43,394 results match your criteria statistically decrease

Comparison of Bone Mineral Density and Markers of Bone Turnover in Osteoporotic Women after 6-Month Treatment with Alendronate or Bazedoxifene: A Randomized Controlled Trial.

J Bone Metab 2021 May 31;28(2):131-137. Epub 2021 May 31.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: In a randomized controlled trial, we compared the bone mineral densities (BMDs) and blood markers of bone turnover during short-term treatment of osteoporotic women with bisphosphonate alendronate or bazedoxifene, a selective estrogen receptor modulator.

Methods: Ten and eleven patients were randomized to the alendronate and bazedoxifene groups, respectively. BMDs were measured before and after 6 months of treatment. Read More

View Article and Full-Text PDF

Does the power of the laser devices matter for a successful HoLEP procedure? A prospective comparative study.

Int J Clin Pract 2021 Jun 15:e14531. Epub 2021 Jun 15.

Department of Urology, Biruni University School of Medicine, Istanbul, Turkey.

Background: The objectives of this prospective study were to evaluate the efficiency, safety and applicability of medium power (MP) holmium laser devices in the endoscopic enucleation of the enlarged prostate (HoLEP) compared to high power (HP) laser devices.

Methods: From October 2019 to July 2020, a total of 120 consecutive patients planned for HoLEP were divided randomly into two groups formed in terms of the power of the device used. While patients in Group 1 were treated with a MP device (50W) at 39. Read More

View Article and Full-Text PDF

Relationship between hepatic venous anatomy and hepatic venous blood loss during hepatectomy.

Surg Today 2021 Jun 15. Epub 2021 Jun 15.

Division of Hepatobiliary Pancreas Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, Kiyotake 5200, Miyazaki, 889-1692, Japan.

Purpose: Predicting increased blood loss based on anatomical intervascular relationships is essential in major hepatectomy.

Methods: We assessed 63 consecutive patients undergoing anatomical hepatectomy exposing the hepatic vein (HV) trunk at two institutes. Correlations between anatomical alterations of the hepatic inferior vena cava (IVC), HV, hepatic IVC, or right atrium (RA) and the blood loss per standard weight (BLSW) or blood transfusion (n = 18) were analyzed. Read More

View Article and Full-Text PDF

Association of a Sweetened Beverage Tax With Purchases of Beverages and High-Sugar Foods at Independent Stores in Philadelphia.

JAMA Netw Open 2021 Jun 1;4(6):e2113527. Epub 2021 Jun 1.

Department of Medical Ethics and Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Importance: The relationship between a sweetened beverage tax and changes in the prices and purchases of beverages and high-sugar food is understudied in the long term and in small independent food retail stores where sugar-sweetened beverages are among the most commonly purchased items.

Objective: To examine whether a 1.5 cent-per-fluid-ounce excise tax on sugar- and artificially sweetened beverages Philadelphia, Pennsylvania, was associated with sustained changes in beverage prices and purchases, as well as calories purchased from beverages and high-sugar foods, over 2 years at small independent stores. Read More

View Article and Full-Text PDF

Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26289

Department of Gynecology, Tongde Hospital of Zhejiang Province, Hangzhou, China.

Background: Atorvastatin treatment has been suggested as a therapeutic method for women with polycystic ovary syndrome (PCOS) in many clinical studies. Nonetheless, the effects of atorvastatin on insulin resistance in PCOS patients still remain controversial.

Objective: The aim of this report was to evaluate the effects of atorvastatin therapy on the insulin resistance in the treatment of PCOS compared to that of placebo, in order to confer a reference for clinical practice. Read More

View Article and Full-Text PDF

Length of estradiol exposure >100 pg/ml in the follicular phase affects pregnancy outcomes in natural frozen embryo transfer cycles.

Hum Reprod 2021 Jun 14. Epub 2021 Jun 14.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA.

Study Question: Do the length of follicular phase estradiol exposure and the total length of the follicular phase affect pregnancy and live birth outcomes in natural frozen embryo transfer (FET) cycles?

Summary Answer: An estradiol level >100 pg/ml for ≤4 days including the LH surge day is associated with worse pregnancy and live birth outcomes; however, the total length of the follicular phase is not associated with pregnancy and live birth outcomes.

