40,818 results match your criteria state oxidative


Reduction of cytotoxicity and DNA double-strand break effects of wastewater by ferrate(VI): Roles of oxidation and coagulation.

Water Res 2021 Sep 15;205:117667. Epub 2021 Sep 15.

Environmental Simulation and Pollution Control State Key Joint Laboratory, State Environmental Protection Key Laboratory of Microorganism Application and Risk Control (SMARC), School of Environment, Tsinghua University, Beijing 100084, China.

Ferrate(VI) (Fe(VI)) can oxidize individual pollutants, but the pollutant oxidation does not necessarily result in toxicity reduction. Besides, Fe(VI) resultant Fe(III) particles has previously been used to remove heavy metals, but its influence on organic matter and toxicity of wastewater is unknown. This study investigated influence of Fe(VI) on the cytotoxicity and DNA double-strand break (DSB) effects of secondary effluents from wastewater treatment plants to Chinese hamster ovary cells. Read More

View Article and Full-Text PDF
September 2021

Metabolomic insights into the inhibition mechanism of methyl N-methylanthranilate: A novel quorum sensing inhibitor and antibiofilm agent against Pseudomonas aeruginosa.

Int J Food Microbiol 2021 Sep 11;358:109402. Epub 2021 Sep 11.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

The quorum sensing (QS) inhibition effect of methyl N-methylanthranilate (MMA) from Pericarpium Citri Reticulatae Chachiensis against foodborne pathogen Pseudomonas aeruginosa was reported for the first time. MMA effectively attenuated QS related virulence factors production and biofilm formation, while suppressed expression of a dozen of QS related genes. Untargeted LC-MS metabolomics revealed 108 significantly altered metabolites after MMA treatment. Read More

View Article and Full-Text PDF
September 2021

An alternative, zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants.

Mol Plant 2021 Sep 18. Epub 2021 Sep 18.

Biological and Environmental Sciences and Engineering Division, Center for Desert Agriculture, The BioActives Lab, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia. Electronic address:

Abscisic acid (ABA) is an important carotenoid-derived phytohormone that plays essential roles in plant response to biotic and abiotic stresses as well as in various physiological and developmental processes. In Arabidopsis, ABA biosynthesis starts with the epoxidation of zeaxanthin by the ABA DEFICIENT 1 (ABA1) enzyme, leading to epoxycarotenoids, e.g. Read More

View Article and Full-Text PDF
September 2021

Alternative Splicing and Liver Disease.

Ann Hepatol 2021 Sep 18:100534. Epub 2021 Sep 18.

Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149 Trieste, Italy. Electronic address:

Alternative splicing produces complex and dynamic changes in the protein isoforms that are necessary for the proper biological functioning of the metabolic pathways involved in liver development and hepatocyte homeostasis. Changes in the physiological state of alternatively spliced forms are increasingly linked to liver pathologies. This may occur when the expression or function of the set of proteins controlling the alternative splicing processes are altered by external effectors such as oxidative stress and other environmental variations. Read More

View Article and Full-Text PDF
September 2021

Redox metabolism: ROS as specific molecular regulators of cell signaling and function.

Mol Cell 2021 Sep;81(18):3691-3707

MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes are indispensable for organismal physiology and life itself. The term reactive oxygen species (ROS) describes a set of distinct molecular oxygen derivatives produced during normal aerobic metabolism. Read More

View Article and Full-Text PDF
September 2021

Switching the Mechanism of NADH Photooxidation by Supramolecular Interactions.

Chemistry 2021 Sep 21. Epub 2021 Sep 21.

University of Ulm, Institute of Inorganic Chemistry I Materials and Catalysis, Albert-Einstein-Allee 11, 89081, Ulm, GERMANY.

A series of three Ru(II) polypyridine complexes was investigated for the selective photocatalytic oxidation of NAD(P)H to NAD(P) + in water. A combination of (time-resolved) spectroscopic studies and photocatalysis experiments revealed that ligand design can be used to control the mechanism of the photooxidation: For prototypical Ru(II) complexes a 1 O 2 pathway was found. Rudppz ([(tbbpy) 2 Ru(dppz)]Cl 2 , tbbpy = 4,4´-di- tert -butyl-2,2´-bipyridine, dppz = dipyrido[3,2-a:2',3'-c]phenazine), instead, initiated the cofactor oxidation by electron transfer from NAD(P)H enabled by supramolecular binding between substrate and catalyst. Read More

View Article and Full-Text PDF
September 2021

Low-dose cyclooxygenase-2 (COX-2) inhibitor celecoxib plays a protective role in the rat model of neonatal necrotizing enterocolitis.

