403,498 results match your criteria statistical analysis


Efficacy and safety of photodynamic therapy mediated by 5-aminolevulinic acid for the treatment of cervical intraepithelial neoplasia 2: a single-center, prospective, cohort Study.

Photodiagnosis Photodyn Ther 2021 Aug 1:102472. Epub 2021 Aug 1.

Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191, 49 North Garden Rd., Haidian District, Beijing, China. Electronic address:

Background Photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (5-ALA) is a possible minimally-invasive treatment for cervical intraepithelial neoplasia (CIN). The present study was carried out to investigate the effect of 5-ALA-PDT on CIN2 and the influencing factors of 5-ALA-PDT. Methods Patients diagnosed as CIN2 who met the inclusion criteria were enrolled in this study sequentially from January 2019 to April 2020. Read More

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Frequency of auto-antibodies of type 1 diabetes in adult patients with celiac disease.

J Clin Lab Anal 2021 Aug 4:e23941. Epub 2021 Aug 4.

Laboratory of Immunology, Farhat Hached University Hospital of Sousse, Sousse, Tunisia.

Both celiac disease (CD) and type 1 diabetes (T1D) are autoimmune diseases resulting from a complex interplay between genetic susceptibility and environmental factors.

Aim: In this retrospective study, we determined the frequency of auto-antibodies of T1D in adult patients with active CD.

Materials And Methods: Eighty adult patients with active CD were included in our study. Read More

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Predictors of recovery rate among undernourished HIV-positive adults treated with ready-to-use therapeutic food at Debre Markos Comprehensive Specialized Hospital: A retrospective cohort study.

PLoS One 2021 4;16(8):e0255465. Epub 2021 Aug 4.

Department of Nursing, College of Health Science, Debre Markos University, Debre Markos, Ethiopia.

Background: Nutritional support is becoming more widely acknowledged as a crucial component of the key package of care for HIV/AIDS patients. This nutritional support is exceptionally important for patients in sub-Saharan Africa, including Ethiopia, where HIV/AIDS is very prevalent. However, there is a lack of evidence on the recovery rate and predictors at the study site and at large in Ethiopia. Read More

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Menstrual hygiene practice among female adolescents and its association with knowledge in Ethiopia: A systematic review and meta-analysis.

PLoS One 2021 4;16(8):e0254092. Epub 2021 Aug 4.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: Previous studies on menstrual hygiene practice were largely inconsistent and single national evidence is required. Thus, this study aimed to assess the pooled prevalence of menstrual hygiene and its association with knowledge about menstrual hygiene among female adolescents in Ethiopia.

Methods: The study was designed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-2015 Guidelines). Read More

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Survival and Predictive Factors of Chemotherapy With FOLFIRINOX as First-Line Therapy in Metastatic Pancreatic Cancer: A Retrospective Multicentric Analysis.

Pancreas 2021 Aug 3. Epub 2021 Aug 3.

From the Department of Gastroenterology, Hautepierre Hospital, Strasbourg, France Inserm 1113 IRFAC, University of Strasbourg Department of Oncology, ICANS, Strasbourg Department of Gastroenterology, Emile Muller Hospital, Mulhouse.

Objectives: The use of FOLFIRINOX (a combination of oxaliplatin, irinotecan, fluorouracil, and leucovorin) is one of the therapeutic standards in pancreatic adenocarcinoma. We analyzed progression-free survival (PFS) and overall survival (OS) and their predictive factors in patients treated with FOLFIRINOX as first-line therapy in metastatic pancreatic cancer.

Methods: This multicenter retrospective analysis included patients treated with FOLFIRINOX between 2011 and 2015. Read More

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Structured Reporting of Computed Tomography Examinations in Post-Lung Transplantation Patients.

J Comput Assist Tomogr 2021 Aug 2. Epub 2021 Aug 2.

From the Department of Radiology Department of Internal Medicine V-Pulmonology, University Hospital, LMU Munich Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Helmholtz Center Munich Department of Radiology, Asklepios Lung Center Munich-Gauting, Munich, Germany.

