62,550 results match your criteria statistical comparison

Thresholds, Firing Rates, and Order of Recruitment of Anterior Temporalis Muscle Single-Motor Units During Experimental Masseter Muscle Pain.

J Oral Facial Pain Headache 2021 Spring;35(2):93-104

Aims: To test the hypothesis that, in comparison with control, experimental noxious stimulation of the right masseter muscle would result in significant changes in the firing rates, thresholds, and recruitment orders of single-motor units (SMUs) of the nonpainful, synergistic right anterior temporalis muscle during goal-directed isometric biting task performance.

Methods: Twenty healthy volunteers received an infusion of hypertonic saline (HS; 5% sodium chloride) into the right masseter to produce pain intensity of 40 to 60 on a 100-mm visual analog scale (VAS). Isotonic saline (IS) infusion was a control. Read More

View Article and Full-Text PDF

The effect of different chelators on the dislodgement resistance of MTA Repair HP, MTA Angelus, and MTA Flow.

Odontology 2021 Jun 15. Epub 2021 Jun 15.

Department of Endodontics, Faculty of Dentistry, Antalya Bilim University, Antalya, Turkey.

The aim of this study was to investigate the influence of various irrigants on the dislodgement resistance of MTA Repair HP, MTA Angelus, and MTA Flow to root dentin. Three slices (1.0 ± 0. Read More

View Article and Full-Text PDF

Overcoming stochastic variations in culture variables to quantify and compare growth curve data.

Bioessays 2021 Jun 14:e2100108. Epub 2021 Jun 14.

Molecular & Cellular Biochemistry Department, Indiana University, Bloomington, Indiana, USA.

The comparison of growth, whether it is between different strains or under different growth conditions, is a classic microbiological technique that can provide genetic, epigenetic, cell biological, and chemical biological information depending on how the assay is used. When employing solid growth media, this technique is limited by being largely qualitative and low throughput. Collecting data in the form of growth curves, especially automated data collection in multi-well plates, circumvents these issues. Read More

View Article and Full-Text PDF

Erectile Function Following Surgery for Benign Prostatic Obstruction: A Systematic Review and Network Meta-analysis of Randomised Controlled Trials.

Eur Urol 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Life Sciences and Medicine, King's College London, London, UK; Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Context: Benign prostatic obstruction (BPO) is associated with sexual dysfunction. Furthermore, numerous BPO interventions may themselves impact sexual function.

Objective: To perform a systematic review with network meta-analysis to evaluate how BPO interventions affect erectile function. Read More

View Article and Full-Text PDF

[Dietary patterns of Roma population and total population in Spain].

Gac Sanit 2021 Jun 11. Epub 2021 Jun 11.

Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Universidad de Alicante, Alicante, España; Federación de Asociaciones Gitanas (FAGA), Alicante, España.

Objective: The NAOS (Nutrición, Actividad Física y Prevención de la Obesidad) strategy implemented by Spanish Ministry of Health proposes a range of healthy dietary guidelines. The objective of this article is to analyze the degree these nutritional patterns are monitored by the Roma population, compared to the rest of the population, compared to the total Spanish population.

Methods: Data from the 2012 National Health Survey and the 2014 Roma Health Survey were compared. Read More

View Article and Full-Text PDF

A new approach for interpretability and reliability in clinical risk prediction: Acute coronary syndrome scenario.

Artif Intell Med 2021 Jul 13;117:102113. Epub 2021 May 13.

Cardiology Department, Leiria Hospital Centre, Leiria, Portugal. Electronic address:

Introduction: The risk prediction of the occurrence of a clinical event is often based on conventional statistical procedures, through the implementation of risk score models. Recently, approaches based on more complex machine learning (ML) methods have been developed. Despite the latter usually have a better predictive performance, they obtain little approval from the physicians, as they lack interpretability and, therefore, clinical confidence. Read More

View Article and Full-Text PDF

Comparative Bioavailability of Amphetamine Extended-Release Oral Suspension and Extended-Release Mixed Amphetamine Salts.

CNS Spectr 2021 Apr;26(2):163

Tris Pharma, Inc., Monmouth Junction, NJ, USA.

