 2021 Apr 14.

Department of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Electronic address:

Background: Periodontitis is a noncommunicable inflammatory disease of the soft tissue and bone surrounding the teeth in the jaw, which affects susceptible individuals with poor oral hygiene. A growing interest has been seen in the use of dietary supplements and natural products for the treatment and prevention of periodontitis. Vitamin E consists of two major groups, namely tocopherols and tocotrienols, which are botanical lipophilic compounds with excellent anti-inflammatory and antioxidant properties. Read More

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Trypanosoma cruzi co-infections with other vector borne diseases are frequent in dogs from the pacific coast of Ecuador.

Microb Pathog 2021 Apr 14:104884. Epub 2021 Apr 14.

Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México, C.P. 50200, Mexico.

Dogs are a reservoir for Chagas disease, caused by Trypanosoma cruzi (T. cruzi), and other companion vector-borne diseases, including ehrlichiosis (Ehrlichia canis and Ehrlichia ewingii), anaplasmosis (Anaplasma phagocytophilum and Anaplasma platys), dirofilariasis (Dirofilaria immitis) and Lyme disease (Borrelia burgdorferi). This study has two key objectives: 1) to determine seroreactivity against T. Read More

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Using Quality Improvement Science to Create a Navigator in the Electronic Health Record for the Consolidation of Patient Information Surrounding Pediatric End-of-Life Care.

J Pain Symptom Manage 2021 Apr 14. Epub 2021 Apr 14.

Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.

Background: It is important to document the domains surrounding end-of-life (EOL) care in the electronic health record (EHR). No pediatric navigator exists for these purposes.

Measures: Medical charts were reviewed for documentation surrounding code status and care at the time of death from January 2017 to June 2019. Read More

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Brain Metastases: An Update on Multi-disciplinary Approach of Clinical Management.

Neurochirurgie 2021 Apr 14. Epub 2021 Apr 14.

Department of Neurosurgery, University of Wisconsin School of Medicine & Public Health, UW Carbone Cancer Center, Madison, WI, USA. Electronic address:

Importance: Brain metastasis (BM) is the most common malignant intracranial neoplasm in adults with over 100,000 new cases annually in the United States and outnumbering primary brain tumors 10:1.

Observations:  The incidence of BM in adult cancer patients ranges from 10-40%, and is increasing with improved surveillance, effective systemic therapy, and an aging population. The overall prognosis of cancer patients is largely dependent on the presence or absence of brain metastasis, and therefore, a timely and accurate diagnosis is crucial for improving long-term outcomes, especially in the current era of significantly improved systemic therapy for many common cancers. Read More

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Between-Center Variation in High-Priority Listing Status under the New Heart Allocation Policy.

Am J Transplant 2021 Apr 17. Epub 2021 Apr 17.

Department of Medicine, University of Chicago, Chicago, IL, USA.

Under the new U.S. heart allocation policy, transplant centers listed significantly more candidates at high priority statuses (Status 1 and 2) with mechanical circulatory support devices than expected. Read More

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Allopurinol for fibromyalgia pain in adults: a randomized controlled trial.

Pain Pract 2021 Apr 17. Epub 2021 Apr 17.

Department of Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Background: Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used in the treatment of hyperuricemia and gout. Since it is well known that purines exert multiple effects on pain transmission, we hypothesized that the inhibition of xanthine oxidase by allopurinol could be a valid strategy to treat pain in humans. This study aimed to compare the analgesic efficacy of oral allopurinol versus placebo as an adjuvant therapy in patients displaying fibromyalgia. Read More

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Outcome after Haematopoietic Stem Cell Transplantation in Patients with Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: a French Study from the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).

Am J Hematol 2021 Apr 17. Epub 2021 Apr 17.

Department of Hematology, Inserm U1163, IMAGINE Institute, Paris University, Necker Hospital, Paris, France.