Objective: The aim of this study was to evaluate the benefits and potential of structured reports (SR) for chest computed tomography after lung transplantation.

Methods: Free-text reports (FTR) and SR were generated for 49 computed tomography scans. Clinical routine reports were used as FTR. Read More

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Mucous Fistula Refeeding Promotes Earlier Enteral Autonomy in Infants with Small Bowel Resection.

J Pediatr Gastroenterol Nutr 2021 Aug 3. Epub 2021 Aug 3.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Emory University - Children's Healthcare of Atlanta at Egleston, Atlanta, GA Department of Pediatrics, Division of Pediatric Gastroenterology, Emory University School of Medicine, Atlanta, GA Department of Surgery, Division of Pediatric Surgery, Emory University School of Medicine, Atlanta, GA Department of Pediatrics, Pediatrics Biostatistics Core, Emory University School of Medicine, Atlanta, GA.

Objective: Infants requiring intestinal resection due to necrotizing enterocolitis (NEC) or small bowel atresia (SBA) may benefit from mucous fistula refeeding (MFR) of enterostomy output to improve nutrition and bowel adaptation before reanastomosis. Previous series demonstrated improved outcomes with MFR but did not account for varied patient characteristics as potential sources of bias. We performed a cohort analysis using multivariable adjusted models to compare outcomes of patients with and without MFR. Read More

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A connection between pattern classification by machine learning and statistical inference with the General Linear Model.

IEEE J Biomed Health Inform 2021 Aug 4;PP. Epub 2021 Aug 4.

A connection between the general linear model (GLM) with frequentist statistical testing and machine learning (MLE) inference is derived and illustrated. Initially, the estimation of GLM parameters is expressed as a Linear Regression Model (LRM) of an indicator matrix; that is, in terms of the inverse problem of regressing the observations. Both approaches, i. Read More

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A Variable Selection Algorithm for Creating Replicable Factor Structures.

Multivariate Behav Res 2021 Aug 4:1-23. Epub 2021 Aug 4.

University of Texas at San Antonio.

Exploratory and confirmatory factor analyses are commonly employed to identify and explore underlying factor structures. Unfortunately, when variable selection is involved, results often fluctuate across studies making it difficult to determine the "best" and most replicable factor structure. This study proposes a new factor analysis variable selection algorithm called the (RFAS) that incorporates sound statistical and psychometric practices when selecting the final factor structure, while simultaneously examining the observed variables and factor structures replicability. Read More

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Implementing a new dose-response model for estimating infection probability of based on the key events dose-response framework.

Appl Environ Microbiol 2021 Aug 4:AEM0129921. Epub 2021 Aug 4.

Graduate School of Agricultural Science, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.

Understanding the dose-response relationship between ingested pathogenic bacteria and infection probability is a key factor for appropriate risk assessment of foodborne pathogens. The objectives of this study were to develop and validate a novel mechanistic dose-response model for and simulate the underlying mechanism of foodborne illness during digestion. Bacterial behavior in the human gastrointestinal environment, including survival at low pH in the gastric environment after meals, transition to intestines, and invasion to intestinal tissues, was described using a Bayesian statistical model based on the reported experimental results of each process while considering physical food types (liquid or solid) and host age (young adult or elderly). Read More

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Pain knowledge of patients and family caregivers as predictors of pain management outcomes in cancer patients: a multicenter study in China.

Support Care Cancer 2021 Aug 4. Epub 2021 Aug 4.

Nursing Department, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian district, Beijing, 100142, China.

Purpose: The purposes of this study were to evaluate the current situation of pain management outcomes, patients' pain knowledge, and family caregivers' pain knowledge in China and explore the impact of pain knowledge of patients and family caregivers on pain management outcomes.

