84,722 results match your criteria statistical analyses

Towards standardization of lymph-node ratio classifications: Validation and comparison of different lymph node ratio classifications for predicting prognosis of patients with resected gastric cancer.

Ann Diagn Pathol 2021 Mar 31;52:151738. Epub 2021 Mar 31.

Complutense University of Madrid, Av. Séneca 2, 28040 Madrid, Spain; Hospital General Universitario Gregorio Marañón, c/ Dr. Esquerdo n° 46, 28007 Madrid, Spain.

Introduction: The TNM staging system is the main prognostic tool for GC, but the number of metastatic lymph nodes (LN) can be affected by surgical, pathological, tumor or host factors. Several authors have shown that lymph node ratio (LNR) may be superior to TNM staging in GC. However, cut-off values vary between studies and LNR assessment is not standardized. Read More

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Analysis of volatiles organic compounds in Venice lagoon water reveals COVID 19 lockdown impact on microplastics and mass tourism related pollutants.

Teresa Cecchi

Sci Total Environ 2021 Apr 7;783:146951. Epub 2021 Apr 7.

ITT MONTANI, Via Montani 7, 63900 Fermo, FM, Italy.. Electronic address:

The Lagoon of Venice is a continuously evolving ecosystem that rapidly responds to anthropic stressors. The UNESCO World Heritage site "Venice and its Lagoon", is one of the top tourist destinations in the world. Mass tourism increases marine litter, water traffic emissions, solid waste, and sewage release. Read More

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Surgical outcomes of different approaches in robotic assisted thyroidectomy for thyroid cancer: A systematic review and Bayesian network meta-analysis.

Int J Surg 2021 Apr 14:105941. Epub 2021 Apr 14.

Center of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, PR China. Electronic address:

Background: The aim of the study was to assess the feasibility, safety, and potential benefits of four approaches of robotic assisted thyroidectomy (RT). The approaches mentioned above are also compared with traditional open thyroidectomy (OPEN).

Materials And Methods: Medline, Embase, Cochrane library (CENTRAL) and Web of Science databases were searched up to 13 Dec, 2019. Read More

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Comparison of A-Scan ultrasonography and the Lenstar optical biometer in Guinea pig eyes.

Exp Eye Res 2021 Apr 14:108578. Epub 2021 Apr 14.

Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China. Electronic address:

Objective: To compare the biometric parameters provided by A-scan ultrasonography and the Lenstar optical biometer in guinea pig eye, including anterior segment depth (ASD), lens thickness (LT), vitreous chamber depth (VCD), and axial length (AL), and differences of them between treated form deprivation (FD) eyes and untreated fellow eyes after 4 weeks of FD.

Methods: Three-week-old guinea pigs (N = 41) were subjected to biometric measurements before monocular FD (baseline) and after a 4-week FD. Statistical analyses included within-subject standard deviation (SD), coefficient of variation (CV), and intraclass correlation coefficient (ICC), used to evaluate repeatability for both the A-scan ultrasonography and the Lenstar individually, and correlation and Bland-Altman analyses were used to assess agreement between the two methods. Read More

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Molecular Analysis of Targeted Insecticide Resistance Gene Mutations in Field-Caught Mosquitos of Medical Importance From Saudi Arabia.

J Med Entomol 2021 Apr 17. Epub 2021 Apr 17.

Public Health Pests Laboratory, Municipality of Jeddah Governorate, Jeddah 21577, Saudi Arabia.

Gene mutations on target sites can be a valuable indicator of the status of insecticide resistance. Jeddah, a global commercial and major port-of-entry city, is bearing the brunt of dengue disease burden in Saudi Arabia. In the current study, six genotypes of three codon combinations (989, 1016, and 1534) were observed on voltage-gated sodium channel (VGSC) gene in Jeddah's Aedes aegypti population, with PGF/PGC as the dominant one. Read More

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Professional development training preferences of occupational therapists working with older adults in Australia: A discrete choice experiment.

Aust Occup Ther J 2021 Apr 16. Epub 2021 Apr 16.

College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

Introduction: Members of the public expect occupational therapists to provide evidence-based practice. Participation in professional development activities is essential to update knowledge and acquire skills to enable delivery of evidence-based assessment and intervention. Therapists commonly choose to participate in professional development through attending training workshops. Read More

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Factors Associated with HIV and Vulnerability Contexts for Women in Brazil.

Arch Sex Behav 2021 Apr 16. Epub 2021 Apr 16.

Department of Collective Health, School of Nursing, Federal University of Rio Grande do Sul, 90620-110, Porto Alegre, Brazil.

The purpose of this study was to identify factors associated with HIV and vulnerability contexts for women in Porto Alegre, Brazil. The participants were 1326 women recruited by complex sampling design, divided into two groups: 640 women with HIV (WLH) and 686 women who did not have HIV (WNLH). Gross and weighted statistical analyses were performed. Read More

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Increasing Volume-Targeted Ventilation Use in the NICU.