Purpose: This open-label, single-dose, randomized, two-period, two-treatment, two-sequence, crossover study evaluated the comparative bioavailability between amphetamine extended-release oral suspension (treatment A: AMPH EROS, Dyanavel XR 2.5 mg/mL, 18.8 mg amphetamine base per 7. Read More

View Article and Full-Text PDF

Towards theoretical spectroscopy with error bars: systematic quantification of the structural sensitivity of calculated spectra.

Chem Sci 2019 Dec 27;11(7):1862-1877. Epub 2019 Dec 27.

Technische Universität Braunschweig, Institute of Physical and Theoretical Chemistry Gaußstraße 17 38106 Braunschweig Germany

Molecular spectra calculated with quantum-chemical methods are subject to a number of uncertainties (, errors introduced by the computational methodology) that hamper the direct comparison of experiment and computation. Judging these uncertainties is crucial for drawing reliable conclusions from the interplay of experimental and theoretical spectroscopy, but largely relies on subjective judgment. Here, we explore the application of methods from uncertainty quantification to theoretical spectroscopy, with the ultimate goal of providing systematic error bars for calculated spectra. Read More

View Article and Full-Text PDF
December 2019

The geographic distribution of bioavailable strontium isotopes in Greece - A base for provenance studies in archaeology.

Sci Total Environ 2021 Jun 4;791:148156. Epub 2021 Jun 4.

Department of Research, Collections and Conservation, Environmental Archaeology and Materials Science, National Museum of Denmark, Kongens Lyngby DK 2800, Denmark. Electronic address:

Sr isotopes are a powerful tool used to reconstruct human mobility in archaeology. This requires extensive bioavailable Sr/Sr baselines used as reference for deciphering potential areas of origin. We define the first extensive bioavailable Sr isotope baselines for the different geographical regions and surface lithologies of Greece by combining new Sr data with previously published bioavailable Sr/Sr data. Read More

View Article and Full-Text PDF

Intravesical gemcitabine for non-muscle invasive bladder cancer.

Cochrane Database Syst Rev 2021 Jun 14;6:CD009294. Epub 2021 Jun 14.

Urology Section, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.

Background: It remains unclear whether people with non-muscle invasive bladder cancer (NMIBC) benefit from intravesical gemcitabine compared to other agents in the primary or recurrent setting following transurethral resection of a bladder tumor. This is an update of a Cochrane Review first published in 2012. Since that time, several randomized controlled trials (RCTs) have been reported, making this update relevant. Read More

View Article and Full-Text PDF

Accuracy of registration techniques and vascular imaging modalities in fusion imaging for aortic endovascular interventions: a phantom study.

CVIR Endovasc 2021 Jun 14;4(1):51. Epub 2021 Jun 14.

Department for Radiology and Neuroradiology, Sana Hospital, Lübeck, Germany.

Background: This study aimed to assess the error of different registration techniques and imaging modalities for fusion imaging of the aorta in a standardized setting using a anthropomorphic body phantom.

Materials And Methods: A phantom with the 3D printed vasculature of a patient suffering from an infrarenal aortic aneurysm was constructed. Pulsatile flow was generated via an external pump. Read More

View Article and Full-Text PDF

Renal Protective Effect of Everolimus in Liver Transplantation: A Prospective Randomized Open-Label Trial.

Transplant Direct 2021 Jul 8;7(7):e709. Epub 2021 Jun 8.

Department of Health Policy and Administration, Pennsylvania State University, University Park, PA.

Renal dysfunction is associated with poor long-term outcomes after liver transplantation. We examined the renal sparing effect of everolimus (EVR) compared to standard calcineurin inhibitor (CNI) immunosuppression with direct measurements of renal function over 24 months.

Methods: This was a prospective, randomized, open-label trial comparing EVR and mycophenolic acid (MPA) with CNI and MPA immunosuppression. Read More

View Article and Full-Text PDF

Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study.

Biomed Res Int 2021 3;2021:5512091. Epub 2021 Jun 3.

Institute of Dental Medicine, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague 121 11, Czech Republic.

This study is aimed at proving the clinical benefit of the MELISA® test in the minimization or complete elimination of health problems in patients with confirmed hypersensitivity to metals used for tissue replacements. A group of 305 patients aged 20-75 years with previously proven metal hypersensitivity (initial MELISA® test), mainly to titanium and then to another fifteen metals, was chosen from the database at the Institute of Dental Medicine. From these patients, a final group of 42 patients agreed to participate in the study, 35 of which were female and 7 were male. Read More

View Article and Full-Text PDF

Effect of number of uses and sterilization on the instrumented area and resistance of reciprocating instruments.

