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Anticoagulant Treatment for Pediatric Infection-Related Cerebral Venous Thrombosis.

Pediatr Neurol 2021 Dec 28;128:20-24. Epub 2021 Dec 28.

Bayer AG, Wuppertal, Germany.

Background: We aimed to describe the clinical presentation, risk of bleeding and recurrent thrombosis, and perioperative anticoagulant management of children with cerebral venous thrombosis (CVT) and an associated head or neck infection.

Methods: In this subgroup analysis of the EINSTEIN-Jr study, we included children with CVT and an associated head or neck infection who received therapeutic anticoagulants with either low-molecular-weight heparin (with or without subsequent vitamin K antagonists) or rivaroxaban for a period of 3 months. Analyses are descriptive. Read More

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December 2021

Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.

Biomed Pharmacother 2022 Jan 12;147:112623. Epub 2022 Jan 12.

Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: A better understanding of the evolution of cirrhosis after hepatitis C virus (HCV) clearance is essential since the reversal of liver injury may not happen. We aimed to assess the evolution of plasma metabolites after direct-acting antivirals (DAAs) therapy and their association with liver disease scores in HIV/HCV-coinfected patients with advanced HCV-related cirrhosis.

Methods: We performed a prospective study in 49 cirrhotic patients who started DAAs therapy. Read More

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January 2022

Intimacy in Psychotherapy: An Exploratory Survey Among Therapists.

Arch Sex Behav 2022 Jan 15. Epub 2022 Jan 15.

Mental Health and Wellbeing Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.

A certain level of intimacy is necessary in psychotherapeutic relationships for them to be effective, but it can sometimes develop further into more intimate feelings and behaviors related to friendship and sexuality, into friendship, or even into sexual relationships. In this study, a self-administered questionnaire was sent to psychotherapists in Flanders (Belgium), asking about the occurrence of these situations. It provides an overview of these occurrences and comparative data to view for generational and cultural differences with previous studies. Read More

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January 2022

An audit of dental assessments including orthopantomography and timing of dental extractions before radiotherapy for head and neck cancer.

Br Dent J 2022 Jan 14;232(1):38-43. Epub 2022 Jan 14.

Faculty of Health and Social Care, Edge Hill University, Ormskirk, UK; Liverpool Head and Neck Centre, Liverpool University Hospitals Aintree, Liverpool, UK.

Introduction Head and neck cancer (HNC) patients should receive a dental assessment at an appropriate time before commencing radiotherapy (RT), to prevent complications such as osteoradionecrosis (ORN) if extractions are required. A recent orthopantomogram radiograph (OPG) is part of this assessment.Aim To compare the delivery of pre-RT dental assessment at the Regional Oncology Centre against national guidelines in regard to OPG assessments and timing of extractions. Read More

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January 2022

Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection.

PLoS Negl Trop Dis 2022 Jan 14;16(1):e0009192. Epub 2022 Jan 14.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Background: Echinococcus multilocularis causes alveolar echinococcosis (AE), a rising zoonotic disease in the northern hemisphere. Treatment of this fatal disease is limited to chemotherapy using benzimidazoles and surgical intervention, with frequent disease recurrence in cases without radical surgery. Elucidating the molecular mechanisms underlying E. Read More

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January 2022

Healing of a Chronic Pressure Injury in a Patient Treated With Medical Cannabis for Pain and Sleep Improvement: A Case Report.

Wound Manag Prev 2021 Oct;67(10):42-47

Neurology Centre of Toronto, Toronto, Canada.

Background: A small body of evidence suggests medical cannabis may facilitate wound healing, but the exact mechanism of this effect is unclear.

Purpose: This case report describes a patient with a pressure injury (PI) who received cannabis oil treatment for pain management and sleep improvement.