Pediatrics 2021 Apr 16. Epub 2021 Apr 16.

Division of Neonatology, School of Medicine, Indiana University, Indianapolis, Indiana.

Background: In preterm infants who require mechanical ventilation (MV), volume-targeted ventilation (VTV) modes are associated with lower rates of bronchopulmonary dysplasia compared with pressure-limited ventilation. Bronchopulmonary dysplasia rates in our NICU were higher than desired, prompting quality improvement initiatives to improve MV by increasing the use of VTV.

Methods: We implemented and tested interventions over a 3-year period. Read More

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Histological evaluation of inferior alveolar nerve injury after osteotomy of mandibular buccal cortex using piezoelectric versus conventional rotary devices: a split-mouth randomised study in rabbits.

Br J Oral Maxillofac Surg 2020 Aug 29. Epub 2020 Aug 29.

Department of Biostatistics and Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran.

Up until now, only a limited number of evidence-based studies with different results has evaluated traumatic nerve injury after maxillofacial surgery using piezoelectric devices versus rotary instruments. The present experiment was performed to evaluate damage to the inferior alveolar nerve (IAN), histologically, after osteotomy of the buccal cortex of the mandible using piezoelectric devices versus surgical handpieces. Forty rabbits underwent bilateral osteotomy of the mandibular buccal cortex. Read More

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Current surgical practice for multi-level degenerative cervical myelopathy: Findings from an international survey of spinal surgeons.

J Clin Neurosci 2021 May 17;87:84-88. Epub 2021 Mar 17.

Division of Neurosurgery, Addenbrooke's Hospital and University of Cambridge, Cambridge, United Kingdom; Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Degenerative cervical myelopathy (DCM) results from compression of the cervical spine cord as a result of age related changes in the cervical spine, and affects up to 2% of adults, leading to progressive disability. Surgical decompression is the mainstay of treatment, but there remains significant variation in surgical approaches used. This survey was conducted in order to define current practice amongst spine surgeons worldwide, as a possible prelude to further studies comparing surgical approaches. Read More

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High prevalence of developmental venous anomaly in adult patients with midline thalamic diffuse gliomas.

J Clin Neurosci 2021 May 11;87:59-65. Epub 2021 Mar 11.

Department of Neurosurgery, West China Hospital, Chengdu, Sichuan Province, PR China. Electronic address:

Objective: This study aimed to assess the prevalence of developmental venous anomaly (DVA) in patients with thalamic glioma. Furthermore, we explored the association between DVA and some important biomarkers, such as IDH1 mutation, and H3K27M mutation.

Patients And Methods: Patients who received tumor resection in West China Hospital between August 2009 and October 2017 were enrolled. Read More

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Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms - Findings from Helsinki Birth Cohort Study.

J Psychosom Res 2021 Apr 10:110488. Epub 2021 Apr 10.

Folkhälsan Research Center, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. Read More

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The effectiveness of PROLOTHERAPY for recalcitrant Medial TIBIAL Stress Syndrome: a prospective consecutive CASE series.

J Foot Ankle Res 2021 Apr 16;14(1):32. Epub 2021 Apr 16.

Centre for Sports and Exercise Medicine, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.

Background: Medial tibial stress syndrome (MTSS) is one of the most common lower leg injuries in sporting populations. It accounts for between 6 and 16% of all running injuries, and up to 53% of lower leg injuries in military recruits. Various treatment modalities are available with varying degrees of success. Read More

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Analysis of single nucleotide polymorphisms in chronic beryllium disease.

Respir Res 2021 Apr 16;22(1):107. Epub 2021 Apr 16.

Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.

Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Read More

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Subjective health complaints in early adolescence reflect stress: A study among adolescents in Western Sweden.

Scand J Public Health 2021 Apr 16:14034948211008555. Epub 2021 Apr 16.

School of Public Health and Community Medicine, Institute of Medicine, Gothenburg University, Gothenburg, Sweden.

Mental health problems are common among Swedish adolescents and are sometimes referred to as 'stress-related'. The overall aim of this study is to do an analysis of subjective health complaints (SHCs) and perceived general stress among adolescents in Sweden, both their prevalence and association, by gender, migration background, family structure and socioeconomic conditions. Data from the baseline (comprising 2283 adolescents aged 13) of the STudy of Adolescence Resilience and Stress (STARS) study in Västra Götaland in Sweden were used. Read More

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The benefit of intravenous thrombolysis prior to mechanical thrombectomy within the therapeutic window for acute ischemic stroke.

Clin Imaging 2021 Apr 5;79:3-7. Epub 2021 Apr 5.