Restor Dent Endod 2021 May 29;46(2):e28. Epub 2021 Apr 29.

Graduation Program in Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.

Objectives: This study evaluated the effect of repeated uses and autoclaving in the instrumented area, fracture resistance, and time of instrumentation of thermally treated nickel-titanium reciprocating systems.

Materials And Methods: Two hundred simulated canals were instrumented using Reciproc Blue and WaveOne Gold. Each file was used up to 10 times or until fracture. Read More

View Article and Full-Text PDF

Data-powered augmented volcano plots for homogeneous catalysis.

Chem Sci 2020 Sep 21;11(44):12070-12080. Epub 2020 Sep 21.

Laboratory for Computational Molecular Design, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL) 1015 Lausanne Switzerland

Given the computational resources available today, data-driven approaches can propel the next leap forward in catalyst design. Using a data-driven inspired workflow consisting of data generation, statistical analysis, and dimensionality reduction algorithms we explore trends surrounding the thermodynamics of a model hydroformylation reaction catalyzed by group 9 metals bearing phosphine ligands. Specifically, we introduce "augmented volcano plots" as a means to easily visualize the similarity of each catalyst's complete catalytic cycle energy profile to that of a hypothetical ideal reference profile without relying upon linear scaling relationships. Read More

View Article and Full-Text PDF
September 2020

Stationary distribution and density function expression for a stochastic SIQRS epidemic model with temporary immunity.

Nonlinear Dyn 2021 Jun 8:1-25. Epub 2021 Jun 8.

Nonlinear Analysis and Applied Mathematics(NAAM)-Research Group, Department of Mathematics, King Abdulaziz University, Jeddah, Saudi Arabia.

Recently, considering the temporary immunity of individuals who have recovered from certain infectious diseases, Liu et al. (Phys A Stat Mech Appl 551:124152, 2020) proposed and studied a stochastic susceptible-infected-recovered-susceptible model with logistic growth. For a more realistic situation, the effects of quarantine strategies and stochasticity should be taken into account. Read More

View Article and Full-Text PDF

Photoperiod-induced alterations in biomarkers of oxidative stress and biochemical pathways in rats of different ages: Focus on individual physiological reactivity.

Chronobiol Int 2021 Jun 14:1-19. Epub 2021 Jun 14.

Department of Ecology and Nature Protection, T.G. Shevchenko National University "Chernihiv Collegium", Chernihiv, Ukraine.

Effects of photoperiodicity caused by both the age and individual physiological reactivity estimated by resistance to hypobaric hypoxia on the levels of lipid peroxidation, protein oxidation (aldehydic and ketonic derivatives), total antioxidant capacity, activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase), and biochemical parameters of aerobic and anaerobic pathways in hepatic tissue depending on the blood melatonin level were studied. The study was carried out on 96 6- and 21-month-old male rats divided into hypoxia resistance groups (LR, low resistance, HR, high resistance). The analyses were conducted at four photoperiods: winter (January), spring (March), summer (July), and autumn (October). Read More

View Article and Full-Text PDF

Structural Comparison of Diplonemid Communities around the Izu Peninsula, Japan.

Microbes Environ 2021 ;36(2)

Deep-Sea Biodiversity Research Group, Research Institute for Global Change, Japan Agency for Marine-Earth Science and Technology (JAMSTEC).

Diplonemea (diplonemids) is one of the most abundant and species-rich protist groups in marine environments; however, their community structures among local and seasonal samples have not yet been compared. In the present study, we analyzed four diplonemid community structures around the Izu Peninsula, Japan using barcode sequences amplified from environmental DNA. These sequences and the results of statistical analyses indicated that communities at the same site were more similar to each other than those in the same season. Read More

View Article and Full-Text PDF
January 2021

Conservative versus tailored surgical treatment in patients with first time lateral patella dislocation: a randomized-controlled trial.

J Orthop Surg Res 2021 Jun 13;16(1):378. Epub 2021 Jun 13.

CLARAHOF Orthopaedics, Merian-Iselin-Hospital - Swiss Olympic Medical Center, Clarahofweg 19a, 4058, Basel, Switzerland.

