115,934 results match your criteria standardized diagnostic

Accuracy of imaging modalities at detecting extracapsular spread of cervical lymph node metastases in HPV-associated oropharyngeal cancer: a systematic review protocol of diagnostic test accuracy.

JBI Evid Synth 2021 Sep 22. Epub 2021 Sep 22.

JBI, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia Department of Otolaryngology, Head and Neck Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia.

Objective: The objective of this review is to evaluate the accuracy of different imaging modalities in detecting extracapsular spread (ECS) of cervical lymph node metastases in human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC).

Introduction: Extracapsular spread of lymph node metastases is associated with poor prognosis, and its detection in head and neck cancer is crucial for treatment planning. Commonly used imaging modalities to detect ECS in OPSCC include computed tomography, magnetic resonance imaging, positron emission tomography, and ultrasonography. Read More

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September 2021

Systematic review on the association between respiratory virus real-time PCR cycle threshold values and clinical presentation or outcomes.

J Antimicrob Chemother 2021 Sep;76(Supplement_3):iii33-iii49

Université de Paris, IAME, INSERM, Paris, France.

Objectives: It is unclear whether real-time (rt)-PCR cycle threshold (Ct) values can be utilized to guide clinical and infection-control decisions. This systematic review assesses the association between respiratory pathogen rt-PCR Ct values and clinical presentation or outcomes.

Methods: We searched MEDLINE, EMBASE and Cochrane library databases on 14-17 January 2020 for studies reporting the presence or absence of an association between Ct values and clinical presentation or outcomes, excluding animal studies, reviews, meta-analyses, and non-English language studies. Read More

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September 2021

A window into racial and socioeconomic status disparities in preschool disciplinary action using developmental methodology.

Ann N Y Acad Sci 2021 Sep 23. Epub 2021 Sep 23.

Institute for Policy Research and Institute for Innovations in Developmental Sciences, Evanston, Illinois.

There are large differences in expulsions and suspensions on the basis of race starting in preschool and divergent explanations for their cause. The current study explores how developmental methodology can shed light on this vexing issue. We leverage two measures: (1) childcare provider complaints about children's behavior and their recommended disciplinary action (measured by parent report); and (2) observed disruptive behavior measured by a laboratory-based standardized observation tool, the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS), among a large, sociodemographically diverse sample of children (n   430; mean age   4. Read More

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September 2021

Updated pathology reporting standards for bladder cancer: biopsies, transurethral resections and radical cystectomies.

World J Urol 2021 Sep 23. Epub 2021 Sep 23.

Department of Pathology and Laboratory Medicine and Urology, University of Tennessee Health Science, Memphis, TN, USA.

Aim: Optimal management of bladder cancer requires an accurate, standardised and timely pathological diagnosis, and close communication between surgeons and pathologists. Here, we provide an update on pathology reporting standards of transurethral resections of the bladder and cystectomies.

Methods: We reviewed recent literature, focusing on developments between 2013 and 2021. Read More

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September 2021

Is the appendix a good organ to diagnose total colonic aganglionosis?

Pediatr Surg Int 2021 Sep 23. Epub 2021 Sep 23.

International Center for Colorectal and Urogenital Care, Division of Pediatric Surgery, Children's Hospital Colorado, 13213 E 16th Ave, Anschutz Medical Campus, Box 323, Aurora, CO, 80045, USA.

Purpose: The use of the appendix for diagnosis of Total Colonic Aganglionosis (TCA) remains controversial. This study aimed to categorize the presence of ganglion cells in the appendix and determine its reliability as a histological specimen for the diagnosis of TCA.

Methods: This was a combined retrospective and prospective study. Read More

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September 2021

[Metabolic imaging in lymphoid hemopathies].

Emmanuel Itti

Rev Prat 2021 May;71(5):540-542

Service de médecine nucléaire, CHU Henri-Mondor, Créteil, France.

Metabolic imaging in lymphoid hemopathies. 18F-FDG positron emission tomography evaluates the metabolism of tumours and has become unavoidable in the management of lymphoid hemopathies. This technique allows precise staging of lymphomas at diagnosis and provides a standardized evaluation of therapeutic response, even early after treatment onset, using the Lugano classification. Read More

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[Spontaneous Hypoglycemia: A Diagnostic Challenge].

Dtsch Med Wochenschr 2021 Oct 22;146(19):1294-1297. Epub 2021 Sep 22.

Zentrum für Endokrinologie, Diabetologie & Osteologie, Universitätsklinikum Marburg UKGM.

History:  A 59-year-old woman presented for an endocrinological evaluation of recurrent spontaneous hypoglycemia. The complaints always regressed after carbohydrate intake. Due to classic congenital adrenal hyperplasia, the patient received substitution therapy with hydrocortisone for decades. Read More

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October 2021

Injury-related treatments and outcomes in preschool children with autism spectrum disorder: Study to Explore Early Development (SEED).