What Is Known Already: An estradiol level that increases above 100 pg/ml and continues to increase is indicative of the selection and development of a dominant follicle. In programmed FET cycles, a limited duration of follicular phase estradiol of <9 days results in worse pregnancy rates, but a prolonged exposure to follicular phase estradiol for up to 4 weeks does not affect pregnancy outcomes. Read More

View Article and Full-Text PDF

Changes in the geometry of modern daily disposable soft contact lenses during wear.

Sci Rep 2021 Jun 14;11(1):12460. Epub 2021 Jun 14.

Division of Ophthalmology and Optometry, Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, ul. Ujejskiego 75, 85-168, Bydgoszcz, Poland.

The geometry of contact lenses can be altered by wear but determining the changes that occur in soft contact lenses (SCLs) is challenging. This study aimed to investigate the shape alterations of daily disposable SCLs after wear using swept-source optical coherence tomography (SS-OCT). Forty-five eyes with myopia of - 3. Read More

View Article and Full-Text PDF

Efficacy and safety of a self-developed home-based enhanced knee flexion exercise program compared with standard supervised physiotherapy to improve mobility and quality of life after total knee arthroplasty: a randomized control study.

J Orthop Surg Res 2021 Jun 14;16(1):382. Epub 2021 Jun 14.

Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Rd, Shanghai, 200072, People's Republic of China.

Background: This randomized controlled study compared standard supervised physiotherapy (SPT) with a self-developed, home-based, enhanced knee flexion exercise program involving a low stool (KFEH) in patients who underwent total knee arthroplasty (TKA).

Methods: Patients were recruited from July 2014 to December 2015 and randomly assigned to one of two groups: KFEH (n = 60) and SPT (n = 59). Outcomes (joint function) were evaluated according to the Knee Society Score (KSS), visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and range of motion (ROM) assessment at selected time points (preoperatively; 1 week; 1, 3, and 6 months; and 1 year after surgery). Read More

View Article and Full-Text PDF

Comparison of intravascular access methods applied by nurses wearing personal protective equipment in simulated COVID-19 resuscitation: A randomized crossover simulation trial.

Am J Emerg Med 2021 Jun 3;49:189-194. Epub 2021 Jun 3.

Polish Society of Disaster Medicine, Warsaw, Poland; Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland. Electronic address:

Background: Prehospital emergency care of children is challenging. In the era of the COVID-19 pandemic, when medical personnel should use personal protective equipment against aerosol-generating procedures, the efficiency of medical procedures may decrease. The study objective was to evaluate the effectiveness of different intravascular access methods applied by nurses wearing biosafety Level-2 suits in simulated paediatric COVID-19 resuscitation. Read More

View Article and Full-Text PDF

Clinical Profile and Long-Term Outcome in Neonatal Cerebral Sinus Venous Thrombosis.

Pediatr Neurol 2021 May 15;121:20-25. Epub 2021 May 15.

Department of Pediatrics, Section of Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, Texas. Electronic address:

Background: Neonatal cerebral sinus venous thrombosis (CSVT) causes high morbidity and mortality. Factors associated with either favorable or unfavorable long-term outcomes have not been clearly established. This study aimed to determine the factors involved in long-term neurological outcomes in patients with neonatal CSVT. Read More

View Article and Full-Text PDF

Prevalence and cost of surgical treatment for female stress urinary incontinence in Brazil: a comparison between abdominal and vaginal approaches.

Int J Clin Pract 2021 Jun 14:e14527. Epub 2021 Jun 14.

Urology Division, Faculdade de Medicina do ABC do Centro Universitário de Saúde ABC, Santo André, SP, Brazil.

Objective: Report the progress of the treatment of female stress urinary incontinence (SUI) in Brazil through vaginal and abdominal approaches and the direct costs by hospitalization, using DATASUS - a public entity of the Strategic and Participative Management Secretary of Health Ministry, with the responsibility of collecting, processing and disseminating public health information.

Design: Epidemiological study using the Brazilian Public Health Data Center System (DATASUS).

Participants/materials, Setting, Methods: Data collected on all hospital admissions associated with treatment from 2008 to 2019 from the DATASUS. Read More

View Article and Full-Text PDF

Effectiveness of Perioperative Opioid Educational Initiatives: A Systematic Review and Meta-Analysis.

Anesth Analg 2021 Jun 11. Epub 2021 Jun 11.

