953 results match your criteria started prostaglandin

Endothelial Cell Participation in Inflammatory Reaction.

Int J Mol Sci 2021 Jun 13;22(12). Epub 2021 Jun 13.

Faculté de Médecine, Université Denis Diderot Paris, 75013 Paris, France.

Inflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept of the inflammation process. The function of the endothelium appeared to be crucial as a regulator or the initiator of the inflammatory process. Read More

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Extracorporeal Membrane Oxygenation as a Rescue Therapy for Postoperative Diastolic Dysfunction and Refractory Chylothorax.

ASAIO J 2021 05;67(5):e99-e101

Pediatric Cardiac Intensive Care Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

This is the first published case, as far as we know, of a term neonate with refractory chylothorax secondary to diastolic dysfunction in the cardiac postoperative period, where extracorporeal membrane oxygenation (ECMO) was used to improve the physiologic derangements, thus allowing resolution of the chylous effusion. The infant was prenatally diagnosed with d-transposition of the great arteries. He was started on prostaglandin infusion and underwent balloon atrial septostomy followed by arterial switch operation. Read More

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Critical congenital heart disease in neonates: a review article.

Curr Pediatr Rev 2021 Feb 19. Epub 2021 Feb 19.

Department of Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra. India.

Critical congenital heart defects (CCHDs) are serious malformations which remain to be an important cause of neonatal mortality and morbidity. The clinical presentations of CCHD are shock, cyanosis or respiratory distress which may be similar to that of other neonatal conditions. Failure to diagnose these conditions early on after birth may result acute cardiovascular collapse and death. Read More

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February 2021

Evaluation of Immunomodulatory and Antiarthritic Potential of Extracts.

Evid Based Complement Alternat Med 2020 12;2020:8836080. Epub 2020 Dec 12.

Imran Idrees College of Pharmacy, 3 km Daska Road, Sialkot, Pakistan.

The genus of has long been used for the treatment of arthritis and inflammatory disorders. This study was aimed to investigate the immunomodulatory activities of ethanol and -hexane extracts of in the rat model of rheumatoid arthritis. Freund's complete adjuvant (FCA) model was used to induce arthritis in rats. Read More

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December 2020

Diagnostic categorization of erectile dysfunction using duplex color doppler ultrasonography and significance of phentolamine redosing in abolishing false diagnosis of venous leak impotence: A single center experience.

Reddy Ravikanth

Indian J Radiol Imaging 2020 Jul-Sep;30(3):344-353. Epub 2020 Oct 15.

Department of Radiology, Holy Family Hospital, Thodupuzha, Kerala, India.

Background And Aims: Erectile dysfunction (ED) is an inability to achieve and maintain erectile rigidity sufficient for satisfactory sexual performance. It is either organic or psychogenic in origin. This study was aimed at establishing vasculogenic causes among patients being evaluated for ED using Penile Doppler Ultrasound. Read More

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October 2020

Responsiveness of Inhaled Epoprostenol in Respiratory Failure due to COVID-19.

J Intensive Care Med 2021 Mar 25;36(3):327-333. Epub 2020 Nov 25.

Division of Pulmonary, Critical Care and Sleep Medicine, 12230Georgetown University Medical Center, Washington, DC, USA.

Background: Inhaled pulmonary vasodilators are used as adjunctive therapies for the treatment of refractory hypoxemia. Available evidence suggest they improve oxygenation in a subset of patients without changing long-term trajectory. Given the differences in respiratory failure due to COVID-19 and "traditional" ARDS, we sought to identify their physiologic impact. Read More

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Effect of one year krill oil supplementation on depressive symptoms and self-esteem of Dutch adolescents: A randomized controlled trial.

Prostaglandins Leukot Essent Fatty Acids 2020 12 12;163:102208. Epub 2020 Nov 12.

Faculty of Educational Sciences, Open University of the Netherlands, the Netherlands, Heerlen 6419 AT, the Netherlands; Nutrition and Translational Research in Metabolism (School NUTRIM), Maastricht University, 6200 MD Maastricht, The Netherlands.

Introduction: Observational studies have shown a relationship between omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) and depression in adolescents. However, n-3 LCPUFA supplementation studies investigating the potential improvement in depressive feelings in adolescents from the general population are missing.

Methods: A one-year double-blind, randomized, placebo controlled krill oil supplementation trial was conducted in two cohorts. Read More

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December 2020

Why does COVID-19 pathology have several clinical forms?

Bioessays 2020 12 11;42(12):e2000198. Epub 2020 Nov 11.

Physiology Research Center, Department of Medicine, Iran University of Medical Sciences, Tehran, Iran.

