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Effect of Matching Therapists to Patients vs Assignment as Usual on Adult Psychotherapy Outcomes: A Randomized Clinical Trial.

JAMA Psychiatry 2021 Jun 9. Epub 2021 Jun 9.

Outcome Referrals Inc, Framingham, Massachusetts.

Importance: Psychotherapists possess strengths and weaknesses in treating different mental health problems, yet performance information is rarely harnessed in mental health care (MHC). To our knowledge, no prior studies have tested the causal efficacy of prospectively matching patients to therapists with empirically derived strengths in treating patients' specific concerns.

Objective: To test the effect of measurement-based matching vs case assignment as usual (CAU) on psychotherapy outcomes. Read More

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Histidine Triad Nucleotide Binding Protein 1 Attenuates Cardiac Hypertrophy via Suppressing Homeobox A5 Expression.

Circulation 2021 Jun 8. Epub 2021 Jun 8.

Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University, Nanjing, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Nanjing, China.

Cardiac hypertrophy is an important pre-pathology of heart failure, which will ultimately lead to heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. The aim of this study is to elucidate the effects and mechanisms of histidine triad nucleotide binding protein 1 (HINT1) in cardiac hypertrophy and heart failure. Read More

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Intrinsic and extrinsic factors that may influence DNA preservation in skeletal remains: A review.

Forensic Sci Int 2021 Jun 4;325:110859. Epub 2021 Jun 4.

BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. Electronic address:

The identification of skeletal human remains, severely compromised by putrefaction, or highly deteriorated, is important for legal and humanitarian reasons. There are different tools that can help in the identification process such as anthropological and genetic studies. The success observed during the last decade in genetic analysis of skeletal remains has been possible especially due to the refinements of DNA extraction and posterior analysis techniques. Read More

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PSYCHOLOGICAL AND PEDAGOGICAL DETERMINANTS OF THE STUDENTS' HEALTHY LIFESTYLE FORMATION BY MEANS OF HEALTH AND FITNESS ACTIVITIES.

Wiad Lek 2021 ;74(5):1074-1078

PRYDNIPROVSKA STATE ACADEMY OF CIVIL ENGINEERING AND ARCHITECTURE, DNIPRO, UKRAINE.

Objective: The aim: Is to investigate the psychological and pedagogical determinants of the students' healthy lifestyle formation by means of health and fitness activities.

Patients And Methods: Materials and methods: The study involved 882 students between the ages of 17 and 23. An analysis of the students' health dynamics during the period of study determined their motivational and value-based attitude to a healthy lifestyle, the level of health competence and the desire of students to implement it in future professional activities, studied the attitude of students to their own health. Read More

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Impact of Forest Management on the Temporal Dynamics of Herbaceous Plant Diversity in the Carpathian Beech Forests over 40 Years.

Biology (Basel) 2021 May 5;10(5). Epub 2021 May 5.

Laboratory of Plant Physiology and Ecology, University of Rzeszów, Rejtana 16C, PL-35-959 Rzeszów, Poland.

In recent years, there has been a growing awareness of the complex dependence of herbaceous plant diversity on forest structure and management. However, among the studies presented so far, those in which the chronosequence (approach based on the assumption of space-for-time substitution) was used, dominate. On the other hand, it is rare to find results based on long-term research on permanent or semi-permanent sampling plots. Read More

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Mechanical evaluation of a patient-specific additively manufactured subperiosteal jaw implant (AMSJI) using finite-element analysis.

Int J Oral Maxillofac Surg 2021 May 28. Epub 2021 May 28.

Department of Mechanical Engineering, Biomechanics section, KU Leuven, Leuven, Belgium. Electronic address:

Edentulism with associated severe bone loss is a widespread condition that hinders the use of common dental implants. An additively manufactured subperiosteal jaw implant (AMSJI) was designed as an alternative solution for edentulous patients with Cawood and Howell class V-VIII bone atrophy. A biomechanical evaluation of this AMSJI for the maxilla in a Cawood and Howell class V patient was performed via finite-element analysis. Read More

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[Effects of use of an eHealth platform e-Vita for COPD patients on disease specific quality of life domains].