Res Autism Spectr Disord 2019 Oct;66

Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, GA 30341 United States.

Background: Evidence about injury management and outcomes in children with autism spectrum disorder (ASD) is limited.

Method: Cross-sectional analyses included children aged 30-68 months with at least one medically attended injury. Standardized diagnostic instruments determined ASD cases. Read More

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October 2019

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research.

Front Neurol 2021 6;12:710332. Epub 2021 Sep 6.

Departmento de Neurologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries. A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. Read More

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September 2021

Natural Language Processing as an Emerging Tool to Detect Late-Life Depression.

Front Psychiatry 2021 6;12:719125. Epub 2021 Sep 6.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Late-life depression (LLD) is a major public health concern. Despite the availability of effective treatments for depression, barriers to screening and diagnosis still exist. The use of current standardized depression assessments can lead to underdiagnosis or misdiagnosis due to subjective symptom reporting and the distinct cognitive, psychomotor, and somatic features of LLD. Read More

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September 2021

Autism Spectrum Screening Checklist (ASSC): The Development of a Scale to Identify High-Risk Individuals Within the Children's Mental Health System.

Front Psychiatry 2021 6;12:709491. Epub 2021 Sep 6.

Faculty of Applied Health Sciences, University of Waterloo, Waterloo, ON, Canada.

Autism Spectrum Disorder (ASD) is a complex childhood onset neurodevelopmental disorder that has become the fastest growing developmental disability. Due to the increased demand for diagnostic assessments and subsequent increased wait times, standardized screening as part of regular clinical practice is needed. More specifically, there is an important need for the development of a more streamlined screening tool within an existing assessment system to identify those at greatest risk of having ASD. Read More

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September 2021

Psychometric properties of a clinical reasoning assessment rubric for nursing education.

BMC Nurs 2021 Sep 22;20(1):177. Epub 2021 Sep 22.

Department of Nursing, Yeoju Institute of Technology, Sejong-ro 338, Yeoju-si, Gyeonggi-do, 12652, South Korea.

Background: Clinical reasoning is a vital competency for healthcare providers. In 2014, a clinical reasoning assessment rubric (CRAR) composed of analysis, heuristics, inference, information processing, logic, cognition and meta-cognition subdomains was developed for osteopathy students.

Methods: This study was conducted to verify the validity and reliability of the CRAR in nursing education. Read More

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September 2021

Review of tumor infiltrating lymphocytes assessment in breast cancer in routine diagnostic practice.

Cesk Patol 2021 ;57(3):161-166

Evaluation of tumor infiltrating lymphocytes (TIL) is gaining importance in many cancers not only because of their prognostic, but also predictive significance. One of the tumors in which the evaluation of TIL is of prognostic importance and has potential predictive impact on the modification of treatment procedures is breast cancer, especially its so-called triple negative, and HER2 positive variants.The aim of this review is to provide an overview of the issue of TIL evaluation in breast cancer, focusing not only on the clinical significance of this evaluation, but especially on the methodological aspects of evaluation and standardized reporting of the results. Read More

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January 2021

The possibilities of molecular testing of somatic aberrations in tumor tissue using NGS in routine practice - current situation in the Czech Republic.

Cesk Patol 2021 ;57(3):147-149

Molecular testing of tumor tissue for the detection of somatic aberrations using NGS is increasingly gaining significance in routine practice. The technical aspects of testing are standardized and currently do not pose a problem. However, the situation is evolving very rapidly regarding the indication of testing, which depends on the sometimes rapidly developing medical knowledge and needs in clinical practice. Read More

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January 2021

Impact of era of diagnosis on cause-specific late mortality among 77 423 five-year European survivors of childhood and adolescent cancer: the PanCareSurFup consortium.

Int J Cancer 2021 Sep 22. Epub 2021 Sep 22.

German Childhood Cancer Registry (GCCR), Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg University Mainz, Germany.

Late mortality of European five-year survivors of childhood or adolescent cancer has dropped over the last 60 years, but excess mortality persists. There is little information concerning secular trends in cause-specific mortality among older European survivors. PanCareSurFup pooled data from 12 cancer registries and clinics in 11 European countries from 77 423 five-year survivors of cancer diagnosed before age 21 between 1940 to 2008 followed for an average age of 21 years and a total of 1. Read More

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September 2021

Computational Fluid Dynamics Modeling of Nasal Obstruction and Associations with Patient-Reported Outcomes.