The outbreak of a new, potentially fatal virus, SARS-COV-2, which started in December 2019 in Wuhan, China, and since developed into a pandemic has stimulated research for an effective treatment and vaccine. For this research to be successful, it is necessary to understand the pathology of the virus. So far, we know that this virus can harm different organs of the body. Read More

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December 2020

Low-dose prostaglandin E1 is safe and effective for critical congenital heart disease: is it time to revisit the dosing guidelines?

Cardiol Young 2021 Jan 3;31(1):63-70. Epub 2020 Nov 3.

Nemours Cardiac Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

Introduction: Prostaglandin E1 is used to maintain ductal patency in critical congenital heart disease (CHD). The standard starting dose of prostaglandin E1 is 0.05 µg/kg/minute. Read More

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January 2021

Severe pulmonary arterial hypertension and interstitial pneumonia related to systemic lupus erythematosus successfully treated with mycophenolate mofetil: A novel case report.

Lupus 2020 Dec 11;29(14):1955-1960. Epub 2020 Sep 11.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Background: Pulmonary arterial hypertension (PAH) and interstitial pneumonia (IP) are relatively rare complications of systemic lupus erythematosus (SLE) and are associated with a poor prognosis. Overcoming these complications is a challenge for improving the prognosis.

Case Report: A 41-year-old woman was diagnosed with SLE complicated by IP at the age of 21 years and with antiphospholipid syndrome at the age of 32 years at another hospital. Read More

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December 2020

Home versus inpatient induction of labour for improving birth outcomes.

Cochrane Database Syst Rev 2020 08 27;8:CD007372. Epub 2020 Aug 27.

University Maternity Hospital Limerick, Limerick, Ireland.

Background: The setting in which induction of labour takes place (home or inpatient) is likely to have implications for safety, women's experiences and costs. Home induction may be started at home with the subsequent active phase of labour happening either at home or in a healthcare facility (hospital, birth centre, midwifery-led unit). More commonly, home induction starts in a healthcare facility, then the woman goes home to await the start of labour. Read More

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The effect of prostacyclin (Iloprost) infusion at a dose of 1 ng/kg/min for 72 hours compared to placebo in mechanically ventilated patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial.

Trials 2020 Aug 26;21(1):746. Epub 2020 Aug 26.

Department of Intensive Care 4131, Rigshospitalet, Copenhagen, Denmark.

Objectives: To investigate the effect of continuous infusion of the potential endothelial cytoprotective agent prostacyclin (Iloprost) 1 ng/kg/min vs. placebo for 72 hours on pulmonary endotheliopathy in mechanically ventilated COVID-19 patients.

Trial Design: A multicenter, randomized (1:1, active: placebo), blinded, parallel group exploratory trial PARTICIPANTS: Inclusion criteria are: Adult patients (>18 years); Confirmed COVID-19 infection; Need for mechanical interventions; Endothelial biomarker soluble thrombomodulin >4ng/ml. Read More

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Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch.

BMC Vet Res 2020 Aug 10;16(1):284. Epub 2020 Aug 10.

Department of Animal Medicine, Production and Health, University of Padua, Padua, Italy.

Background: This is the first report about a vaginal leiomyoma concomitant with an ovarian luteoma in a bitch.

Case Presentation: A 11-year-old intact female Labrador retriever was referred because of anuria, constipation and protrusion of a vaginal mass through the vulvar commissure. The bitch had high serum progesterone concentration (4. Read More

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A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath.

Chest 2020 07 2;158(1):e37-e40. Epub 2020 Jul 2.

Yale University School of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, New Haven, CT. Electronic address:

Case Presentation: A 50-year-old woman with a medical history significant for limited scleroderma (SSc) complicated by interstitial lung disease (ILD) and pulmonary arterial hypertension presented to our institution with acute on chronic shortness of breath. Ten years before presentation, she was diagnosed with SSc. Two years before presentation, she was found to have ILD, for which she was started on mycophenolate mofetil and low-dose prednisone. Read More

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Rapid transition from oral selexipag to parenteral treprostinil in a patient with mixed-etiology pulmonary hypertension.

Am J Health Syst Pharm 2020 07;77(15):1208-1212

Arizona Pulmonary Specialists, Phoenix, AZ.

Purpose: Selexipag is an oral nonprostanoid IP prostacyclin receptor agonist that is indicated for treatment of pulmonary arterial hypertension (PAH). In patients with continued symptoms of PAH despite maximized oral therapy with selexipag and other oral therapies, a transition to parenteral prostacyclin may be warranted. There is a paucity of data regarding how to safely transition from oral selexipag to parenteral treprostinil. Read More

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Visual improvement in a patient with paracentral acute middle maculopathy treated with prostaglandin E1.

Drug Discov Ther 2020 ;14(2):98-99

Department of Sense Organs, La Sapienza University of Rome, Rome, Italy.