Tijdschr Gerontol Geriatr 2020 Dec 10;51(4). Epub 2020 Dec 10.

Leids Universitair Medisch Centrum, afdeling volksgezondheid en eerstelijnszorg, Leiden, Nederland.

Background: Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients' involvement to be able to accept and maintain a healthier lifestyle. Eventhough there is mixed evidence of the impact of eHealth on quality of life (QoL) in different settings. Read More

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December 2020

Conductance-stable liquid metal sheath-core microfibers for stretchy smart fabrics and self-powered sensing.

Sci Adv 2021 May 28;7(22). Epub 2021 May 28.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology & Center for Advanced Low-dimension Materials, Donghua University, Shanghai 201620, China.

Highly conductive and stretchy fibers are crucial components for smart fabrics and wearable electronics. However, most of the existing fiber conductors are strain sensitive with deteriorated conductance upon stretching, and thus, a compromised strategy via introducing merely geometric distortion of conductive path is often used for stable conductance. Here, we report a coaxial wet-spinning process for continuously fabricating intrinsically stretchable, highly conductive yet conductance-stable, liquid metal sheath-core microfibers. Read More

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Novel variants in GUCY2D causing retinopathy and the genotype-phenotype correlation.

Exp Eye Res 2021 May 26;208:108637. Epub 2021 May 26.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, 510060, China. Electronic address:

Leber congenital amaurosis (LCA) is the most severe form of retinopathy and cone/cone-rod dystrophy (CORD) is a common form of inherited retinopathy. Variants in GUCY2D constitute the most common cause of LCA and autosomal dominant CORD (ADCORD). The purpose of this study was to reveal novel variants and document associated phenotypes of patients with GUCY2D-associated retinopathy. Read More

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Distinct effects of calcineurin dependent and independent immunosuppressants on endotoxemia-induced nephrotoxicity in rats: role of androgens.

Clin Exp Pharmacol Physiol 2021 May 27. Epub 2021 May 27.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Evidence suggests that immunosuppressant therapies protect against harmful effects of endotoxemia. In this study, we tested whether calcineurin-dependent (cyclosporine/tacrolimus) and -independent (sirolimus) immunosuppressants variably influence nephrotoxicity induced by endotoxemia and whether this interaction is modulated by testosterone. We investigated the effects of immunosuppressants on renal histopathological, biochemical and inflammatory profiles in endotoxic male rats and the role of androgenic state in the interaction. Read More

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Relationship Between Residual Mitral Regurgitation and Clinical and Quality-of-Life Outcomes After Transcatheter and Medical Treatments in Heart Failure: The COAPT Trial.

Circulation 2021 May 27. Epub 2021 May 27.

Clinical Trials Center, Cardiovascular Research Foundation, New York, NY; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

In the randomized COAPT trial, among 614 heart failure (HF) patients with 3+ or 4+ secondary mitral regurgitation (MR), transcatheter mitral valve repair (TMVr) with the MitraClip reduced MR, HF hospitalizations (HFH), and mortality and improved quality of life compared with guideline-directed medical therapy (GDMT) alone. We sought to examine the prognostic relationship between MR reduction and outcomes after TMVr and GDMT alone. Outcomes in COAPT between 30 days and 2 years were examined based on the severity of residual MR at 30 days. Read More

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Distinct Coagulopathy With Myocardial Injury and Pulmonary Embolism in COVID-19.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211019559

Creighton University, Phoenix, AZ, USA.

