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Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin.

Thromb Haemost 2021 Jun 15. Epub 2021 Jun 15.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands.

Background:  Sunitinib is a multitarget tyrosine kinase inhibitor (TKI) used for cancer treatment. In platelets, sunitinib affects collagen-induced activation under noncoagulating conditions. We investigated (1) the effects of sunitinib on thrombus formation induced by other TK-dependent receptors, and (2) the effects under coagulating conditions. Read More

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Impact of intensity of behavioral treatment, with or without medication treatment, for opioid use disorder on HIV outcomes in persons with HIV.

J Subst Abuse Treat 2021 May 29;132:108509. Epub 2021 May 29.

Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA; VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. Electronic address:

Background: Persons with HIV (PWH) and opioid use disorder (OUD) can have poor health outcomes. We assessed whether intensity of behavioral treatment for OUD (BOUD) with and without medication for OUD (MOUD) is associated with improved HIV clinical outcomes.

Methods: We used Veterans Aging Cohort Study (VACS) data from 2008 to 2017 to identify PWH and OUD with ≥1 BOUD episode. Read More

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Annual Costs Incurred in Managing Adverse Drug Reactions Attributable to Fixed-Dose Combination Highly Active Antiretroviral Therapy in an Outpatient Antiretroviral Clinic in Gauteng: A Budget Impact Analysis.

Value Health Reg Issues 2021 Jun 12;25:142-149. Epub 2021 Jun 12.

School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Objectives: This study aimed to identify adverse drug reactions (ADRs) attributable to tenofovir (TDF)- and zidovudine (AZT)-based fixed-dose combinations of highly active antiretroviral (ARV) therapy and subsequently determine the annual costs incurred in managing these ADRs and the budget implications in an outpatient ARV clinic in Mamelodi, Pretoria.

Methods: This retrospective cohort study reviewed deidentified clinical data for ADRs. Medical charts of human immunodeficiency virus-positive patients, who were receiving either TDF- or AZT-based fixed-dose combinations of ARV therapy, were analyzed. Read More

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From hospital unit to intestinal failure center: Twenty years of history.

Clin Nutr 2021 Apr 27;40(6):3787-3792. Epub 2021 Apr 27.

Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Care, Jagiellonian University, Krakow, Poland.

Aim: Home parenteral nutrition (HPN) is one of the most demanding medical therapies as it is the only option for patients for intestinal failure (IF). No unequivocal policy on how to start and progress with HPN has ever been presented. The IF Center at the Stanley Dudrick's Memorial Hospital in Skawina is one of the biggest centers in Poland, celebrating its twentieth birthday last year. Read More

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Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs.

Mol Cell Proteomics 2021 Jun 12:100109. Epub 2021 Jun 12.

Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Many small open reading frames (smORFs) embedded in lncRNA transcripts have been shown to encode biologically functional polypeptides (smORFs-encoded polypeptides, SEPs) in different organisms. Despite significant advances in genomics, bioinformatics and proteomics that largely enabled the discovery of novel SEPs, their identification across different biological samples is still hampered by their poor predictability, diminutive size and low relative abundance. Here, we take advantage of NONCODE, a repository containing the most complete collection and annotation of lncRNA transcripts from different species, to build a novel database that attempts to maximize a collection of SEPs from human and mouse lncRNA transcripts. Read More

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Yawn-like behavior in captive common bottlenose dolphins (Tursiops truncatus).

Behav Processes 2021 Jun 12:104444. Epub 2021 Jun 12.

Graduate School of Bioresources, Mie University, 1577 Kurimamachiya-cho, Tsu, Mie, 514-8507, Japan.

Yawning is an involuntary action that begins with a slow opening of the mouth with inhalation, followed by a maximum gaping phase, and ends with a short exhalation and the closing of the mouth. A wide variety of vertebrate species, including humans, yawn. Here, we report underwater yawn-like behavior in three captive common bottlenose dolphins, inferred from 119-h of observations. Read More

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Features of post-endoscopic submucosal dissection electrocoagulation syndrome for early gastric neoplasm.

J Gastroenterol Hepatol 2021 Jun 15. Epub 2021 Jun 15.

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Background And Aim: Post-endoscopic submucosal dissection electrocoagulation syndrome (PECS) has become a common adverse event after colorectal endoscopic submucosal dissection (ESD) and esophageal ESD. However, little is known about PECS after gastric ESD. Therefore, this study aimed to investigate the clinical features of PECS after gastric ESD. Read More

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Thiazolidinediones and Glucagon-like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

CARIM School for Cardiovascular Disease, Maastricht University, Maastricht, the Netherlands.