The authors present the use of prostaglandin E1 (PGE1) for the treatment of an acute paracentral acute middle maculopathy (PAMM). A 78-year-old white female was seen with a sudden loss of vision in her left eye (OS) to 20/200 noted upon awakening. The right eye (OD) saw 20/20. Read More

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October 2020

A case of pulmonary arterial hypertension with chronic hepatitis that resulted in hepatosplenomegaly after administration of prostaglandin I2.

J Cardiol Cases 2020 May 19;21(5):182-185. Epub 2020 Feb 19.

Department of Cardiovascular Medicine, Kanazawa University Hospital, Kanazawa, Japan.

The prognosis of pulmonary arterial hypertension (PAH) has significantly improved over the past two decades due to advances in medications, including pulmonary vasodilators. However, the side effects of these drugs remain problematic in some patients. A 51-year-old woman with chronic hepatitis C was diagnosed with PAH 7 years before presenting to our hospital. Read More

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iStent inject trabecular micro-bypass stents with topical prostaglandin as standalone treatment for open-angle glaucoma: 4-year outcomes.

Clin Exp Ophthalmol 2020 08 12;48(6):767-774. Epub 2020 May 12.

Minnesota Eye Consultants, Minneapolis, Minnesota, USA.

Importance: Long-term data are needed regarding effective and safe glaucoma treatment modalities.

Background: This study evaluated 4-year outcomes of second-generation trabecular micro-bypass stent implantation (iStent inject) combined with topical travoprost in open-angle glaucoma (OAG).

Design: Prospective, non-randomized, multi-surgeon study at a tertiary care ophthalmology centre. Read More

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A Case of Delayed Presentation of Transposition of the Great Arteries.

Pediatr Emerg Care 2020 Feb 22. Epub 2020 Feb 22.

From the Western Michigan University School of Medicine, Kalamazoo, MI.

Intro: Transposition of the great arteries (TGA) is a rare cyanotic congenital heart defect (CHD) typically presenting the first month of life. Late presentations may occur in patients with associated cardiac anomalies allowing for mixing of oxygenated and deoxygenated blood, such as ventral septal defects or large atrial septal defects (ASD). We present a case of a late-presenting TGA with no ventral septal defect, and only small ASD and patent ductus arteriosus (PDA). Read More

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February 2020

Early resynchronization of non-pregnant beef cows based in corpus luteum blood flow evaluation 21 days after Timed-AI.

Theriogenology 2020 Apr 29;146:26-30. Epub 2020 Jan 29.

University José do Rosário Vellano - UNIFENAS, Alfenas, MG, 37130-000, Brazil; Embrapa Recursos Genéticos e Biotecnologia, Brasília, DF, 70770-917, Brazil.

The study aimed to verify whether a hormone protocol started at Day 13 (D13) after Timed Artificial Insemination (TAI) influences the conception rate. Nelore cows (primiparous and multiparous) from two commercial beef farms (n = 1,431) were first TAI (D0). Timed AI was performed in lots (TAI Lots) ranging from 187 to 346 cows. Read More

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The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats.

J Ethnopharmacol 2020 May 6;253:112653. Epub 2020 Feb 6.

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Ethnopharmacological Relevance: Oxidative stress during inflammation can increase inflammation and damage tissue. Nigella sativa L. (NS) showed many pharmacological properties including antioxidant and anti-inflammatory activities. Read More

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Changes in Prostaglandin-associated Periorbital Syndrome After Switch from Conventional Prostaglandin F2α Treatment to Omidenepag Isopropyl in 11 Consecutive Patients.

J Glaucoma 2020 04;29(4):326-328

Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Purpose: We evaluated the recovery of patients with PAPS for whom the treatment regimen switched from conventional prostaglandin F2α analogues to a new selective prostaglandin-EP2 agonist: omidenepag isopropyl.

Patients And Methods: From November 2018 to July 2019, we prospectively evaluated 11 patients who had been using conventional PGF2α drugs. Digital photographs of the patients were taken before the start of omidenepag isopropyl therapy and ~3 and 6 months after. Read More

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Ebstein's anomaly with 'reversible' functional pulmonary atresia.

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Pediatric Cardiology, Hospital Santa Cruz, Carnaxide, Portugal.

We present the case of an infant with prenatal diagnosis, at 32 weeks gestation, of Ebstein's anomaly without anterograde flow from right ventricular to pulmonary atresia (PA)-functional PA with flow reversal in the ductus arteriosus. Prostaglandin E1 was started after birth. Chest X-ray showed severe cardiomegaly and echocardiogram confirmed Ebstein's anomaly with a thickened non-opening pulmonary valve without anterograde flow but with mild regurgitation. Read More

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December 2019

Reproductive performance of goats treated with free gonadorelin or nanoconjugated gonadorelin at estrus.