Department of Anesthesiology, Hospital for Special Surgery, New York, New York.

Background: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid education on postoperative opioid consumption patterns including opioid cessation, number of pills consumed, and opioid prescription refills. Read More

View Article and Full-Text PDF

Study of Haloperidol for Abdominal Pain in the Emergency Department (SHAPE).

West J Emerg Med 2021 May 5;22(3):623-627. Epub 2021 May 5.

Cleveland Clinic Enterprise Services Institute, Enterprise Quality and Safety, Cleveland, Ohio.

Introduction: Intravenous haloperidol has been shown to decrease milligram morphine equivalents (MME) of analgesia and reduce hospital admissions for diabetic gastroparesis. The objective of this study was to evaluate whether haloperidol decreases MME for the treatment of non-specific abdominal pain diagnoses in the emergency department (ED), including gastroparesis, cyclic vomiting, cannabinoid hyperemesis syndrome, and unspecified abdominal pain. The primary outcome compared the difference in MME between encounters. Read More

View Article and Full-Text PDF

Palliative Integration Into Ambulatory Oncology: An Advance Care Planning Quality Improvement Project.

J Adv Pract Oncol 2021 May 1;12(4):376-386. Epub 2021 May 1.

University of South Alabama, Mobile, Alabama.

Advance care planning (ACP) is essential to ensuring that patient-centered end-of-life goals are respected if a health crisis occurs. Advanced practitioner barriers to ACP include insufficient time and limited confidence in discussions. The purpose of this quality improvement project was to increase advanced cancer patients' electronic health record (EHR) documented surrogate decision maker and ACP documentation by 25% over 8 weeks. Read More

View Article and Full-Text PDF

Parathyroid Changes After RAI in Patients With Differentiated Thyroid Carcinoma.

Front Endocrinol (Lausanne) 2021 27;12:671787. Epub 2021 May 27.

Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China.

Objective: The purpose of this study was to investigate parathyroid hormone (PTH), serum calcium, phosphorus, and 25-hydroxyvitamin D (25-OH-VD) changes before and after radioactive iodine (RAI) in differentiated thyroid carcinoma (DTC) patients at different time points.

Methods: A total of 259 DTC patients who received RAI were prospectively enrolled. We evaluated PTH, serum calcium, phosphorus, and 25-OH-VD levels at baseline pre-RAI, five days, six weeks, and six months post-RAI, respectively. Read More

View Article and Full-Text PDF

Shift From a Traditional to a Distance Learning Environment during the COVID-19 Pandemic: University Students' Engagement and Interactions.

Sci Educ (Dordr) 2021 Jun 8:1-30. Epub 2021 Jun 8.

Department of Environment, Ionian University, M. Minotou-Giannopoulou, 29100 Zakynthos, Greece.

The paper reports a study aimed at investigating tertiary education students' engagement and interactions in the traditional face-to-face learning environment and the sequentially applied distance online learning environment imposed by the sudden upsurge of a worldwide health emergency, the COVID-19 pandemic in Spring 2020. The study took place in four distinct science learning communities formed by a total of 347 undergraduate students attending three different academic majors (Chemistry, Environmental Science, and Food Science and Technology) and 13 postgraduate students attending a Masters program related to Chemistry Education, in two Greek universities. The majority of the measured variables were shown to depend on the institution, the academic major, and the semester of study, although to a varying degree. Read More

View Article and Full-Text PDF

Student-run Clinic Effect on Emergency Department Utilization (SCEEDU): An Analysis of the DAWN Clinic Impact in Colorado.

J Health Care Poor Underserved 2021 ;32(2):1069-1082

Background: Student-run free clinics (SRFCs) provide care to medically underserved individuals who may otherwise utilize the emergency department (ED) for primary care.

Objective: Evaluate the effect of enrollment at the DAWN SRFC in Aurora, Colorado on University of Colorado ED utilization.

Methods: Th is was a retrospective longitudinal analysis of 164 patients who established care at the DAWN clinic and were also seen at the nearby ED over an eight-year period. Read More

View Article and Full-Text PDF
January 2021

The relationship between functional head impulse test and age in healthy individuals.

J Vestib Res 2021 Jun 7. Epub 2021 Jun 7.

Başkent University, Faculty of Medicine ENT Clinic, Ankara, Turkey.