Authors:
Ling Sun

Bioengineered 2021 Dec;12(1):7234-7245

Neonatal Intensive Care Unit, Yantaishan Hospital, Yantai, China.

This study aims to investigate the effects of the cyclooxygenase-2 (COX-2) inhibitor celecoxib on neonatal necrotizing enterocolitis (NEC) in rats. After treatment with a low dose of celecoxib (0.5, 1, or 1. Read More

View Article and Full-Text PDF
December 2021

Modafinil attenuates the neuroinflammatory response after experimental traumatic brain injury.

J Neurosurg Sci 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Gazi University Hospital, Ankara, Turkey.

Background: Modafinil has been proven to exert anti-inflammatory, anti-oxidative and neuroprotective effects on numerous neurological disorders. However, its effects after traumatic brain injury (TBI) has not been yet explore. This study aimed to explore if Modafinil can attenuate the neuroinflammatory phase of TBI and clarify the possible underlying mechanisms. Read More

View Article and Full-Text PDF
September 2021

[Prospects for using low-dose radiation in the complex therapy for COVID-19].

Vopr Virusol 2021 Sep 17;66(4):252-258. Epub 2021 Sep 17.

FSBI «State Research Center - Burnasyan Federal Medical Biophysical Center» of Federal Medical Biological Agency of Russia; FSBIS Vavilov Institute of General Genetics of Russian Academy of Sciences.

This review presents the literature data of new approaches for the treatment of COVID-19 with low doses of radiation (LDR). In addition, data on the use of LDR for the treatment of various disorders, in particular pneumonia, a number of inflammatory processes of various etiology, as well as Alzheimer's disease are discussed. The mechanisms of LDR action are briefly described, associated with the activation of the immune system and antiinflammatory response due to the effect on the processes of oxidative stress, which is reflected in an increase in the activity of cytokines (interleukin- (IL-) 6), changes in the expression of a number of genes (such as P53 and NF-κB (p65)) and long non-coding RNAs (ncRNAs) (the authors' own data are presented). Read More

View Article and Full-Text PDF
September 2021

Mass Spectrometry-Based Quantitative Cysteine Redox Proteome Profiling of Isolated Mitochondria Using Differential iodoTMT Labeling.

Methods Mol Biol 2022 ;2363:215-234

Institute of Plant Biology and Biotechnology, University of Münster, Münster, Germany.

Mitochondria are central hubs of redox biochemistry in the cell. An important role of mitochondrial carbon metabolism is to oxidize respiratory substrates and to pass the electrons down the mitochondrial electron transport chain to reduce oxygen and to drive oxidative phosphorylation. During respiration, reactive oxygen species are produced as a side reaction, some of which in turn oxidize cysteine thiols in proteins. Read More

View Article and Full-Text PDF
January 2022

Markers for Mitochondrial ROS Status.

Methods Mol Biol 2022 ;2363:199-213

Department of Plant Bioenergetics, Institute of Experimental Plant Biology and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland.

Mitochondria actively participate in oxygenic metabolism and are one of the major sources of reactive oxygen species (ROS) production in plant cells. However, instead of measuring ROS concentrations in organelles it is more worthwhile to observe active ROS generation or downstream oxidation products, because the steady state level of ROS is easily buffered. Here, we describe how to measure the in vitro production of superoxide anion radicals (O·) by mitochondria and the release of O· into the cytosol. Read More

View Article and Full-Text PDF
January 2022

The Role of Oxidative Stress, Inflammation, and Advanced Glycation End Product in Skin Manifestations of Diabetes Mellitus.

Authors:
Lili Legiawati

Curr Diabetes Rev 2021 Sep 19. Epub 2021 Sep 19.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia - dr. Cipto Mangunkusumo National General Hospital Jakarta, Jakarta 10430. Indonesia.