In this article, we report a case of a 61-year-old male who was diagnosed with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), presenting with acute respiratory distress syndrome requiring intubation and hemodynamic support, marked D-Dimer and troponin I elevation, worsening ST-elevation myocardial infarction on repeat electrocardiograms, and a negative coronary angiogram ruling out a coronary artery thrombosis or occlusion. With worsening diffuse ST-segment elevation on electrocardiograms and reduced ejection fraction on echocardiography in the setting of systemic inflammation, fulminant myocarditis was highly suspected. Despite optimal medical treatment, the patient's condition deteriorated and was complicated by cardiac arrest that failed resuscitation. Read More

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Trajectories of frailty, physical function, and physical activity levels in elderly patients with heart failure: impacts of interruption and resumption of outpatient cardiac rehabilitation due to COVID-19.

Int J Rehabil Res 2021 May 24. Epub 2021 May 24.

Department of Shizuoka Physical Therapy, Faculty of Health Science, Tokoha University Department of Cardiovascular Rehabilitation, Omote-jyunkankika Cardiovascular Clinic, Shizuoka Anti-Aging Center, Ginza Hospital, Tokyo Department of Cardiology, Omote-jyunkankika Cardiovascular Clinic, Shizuoka, Japan.

During the nationwide state of emergency, many hospitals could not provide outpatient cardiac rehabilitation for cardiac disease patients in order to minimize coronavirus disease 2019 (COVID-19) incidence. The purpose of this study was to examine the trajectories of frailty, physical function and physical activity levels due to interruption and resumption of outpatient cardiac rehabilitation by COVID-19 in elderly heart failure patients. Fifteen patients who did not attend outpatient cardiac rehabilitation during the state of emergency but resumed it after the state of emergency were included. Read More

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Increased hydraulic constraints in Eucalyptus plantations fertilized with potassium.

Plant Cell Environ 2021 May 25. Epub 2021 May 25.

CIRAD, UMR Eco&Sols, Montpellier, France.

Fertilization is commonly used to increase growth in forest plantations, but it may also affect tree water relations and responses to drought. Here, we measured changes in biomass, transpiration, sapwood-to-leaf area ratio (A :A ) and sap flow driving force (ΔΨ) during the 6-year rotation of tropical plantations of Eucalyptus grandis under controlled conditions for throughfall and potassium (K) fertilization. K fertilization increased final tree height by 8 m. Read More

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High-risk surgeries, anesthetic challenges, and real benefits of peripheral regional techniques revisited.

Niger J Clin Pract 2021 May;24(5):782-785

Department of Surgery, Delta State University Teaching Hospital, Oghara, Delta State, Nigeria.

Patients with high-risk conditions for surgery may benefit from some form of regional block when neuroaxial regional blocks may be life threatening. Despite the increased use of ultrasound-guided peripheral regional blocks internationally, local infiltration and targeted nerve blocks aided by knowledge of anatomical landmarks remain helpful in these two patients presented. A 48-year old woman, presented with bleeding left breast mass, mild respiratory distress, and radiological features of lung metastases (Carcinoma of the breast stage 4). Read More

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A case report of endocarditis and spondylitis caused by Brucella melitensis biovar 3.

BMC Infect Dis 2021 May 20;21(1):460. Epub 2021 May 20.

School of Animal Science and Technology, Shihezi University, Shihezi City, 832000, Xinjiang, China.

Background: This case report describes the clinical process of a shepherd who suffered brucellosis-related endocarditis (BE) and spondylitis (BS) and was infected with Brucella melitensis biovar 3 (B. melitensis biovar 3).

Case Presentation: A 55-year-old male patient was admitted to The First Affiliated Hospital of Shihezi University on October 11, 2018, due to over 3 months of intermittent fever, back pain, and heart trouble. Read More

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Policing pain: A qualitative study of non-criminal justice approaches to managing opioid overdose during the COVID-19 pandemic.

J Prev Interv Community 2021 May 17:1-16. Epub 2021 May 17.

Department of Criminal Justice, Penn State University, Greater Allegheny, McKeesport, PA, USA.

Opioid related drug overdose deaths are a leading cause of death and injury in the United States. While research demonstrates that where people live has a major impact on drug use and abuse, most work looks at social dynamics at the county level or under the rubric of the urban/rural divide. Only recently, scholarship has become attuned to the post-industrialized areas located on the fringes of urban cores. Read More

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Effects of ethanol and n-butanol on the fluidity of supported lipid bilayers.