Methods: A total of 410 patient-family caregiver dyads were assessed by Brief Pain Inventory (BPI), the Pain Knowledge subscales of Patient Pain Questionnaire (PPQ), and Family Pain Questionnaire (FPQ). The difference in pain management outcomes was analyzed using bivariate analysis first, and then variables with statistical significance in bivariate analysis were included in multivariable linear regression analysis. Read More

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Metabolomics in Diabetic Retinopathy: A Systematic Review.

Invest Ophthalmol Vis Sci 2021 Aug;62(10)

School of Public Health, Medical College of Soochow University, Suzhou, China.

Purpose: Diabetic retinopathy (DR), a common microvascular complication of diabetes, is the leading cause of acquired blindness in the working-age population. Individuals with diabetes still develop DR despite appropriate glycemic and blood pressure control, highlighting the pressing need to identify useful biomarkers for risk stratification. The purpose of this review is to systematically summarize potential metabolic biomarkers and pathways of DR, which could facilitate developing an understanding of the disease mechanisms, as well as new therapeutic measures. Read More

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[Evaluative Matrix of the Longitudinal Bond in primary healthcare: statistical validation in a health territory in the city of Rio de Janeiro, Brazil].

Cad Saude Publica 2021 28;37(7):e00190220. Epub 2021 Jul 28.

Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

In keeping with the process of institutionalization of evaluation of primary healthcare in Brazil, we developed the Evaluative Matrix of the Longitudinal Bond (MAVIL in Portuguese), a simple and concise evaluative tool. MAVIL is structured according to three dimensions in the concept of longitudinal bond: Dimension 1 - recognition of the basic health unit (UBS in Portuguese) as a regular source of care, Dimension 2 - healthcare worker/patient interpersonal relationship, and Dimension 3 - continuity of information. The instrument consists of a structured set of 12 criteria, 20 indicators and respective questions, and verification items submitted to various validation stages. Read More

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Analysis of decannulation time and oral intake recovery in oral cancer patients.

Codas 2021 2;33(4):e20190236. Epub 2021 Aug 2.

Departamento de Fonoaudiologia, Faculdade de Medicina, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil.

Purpose: to analyze the time of decannulation and oral diet release of patients undergoing oral cancer surgery at the Hospital Alberto Cavalcante and to verify which factors are associated with the time of decannulation and oral diet release.

Methods: an observational study of the database of 33 adult patients surgically treated with oral cancer and served between 2012 and 2017. The socio-demographic variables (age and gender) and clinical variables (type of surgery, surgical extension, type of reconstruction, clinical conditions and times of decannulation and reintroduction of the oral route) were collected through electronic medical records analysis. Read More

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Individual and Combined Performance of Indicators of Overall and Central Obesity to Estimate Coronary Risk in ELSA-Brasil Participants.

Arq Bras Cardiol 2021 Jul 30. Epub 2021 Jul 30.

Universidade Federal da Bahia - Instituto de Saúde Coletiva, Salvador, BA - Brasil.

Background: Anthropometric indicators have been used in clinical practice and epidemiological studies for screening of health risk factors.

Objectives: To evaluate the individual discriminatory power of body adiposity index (BAI), body mass index (BMI), waist circumference (WC) and waist-hip-ratio (WHR) to identify individuals at risk for coronary heart disease and to evaluate whether combinations of anthropometric indicators of overall obesity with indicators of central obesity improve predictive ability in adults.

Methods: A total of 15,092 participants (54. Read More

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Exploring the Expression Differences Between Professionals and Laypeople Toward the COVID-19 Vaccine: A Text Mining Approach.

J Med Internet Res 2021 Aug 1. Epub 2021 Aug 1.

School of Journalism and Communication, Tsinghua University, 30 Shuangqing Road, Haidian District, Beijing, Beijing, CN.

Background: COVID-19 is still rampant all over the world. Until now, the COVID-19 vaccine is the most promising measure to subdue contagion and achieve herd immunity. However, public vaccination intention is suboptimal. Read More

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Leadership and community healthcare reform: a study using the Competing Values Framework (CVF).