Methods: A 37-year-old woman with multiminicore disease, scoliosis, short-chain acyl-CoA dehydrogenase deficiency, and epilepsy presented to the Neurology Centre of Toronto with chronic pain and sleep disturbance, including difficulty initiating and maintaining sleep. Read More

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October 2021

Surgical Wound Dehiscence Treatment With Low-Level Laser Therapy and Barbatimão: A Case Report.

Wound Manag Prev 2021 Oct;67(10):18-22

School of Nursing, University of Campinas, Campinas, São Paulo, Brazil.

Background: Low-level laser therapy (LLLT) and a gel containing an extract of Barbatimão, a native Brazilian tree, have shown promising results in both preclinical and clinical wound healing studies.

Purpose: To describe the treatment of surgical wound dehiscence with LLLT and Barbatimão gel.

Case Study: A 54-year-old woman without comorbidities underwent abdominoplasty at another health facility. Read More

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October 2021

Dabrafenib- and trametinib-associated glomerular toxicity: A case report.

Authors:
Eunmi Jo Harin Rhee

Medicine (Baltimore) 2022 Jan;101(1):e28485

Department of Nephrology, Pusan National University School of Medicine, Busan, Republic of Korea.

Rationale: Combined treatment with dabrafenib, a B-RAF inhibitor, and trametinib, a mitogen-activated protein kinase inhibitor, is an effective option for patients with metastatic melanoma. A few cases of acute kidney injury associated with tubulointerstitial nephritis and 1 case of nephrotic syndrome have been reported in patients on this drug combination; however, progressive renal injury has not been reported. In this case study, we report a patient with metastatic melanoma who developed glomerular capillary endothelial toxicity and progressive glomerular sclerosis during combination therapy. Read More

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January 2022

Cushing's syndrome due to ectopic adrenocorticotropin secretion by a parotid carcinoma.

Arch Endocrinol Metab 2022 Jan 13. Epub 2022 Jan 13.

Centro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.

We report a rare case of Cushing's syndrome in a 37-year-old female who initially presented with localized acinic cell carcinoma of the parotid gland. In January 2014, she underwent a right parotidectomy with facial nerve preservation and adjuvant radiotherapy. In August 2018, she presented a histologically-proven local regional relapse. Read More

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January 2022

Evaluation of an Optical Defocus Treatment for Myopia Progression Among Schoolchildren During the COVID-19 Pandemic.

JAMA Netw Open 2022 Jan 4;5(1):e2143781. Epub 2022 Jan 4.

Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.

Importance: Myopia progression has been found to be worsening during the COVID-19 pandemic. It is important to control the rapid myopia progression in this period.

Objective: To analyze the association of COVID-19-related lockdown measures with myopia progression in schoolchildren and to compare the performance of defocus incorporated multiple segments (DIMS) lens with that of single vision lens (SVL) treatment in reducing myopia progression. Read More

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January 2022

Preliminary Effectiveness of a Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2022 Jan 14;11(1):e30186. Epub 2022 Jan 14.

Omni Institute, Denver, CO, United States.

Background: Alcohol use disorder is a chronic disorder with a high likelihood of relapse. The consistent monitoring of blood alcohol concentration through breathalyzers is critical to identifying relapse or misuse. Smartphone apps as a replacement of or in conjunction with breathalyzers have shown limited effectiveness. Read More

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January 2022

Characteristics and accurate identification of Pantoea dispersa with a case of spontaneous rupture of hepatocellular carcinoma in China: A case report.

Medicine (Baltimore) 2022 Jan;101(2):e28541

Clinical Laboratory Center, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, PR China.

Introduction: Pantoea dispersa belongs to the genus Pantoea, which is isolated from Enterobacteriaceae. It has been reported to cause some kinds of infections, but there are few detailed studies on it, especially its characteristics and identification methods, which has caused a lot of trouble in clinical work.

Patient Concerns: A 51-year-old Chinese man was admitted to our hospital with a 7-hour history of progressive abdominal pain. Read More

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January 2022

Immune checkpoint inhibitor-induced refractory polyarthritis rapidly improved by sarilumab and monitoring with joint ultrasonography: A case report.

