585 results match your criteria standardised extract

An Investigation into the Effects of a Curcumin Extract (Curcugen) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study.

Nutrients 2021 Dec 23;14(1). Epub 2021 Dec 23.

College of Science, Health, Engineering and Education, Murdoch University, Perth, WA 6150, Australia.

Curcumin, a phytochemical from the spice turmeric, has anti-inflammatory properties and has been shown to have pain-relieving effects. In this 8-week, randomised, double-blind, placebo-controlled study, 101 adults with knee osteoarthritis received either 500 mg twice daily of a standardised curcumin extract (Curcugen) or placebo. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score (KOOS), knee pain ratings, Japanese Orthopaedic Association Score for Osteoarthritic Knees (JOA), PROMIS-29, and performance-based testing comprising the 40-m fast-paced walk test, 6-min walk test, timed up-and-go test, and 30-s chair stand test. Read More

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December 2021

Anthelmintic potency of L. extracts against and non-targeted identification of the bioactive compounds.

Saudi J Biol Sci 2022 Jan 17;29(1):541-549. Epub 2021 Sep 17.

Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Alice 5700, South Africa.

Traditional healers and ethnoveterinary therapists use several medicinal plants, such as L., to treat endoparasite infections. has been established by researchers to be effective agasint a few parasitic worms. Read More

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January 2022

Effectiveness and feasibility of telerehabilitation in patients with COVID-19: a protocol for a systematic review and meta-analysis.

BMJ Open 2022 01 6;12(1):e058932. Epub 2022 Jan 6.

Department of Nursing, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia.

Introduction: Respiratory rehabilitation is the use of exercise, education, and behavioural interventions to alleviate symptoms and improve quality of life. Recent studies highlight that respiratory rehabilitation is effective and safe for patients with COVID-19. We aim to evaluate the effectiveness and feasibility of respiratory telerehabilitation on patients infected with COVID-19 by conducting a systematic review and meta-analysis. Read More

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January 2022

Safety of (Tongkat Ali) root extract as a novel food pursuant to Regulation (EU) 2015/2283.

EFSA J 2021 Dec 22;19(12):e06937. Epub 2021 Dec 22.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on (Tongkat Ali) root extract as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is standardised water extract prepared from the dried ground root chips of Tongkat Ali ( Jack) and proposed by the applicant to be used as food supplement in amounts up to 200 mg/day. The target population is the adult population, except pregnant and lactating women. Read More

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December 2021

Detecting Cognitive Impairment Status Using Keystroke Patterns and Physical Activity Data among the Older Adults: A Machine Learning Approach.

J Healthc Eng 2021 20;2021:1302989. Epub 2021 Dec 20.

Smart H&B Technology Laboratory, Department of Electronic Engineering, Kwangwoon University, Seoul 139-701, Republic of Korea.

Cognitive impairment has a significantly negative impact on global healthcare and the community. Holding a person's cognition and mental retention among older adults is improbable with aging. Early detection of cognitive impairment will decline the most significant impact of extended disease to permanent mental damage. Read More

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January 2022

Informant-based assessment instruments for dementia in people with intellectual disability: A systematic review and standardised evaluation.

Res Dev Disabil 2022 Feb 27;121:104148. Epub 2021 Dec 27.

Faculty of Psychology, University of Vienna, Vienna, Austria.

Background: Dementia in people with intellectual disability (ID) is frequent but hard to recognise. Evidence-based recommendations for suitable instruments are lacking.

Aims: The present study set out to evaluate informant-based dementia assessment instruments and to provide evidence-based recommendations for instruments most suitable in clinical practice and research. Read More

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February 2022

Use of glucose for pain management in premature neonates: a systematic review and meta-analysis protocol.

BMJ Open 2021 Dec 9;11(12):e052901. Epub 2021 Dec 9.

Nursing Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil

Introduction: Therapeutic management of neonatal pain is essential to reduce changes in initial and subsequent development. Although glucose has been shown to be effective in relieving pain, concentrations and dosages remain to be standardised. The objective of this systematic review and meta-analysis is to identify the efficacy of glucose as an analgesic in preterm infants. Read More

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December 2021

Evaluation of the safety and healing potential of a fibroin-aloe gel film for the treatment of diabetic foot ulcers.

J Wound Care 2021 Dec;30(12):1020-1028

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.

Objective: This study aimed to develop a wound dressing prepared from the blending of silkworm fibroin and aloe gel extract for use in the treatment of diabetic foot ulcers (DFUs).