Leadersh Health Serv (Bradf Engl) 2021 Aug;ahead-of-print(ahead-of-print)

School of Nursing and Midwifery, Trinity College, The University of Dublin, Dublin, Ireland.

Purpose: The Health Service Executive in Ireland seeks to further develop healthcare in the community. It has identified that this reform requires developing leadership amongst the staff. This study aims to identify what kind of leadership staff in community healthcare observe in practice and their leadership preferences. Read More

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Core competencies and challenges among nurses transitioning into positions of leadership - a Caribbean perspective.

Leadersh Health Serv (Bradf Engl) 2021 Aug;ahead-of-print(ahead-of-print)

Director WHO/PAHO Collaborating Centre, Dalhousie University, Nova Scotia Health Authority, Centre for Clinical Research, Halifax, Canada.

Purpose: Nurses are a significant part of the professional workforce, but leaders may be promoted without the requisite competencies. This study aims to explore the perspectives of nurse managers about the core competencies necessary for promotion as leaders in health.

Design/methodology/approach: This was a mixed-methods study that targeted nurses ( = 126) who were promoted in four Caribbean countries over the past five years. Read More

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Operational characteristics of generalized pairwise comparisons for hierarchically ordered endpoints.

Pharm Stat 2021 Aug 3. Epub 2021 Aug 3.

International Drug Development Institute, Louvain-la-Neuve, Belgium.

The method of generalized pairwise comparisons (GPC) is a multivariate extension of the well-known non-parametric Wilcoxon-Mann-Whitney test. It allows comparing two groups of observations based on multiple hierarchically ordered endpoints, regardless of the number or type of the latter. The summary measure, "net benefit," quantifies the difference between the probabilities that a random observation from one group is doing better than an observation from the opposite group. Read More

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Predictors of postoperative recurrence in patients with non-metastatic pT3a renal cell carcinoma.

Int J Urol 2021 Aug 3. Epub 2021 Aug 3.

Department of, Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.

Objective: To analyze the effect of patterns of extrarenal tumor extension with other pathological factors on postoperative recurrence in patients with non-metastatic pT3a renal cell carcinoma.

Methods: We retrospectively reviewed 587 non-metastatic renal cell carcinoma patients who underwent radical surgery between 2006 and 2017 at Kansai Medical University Hospital, Hirakata, Osaka, Japan. We extracted a subset of 114 patients with pT3a of predominant histological types: 93 with clear cell renal cell carcinoma (81. Read More

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"Long-term statistical assessment of meteorological indicators and COVID-19 outbreak in hot and arid climate, Bahrain".

Environ Sci Pollut Res Int 2021 Aug 4. Epub 2021 Aug 4.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, People's Republic of China.

The COVID-19 pandemic has significantly impacted the global lifestyle, and the spreading of the virus is unprecedented. This study is aimed at assessing the association between the meteorological indicators such as air temperature (°C), relative humidity (%), wind speed (w/s), solar radiation, and PM with the COVID-19 infected cases in the hot, arid climate of Bahrain. Kendall and Spearman rank correlation coefficients and quantile on quantile regression were used as main econometric analysis to determine the degree of the relationship between related variables. Read More

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Hydrogeochemistry, identification of hydrogeochemical evolution mechanisms, and assessment of groundwater quality in the southwestern Ordos Basin, China.

Environ Sci Pollut Res Int 2021 Aug 3. Epub 2021 Aug 3.

School of Engineering and Technology, China University of Geosciences (Beijing), Beijing, 100083, People's Republic of China.

Understanding the evolution process of hydrogeochemistry and groundwater quality is essential for water supply and health in the southwestern Ordos Basin, where groundwater is a vital source for drinking. This study systematically illustrates the hydrogeochemical characteristics and evolution mechanism based on the groundwater samples (n = 67) collected from Loess area by integrating multivariate statistical methods and hydrogeochemical methods. Furthermore, the entropy water quality index (EWQI) and water quality indices combined with spatial analysis were employed to evaluate the suitability of groundwater for drinking and irrigation purposes and analyze the spatial variation of water quality. Read More

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The efficacy and safety of rivaroxaban in coronary artery disease patients with heart failure and sinus rhythm: a systematic review and meta-analysis.