Background: Patellar instability has a high incidence and occurs particularly in young and female patients. If the patella dislocates for the first time, treatment is usually conservative. However, this cautious approach carries the risk of recurrence and of secondary pathologies such as osteochondral fractures. Read More

View Article and Full-Text PDF

EXPRESS: Serum Carbohydrate Antigen72-4 levels decrease with age in females but not males in Beijing, China.

Ann Clin Biochem 2021 Jun 12:45632211026961. Epub 2021 Jun 12.

Wangjing Hospital, China Academy of Chinese Medical Sciences, Department of Clinical Laboratory, Beijing, China.

Objective: Carbohydrate antigen 72-4 (CA72-4) is widely used in the diagnosis and monitoring of many cancers. However, there are few studies on the differences of CA72-4 levels in terms of age and gender.

Methods: 10957 healthy subjects were divided into two groups according to gender and three age groups. Read More

View Article and Full-Text PDF

Exact sequential test for clinical trials and post-market drug and vaccine safety surveillance with Poisson and binary data.

Stat Med 2021 Jun 13. Epub 2021 Jun 13.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

In sequential analysis, hypothesis testing is performed repeatedly in a prospective manner as data accrue over time to quickly arrive at an accurate conclusion or decision. In this tutorial paper, detailed explanations are given for both designing and operating sequential testing. We describe the calculation of exact thresholds for stopping or signaling, statistical power, expected time to signal, and expected sample sizes for sequential analysis with Poisson and binary type data. Read More

View Article and Full-Text PDF

Medial patellofemoral ligament reconstruction with and without trochleoplasty for patients with patella instability-correlation of trochlear dysplasia and patient outcome, classification and outcome measure in the past decade-a systematic review.

Eur J Orthop Surg Traumatol 2021 Jun 12. Epub 2021 Jun 12.

Consortium for Clinical Research and Innovation, Singapore Clinical Research Institute, Singapore, Singapore.

Purpose: The primary aim of the study is to compare the patient outcome in medial patellofemoral ligament reconstruction (MPFLR) or MPFLR concurrent with trochleoplasty (MPFLR + TP) and correlate it with the degree of trochlear dysplasia (TD). The secondary aim is to review TD classification, outcome measure, chronological and geographical trend of such studies in the past decade.

Methods: A systemic review of the literature in the past decade on studies of patients with patella instability and underwent either a MPFLR or MPFLR + TP. Read More

View Article and Full-Text PDF

Effects of Hip Flexion on Knee Extension and Flexion Isokinetic Angle-Specific Torques and HQ-Ratios.

Sports Med Open 2021 Jun 12;7(1):41. Epub 2021 Jun 12.

Institute of Movement and Training Science I, University of Leipzig, Jahnallee 59, 04109, Leipzig, Germany.

Background And Methods: During isokinetic knee strength testing, the knee flexion angles that correspond to the measured torque values are rarely considered. Additionally, the hip flexion angle during seated testing diverges from that in the majority of daily life and sporting activities. Limited information concerning the influence of hip angle, muscle contraction mode, and velocity on the isokinetic knee strength over the entire range of motion (ROM) is available. Read More

View Article and Full-Text PDF

Efficacy of exercise-based interventions in preventing falls among community-dwelling older persons with cognitive impairment: is there enough evidence? An updated systematic review and meta-analysis.

Age Ageing 2021 Jun 11. Epub 2021 Jun 11.

Oregon Research Institute, Eugene, OR 97403, USA.

Objective: Exercise prevents falls in the general older population, but evidence is inconclusive for older adults living with cognitive impairment. We performed an updated systematic review and meta-analysis to assess the potential effectiveness of interventions for reducing falls in older persons with cognitive impairment.

Methods: PubMed, EMBASE, CINAHL, Scopus, CENTRAL and PEDro were searched from inception to 10 November 2020. Read More

View Article and Full-Text PDF

Comparison of Aortic Gradient and Ventricular Mass after Valve Replacement for Aortic Stenosis with Rapid Deployment, Sutureless, and Conventional Bioprostheses.

Cardiology 2021 Jun 11:1-11. Epub 2021 Jun 11.

Department of Cardiovascular Surgery, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Murcia, Spain.