Medicine (Baltimore) 2022 Jan;101(2):e28428

Department of Rheumatology, Yokohama Rosai Hospital, 3211 Kozukue-cho, Kohoku-ku, Yokohama, Kanagawa, Japan.

Rationale: Immune checkpoint inhibitors (ICIs) have shown efficacy for the treatment of various kinds of malignant tumors. However, ICIs can cause immune-related adverse events, such as arthritis. Nevertheless, the treatment of ICI-induced arthritis has not been established yet. Read More

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January 2022

Oral antiplatelet therapy for acute ischaemic stroke.

Cochrane Database Syst Rev 2022 Jan 14;1:CD000029. Epub 2022 Jan 14.

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Background: In people with acute ischaemic stroke, platelets become activated and can cause blood clots to form and block an artery in the brain, resulting in damage to part of the brain. Such damage gives rise to the symptoms of stroke. Antiplatelet therapy might reduce the volume of brain damaged by ischaemia and also reduce the risk of early recurrent ischaemic stroke, thereby reducing the risk of early death and improving long-term outcomes in survivors. Read More

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January 2022

Vulvar pseudotumoral acyclovir-resistant herpes in an HIV-negative, non-immunosuppressed patient: A therapeutic challenge.

Int J Womens Dermatol 2021 Dec 20;7(5Part B):731-736. Epub 2021 Jun 20.

Department of Obstetrics and Gynecology, Michigan Medicine, Ann Arbor, Michigan.

Background: Vulvar pseudotumoral herpes infections have been reported in HIV-positive patients. A 32-year-old HIV-negative woman presented with a 6-month history of a vulvar pseudotumor that had been unresponsive to oral acyclovir and valacyclovir, as well as topical imiquimod.

Objective: This study aimed to evaluate the therapeutic efficacy of a multidrug regimen for vulvar pseudotumor herpes infection in an HIV-negative patient. Read More

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December 2021

Unilateral Isolated Hypoglossal Nerve Palsy Secondary to Tonsillitis.

Cureus 2021 Dec 9;13(12):e20291. Epub 2021 Dec 9.

Department of Head and Neck Surgery-Otolaryngology, Ogaki Municipal Hospital, Ogaki, JPN.

Hypoglossal nerve palsy is usually associated with glossopharyngeal nerve, vagus nerve, and accessory nerve palsy, and the occurrence of hypoglossal nerve palsy alone is rare. We report a case of a 41-year-old man with unilateral isolated hypoglossal nerve palsy. The patient was aware of a leftward deviation of the tongue along with pharyngeal pain. Read More

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December 2021

Central Venous-to-Arterial CO2 Difference-Assisted Goal-Directed Hemodynamic Management During Major Surgery-A Randomized Controlled Trial.

Anesth Analg 2022 Jan 13. Epub 2022 Jan 13.

From the Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, India.

Background: Different goals have guided goal-directed therapy (GDT). Protocols aiming for central venous-to-arterial carbon dioxide gap (DCO2) <6 mm Hg have improved organ function in septic shock. Evidence for use of DCO2 in the perioperative period is scarce. Read More

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January 2022

Choroidopathy and optic neuropathy in systemic lupus erythematosus, a case report.

Arch Soc Esp Oftalmol (Engl Ed) 2022 Jan 23;97(1):34-39. Epub 2021 Dec 23.

Servicio de Oftalmología, Hospital Nacional Edgardo Rebagliati Martins, Seguro Social de Salud - EsSalud, Lima, Peru; Facultad de Medicina Humana Manuel Huamán Guerrero, Universidad Ricardo Palma, Lima, Peru. Electronic address:

Although the associated ocular pathology to systemic lupus erythematosus is not infrequent, its manifestations and importance can be overlooked by rheumatologists and ophthalmologists. We present the case of a 44-year-old male with a history of systemic lupus erythematosus whose disease started with metamorphopsia and subjective alteration of the visual fields of both eyes, with a marked decrease in visual acuity, secondary to bilateral serous retinal detachment and optic neuropathy. He received systemic corticosteroids, biological therapy and posterior subtenon triamcinolone acetonide injections, showing an improvement in visual acuity. Read More

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January 2022

Mineralocorticoid Receptor Antagonist Use and Hard Renal Outcomes in Real-World Patients With Chronic Kidney Disease.