Diabetes mellitus is a metabolic disorder caused by an increase in insulin resistance, a decrease in insulin production, or both of them, resulting in a high level of blood glucose or hyperglycemia. An uncontrolled state of DM may cause complications, namely skin disorder. One or more skin disorders are found amongst 74% of T2DM patients, with the highest percentage is dry skin (47%), followed by infection (10%), diabetic hand (5%), hair loss and diabetic dermopathy (each 4%). Read More

View Article and Full-Text PDF
September 2021

A review of the toxicology of oil in vertebrates: what we have learned following the oil spill.

J Toxicol Environ Health B Crit Rev 2021 Sep 19:1-40. Epub 2021 Sep 19.

Sea Mammal Research Unit, Scottish Oceans Institute, University of St Andrews, St Andrews, UK.

In the wake of the (DWH) oil spill, a number of government agencies, academic institutions, consultants, and nonprofit organizations conducted lab- and field-based research to understand the toxic effects of the oil. Lab testing was performed with a variety of fish, birds, turtles, and vertebrate cell lines (as well as invertebrates); field biologists conducted observations on fish, birds, turtles, and marine mammals; and epidemiologists carried out observational studies in humans. Eight years after the spill, scientists and resource managers held a workshop to summarize the similarities and differences in the effects of DWH oil on vertebrate taxa and to identify remaining gaps in our understanding of oil toxicity in wildlife and humans, building upon the cross-taxonomic synthesis initiated during the Natural Resource Damage Assessment. Read More

View Article and Full-Text PDF
September 2021

Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis.

Bioact Mater 2022 Feb 11;8:368-380. Epub 2021 Jun 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China.

Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Read More

View Article and Full-Text PDF
February 2022

ROS Detection in Colonies with CellROX Green Reagent.

Bio Protoc 2017 Aug 20;7(16):e2508. Epub 2017 Aug 20.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.

We analyzed the reactive oxygen species (ROS) accumulation in the colony-forming green microalga in response to several stress inducers such as NaCl, NaHCO, salicylic acid (SA), methyl jasmonate, and acetic acid. A staining assay using the fluorescent dye CellROX Green was used. CellROX Green is a fluorogenic probe used for measuring oxidative stress in live cells. Read More

View Article and Full-Text PDF

A Robust Panel Based on Mitochondrial Localized Proteins for Prognostic Prediction of Lung Adenocarcinoma.

Oxid Med Cell Longev 2021 9;2021:7569168. Epub 2021 Sep 9.

Affiliated Cancer Hospital and Institute of Guangzhou Medical University; Key Laboratory for Cell Homeostasis and Cancer Research of Guangdong Higher Education Institutes, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510000, China.

Due to high energy and material metabolism requirements, mitochondria are frequently active in tumor cells. Our study found that the high energy metabolism status is positively correlated with the poor prognosis of patients with lung adenocarcinoma. We constructed a scoring system (mitoRiskscore) based on the gene expression of specific mitochondrial localized proteins through univariate and LASSO cox regression. Read More

View Article and Full-Text PDF
September 2021

Understanding Metabolic Remodeling in to Overcome Energy Exigency and Reductive Stress Under Energy-Compromised State.

Front Microbiol 2021 1;12:722229. Epub 2021 Sep 1.

Microbiology and Molecular Biology Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.

Mycobacteria such as , the causative agent of tuberculosis that annually kills several million people worldwide, and , the non-pathogenic fast-growing mycobacteria, require oxidative phosphorylation to meet their energy requirements. We have previously shown that deletion of one of the two copies of gene that codes for the ATP synthase β-subunit establishes an energy-compromised state in . Here we report that upon such deletion, a major routing of electron flux occurs through the less energy-efficient complexes of its respiratory chain. Read More

View Article and Full-Text PDF
September 2021

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges.

Front Cell Neurosci 2021 1;15:711269. Epub 2021 Sep 1.

Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry, CSIC, Madrid, Spain.

Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping reactive oxygen and nitrogen species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing loss has a heterogeneous etiology, genetic alterations, aging, toxins or exposure to noise can cause damage to hair cells at the organ of Corti, the hearing receptor. Read More

View Article and Full-Text PDF
September 2021

Reactivity of a Dinuclear Pd Complex [Pd(μ-PPh)(μ-OAc)(PPh)] with PPh: Implications for Cross-Coupling Catalysis Using the Ubiquitous Pd(OAc)/nPPh Catalyst System.