We evaluated the outcome of 65 French patients with Extranodal NK/T-cell lymphoma, nasal type (ENKTL) undergoing haematopoietic stem cell transplantation (HSCT) (19 allogeneic and 46 autologous). Fifty-four patients (83%), most of which receiving L asparaginase (L-aspa) containing regimens (81%), achieved complete or partial response at time of HCST. After a median follow-up of 79. Read More

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Intravenous high-dose methotrexate based systemic therapy in the treatment of isolated primary vitreoretinal lymphoma: an LOC network study.

Am J Hematol 2021 Apr 17. Epub 2021 Apr 17.

Neurology, APHP, Sorbonne Université, Paris, France.

The treatment of primary vitreoretinal lymphoma (PVRL) remains controversial regarding the use of local, systemic, or combined treatments. The aim of this study was to analyze the efficacy and toxicity of intravenous high-dose methotrexate (IV HD-MTX) based systemic therapy in a uniformly treated population of PVRL patients. From a nationwide French database, we retrospectively selected 59 patients (median age: 70 years, median Karnofsky Performance Status: 90%) with isolated PVRL at diagnosis who received first-line treatment with HD-MTX between 2011-2018. Read More

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[Combined cerebral revascularization for moyamoya disease].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):47-59

Burdenko Neurosurgical Center, Moscow, Russia.

Introduction: Combined cerebral revascularization with direct and indirect components is recognized as the most appropriate method for treating patients with Moyamoya disease all over the world, however, large studies on its effectiveness in Russia have not yet been conducted.

The Aim Of The Study: Was to evaluate the results of combined cerebral revascularization in patients with Moyamoya disease with an analysis of the clinical state and perfusion and angiographic features of neoangiogenesis.

Material And Methods: For the period from 2013 to 2020 in N. Read More

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January 2021

Surgical Margin Status and Survival Following Resection of Sinonasal Mucosal Melanoma.

Laryngoscope 2021 Apr 17. Epub 2021 Apr 17.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Objectives: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer usually managed with surgical resection. This study evaluates the impact of treatment modality and positive surgical margin (PSM) on survival following resection of SNMM.

Study Design: Retrospective study of a national cancer registry. Read More

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The role of sex-differentiated variations in stress hormones, antioxidants, and neuroimmune responses in relation to social interaction impairment in a rodent model of autism.

Metab Brain Dis 2021 Apr 17. Epub 2021 Apr 17.

Central Laboratory, Female Center for Medical Studies and Scientific Section, King Saud University, P O Box 22452, Riyadh, 11495, Saudi Arabia.

Males are more likely to develop autism as a neurodevelopmental disorder than females, but the mechanisms underlying male susceptibility are not fully understood. In this paper, we used a well-characterized propionic acid (PPA) rodent model of autism to study sex differences in stress hormones, antioxidants' status, and the neuroimmune response that may contribute to the preponderance of autism in males. Sprague Dawley rats of both sexes were divided into a saline-treated group as controls and PPA-treated groups, receiving 250 mg/kg of PPA per day for three days. Read More

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Incidence, clinicopathologic, and genetic characteristics of mismatch repair gene-mutated glioblastomas.

J Neurooncol 2021 Apr 17. Epub 2021 Apr 17.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: Glioblastoma (GBM) is the most common and malignant gliomas of adults and recur, resulting in death, despite surgery, radiotherapy, and temozolomide-based chemotherapy. There are a few reports on immunotherapy for the mismatch repair (MMR)-deficient GBMs with high tumor mutational burden (TMB). However, the clinicopathological and genetic features of the MMR genes altered in GBMs have not been elucidated yet. Read More

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Effect of mangrove restoration on sediment properties and bacterial community.

Ecotoxicology 2021 Apr 17. Epub 2021 Apr 17.

School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China.

Mangrove reconstruction is an efficient approach for mangrove conservation and restoration. The present study aimed to explore the effects of mangrove reconstruction on sediment properties and bacterial community. The results showed that mangrove restoration greatly promoted sediment fertility, whereas the improvements were more obvious induced by Kandelia obovata when compared to Avicennia marina. Read More

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Detection of activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted next-generation sequencing: a pilot study.