Background: The use of rapid deployment and sutureless aortic prostheses is increasing. Previous reports have shown promising results on haemodynamic performance and mortality rates. However, the impact of these bioprostheses on left ventricular mass (LVM) regression remains unknown. Read More

View Article and Full-Text PDF

Comparison of the Effects of Hepatic Steatosis on Monoexponential DWI, Intravoxel Incoherent Motion Diffusion-weighted Imaging and Diffusion Kurtosis Imaging.

Acad Radiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Biomedical Engineering, Hanyang University, Seoul, Korea. Electronic address:

Rationale And Objectives: Diffusion-weighted imaging (DWI) techniques have drawn attention for their capability of staging hepatic fibrosis. However, the diagnostic performance of DWI for hepatic fibrosis might be affected by hepatic steatosis because hepatic steatosis and fibrosis may have a similar effect on diffusion/perfusion parameters. Therefore, the purpose of our study is to investigate the effect of hepatic steatosis on DWI parameters. Read More

View Article and Full-Text PDF

Correction pen as a hydrophobic/lipophobic barrier plotter integrated with paper-based chips and a mini UV-torch to implement all-in-one device for determination of carbazochrome.

Anal Chim Acta 2021 Aug 24;1172:338684. Epub 2021 May 24.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt; Department of Analytical Chemistry for Pharmaceuticals, Course of Pharmaceutical Sciences, Graduate School of Biomedical Science, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan. Electronic address:

The design of a cheap, simple, and handy sensing system for rapid quantitation of pharmaceuticals becomes mandatory to ease drug development procedures, quality control, health care, etc. This work describes a simple, innovative, and easily manufactured paper-based device using a correction pen as a plotter for hydrophobic/lipophobic barriers and graphene quantum dots for recognition and quantification of the hemostatic drug carbazochrome, via fluorescence turn-off mechanism mediated by the inner filter effect. A smartphone-based all-in-one device fitted with an inexpensive 365 nm flashlight as a UV light source and a free image processing software was developed for rapid and reliable interpretation of the fluorescence change from the paper-based device upon introduction of the drug. Read More

View Article and Full-Text PDF

A practical guide to estimating the light extinction coefficient with nonlinear models-a case study on maize.

Plant Methods 2021 Jun 12;17(1):60. Epub 2021 Jun 12.

Department of Agronomy, Kansas State University, 1712 Claflin Rd, Manhattan, KS, 66506, USA.

Background: The fraction of intercepted photosynthetically active radiation (fPARi) is typically described with a non-linear function of leaf area index (LAI) and k, the light extinction coefficient. The parameter k is used to make statistical inference, as an input into crop models, and for phenotyping. It may be estimated using a variety of statistical techniques that differ in assumptions, which ultimately influences the numerical value k and associated uncertainty estimates. Read More

View Article and Full-Text PDF

Viral loads, lymphocyte subsets and cytokines in asymptomatic, mildly and critical symptomatic patients with SARS-CoV-2 infection: a retrospective study.

Virol J 2021 Jun 12;18(1):126. Epub 2021 Jun 12.

Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province, 238 East Road of Jingshi, Jinan, 250014, Shandong, People's Republic of China.

Background: Tens of million cases of coronavirus disease-2019 (COVID-19) have occurred globally. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attacks the respiratory system, causing pneumonia and lymphopenia in infected individuals. The aim of the present study is to investigate the laboratory characteristics of the viral load, lymphocyte subset and cytokines in asymptomatic individuals with SARS-CoV-2 infection in comparison with those in symptomatic patients with COVID-19. Read More

View Article and Full-Text PDF

Identifying counties at risk of high overdose mortality burden during the emerging fentanyl epidemic in the USA: a predictive statistical modelling study.

Lancet Public Health 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, University of California, San Diego, CA, USA.

Background: The emergence of fentanyl around 2013 represented a new, deadly stage of the opioid epidemic in the USA. We aimed to develop a statistical regression approach to identify counties at the highest risk of high overdose mortality in the subsequent years by predicting annual county-level overdose death rates across the contiguous USA and to validate our approach against observed overdose mortality data collected between 2013 and 2018.

Methods: We fit mixed-effects negative binomial regression models to predict overdose death rates in the subsequent year for 2013-18 for all contiguous state counties in the USA (ie, excluding Alaska and Hawaii). Read More

View Article and Full-Text PDF