Plast Reconstr Surg 2021 Oct;148(4):592e-600e

From the Department of Otolaryngology-Head and Neck Surgery and Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary; ISC-CNR, Consiglio Nazionale delle Ricerche; Lexma Technology; Max Planck Institute for Dynamics and Self-Organization; and John A. Paulson School of Engineering and Applied Sciences, Harvard University.

Background: Nasal obstruction is a common problem, with significant impact on quality of life. Accurate diagnosis may be challenging because of the complex and dynamic nature of the involved anatomy. Computational fluid dynamics modeling has the ability to identify specific anatomical defects, allowing for a targeted surgical approach. Read More

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October 2021

Prevalence of multiple sclerosis in key cities of Brazil: a study in Passo Fundo, Southern Brazil.

Arq Neuropsiquiatr 2021 Aug;79(8):692-696

Universidade Federal de Minas Gerais, Centro de Investigação em Esclerose Múltipla de Minas Gerais, Belo Horizonte MG, Brazil.

Background: To improve the comparability of multiple sclerosis (MS) prevalence across Brazilian regions, the Brazilian Committee for Treatment and Research in MS has implemented a standardized approach to assess the prevalence of the disease in five key cities, which were deemed representative of their regions in terms of socio-geographical features and where in-person revision of each case was feasible.

Objective: To report the point-prevalence of MS in Passo Fundo, one of the key cities in Southern Brazil.

Methods: We sought to identify all MS patients who were living in Passo Fundo on July 1st, 2015. Read More

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Incidence, prevalence, and mortality of dermatomyositis: a population-based cohort study.

Arthritis Care Res (Hoboken) 2021 Sep 21. Epub 2021 Sep 21.

Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA.

Objective: We aimed to determine the population-based incidence, prevalence, and mortality of dermatomyositis (DM) using European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria.

Methods: This population-based cohort study included incident DM from 1/1/1995 to 12/31/2019. We manually reviewed all individuals with at least one code for DM or polymyositis to determine if they met EULAR/ACR criteria, subspecialty physician diagnosis, and/or Bohan & Peter criteria. Read More

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September 2021

Pain Relief in Short-Lasting Unilateral Neuralgiform Headache with Conjunctival inJection and Tearing Syndrome with Intravenous Ketamine: A Case Report.

Acta Neurol Taiwan 2021 Mar;30(1):35-38

Division of Dental Anesthesiology, Department of Control of Physical Function, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.

Purpose: Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is a rare form of primary headache, classified as trigeminal autonomic cephalalgia. Since the underlying mechanism of the pathogenesis has not yet been determined, a standardized therapeutic strategy for SUNCT is unavailable. We present a case of SUNCT syndrome with successful pain relief by intravenous administration of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist. Read More

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Assessing and Managing Unintentional Weight Loss: A Global Survey of Geriatrician Practice and Their Use of Ice Cream to Address It.

J Frailty Aging 2021 ;10(4):350-356

Michelle Gyenes, School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, @michellegyenes; Samir Sinha, Division of General Internal Medicine and Geriatrics, Sinai Health System and the University Health Network, Toronto, Canada,

Objectives: Unintentional weight loss (UIWL) is common among older adults but lacks standardized methods for its diagnosis and management. With a limited understanding on how geriatricians actually address UIWL, we conducted a survey to examine how they diagnose and manage it, and their opinions regarding the use of ice cream to address it.

Design, Setting, And Participants: An international descriptive, cross-sectional, online survey conducted over a 16-week period in 2019 involving 1131 geriatricians in clinical practice across 51 countries. Read More

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September 2021

Cancer After Pediatric Kidney Transplantation: A Long-term Single-center Experience in Japan.

Transplant Direct 2021 Apr 22;7(4):e687. Epub 2021 Mar 22.

Department of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

Background: The cancer incidence, types, and risk factors after pediatric kidney transplantation (KT) have been reported in the United States, Canada, Europe, Australia, and New Zealand. However, no information is available about cancer in pediatric KT recipients in Asian countries.

Methods: Children aged <20 y who underwent initial KT from 1983 to 2016 were analyzed. Read More

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Comparison of clinicopathological characteristics and prognosis in breast cancer patients with different Breast Imaging Reporting and Data System categories.

Ann Surg Treat Res 2021 Sep 31;101(3):131-139. Epub 2021 Aug 31.

Department of Surgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.

Purpose: The Breast Imaging Reporting and Data System (BI-RADS) is a systematic and standardized scheme of the radiological findings of breast. However, there were different BI-RADS categories between breast cancers as the clinical characteristics in previous studies. We analyzed the association of BI-RADS categories with the clinicopathological characteristics and prognosis of breast cancer. Read More

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September 2021

Micro-Chamber/Thermal Extractor (µ-CTE) as a new sampling system for VOCs emitted by feces.