Domest Anim Endocrinol 2020 04 6;71:106390. Epub 2019 Sep 6.

Department of Animal and Fish Production, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21545, Egypt.

The reproductive performance of goats that received a GnRH analog (gonadorelin) fabricated with or without chitosan-sodium tripolyphosphate (TPP) nanoparticles on the day of estrus (day 0) was evaluated. The chitosan-TPP polymer was conjugated with gonadorelin using an ionic gelation method. Thirty-three multiparous Zaraiebi goats were synchronized for estrus with 2 intramuscular (im) injections of 125 μg prostaglandin F 14 d apart. Read More

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-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect.

BMC Chem 2019 Dec 31;13(1):124. Epub 2019 Oct 31.

1Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Introduction: New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.

Methods: The synthesis of the designed molecules started from easily accessible and versatile -difluoro propargylic derivatives. The desired aromatic systems were obtained using Diels-Alder/aromatization sequences and this was followed by Pd-catalyzed coupling reactions and, when required, final functionalization steps. Read More

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December 2019

Effects of feeding OmniGen-AF® on superovulatory response in donor beef cows: I. Serum progesterone and cortisol, embryo recovery and quality.

Anim Reprod Sci 2019 Nov 31;210:106174. Epub 2019 Aug 31.

112 Withycombe Hall, Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331-6702, United States.

Optimal results in cattle embryo transfer are limited by the variation in ova recovery, fertilization rate and embryo quality experienced with superovulation. Inflammation and immune dysregulation may be contributing factors. This study, evaluated feeding OmniGen-AF® (OG), a nutritional supplement that reduces inflammation and supports immune health, on superovulatory response and serum progesterone and cortisol concentrations in embryo donors treated with two different doses of Folltropin®-V (FSH). Read More

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November 2019

A comparison between labor induction with only Dilapan-S and a combination of mifepristone and Dilapan-S in nulliparous women: a prospective pilot study.

J Matern Fetal Neonatal Med 2021 Sep 1;34(17):2832-2837. Epub 2019 Oct 1.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation, Moscow, Russia.

Objective: The aim of our study was to determine whether the combination of mifepristone and the osmotic dilator Dilapan-S improves the labor induction outcomes as compared to Dilapan-S alone.

Methods: This prospective comparative study included 127 eligible women, of whom 58 underwent cervical ripening with Dilapan-S (12-h exposure, the control group) and 69 with Dilapan-S, with a concurrent pretreatment of 200 mg oral mifepristone (the study group), 8 h before Dilapan-S insertion.

Results: The vaginal delivery rate in the control group and the study group was 60. Read More

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September 2021

[Initial combination therapy for primary open-angle glaucoma].

Vestn Oftalmol 2019 ;135(2):32-38

Novokuznetsk State Institution of Advanced Training of Physicians - branch of Russian Medical Academy of Continuous Professional Education, 5 Stroitelei av., Novokuznetsk, Russian Federation, 654005.

Purpose: To study the efficacy and safety of initial combination therapy in patients with primary open-angle glaucoma (POAG).

Material And Methods: The study included 111 patients (161 eyes) with stages II-III b-c of POAG aged 46 to 89 years (mean age 70.8±8. Read More

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Cellular and physiological upregulation of inducible nitric oxide synthase, arginase, and inducible cyclooxygenase in wound healing.

J Cell Physiol 2019 12 3;234(12):23618-23632. Epub 2019 Jun 3.

Histology and Cell Biology, Minia University, Minia, Egypt.

Wound repair is regulated by overlapping cellular, physiological and biochemical events. Prostaglandins and nitric oxide have been a focus for inflammation research particularly since the discovery of their inducible isoforms nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Study of the cellular expression of iNOS and COX-2 and arginase which competes with iNOS for its substrate, in an in vivo model of wound healing could reveal important roles for these enzymes in the physiological progression of wound repair. Read More

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December 2019

Resynchronisation as an Element of Improving Cattle Reproduction Efficiency.

J Vet Res 2019 Mar 22;63(1):107-115. Epub 2019 Mar 22.

Veterinary Centre of Nicolaus Copernicus University, 87-100 Toruń, Poland.

Oestrus resynchronisation (RES, Resynch) programmes for non-pregnant cows allow shortening the period between an unsuccessful insemination and the next attempt on the same cow. The protocol of oestrus RES may be started after ruling out pregnancy by means of ultrasonography carried out 28 days after insemination or after performing a test for pregnancy-specific glycoproteins (PAG) in blood or milk. The Resynch protocol can be based on a double application of prostaglandins, the OvSynch protocol, or hormonal therapy with exogenous sources of progesterone (CIDR intravaginal devices). Read More

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