Northwestern University Feinberg School of Medicine, Department of Radiology, 676 N St Clair St, Chicago, IL 60611, United States of America.

The increase in risk for acute ischemic stroke (AIS) with age is well established. If not treated properly and promptly, AIS can result in permanent neurological damage and even death. This literature review assesses the clinical outcomes of AIS patients treated with both intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT) compared to those treated solely with mechanical thrombectomy. Read More

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Urine proteome changes in a chronic unpredictable mild stress (CUMS) mouse model of major depressive disorder.

J Pharm Biomed Anal 2021 Apr 6;199:114064. Epub 2021 Apr 6.

Department of Biochemistry and Molecular Biology, Beijing Normal University, Gene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing, 100875, China. Electronic address:

Major depressive disorder (MDD) is a prevalent complex psychiatric disorder, and there are no effective biomarkers for clinical diagnosis. Urine is not subjected to homeostatic control, allowing it to reflect the sensitive changes that occur in various diseases. In this study, we examined the urine proteome changes in a chronic unpredictable mild stress mouse model of MDD. Read More

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Does participation in ethics discussions have an impact on ethics decision-making? A cross-sectional study among healthcare professionals in paediatric oncology.

Eur J Oncol Nurs 2021 Mar 27;52:101950. Epub 2021 Mar 27.

Childhood Cancer Research Unit, Department of Women's & Children's Health, Karolinska Institutet, Stockholm, Sweden; Paediatric Haematology and Oncology, Astrid Lindgren Children's Hospital, Stockholm, Sweden.

Purpose: The overall aim of this study was to describe perceptions of the decision-making process in relation to participation/non-participation in ethics discussions among healthcare professionals in paediatric oncology.

Methods: Healthcare professionals, working at three paediatric units where ethics discussions where performed answered a study-specific questionnaire focusing on perceptions of involvement, influence, responsibility and understanding of ethics decision-making. Statistical analyses included descriptive statistics, non-parametric paired t-tests and correlation tests. Read More

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Trauma outcomes for blunt and penetrating injuries by mode of transportation and day/night shift.

Am J Emerg Med 2021 Apr 13;48:79-82. Epub 2021 Apr 13.

Department of Surgery, Division of Trauma and Surgical Critical Care, Kendall Regional Medical Center, Miami, FL, USA. Electronic address:

Background: Effective management of trauma patients is dependent on pre-hospital triage systems and proper in-hospital treatment regardless of time of admission. We aim to investigate any differences in adjusted all-cause mortality between day vs. night arrival for adult trauma patients who were transported to the hospital via ground emergency medical services (GEMS) and helicopter emergency medical services (HEMS) and to determine if care/outcomes are inferior when admitted during the night shift as compared to the day shift. Read More

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Association of metabolites with obesity based on two gene variants, MC4R and BDNF.

Biochim Biophys Acta Mol Basis Dis 2021 Apr 13:166144. Epub 2021 Apr 13.

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. Electronic address:

Previous genome-wide association analyses for obesity related genes demonstrated the association of BDNF variant rs6265 and MC4R gene variant rs17782313 with body mass index (BMI). However, the associated metabolite pathways are still behind the curtain. The aimed of current study is to investigate the associations of metabolic changes in obesity with MC4R gene variant rs17782313 and BDNF variant rs6265. Read More

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Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.

Int J Biol Macromol 2021 Apr 13. Epub 2021 Apr 13.

University of Pittsburgh School of Medicine, Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address:

The current COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)shows similar pathology to MERS and SARS-CoV, with a current estimated fatality rate of 1.4%. Open reading frame 10 (ORF10) is a unique SARS-CoV-2 accessory protein, which contains eleven cytotoxic T lymphocyte (CTL) epitopes each of nine amino acids in length. Read More

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Peer influence in adolescent drinking behavior: A meta-analysis of stochastic actor-based modeling studies.

PLoS One 2021 16;16(4):e0250169. Epub 2021 Apr 16.

Department of Sociology, National Research University Higher School of Economics, Saint Petersburg, Russian Federation.

Objectives: To measure the effects of peer influence and peer selection on drinking behavior in adolescence through a rigorous statistical approach designed to unravel these interrelated processes.

Methods: We conducted systematic searches of electronic databases, thesis collections and conference proceedings to identify studies that used longitudinal network design and stochastic actor-oriented modeling to analyze drinking behavior in adolescents. Parameter estimates collected from individual studies were analyzed using multilevel random-effects models. Read More

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Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies.

PLoS One 2021 16;16(4):e0249305. Epub 2021 Apr 16.

Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, United States of America.