Hypertension 2022 Jan 14:HYPERTENSIONAHA12118360. Epub 2022 Jan 14.

Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan. (T.O., K.H., Y.A., S.K., Y.D., Y.I.).

Background: Real-world evidence about mineralocorticoid receptor antagonist (MRA) use has been limited in chronic kidney disease, particularly regarding its association with hard renal outcomes.

Methods: In this retrospective cohort study, adult chronic kidney disease outpatients referred to the department of nephrology at an academic hospital between January 2005 and December 2018 were analyzed. The main inclusion criteria were estimated glomerular filtration rate ≥10 and <60 mL/min per 1. Read More

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January 2022

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

"Facilitating HIV status adjustment: Qualitative insights from the Tambua Mapema proof-of-concept study in Kenya".

PLoS One 2022 13;17(1):e0261255. Epub 2022 Jan 13.

School of Public Health, Brown University, Providence, Rhode Island, United States of America.

Systematic efforts are needed to prepare persons newly diagnosed with acute or chronic HIV infection to cope. We examined how patients dealt with this news, looking at how readiness to accept an HIV diagnosis impacted treatment outcomes, prevention of transmission, and HIV status disclosure. We examined vulnerability and agency over time and considered implications for policy and practice. Read More

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January 2022

Impact of the DREAMS Program on New HIV Diagnoses in Adolescent Girls and Young Women Attending Antenatal Care - Lesotho, 2015-2020.

MMWR Morb Mortal Wkly Rep 2022 Jan 14;71(2):48-51. Epub 2022 Jan 14.

Lesotho is a small, landlocked country in southern Africa with a population of approximately 2 million persons, approximately two thirds of whom live in rural areas (1). Lesotho has the second highest prevalence of HIV infection in the world (2). In 2017, 25. Read More

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January 2022

Site-Specific Characterization of Heat-Induced Disulfide Rearrangement in Beta-Lactoglobulin by Liquid Chromatography-Mass Spectrometry.

J Agric Food Chem 2022 Jan 13. Epub 2022 Jan 13.

Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, Frederiksberg 1958, Denmark.

Disulfides are important for maintaining the protein native structure, but they may undergo rearrangement in the presence of free Cys residues, especially under elevated temperatures. Disulfide rearrangement may result in protein aggregation, which is associated with pathologies in organisms and protein functionality in food systems. In a food context, it is therefore important to understand the process of disulfide rearrangement on a site-specific level in order to control aggregation. Read More

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January 2022

Interaction between xylanase and a proton pump inhibitor on broiler chicken performance and gut function.

Anim Nutr 2022 Mar 22;8(1):277-288. Epub 2021 Sep 22.

AB Vista, Marlborough, Wiltshire, SN8 4AN, United Kingdom.

Three hundred thirty-six Ross 308 male broiler chicks were used in a 21-d study to explore performance and gut function when treated with a proton pump inhibitor (PPI; 0 or 89 mg/kg) in a 2 × 2 factorial arrangement with a xylanase (Xyl; 0 or 0.1 g/kg) to determine if the beneficial activity of arabinoxylan (AX) depolymerisation, through arabinoxylo-oligosaccharides (AXOS) production, starts in the upper gastrointestinal tract. Treatment with the PPI started from d 14, and by d 21 animal performance had deteriorated ( < 0. Read More

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Radiological evaluation of pseudofracture after the administration of asfotase alfa in an adult with benign prenatal hypophosphatasia: A case report.

Bone Rep 2022 Jun 29;16:101163. Epub 2021 Dec 29.

Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Japan.