J Egypt Natl Canc Inst 2021 Apr 17;33(1):10. Epub 2021 Apr 17.

Clinical Oncology Department, School of Medicine, Cairo University, Cairo, Egypt.

Background: Breast cancer (BC) is the 2 most prevalent malignancy worldwide and is the most prevalent cancer among Egyptian women. The number of newly described cancer-associated genes has grown exponentially since the emergence of next-generation sequencing (NGS) technology. We aim to identify activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted NGS technology. Read More

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Burnout among healthcare professionals during COVID-19 pandemic: a cross-sectional study.

Int Arch Occup Environ Health 2021 Apr 17. Epub 2021 Apr 17.

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To describe the prevalence of burnout among healthcare professionals dealing with COVID-19 patients and the associated factors.

Methods: In this cross-sectional survey, healthcare workers at six university-affiliated hospitals, who had been taking care of COVID-19 patients were studied. Age, gender, marital status, having children, hospital, job category, experience, and work load, as well as the level of burnout in each subscale were measured. Read More

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Comparison of treatment modalities for selected advanced laryngeal squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2021 Apr 17. Epub 2021 Apr 17.

Department of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology (Shandong University), Qilu Hospital of Shandong University, Jinan, Shandong, China.

Purpose: The authors aimed to clarify the optimal treatment strategy and the indication of different treatments in managing advanced laryngeal squamous cell carcinoma (LSCC).

Methods: A total of 9700 patients with advanced (T3-4aN0-3M0) LSCC who treated with (1) surgery alone, (2) surgery plus adjuvant radiation with or without chemotherapy (aCRT/RT), or (3) definitive CRT/RT was retrieved from the SEER database. The propensity score matching (PSM) was applied to balance confounding factors. Read More

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Social stress and risk of declining cognition: a longitudinal study of men and women in the United States.

Soc Psychiatry Psychiatr Epidemiol 2021 Apr 17. Epub 2021 Apr 17.

Division of Geriatrics, David Geffen School of Medicine, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

Limited research is available on the relationship between social stress and risk of declining cognition. We sought to examine whether social stress has adverse effects on risk of declining episodic memory and executive functioning in aging individuals. We used data from the MIDUS study, a national probability sample of non-institutionalized, English speaking respondents aged 25-74 living in the 48 contiguous states of the United States. Read More

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Soluble alpha klotho in acromegaly: Comparison to traditional markers of disease activity.

J Clin Endocrinol Metab 2021 Apr 17. Epub 2021 Apr 17.

Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich, Germany.

Context: Soluble alpha klotho (sαKL) has been linked to growth hormone (GH) action, but systematic evaluation and comparison to traditional biomarkers in acromegaly are lacking.

Objective: To evaluate the potential of sαKL to aid classification of disease activity.

Design And Setting: Retrospective study at two academic centers. Read More

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Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children with Cerebral Palsy.

Indian Pediatr 2021 Apr 17. Epub 2021 Apr 17.

Department of Orthopedics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

Objectives: To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age and gender matched controls.

Methods: A cross-sectional study enrolled thirty children in each group: CP with epilepsy, CP without epilepsy, and healthy controls and bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.

Results: Z scores of BMD [-1. Read More

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Instrumentally assessed gait quality is more relevant than gait endurance and velocity to explain patient-reported walking ability in early stage Multiple Sclerosis.

Eur J Neurol 2021 Apr 17. Epub 2021 Apr 17.

IRCSS Fondazione Don Carlo Gnocchi, Milan, Italy.

Background: People with Multiple Sclerosis (PwMS) often report walking limitations even when the gold-standard Expanded Disability Status Scale (EDSS) indicates normal walking endurance/autonomy. The present multicenter study on early-stage PwMS aims at analyzing which aspects are associated to patient-reported walking limitations measured with 12-item Multiple Sclerosis Walking Scale (MSWS-12).

Methods: Eighty-two PwMS (EDSS≤2. Read More

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