Chem Phys Lipids 2021 May 13;238:105091. Epub 2021 May 13.

Michigan State University, Department of Chemistry, 578 S. Shaw Lane, East Lansing, MI, 48824, USA. Electronic address:

The interactions of molecules such as short-chain alcohols with the mammalian plasma membrane are thought to play a role in anesthetic effects. We have examined the concentration-dependent effects of ethanol and n-butanol on the fluidity of planar model lipid bilayer structures supported on mica. The supported model bilayer was composed of 1,2-dioleoyl-sn-phosphatidylcholine (DOPC), cholesterol, and sphingomyelin, and the bilayers were formed by vesicle fusion from extruded unilamellar vesicles (133 nm diameter, polydispersity index of 0. Read More

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THE LIFE AND DEATH OF AN AMERICAN STATESMAN.

Am J Med Sci 2021 May 13. Epub 2021 May 13.

Emeritus Professor of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA.

John Hay was born in a small mid-western town and sent by his physician father to Brown University for his education. He returned to Springfield IL where he was hired by Abraham Lincoln as a personal secretary and stayed with Lincoln through the assassination. He then returned to private life, married into a wealthy family and developed a successful literary and investment career. Read More

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Spatial distribution of PM-bound elements in eighteen cities over China: policy implication and health risk assessment.

Environ Geochem Health 2021 May 12. Epub 2021 May 12.

Key Laboratory of Aerosol Chemistry & Physics (KLACP), Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710061, China.

In this study, 30 elements in fine particulate matter (PM) were measured in 18 Chinese cities in 2013. Elemental pollution in northern, southwest, and central China were severe, attributing to excessive coal and biomass combustion in these regions. The concentrations of S, Cl, and K in these areas were 8. Read More

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microRNA-9-5p protects liver sinusoidal endothelial cell against oxygen glucose deprivation/reperfusion injury.

Open Life Sci 2021 19;16(1):375-383. Epub 2021 Apr 19.

Department of Anesthesiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Beijing 102218, China.

Background: Maintenance of the function and survival of liver sinusoidal endothelial cells (LSECs) play a crucial role in hepatic ischemia/reperfusion (I/R) injury, a major cause of liver impairment during the surgical treatment. Emerging evidence indicates a critical role of microRNAs in I/R injury. This study aims to investigate whether miR-9-5p exerts a protective effect on LSECs. Read More

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Establishment of soil strength in a nourished wetland using thin layer placement of dredged sediment.

PLoS One 2021 11;16(5):e0251420. Epub 2021 May 11.

US Army Corps of Engineers, Research and Development Center, Vicksburg, Mississippi, United States of America.

Coastal wetlands are experiencing accelerated rates of fragmentation and degradation due to sea-level rise, sediment deficits, subsidence, and salt-water intrusion. This reduces their ability to provide ecosystem benefits, such as wave attenuation, habitat for migratory birds, and a sink for carbon and nitrogen cycles. A deteriorated back barrier wetland in New Jersey, USA was nourished through thin layer placement (TLP) of dredged sediment in 2016. Read More

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Digital Biomarkers of Cognitive Frailty: The Value of Detailed Gait Assessment Beyond Gait Speed.

Gerontology 2021 May 10:1-10. Epub 2021 May 10.

Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

Background: Cognitive frailty (CF), defined as the simultaneous presence of cognitive impairment and physical frailty, is a clinical symptom in early-stage dementia with promise in assessing the risk of dementia. The purpose of this study was to use wearables to determine the most sensitive digital gait biomarkers to identify CF.

Methods: Of 121 older adults (age = 78. Read More

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Critical Role of Lkb1 in the Maintenance of Alveolar Macrophage Self-Renewal and Immune Homeostasis.