Organometallics 2021 Sep 19;40(17):2995-3002. Epub 2021 Aug 19.

Department of Chemistry, University of York, Heslington, York, North Yorkshire YO10 5DD, United Kingdom.

[Pd (μ-PPh)(μ-OAc)(PPh)] is the reduction product of Pd(OAc)(PPh), generated by reaction of 'Pd(OAc)' with two equivalents of PPh. Here, we report that the reaction of [Pd (μ-PPh)(μ-OAc)(PPh)] with PPh results in a nuanced disproportionation reaction, forming [Pd(PPh)] and a phosphinito-bridged Pd-dinuclear complex, namely [Pd (μ-PPh){κ-P,O-μ-P(O)Ph}(κ-PPh)]. The latter complex is proposed to form by abstraction of an oxygen atom from an acetate ligand at Pd. Read More

View Article and Full-Text PDF
September 2021

N-doped MoS-nanoflowers as peroxidase-like nanozymes for total antioxidant capacity assay.

Anal Chim Acta 2021 Oct 8;1180:338740. Epub 2021 Jun 8.

Key Lab of Bioelectrochemistry & Environmental Analysis of Gansu, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China.

Total Antioxidant Capacity (TAC) Assay plays an important role in evaluating the quality of antioxidant food and monitoring the oxidative stress level of human body. It is mainly achieved by measuring the contents of antioxidants such as AA, L-Cys and GSH, while TAC can be detected by using peroxidase-like activity of artificial nanoenzyme materials. In this work, the N-Doped, defect-rich N-MoSNFs nano-materials were used to build the nano enzyme, which has strong stability and high peroxidase-like activity. Read More

View Article and Full-Text PDF
October 2021

Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes.

Clin Epigenetics 2021 Sep 19;13(1):177. Epub 2021 Sep 19.

Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR, 97006, USA.

Background: Maternal smoking during pregnancy (MSDP) affects development of multiple organ systems including the placenta, lung, brain, and vasculature. In particular, children exposed to MSDP show lifelong deficits in pulmonary function and increased risk of asthma and wheeze. Our laboratory has previously shown that vitamin C supplementation during pregnancy prevents some of the adverse effects of MSDP on offspring respiratory outcomes. Read More

View Article and Full-Text PDF
September 2021

Melatonin alleviates aluminum-induced growth inhibition by modulating carbon and nitrogen metabolism, and reestablishing redox homeostasis in Zea mays L.

J Hazard Mater 2021 Sep 12;423(Pt B):127159. Epub 2021 Sep 12.

College of Agriculture, Shanxi Agricultural University, Taigu, Shanxi 030800, China. Electronic address:

Melatonin, a regulatory molecule, performs pleiotropic functions in plants, including aluminum (Al) stress mitigation. Here, we conducted transcriptomic and physiological analyses to identify metabolic processes associated with the alleviated Al-induced growth inhibition of the melatonin-treated (MT) maize (Zea mays L.) seedlings. Read More

View Article and Full-Text PDF
September 2021

N-γ-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans.

Phytomedicine 2021 Sep 4;92:153733. Epub 2021 Sep 4.

Department of Bioenvironmental Systems Engineering, National Taiwan University, No. 1 Roosevelt Road, Sec. 4, Taipei 106, Taiwan. Electronic address:

Background: Parkinson's disease (PD) is a common neurodegenerative disease, yet fundamental treatments for the disease remain sparse. Thus, the search for potentially efficacious compounds from medicinal plants that can be used in the treatment of PD has gained significant interest.

Purpose: In many medicinal plants, selenium is primarily found in an organic form. Read More

View Article and Full-Text PDF
September 2021

Graphene oxide toxicity in W flies.

Sci Total Environ 2021 Sep 11;805:150302. Epub 2021 Sep 11.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China; Institute of Quantitative Biology and College of Life Sciences, Zhejiang University, 310058 Hangzhou, China.

The risk of graphene oxide (GO) exposure to various species has been greatly amplified in recent years due to its booming production and applications in various fields. However, a deep understanding of the GO biosafety lags its wide applications. Herein, we used W flies as a model organism to study GO toxicity at relatively low concentrations. Read More

View Article and Full-Text PDF
September 2021

Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids.