Thiazolidinediones (TZDs) and glucagon-like peptide-1 (GLP-1) receptor agonists are potential pharmacological treatment options for patients at risk of nonalcoholic fatty liver disease (NAFLD). Therefore, we examined the association between the risk of NAFLD and the use of thiazolidinediones and GLP-1 receptor agonists compared with the use of sulfonylureas (SUs) and insulins. Additionally, we calculated the incidence of hepatocellular carcinoma (HCC) in users of TZDs and GLP-1 receptor agonists. Read More

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Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic.

PLoS One 2021 15;16(6):e0253327. Epub 2021 Jun 15.

Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.

Background: The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large aneurysms reduces ruptures and AAA-related mortality. AAA screening services have been disrupted following COVID-19 but it is not known how this may impact AAA-related mortality, or where efforts should be focussed as services resume. Read More

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A Resident-Led Intervention to Increase Initiation of Buprenorphine Maintenance for Hospitalized Patients With Opioid Use Disorder.

J Hosp Med 2021 Jun;16(6):339-344

Department of Pediatrics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Hospitalized patients with opioid use disorder (OUD) are rarely started on buprenorphine or methadone maintenance despite evidence that these medications reduce all-cause mortality, overdoses, and hospital readmissions.

Objective: To assess whether clinician education and a team of residents and hospitalist attendings waivered to prescribe buprenorphine increased the rate of starting patients with OUD on buprenorphine maintenance.

Design, Setting, And Participants: Quality improvement study conducted at a large, urban, academic hospital in Maryland involving hospitalized patients with OUD on internal medicine resident services. Read More

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Which variables may affect underwater glide performance after a swimming start?

Eur J Sport Sci 2021 Jun 15:1-20. Epub 2021 Jun 15.

University of Castilla-La Mancha, Sport Training Lab, Toledo, Spain.

The underwater phase is perhaps the most important phase of the swimming start. To improve performance during the underwater phase, it is necessary to improve our understanding of the key variables affecting this phase. The main aim of this study was to identify key kinematic variables that are associated with the performance of an underwater glide of a swimming start, when performed at streamlined position without underwater undulatory swimming. Read More

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Academic Medicine Faculty Perceptions of Work-Life Balance Before and Since the COVID-19 Pandemic.

JAMA Netw Open 2021 Jun 1;4(6):e2113539. Epub 2021 Jun 1.

Office of Faculty Affairs, The University of Texas Southwestern, Dallas.

Importance: How the COVID-19 pandemic has affected academic medicine faculty's work-life balance is unknown.

Objective: To assess the association of perceived work-life conflict with academic medicine faculty intention to leave, reducing employment to part time, or declining leadership opportunities before and since the COVID-19 pandemic.

Design, Settings, And Participants: An anonymous online survey of medical, graduate, and health professions school faculty was conducted at a single large, urban academic medical center between September 1 and September 25, 2020. Read More

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Effects of Intravenous Eptinezumab vs Placebo on Headache Pain and Most Bothersome Symptom When Initiated During a Migraine Attack: A Randomized Clinical Trial.

JAMA 2021 Jun;325(23):2348-2356

Lundbeck La Jolla Research Center, San Diego, California.

Importance: Intravenous eptinezumab, an anti-calcitonin gene-related peptide antibody, is approved for migraine prevention in adults. It has established onset of preventive efficacy on day 1 after infusion.

Objective: To evaluate the efficacy of and adverse events related to eptinezumab when initiated during a migraine attack. Read More

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Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2-March 18, 2020.

Clin Infect Dis 2021 Jun 15. Epub 2021 Jun 15.

All of Us Research Program, National Institutes of Health, Bethesda, MD.

Background: With limited SARS-CoV-2 testing capacity in the US at the start of the epidemic (January - March), testing was focused on symptomatic patients with a travel history throughout February, obscuring the picture of SARS-CoV-2 seeding and community transmission. We sought to identify individuals with SARS-CoV-2 antibodies in the early weeks of the US epidemic.

Methods: All of Us study participants in all 50 US states provided blood specimens during study visits from January 2 to March 18, 2020. Read More

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Secukinumab in the treatment for patients with juvenile enthesitis related arthritis non-responsive to anti-TNF treatment according the Juvenile Spondyloarthritis Disease Activity Index.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Hamburg Center for Paediatric and Adolescent Rheumatology, Am Schön Klinik Eilbek, Hamburg, Germany.

Objectives: To review the effectiveness of secukinumab (SEC) in patients with juvenile idiopathic enthesitis related arthritis (ERA), who had partial or no response on anti-TNF therapy.

Methods: We conducted a retrospective monocentric chart review of patients with ERA, who were treated with SEC, until March 15th 2019. We used the JADAS10 and the Juvenile Spondyloarthritis Disease Activity Index (jspADA) to evaluate response. Read More

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Comparing cyberbullying prevalence and process before and during the COVID-19 pandemic.