Methods: Fibroin extracted from silkworm cocoons and aloe gel extract were dissolved in deionised water. pH levels were then adjusted with lactic acid solution. Read More

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December 2021

A systematic review on mobile health applications for foodborne disease outbreak management.

BMC Public Health 2021 Dec 8;21(1):2228. Epub 2021 Dec 8.

Centre for Enteric Diseases, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, Johannesburg, South Africa.

Background: Foodborne disease outbreaks are common and notifiable in South Africa; however, they are rarely reported and poorly investigated. Surveillance data from the notification system is suboptimal and limited, and does not provide adequate information to guide public health action and inform policy. We performed a systematic review of published literature to identify mobile application-based outbreak response systems for managing foodborne disease outbreaks and to determine the elements that the system requires to generate foodborne disease data needed for public action. Read More

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December 2021

Non-invasive ventilation in the palliative care of patients with chronic obstructive pulmonary disease: a scoping review protocol.

BMJ Open 2021 Dec 2;11(12):e048344. Epub 2021 Dec 2.

Lovisenberg Diaconal University College, Oslo, Norway.

Introduction: Patients with advanced chronic obstructive pulmonary disease (COPD) experience a great symptom burden. Breathlessness is a very frequently reported symptom that negatively affects all aspects of daily life and could lead to fear of dying. Non-invasive ventilation (NIV) could be an important palliative measure to manage breathlessness in patients with advanced COPD. Read More

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December 2021

Using text mining techniques to extract prostate cancer predictive information (Gleason score) from semi-structured narrative laboratory reports in the Gauteng province, South Africa.

BMC Med Inform Decis Mak 2021 11 25;21(1):330. Epub 2021 Nov 25.

Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of Witwatersrand and National Health Laboratory Service (NHLS), 7 York Road, Parktown, Johannesburg, South Africa.

Background: Prostate cancer (PCa) is the leading male neoplasm in South Africa with an age-standardised incidence rate of 68.0 per 100,000 population in 2018. The Gleason score (GS) is the strongest predictive factor for PCa treatment and is embedded within semi-structured prostate biopsy narrative reports. Read More

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November 2021

Using natural language processing to understand, facilitate and maintain continuity in patient experience across transitions of care.

Int J Med Inform 2022 01 11;157:104642. Epub 2021 Nov 11.

Patient Safety Translational Research Centre, Institute of Global Health Innovation, Imperial College London, London, UK.

Background: Patient centred care necessitates that healthcare experiences and perceived outcomes be considered across all transitions of care. Information encoded within free-text patient experience comments relating to transitions of care are not captured in a systematic way due to the manual resource required. We demonstrate the use of natural language processing (NLP) to extract meaningful information from the Friends and Family Test (FFT). Read More

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January 2022

Palliative care for people who use substances during communicable disease epidemics and pandemics: a scoping review protocol.

BMJ Open 2021 10 27;11(10):e053124. Epub 2021 Oct 27.

Department of Supportive Care, University Health Network, Toronto, Ontario, Canada.

Introduction: Communicable disease epidemics and pandemics magnify the health inequities experienced by marginalised populations. People who use substances suffer from high rates of morbidity and mortality and should be a priority to receive palliative care, yet they encounter many barriers to palliative care access. Given the pre-existing inequities to palliative care access for people with life-limiting illnesses who use substances, it is important to understand the impact of communicable disease epidemics and pandemics such as COVID-19 on this population. Read More

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October 2021

"Surviving to thriving": a meta-ethnography of the experiences of healthcare staff caring for persons with COVID-19.

BMC Health Serv Res 2021 Oct 21;21(1):1131. Epub 2021 Oct 21.

Department of General Nursing, School of Nursing and Midwifery, University for Development Studies, Tamale, Ghana.

Background: The emergence of the Coronavirus disease has heightened the experience of emotional burden among healthcare staff. To guide the development of support programmes, this review sought to aggregate and synthesise qualitative studies to establish a comparative understanding of the experiences of healthcare staff caring for persons with the disease.

Design: A meta-ethnography approach was used to aggregate and synthesise primary qualitative studies. Read More

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October 2021

Systematic review of occupational hazards at postharvest grain operations.

Inj Prev 2021 Oct 16. Epub 2021 Oct 16.

Department of Agricultural Engineering, Campus Cachoeira do Sul, Federal University of Santa Maria, Santa Maria, RS, Brazil

Introduction: Agriculture stands out in relation to the high number of occupational incidents and diseases. In this sense, grains postharvest operations, such as receiving, precleaning, drying, storage and shipping the grains, are highlighted in the number of injuries and fatalities.