Front Immunol 2021 22;12:629281. Epub 2021 Apr 22.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Alveolar macrophages (AMs) are pivotal for maintaining lung immune homeostasis. We demonstrated that deletion of liver kinase b1 (Lkb1) in CD11c cells led to greatly reduced AM abundance in the lung due to the impaired self-renewal of AMs but not the impeded pre-AM differentiation. Mice with Lkb1-deficient AMs exhibited deteriorated diseases during airway (. Read More

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Subtypes of depression characterized by different cognitive decline and brain activity alterations.

J Psychiatr Res 2021 Jun 29;138:413-419. Epub 2021 Apr 29.

Psychiatric Laboratory and Mental Health Center, The State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address:

Depression is characterized by the heterogeneity in anti-depressant treatment response and clinical outcomes. Cognitive impairment may be one of the more practically important aspects of depression. A new approach was to identify neuropsychologically derived depression subtypes based on the trajectory of neuro-cognition such as intelligence quotient (IQ) change. Read More

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Uterine Insulin Sensitivity Defects Induced Embryo Implantation Loss Associated with Mitochondrial Dysfunction-Triggered Oxidative Stress.

Oxid Med Cell Longev 2021 12;2021:6655685. Epub 2021 Apr 12.

State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100193, China.

Methods And Results: Herein, a comprehensive proteomic analysis was conducted on proliferative endometria from sows with low and normal reproductive performance (LRP and NRP, respectively). Enrichment analysis of differentially expressed proteins revealed alterations in endometrial remodeling, substance metabolism (mainly lipid, nitrogen, and retinol metabolism), immunological modulation, and insulin signaling in LRP sows. Importantly, aberrant lipid metabolite accumulation and dysregulation of insulin signaling were coincidently confirmed in endometria of LPR sows, proving an impaired insulin sensitivity. Read More

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Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health.

Front Endocrinol (Lausanne) 2021 19;12:656831. Epub 2021 Apr 19.

Laboratory of Experimental Physiology, Department of Physiological Sciences, Biological and Health Sciences Centre, Federal University of Maranhão, São Luís, Brazil.

Background: The metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as the polycystic ovary syndrome (PCOS). While consumption of a diet rich in carbohydrates is linked to the development of MetS, it is still unclear if this diet leads to ovarian dysfunction and PCOS.

Objectives: We investigated the influence of a high-sucrose diet (HSD) on the ovarian milieu of Wistar rats and studied the correlation between high consumption of sugary drinks and the prevalence of PCOS in women. Read More

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Identification of the main aroma compounds in Chinese local chicken high-quality meat.

Food Chem 2021 Oct 23;359:129930. Epub 2021 Apr 23.

Chinese Academy of Agricultural Science, State Key Laboratory of Animal Nutrition, Beijing 100193, China. Electronic address:

Chicken meat flavor has deteriorated with the increase of meat production. With the aim to identify the main aroma compounds in chicken meat, 972 Chinese local chickens are used to analyze the volatile organic compounds (VOCs) in meat by gas chromatography-mass spectrometry analysis. The results revealed that various VOCs present in the meat belong to aldehyde, alcohol and alkane classes. Read More

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October 2021

Collapsing focal segmental glomerulosclerosis in a patient with oral cavity cancer: A case report.

Medicine (Baltimore) 2021 May;100(18):e25857

Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National University Medical School.

Rationale: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerular diseases, leading to end-stage renal disease. Among the 5 variants of FSGS, the collapsing variant is rare and has the worst prognosis. Solid and hematologic malignancies are associated with glomerular diseases, such as membranous nephropathy, minimal change disease, and FSGS. Read More

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Different sterilization and disinfection methods used for human tendons - a systematic review using mechanical properties to evaluate tendon allografts.

BMC Musculoskelet Disord 2021 Apr 30;22(1):404. Epub 2021 Apr 30.

Cooperation Research Center for Biomechanics, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Budapest, Hungary.

Background: It is important to know the biomechanical properties of an allograft. This is because when looking to do a transplant of a tendon, the tendon must have very similar biomechanical properties to the original tendon. To use tendon allografts, it is critical to properly sterilize the tendon before implantation. Read More

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