Biomed Pharmacother 2021 Sep 15;143:112142. Epub 2021 Sep 15.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar; Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar; Department of Dermatology and Venereology, Rumailah Hospital, Hamad Medical Corporation, Doha 3050, Qatar; Laboratory Animal Research Center, Qatar University, Doha 2713, Qatar. Electronic address:

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, progression and stemness of cancer cells. Moreover, cancer cells maintain a delicate balance between ROS and antioxidants to promote pathogenesis and clinical challenges via targeting a battery of signaling pathways converging to cancer hallmarks. Read More

View Article and Full-Text PDF
September 2021

ADME/T-based strategies for paraquat detoxification: Transporters and enzymes.

Environ Pollut 2021 Sep 9;291:118137. Epub 2021 Sep 9.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macau, China. Electronic address:

Paraquat (PQ) is a toxic, organic herbicide for which there is no specific antidote. Although banned in some countries, it is still used as an irreplaceable weed killer in others. The lack of understanding of the precise mechanism of its toxicity has hindered the development of treatments for PQ exposure. Read More

View Article and Full-Text PDF
September 2021

Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved.

Neurochem Int 2021 Sep 16;150:105188. Epub 2021 Sep 16.

Laboratorio de Dolor en Cáncer, Instituto de Investigaciones en Medicina Traslacional CONICET - Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina; Facultad de Ciencias Biomédicas, Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina. Electronic address:

After different types of acute central nervous system insults, including stroke, subarachnoid haemorrhage and traumatic brain and spinal cord injuries, secondary damage plays a central role in the induction of cell death, neurodegeneration and functional deficits. Interestingly, secondary cell death presents an attractive target for clinical intervention because the temporal lag between injury and cell loss provides a potential window for effective treatment. While primary injuries are the direct result of the precipitating insult, secondary damage involves the activation of pathological cascades through which endogenous factors can exacerbate initial tissue damage. Read More

View Article and Full-Text PDF
September 2021

Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats.

Eur J Pharmacol 2021 Sep 15;910:174507. Epub 2021 Sep 15.

Department of Neurology, The First Affiliated Hospital (People's Hospital of Hunan Province), Hunan Normal University, Changsha, 410005, China. Electronic address:

Intracerebral hemorrhage (ICH) is a devastating disease, and there is currently no specific pharmacological treatment that can improve clinical outcomes. Y-2 sublingual tablets, each containing 30 mg edaravone and 6 mg (+)-borneol, is undergoing a phase III clinical trial for treatment of ischemic stroke in China. The purpose of the present study is to investigate the efficacy and potential mechanism of Y-2 in a rat model of collagenase IV injection induced ICH. Read More

View Article and Full-Text PDF
September 2021

Knockdown of NON-YELLOW COLORING 1 (NYC1)-like gene or chlorophyllin application enhanced chlorophyll accumulation with antioxidant roles in suppressing heat-induced leaf senescence in perennial ryegrass.

J Exp Bot 2021 Sep 18. Epub 2021 Sep 18.

Department of Plant Biology, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA.

Loss of chlorophyll (Chl) and oxidative damages co-occur during heat-induced leaf senescence. This study aimed to determine the functions of Chl catabolic gene, NON-YELLOW COLORING 1 (NYC1)-like (NOL) in regulating heat-induced leaf senescence and to characterize antioxidant roles of a Chl derivative, sodium copper chlorophyllin (SCC), in suppressing heat-induced leaf senescence. In two separate experiments, one by comparing NOL RNAi transgenic and wild-type plants, and the other by analyzing the effects of sodium copper chlorophyllin (SCC, 1 mM) treatment, perennial ryegrass (Lolium perenne) were exposed to heat stress (38/35 oC, day/night) or optimal temperature (25/20 oC). Read More

View Article and Full-Text PDF
September 2021

Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats.

Environ Sci Pollut Res Int 2021 Sep 17. Epub 2021 Sep 17.

Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Nowadays, plastic pollution and in particular nano(micro)plastics is considered as an issue of global concern in environmental samples. The present work was conducted to clarify the oxidative stress of polystyrene nanoplastics (PS-NPs) exposure and physiological response of male Wistar rats. Animals were treated orally with PS-NPs at four doses (1, 3, 6, and10 mg/kg-day) for 5 weeks. Read More

View Article and Full-Text PDF
September 2021