J Soc Psychol 2021 Jun 15:1-11. Epub 2021 Jun 15.

Iowa State University.

The psychological consequences of the global COVID-19 pandemic are just now starting to be understood; however, the behavioral consequences are less understood. Thus, the current report examined whether cyberbullying processes and frequency are affected by the COVID-19 pandemic. We compared US adult participant data from six months before the start of the pandemic (July 2019; n = 181) to data collected in the middle of the pandemic (May, 2020; n = 173) to determine if there are any significant differences in anonymity perceptions, belief in the irrelevance of muscularity for online bullying (BIMOB), cyberbullying attitudes, and cyberbullying perpetration. Read More

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Coaching Teachers to Improve Students' School Readiness Skills: Indirect Effects of Teacher-Student Interaction.

Child Dev 2021 Jun 15. Epub 2021 Jun 15.

University of Virginia.

This study examined indirect associations of MyTeachingPartner coaching with pre-K students' (N = 1,570; 73% low income) school readiness, via improvements of teachers' (N = 393; 47% Black; 41% Head Start) classroom interactions. Data were collected across 2008-2009 and 2009-2010 in 10 urban sites across the eastern United States. The number of completed coaching cycles was examined as a predictor of teacher-student interactions, as were direct or indirect associations with students' literacy, receptive language, and working memory skills. Read More

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Thromboinflammation in COVID-19: The Clot Thickens.

Br J Pharmacol 2021 Jun 14. Epub 2021 Jun 14.

Department of Life Sciences, The Centre for Inflammation Research and Translational Medicine (CIRTM), Brunel University London, Uxbridge, Middlesex, UB8 3PH, UK.

Since the start of the coronavirus SARS-Cov-2 pandemic, a disease that has become one of the world's greatest global health challenges, the role of the immune system has been at the forefront of scientific studies. The pathophysiology of COVID-19 is complex, which is evident in those at higher risk for poor outcome. Multiple systems contribute to thrombosis and inflammation seen in COVID-19 patients, including neutrophil and platelet activation, and endothelial dysfunction. Read More

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Returning to dialysis after kidney allograft failure: the experience of the Italian Registry of Paediatric Chronic Dialysis.

Pediatr Nephrol 2021 Jun 14. Epub 2021 Jun 14.

Dialysis Unit, Department of Pediatrics, IRCCS Giannina Gaslini, Genova, Italy.

Background: The need for dialysis after kidney allograft failure (DAGF) is among the top five reasons for dialysis initiation, making this an important topic in clinical nephrology. However, data are scarce on dialysis choice after transplantation and clinical outcomes for DAGF in children.

Methods: Patients receiving chronic dialysis < 18 years were recorded from January 1991 to January 2019 by the Italian Registry of Pediatric Chronic Dialysis (IRPCD). Read More

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Nasal high-frequency jet ventilation (NHFJV) as a novel means of respiratory support in extremely low birth weight infants.

J Perinatol 2021 Jun 14. Epub 2021 Jun 14.

Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objective: Describe our experience of successfully using nasal high-frequency jet ventilation (NHFJV) in extremely low birth weight infants with respiratory failure.

Study Design: A retrospective review was conducted on 16 infants with birth weights <1000 g who received NHFJV from 2015 to 2019. Successful use was defined as avoiding intubation for at least 72 hours and demonstrating tolerance after being placed on NHFJV. Read More

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Seventy eight children born small for gestational age without catch-up growth treated with growth hormone from the prepubertal stage until adult height age. An evaluation of puberty and changes in the metabolic profile.

Endocrinol Diabetes Nutr 2021 Jun 11. Epub 2021 Jun 11.

Pediatric Endocrinology Unit, Vall d'Hebron University Hospital, Barcelona, Spain; Vall d'Hebron Research Institut, Paediatric Endocrinology, Vall d'Hebron University Hospital, Barcelona, Spain; Autonomous University of Barcelona, Barcelona, Spain.

A wide variation in height gain rate is observed in children small for gestational age (SGA) treated with growth hormone (GH). The aim of this study was to evaluate prepubertal and pubertal growth, height gain attained at adult age and to assess potential predictive factors in catch-up growth. Changes in metabolic profile were also analyzed. Read More

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Effect of the type of specialized nutrition support on the course of the patient with amyotrophic lateral sclerosis (ALS). Interhospital registry SCLEDyN.

Endocrinol Diabetes Nutr 2021 Jun 11. Epub 2021 Jun 11.

Hospital Clínico Universitario de Valladolid, Valladolid, España; Instituto de Investigación en Endocrinología y Nutrición (IENVA), Universidad de Valladolid, Valladolid, España.

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which specialized nutritional support is essential. The objectives of our study were to describe nutritional support at the beginning of follow-up and its impact on anthropometry and survival.