Genetic studies have shifted to sequencing-based rare variants discovery after decades of success in identifying common disease variants by Genome-Wide Association Studies using Single Nucleotide Polymorphism chips. Sequencing-based studies require large sample sizes for statistical power and therefore often inadvertently introduce batch effects because samples are typically collected, processed, and sequenced at multiple centers. Conventionally, batch effects are first detected and visualized using Principal Components Analysis and then controlled by including batch covariates in the disease association models. Read More

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Loving-Kindness Meditation vs Cognitive Processing Therapy for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial.

JAMA Netw Open 2021 Apr 1;4(4):e216604. Epub 2021 Apr 1.

Center of Excellence in Substance Addiction Treatment and Education, VA Puget Sound Health Care System, Seattle, Washington.

Importance: Additional options are needed for treatment of posttraumatic stress disorder (PTSD) among veterans.

Objective: To determine whether group loving-kindness meditation is noninferior to group cognitive processing therapy for treatment of PTSD.

Design, Setting, And Participants: This randomized clinical noninferiority trial assessed PTSD and depression at baseline, posttreatment, and 3- and 6-month follow-up. Read More

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Medialization of the Hip's Center with Periacetabular Osteotomy: Validation of Assessment with Plain Radiographs.

Clin Orthop Relat Res 2021 May;479(5):1040-1049

L. M. Fowler, J. J. Nepple, C. Devries, J. C. Clohisy, Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Background: Periacetabular osteotomy (PAO) increases acetabular coverage of the femoral head and medializes the hip's center, restoring normal joint biomechanics. Past studies have reported data regarding the degree of medialization achieved by PAO, but measurement of medialization has never been validated through a comparison of imaging modalities or measurement techniques. The ilioischial line appears to be altered by PAO and may be better visualized at the level of the inferior one-third of the femoral head, thus, an alternative method of measuring medialization that begins at the inferior one-third of the femoral head may be beneficial. Read More

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The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior.

Purinergic Signal 2021 Apr 16. Epub 2021 Apr 16.

Laboratório de Neurobiologia da Dor e Inflamação, Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC, 88040-900, Brazil.

The role of peripheral adenosine receptors in pain is a controversial issue and seems to be quite different from the roles of spinal and central adenosine receptors. The present study is aimed at clarifying the role of these receptors in peripheral nociception. To clarify this, studies were done on Swiss mice with adenosine receptor agonists and antagonists. Read More

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Psychopathological Syndromes Across Affective and Psychotic Disorders Correlate With Gray Matter Volumes.

Schizophr Bull 2021 Apr 16. Epub 2021 Apr 16.

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Introduction: More than a century of research on the neurobiological underpinnings of major psychiatric disorders (major depressive disorder [MDD], bipolar disorder [BD], schizophrenia [SZ], and schizoaffective disorder [SZA]) has been unable to identify diagnostic markers. An alternative approach is to study dimensional psychopathological syndromes that cut across categorical diagnoses. The aim of the current study was to identify gray matter volume (GMV) correlates of transdiagnostic symptom dimensions. Read More

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The topology of ventricle surfaces and its application in the analysis of hydrocephalic ventricles: a proof-of-concept study.

Neuroradiology 2021 Apr 15. Epub 2021 Apr 15.

Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Purpose: The cerebral ventricles deform in a non-uniform fashion in response to increased CSF volume and/or pressure in hydrocephalic syndromes. Current research is focused on volumetric analyses, while topological analysis of ventricular surfaces remains understudied. We developed a method of quantitatively modeling the curvature of ventricular surfaces to analyze changes in ventricular surfaces in normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD), using the left frontal horn as an example. Read More

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Similarities and differences between study designs in short- and long-term outcomes of laparoscopic versus open low anterior resection for rectal cancer: A systematic review and meta-analysis of randomized, case-matched, and cohort studies.

Ann Gastroenterol Surg 2021 Mar 21;5(2):183-193. Epub 2020 Nov 21.

Department of Surgery Kyoto University Graduate School of Medicine Kyoto Japan.

Aim: Randomized controlled trials (RCT) are the gold standard in surgical research, and case-matched studies, such as studies with propensity score matching, are expected to serve as an alternative to RCT. Both study designs have been used to investigate the potential superiority of laparoscopic surgery to open surgery for rectal cancer, but it remains unclear whether there are any differences in the findings obtained using these study designs. We aimed to examine similarities and differences between findings from different study designs regarding laparoscopic surgery for rectal cancer. Read More

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Longitudinal Uses of the Population Assessment of Tobacco and Health Study.

Tob Regul Sci 2021 Jan;7(1):3-16

Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Objectives: The Population Assessment of Tobacco and Health (PATH) Study is a nationally representative study of the US population on tobacco use and its effects on health, with 3 waves of data collection between 2013 and 2016. Prior work described the methods of the first wave. In this paper, we describe the methods of the subsequent 2 waves and provide recommendations for how to conduct longitudinal analyses of PATH Study data. Read More

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January 2021