Background: fHIT is an easily applicable test battery that indirectly evaluates the vestibulo-ocular reflex (VOR) from a functional perspective.

Aims/objectives: The aim of this study was to Individuals determine the correlation between age and the percentage of correct answers (% CA) obtained in the functional head impulse test (fHIT) in healthy individuals.

Material And Methods: A total of 105 volunteers, 50 males and 55 females, between the ages of 18 and 70 years, participated in the study. Read More

View Article and Full-Text PDF

Physical Function and Survival in Older Adults: A longitudinal study accounting for time-varying effects.

Arch Gerontol Geriatr 2021 May 24;96:104440. Epub 2021 May 24.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec; Department of Medicine, McGill University Montreal, Quebec; Research Institute of the McGill University Health Centre, Montreal, Quebec.

Purpose Of The Study: Variation in physical function in older adults over time raises several methodological challenges in the study of its association with survival, many of which have largely been overlooked in previous studies. The objective of this study is to examine the relationship between time-varying measures of physical function and survival in men and women aged 70 years and over, while accounting for the time-varying effects of health and lifestyle characteristics.

Methods: 1,846 women and 1,245 men in the Cardiovascular Health Study followed annually for up to 10 years beginning at age 70-74 years were included. Read More

View Article and Full-Text PDF

Comparison of opioid rotation on pain, symptoms, and daily opioid dose in a supportive care clinic.

Ann Palliat Med 2021 Jun 9. Epub 2021 Jun 9.

Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.

Background: Opioid rotation (OR) is used to decrease patients' cancer-related pain and mitigate opioidinduced adverse effects. There is limited evidence regarding its effect on symptoms and morphine equivalent daily dose (MEDD). The objective of this study was to investigate the effects o. Read More

View Article and Full-Text PDF

Trends in environmental chemical concentrations in the Canadian population: Biomonitoring data from the Canadian Health Measures Survey 2007-2017.

Environ Int 2021 Jun 9;155:106678. Epub 2021 Jun 9.

Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.

Ten years of nationally representative biomonitoring data collected between 2007 and 2017 are available from the Canadian Health Measures Survey (CHMS). These data establish baseline environmental chemical concentrations in the general population. Here we sought to evaluate temporal trends in environmental chemical exposures in the Canadian population by quantifying changes in biomarker concentrations measured in the first five two-year cycles of the CHMS. Read More

View Article and Full-Text PDF


J Stomatol Oral Maxillofac Surg 2021 Jun 9. Epub 2021 Jun 9.

Professor, Chief of the Service de Stomatologie et de Chirurgie Maxillo-faciale de la Pitié Salpétrière (France).

Objective: This pilot randomized crossover study evaluated the outcomes of two custom-made mandibular retention devices (MRDs), a computer-aided design (CAD)/computer-aided manufacturing (CAM) device (Narval CC™) and a non-CAD/CAM device (Narval™), on oropharyngeal airway volume in patients with obstructive sleep apnoea (OSA).

Methods: 12 OSA patients were recruited from an University Hospital for MRD therapy with either CAD/CAM or non-CAD/CAM first. A cone-beam computed tomography evaluation (CBCT) and polysomnography assessment was performed during baseline assessment and at the end of each study period. Read More

View Article and Full-Text PDF

Medicaid Expansion Association with End-Stage Liver Disease Mortality Depends on Leniency of Medicaid Hepatitis C Virus Coverage.

Liver Transpl 2021 Jun 12. Epub 2021 Jun 12.

Department of Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.

Background And Aims: The Affordable Care Act (ACA) expanded Medicaid around the same time that direct-acting antivirals (DAAs) became widely available for the treatment of hepatitis C virus (HCV). However, there is significant variation in Medicaid HCV treatment eligibility criteria between states. We explored the combined effects of Medicaid expansion and leniency of HCV coverage under Medicaid on liver outcomes. Read More

View Article and Full-Text PDF

Chronobiological evaluation and an intervention study on timing of food intake in the treatment of obesity.

Int J Clin Pract 2021 Jun 12:e14502. Epub 2021 Jun 12.

Department of Family Medicine, Düzce University Medical Faculty, Duzce, Turkey.

Background: The chronotype of patients who cannot reach their ideal weight despite diet and exercise may play a role in this resistance. In this study, the relationship between BMI and chronobiological preferences was examined and a weight loss program was applied to refractory obese patients with evening type (ET).