Methods: An interhospital registry was created for the hospitals of Castilla-León through a web platform designed for this purpose. Read More

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Prometaphase.

Semin Cell Dev Biol 2021 Jun 11. Epub 2021 Jun 11.

Chromosome Instability & Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. Electronic address:

The establishment of a metaphase plate in which all chromosomes are attached to mitotic spindle microtubules and aligned at the cell equator is required for faithful chromosome segregation in metazoans. The achievement of this configuration relies on the precise coordination between several concurrent mechanisms that start upon nuclear envelope breakdown, mediate chromosome capture at their kinetochores during mitotic spindle assembly and culminate with the congression of all chromosomes to the spindle equator. This period is called 'prometaphase'. Read More

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A Case Report of Torsade de Pointes and Brugada Pattern Associated with Loperamide Misuse and Supratherapeutic Loperamide Concentrations.

J Emerg Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Emergency Medicine, Denver Health and Hospital Authority, Denver, Colorado; Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, Colorado.

Background: Loperamide, commonly sold under the brand name Imodium® (Johnson & Johnson, Fort Washington, PA), is a widely available, over-the-counter antidiarrheal medication that possesses µ-opioid agonist properties and can have catastrophic cardiac events when misused or abused. Since the start of the opioid epidemic in the United States, there has been an increasing number of case reports and deaths linking loperamide abuse with cardiac events such as torsades de pointes (TdP) and Brugada syndrome.

Case Report: This case report presents a 22-year-old man who presented in cardiac arrest from polymorphic ventricular tachycardia consistent with TdP and a Type 1 Brugada pattern after intentional loperamide abuse. Read More

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"Ladies and gentlemen, please start your engines!": why you should gamify your cognitive stimulation interventions for dementia patients.

Authors:
W Trapp

Int Psychogeriatr 2021 Jun 15:1-3. Epub 2021 Jun 15.

Department of Psychiatry and Psychotherapy, Sozialstiftung Bamberg, Bamberg, Germany.

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Impact of COVID-19 pandemic on athletes with disabilities preparing for the Paralympic Games in Tokyo.

BMC Res Notes 2021 Jun 14;14(1):233. Epub 2021 Jun 14.

Department of Adapted Physical Activity, Poznan University of Physical Education, Poznań, Poland.

Objective: The main aim of the study was to assess the impact of COVID-19 pandemic on athletes preparing for the Tokyo 2021 Paralympic Games during 1 month of lockdown in Poland. The study involved 166 athletes (106 male, 66 female), members of either the Polish Paralympic Committee or the Polish Sports Association for the Disabled'Start', two organizations responsible for managing and regulating sports played by persons with disabilities in Poland.

Results: Athletes with disabilities have been strongly affected by the pandemic and the resultant lockdown. Read More

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Increased peak detection accuracy in over-dispersed ChIP-seq data with supervised segmentation models.

BMC Bioinformatics 2021 Jun 14;22(1):323. Epub 2021 Jun 14.

School of Informatics, Computing, and Cyber Systems (SICCS), Northern Arizona University, 86011, Flagstaff, AZ, USA.

Background: Histone modification constitutes a basic mechanism for the genetic regulation of gene expression. In early 2000s, a powerful technique has emerged that couples chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq). This technique provides a direct survey of the DNA regions associated to these modifications. Read More

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Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults.

Cancer Res Treat 2021 Jun 14. Epub 2021 Jun 14.

Center for Pediatric Oncology, National Cancer Center, Goyang, Korea.

Purpose: No standard salvage regimen is available for relapsed or refractory sarcoma. We investigated the efficacy and toxicity of the vincristine, irinotecan, and temozolomide combination (VIT) for relapsed or refractory sarcomas of variable histology in children and young adults.

Materials And Methods: We retrospectively reviewed data from the relapsed or refractory sarcoma patients who were treated with VIT. Read More

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Biodegradation of an essential oil UVCB - Whole substance testing and constituent specific analytics yield biodegradation kinetics of mixture constituents.

Chemosphere 2021 Sep 1;278:130409. Epub 2021 Apr 1.

Technical University of Denmark, Department of Environmental Engineering, Building 115, 2800 Kgs, Lyngby, Denmark. Electronic address:

Testing and assessing the persistency, bioaccumulative and toxic properties of UVCBs (substances of Unknown or Variable composition, Complex reaction products or Biological materials) pose major technical and analytical challenges. The main aim of this study was to combine whole substance biodegradation testing with constituent specific analytics for determining primary biodegradation kinetics of the main UVCB constituents. An additional aim was to link the primary biodegradation kinetics of the main constituents to the bioaccumulation potential and baseline toxicity potential of the UVCB. Read More

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September 2021