Eur J Clin Pharmacol 2021 Aug 3. Epub 2021 Aug 3.

Department of Pharmacy, the Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

Purpose: To explore the efficacy and safety of rivaroxaban in patients with coronary artery disease (CAD), heart failure (HF) and sinus rhythm (SR).

Methods: Comprehensive literature searches were conducted using the PubMed, Cochrane Library, Embase, CNKI and Wanfang databases from inception to February 2021. Randomized controlled trials (RCTs) focusing on the efficacy and safety of new oral anticoagulant (NOAC) therapy in CAD and HF patients in SR were eligible. Read More

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Effectiveness of collaboration in older adults: do interprofessional teams improve nutritional status more compared to usual care?

Fam Pract 2021 Aug 4. Epub 2021 Aug 4.

Health Pediatric Department, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.

Background: Ageing is accompanied by many changes that make it more difficult for nutritional needs to be met. Management of malnutrition in older adults requires collaboration among multiple clinical disciplines.

Objective: This study aimed to determine the effectiveness of interprofessional collaboration and practice (IPCP) implementation for older adults with malnutrition compared to usual care. Read More

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Latent Factor Analysis of the PROMIS and Single Assessment Numeric Evaluation in Patients Undergoing Shoulder Surgery.

Mil Med 2021 Aug 4. Epub 2021 Aug 4.

Department of Surgery Division of Orthopaedics, USU-Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.

Introduction: Patient-reported outcomes (PROs) are reporting tools that quantify patients' perceptions of their mental and physical health. Many PROs may inadvertently measure the same or overlapping theoretical constructs (e.g. Read More

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Standardized Neurodevelopmental Surveillance of High-risk Infants Using Telehealth: Implementation Study during COVID-19.

Pediatr Qual Saf 2021 Jul-Aug;6(4):e439. Epub 2021 Jul 28.

Neonatal Network, Nationwide Children's Hospital, Columbus, Ohio.

Introduction: Neurodevelopmental surveillance is critical for high-risk infants following neonatal intensive care discharge and is traditionally performed in-person. COVID-19 interruption of regular surveillance necessitated a rapid development of telehealth models for effective and standardized care.

Methods: We used implementation science and lean methodologies to develop an effective telehealth neurodevelopmental surveillance program for high-risk infants. Read More

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Knowledge of neonatal danger signs and associated factors among mothers attending pediatric immunization clinics in Gidan District Health Centers, North Wollo, Ethiopia.

Heliyon 2021 Jul 12;7(7):e07553. Epub 2021 Jul 12.

Department of Pediatric Nursing, St. Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: The majority of neonatal deaths in developing countries occurred at home due to late recognition of the signs of serious illness by parents or caregivers. In Ethiopia, besides the attempts made to scale-up the maternal and child health services, maternal knowledge of neonatal danger signs is low. Therefore, this study aimed to assess the knowledge of neonatal danger signs and associated factors among mothers attending pediatric immunization clinics in Gidan district health centers, North Wollo, Ethiopia. Read More

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Morphological diversity of northeastern fat-tailed and northwestern thin-tailed indigenous sheep breeds of Ethiopia.

Heliyon 2021 Jul 3;7(7):e07472. Epub 2021 Jul 3.

Debre Birhan Agriculture Research Center, Debre Birhan, Ethiopia.

Characterization of indigenous sheep breeds using morphological traits is essential for designing rational conservation and improvement strategies. This study was conducted to check the morphological diversity of three fat-tailed and three thin-tailed indigenous sheep breeds of Ethiopia. The phenotypic traits such as live body weight and linear body measurements (body length, wither height, chest girth, chest depth, rump height, rump length, ear length, tail length, and pelvic width) were measured and used for analysis. Read More

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