Hypophosphatasia (HPP) is a congenital disorder with decreased activity of tissue-nonspecific alkaline phosphatase. Asfotase alfa is the only treatment approved for HPP and improves the impairment of bone mineralization. Although several previous studies have reported the efficacy of asfotase alfa to treat fractures and pseudofractures in patients with HPP, there are only a few reports with a detailed description of the healing process. Read More

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A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab.

Urol Case Rep 2022 Mar 27;41:101959. Epub 2021 Nov 27.

Departments of Urology, Osaka Rosai Hospital, 1179-3 Nagasone, Kitaku, Sakai City, Osaka, 591-8025, Japan.

A 69-year-old man with a history of non-muscle invasive bladder cancer 12 years ago presented complaining of gross hematuria. He was diagnosed as having invasive T4 bladder cancer with invasion to a branch of the internal iliac artery and received platinum-based chemo-radiation therapy. However, the tumor progressed to extensively infiltrate the pelvic wall, and left leg pain and swelling developed. Read More

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Healing of Severe Herpes Zoster Ophthalmicus Within a Few Days: An Autobiographical Case Report.

Authors:
Tibor Bakacs

Cureus 2021 Dec 9;13(12):e20303. Epub 2021 Dec 9.

Department of Probability, Alfred Renyi Institute of Mathematics; The Eötvös Loránd Research Network, Budapest, HUN.

Herpes zoster (shingles) is caused by the herpes zoster virus and is characterized by pain and unilateral vesicular rash that typically affects one dermatome. Symptoms tend to resolve over 10-15 days. This case report describes the 75-year-old author's herpes zoster ophthalmicus (HZO) accompanied by severe orbital edema. Read More

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December 2021

Central Nervous System Demyelination Related to Tumour Necrosis Factor Alpha Inhibitor.

Mult Scler J Exp Transl Clin 2022 Jan-Mar;8(1):20552173211070750. Epub 2022 Jan 5.

Perron Institute for Neurological and Translational Sciences, Perth, Australia.

Background: An association between tumour necrosis factor alpha (TNF-α) inhibitors exposure and central nervous system (CNS) demyelinating disorders has been postulated but is poorly understood.

Objectives: Describe the clinical spectrum and progress of a cohort of patients who developed demyelinating disorder following exposure to TNF-α inhibitor.

Methods: Retrospective chart review of patients who presented to a single neurologist in Western Australia between May 2003 and July 2020. Read More

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January 2022

Real-world effectiveness of dimethyl fumarate versus fingolimod in a cohort of patients with multiple sclerosis using standardized, quantitative outcome metrics.

Mult Scler J Exp Transl Clin 2022 Jan-Mar;8(1):20552173211069852. Epub 2022 Jan 7.

Biogen, Cambridge, USA.

Background: Prior studies suggest comparable effectiveness of dimethyl fumarate (DMF) and fingolimod (FTY) in multiple sclerosis (MS) using relapse, Expanded Disability Status Score (EDSS), and magnetic resonance imaging (MRI) lesion metrics.

Objective: Compare the real-world effectiveness of DMF versus FTY using quantitative, validated neuroperformance tests, MRI, and serum neurofilament light chain (sNfL) outcomes while controlling for between-group differences.

Methods: Patients were eligible if on DMF or FTY when first enrolled in the MS Partners Advancing Technology and Health Solutions (MS PATHS) network and had ≥1-year follow-up in MS PATHS. Read More

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January 2022

Inappropriate sinus tachycardia-induced cardiomyopathy with severe functional mitral regurgitation and successful treatment with ivabradine.

J Cardiol Cases 2022 Jan 20;25(1):6-9. Epub 2021 Jun 20.

Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto-city, Japan.

Ivabradine increases stroke volume, but does not have a negative impact on blood pressure (BP). Thus, a patient with low BP can benefit from treatment with ivabradine. A 72-year-old Japanese woman with asthma and chronic bronchitis presented with dyspnea. Read More

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January 2022