Sci Rep 2021 Sep 21;11(1):18780. Epub 2021 Sep 21.

Interdisciplinary Centre of Modern Technologies - BioSep, Nicolaus Copernicus University, Wileńska 4, 87-100, Toruń, Poland.

VOCs (volatile organic compounds) are increasingly wished to be used in diagnosis of diseases. They present strategic advantages, when compared to classical methods used, such as simplicity and current availability of performant non-invasive sample collection methods/systems. However, standardized sampling methods are required in order to achieve reproducible results. Read More

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September 2021

Hemoglobin A-Using Epidemiology to Guide Medical Practice: Kelly West Award Lecture 2020.

Elizabeth Selvin

Diabetes Care 2021 Sep 21. Epub 2021 Sep 21.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

The discovery that HbA was a valid and reliable measure of average glucose exposure was one of the most important advances in diabetes care. HbA was rapidly adopted for monitoring glucose control and is now recommended for the diagnosis of diabetes. HbA has several advantages over glucose. Read More

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September 2021

The burden of neck pain in Brazil: estimates from the global burden of disease study 2019.

BMC Musculoskelet Disord 2021 Sep 21;22(1):811. Epub 2021 Sep 21.

Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Background: This study analyzed neck pain estimates in Brazil and its states between 2000 and 2019, in view of the country's lacking epidemiological data.

Methods: An analysis was performed of the GBD 2019 estimates by location, sex, and age, per 100,000 population, with uncertainty intervals (95% UI). Brazilian estimates were compared to global, Mexican, English, and American rates. Read More

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September 2021

[Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells].

Zhonghua Xue Ye Xue Za Zhi 2021 Aug;42(8):660-665

Institute of Hematology, Henan Provincial People's Hospital; Henan Key Laboratory of Hematopathology; Henan Key Laboratory of Stem Cell Differentiation and Modification, People's Hospital of Zhengzhou University; People's Hospital of Henan University, Zhengzhou 450003, China.

To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerated phase/blast phase (AP/BP) during therapy. The clinical data of 410 patients with Ph(+) CML, including 348 patients with primary CML-CP and 62 patients who progressed to CML-AP/BP during treatment, who were admitted to Henan People's Hospital from January 2013 to June 2020 were retrospectively analyzed to categorize into high-risk, non-high-risk, and non-ACA groups according to the ELN2020 criteria. The effects of high- and non-high-risk ACA on biological characteristics, therapy efficacy, and prognosis were compared. Read More

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Prevalence of bruxism in adults with cerebral palsy institutionalized in Lisbon.

Spec Care Dentist 2021 Sep 21. Epub 2021 Sep 21.

Dental Hygiene Program, School of Dental Medicine, University of Lisbon, Lisboa, Portugal.

Objective: To determine the prevalence of bruxism in individuals with cerebral palsy (CP) and evaluating the various factors associated METHODS: One hundred and ten adults diagnosed with CP were selected from six institutions for people with special needs. Data were collected through oral examinations using the diagnostic criteria proposed by the American Academy of Sleep Medicine and the modified scale of Asworth RESULTS: Of the total sample, spastic tetraplegia was the most common type and half of the population presents severe intellectual disability. The prevalence of bruxism was 74,5%. Read More

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September 2021

Influence of Different Implant Types on Bone Levels After Healing and Peri-implant Tissue Reactions Following Peri-implantitis: A Preclinical Study.

Int J Periodontics Restorative Dent 2021 Sep-Oct;41(5):665-673

This study evaluated the influence of different implant types on (1) radiographic marginal bone levels after healing and (2) radiographic and histomorphometric tissue levels and characteristics following ligature-induced peri-implantitis. Four implant types (Standard Plus, Straumann [S]; NobelReplace Tapered, Nobel Biocare [N]; In-Kone Universal, Global D [I]; and twinKon, Global D [T]) were randomly placed in the edentulous healed mandibular ridge of six dogs (T0), for a total of 57 implants placed. After 10 weeks, a peri-implantitis was ligature-induced (T1). Read More

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September 2021

Multiparametric MRI for the improved diagnostic accuracy of Alzheimer's disease and mild cognitive impairment: Research protocol of a case-control study design.

PLoS One 2021 21;16(9):e0252883. Epub 2021 Sep 21.

Gerontology Unit, Department of Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: Alzheimer's disease (AD) is a major neurocognitive disorder identified by memory loss and a significant cognitive decline based on previous level of performance in one or more cognitive domains that interferes in the independence of everyday activities. The accuracy of imaging helps to identify the neuropathological features that differentiate AD from its common precursor, mild cognitive impairment (MCI). Identification of early signs will aid in risk stratification of disease and ensures proper management is instituted to reduce the morbidity and mortality associated with AD. Read More

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September 2021