Method: The study included 50 obese (BMI≥30 kg/m ), 50 overweight (BMI=25-29 kg/m ), and 50 normal normal-weight (BMI<25 kg/m ). Read More

View Article and Full-Text PDF

Analysis of allergen profile in patients sensitized to canine allergen and potential Can f 5 cross-reactivity with human PSA.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211023670

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.

Can f 5 allergy and possible cross-reactivity with human semen in which there are significant amounts of prostate-specific antigen (PSA) are particularly interesting aspects of allergy to dog. The objective of the study was to confirm cross-reactivity between human PSA and Can f 5 in a study of canine sensitised women. A total of 100 women (aged 18-73, 41 on average) with a positive history of animal fur allergy or positive skin prick tests to canine allergens were selected. Read More

View Article and Full-Text PDF

Prophylactic dialysis improves short-term clinical outcome in patients with non-dialysis-dependent chronic kidney disease undergoing cardiac surgery: a meta-analysis of randomized controlled trials.

Coron Artery Dis 2021 Jun 10. Epub 2021 Jun 10.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R.China.

Background: Several studies have reported that prophylactic dialysis can reduce the mortality of non-dialysis-dependent chronic kidney disease (CKD) patients after cardiac surgery. However, the results of complications in these randomized controlled trials (RCTs) were not consistent. We aimed to perform a meta-analysis to systematically evaluate the effect of prophylactic dialysis in these non-dialysis-dependent CKD patients. Read More

View Article and Full-Text PDF

The association between pain scores and disc height change following discectomy surgery in lumbar disc herniation patients: a systematic review and meta-analysis.

Eur Spine J 2021 Jun 10. Epub 2021 Jun 10.

Spine Labs, St. George and Sutherland Clinical School, University of New South Wales, Level 3, WR Pitney Building, Sydney, NSW, 2217, Australia.

Purpose: To evaluate the impact of discectomy on disc height (DH) in lumbar disc herniation (LDH) patients following discectomy surgery and address the association of DH change with pain score change.

Methods: We searched three online databases for randomized controlled trials (RCTs) and observational studies. In LDH patients, eligible for discectomy surgery, the changes in pre- and post-operative back and/or leg pain score and DH and/or disc height index (DHI) were considered as primary outcomes. Read More

View Article and Full-Text PDF

Changes in trends and outcomes of eclampsia: a success story from Qatar.

Qatar Med J 2019 20;2019(1):10. Epub 2019 Sep 20.

Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

Preeclampsia and eclampsia are two hypertensive disorders of pregnancy that significantly contribute to higher morbidity and mortality rates. Eclampsia is the occurrence of seizures in patients with preeclampsia without any previous history of seizure disorders. The incidence and prevalence of eclampsia varies, and there is scarce literature about the prevalence and trends of eclampsia in the Arabian Gulf countries. Read More

View Article and Full-Text PDF
September 2019

Immunomodulatory Activity of Aqueous Gall Extract.

Oman Med J 2021 May 31;36(3):e265. Epub 2021 May 31.

School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.

Objectives: Our study reports the immunomodulatory potency of gall extract . The aqueous extract was prepared and examined for its effects on cell proliferation, phagocytic activity, nitric oxide (NO) production, and cytokine synthesis by murine macrophages.

Methods: Proliferative, phagocytic activity, and NO production of extract-treated and control cells were studied using proliferative assay, flow cytometry, and Griess reaction, respectively. Read More

View Article and Full-Text PDF

Predictive analytics and tailored interventions improve clinical outcomes in older adults: a randomized controlled trial.

NPJ Digit Med 2021 Jun 10;4(1):97. Epub 2021 Jun 10.

Partners Connected Health Innovation, Partners HealthCare, Boston, MA, USA.

This study explored the potential to improve clinical outcomes in patients at risk of moving to the top segment of the cost acuity pyramid. This randomized controlled trial evaluated the impact of a Stepped-Care approach (predictive analytics + tailored nurse-driven interventions) on healthcare utilization among 370 older adult patients enrolled in a homecare management program and using a Personal Emergency Response System. The Control group (CG) received care as usual, while the Intervention group (IG) received Stepped-Care during a 180-day intervention period. Read More

View Article and Full-Text PDF