Aim: To identify and extract qualitative and quantitative data related to the main occupational hazards present in grains postharvest operations at preprocessing and storage facilities. Read More

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October 2021

A starting guide to root ecology: strengthening ecological concepts and standardising root classification, sampling, processing and trait measurements.

New Phytol 2021 11;232(3):973-1122

CEFE, Univ Montpellier, CNRS, EPHE, IRD, 1919 route de Mende, Montpellier, 34293, France.

In the context of a recent massive increase in research on plant root functions and their impact on the environment, root ecologists currently face many important challenges to keep on generating cutting-edge, meaningful and integrated knowledge. Consideration of the below-ground components in plant and ecosystem studies has been consistently called for in recent decades, but methodology is disparate and sometimes inappropriate. This handbook, based on the collective effort of a large team of experts, will improve trait comparisons across studies and integration of information across databases by providing standardised methods and controlled vocabularies. Read More

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November 2021

Is it safe to place implants in patients at risk of MRONJ?

Evid Based Dent 2021 01;22(3):108-109

Restorative Dentistry DCT3, Aberdeen Dental Hospital, Aberdeen, UK.

Data sources Four electronic databases, namely PubMed, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials, were searched from their inception to 16 July 2019. The OpenGrey database was also used to identify unpublished studies.Study selection Eligible study designs included randomised controlled trials, cohort studies, case-control studies and case series with a retrospective, cross-sectional or prospective design related to implant placement in patients with a history of anti-angiogenic or antiresorptive medications. Read More

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January 2021

What is the best mechanical device to clean the teeth in periodontal maintenance patients?

Erfan Shamsoddin

Evid Based Dent 2021 01;22(3):91-93

National Institute for Medical Research Development, Tehran, Iran.

Aim This study evaluates the available clinical evidence with regards to the effectiveness of mechanical oral hygiene devices in patients who are in periodontal maintenance.Data sources A structured online search was conducted in PubMed/Medline, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase. All the databases were explored from initiation to October 2019. Read More

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January 2021

Protective effect of standardised fruit extract of Roxb. ex Choisy against ethanol induced gastric mucosal lesions in Wistar rats.

Ann Med 2021 12;53(1):1696-1708

ICAR-Directorate of Medicinal and Aromatic Plants Research, Boriavi, Anand, India.

Background And Aim: The fruit of is a rich and valuable source of bioactive compounds and is traditionally used for treating wounds and ulcers. The present study was carried out to investigate the protective effect of chromatographically standardized fruit extract of (GCE) on ethanol-induced gastric lesions in rats and its possible mechanisms.

Methods: The effect of GCE (200 and 400 mg/kg body weight) was evaluated by determining various gastric ulcer parameters like gastric wall mucus, non-protein sulfhydryls (NP-SH) content, microvascular permeability, endogenous antioxidant enzyme, and gastric histopathological study. Read More

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December 2021

School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18.

Cochrane Database Syst Rev 2021 09 23;9:CD007651. Epub 2021 Sep 23.

School of Nursing, McMaster University, Hamilton, Canada.

Background: Physical activity among children and adolescents is associated with lower adiposity, improved cardio-metabolic health, and improved fitness. Worldwide, fewer than 30% of children and adolescents meet global physical activity recommendations of at least 60 minutes of moderate to vigorous physical activity per day. Schools may be ideal sites for interventions given that children and adolescents in most parts of the world spend a substantial amount of time in transit to and from school or attending school. Read More

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September 2021

Inflammatory blood parameters as prognostic factors for surgical site infection after primary hip or knee arthroplasty: a systematic review protocol.

BMJ Open 2021 09 21;11(9):e046027. Epub 2021 Sep 21.

Department of Social and Clinical Pharmacy, Charles University Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic

Introduction: Surgical site infection (SSI) is a potential complication of surgical procedure. SSI after implant surgery is a disaster both for patients and surgeons. Although predictive tools for SSI are available, none of them estimate early infection based on inflammatory blood parameters. Read More

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September 2021

Impact of a cancer diagnosis on the income of adult cancer survivors: a scoping review protocol.

BMJ Open 2021 09 16;11(9):e047315. Epub 2021 Sep 16.

Cancer Control Research, BC Cancer, Vancouver, British Columbia, Canada.

Introduction: While the socioeconomic impact of a cancer diagnosis on cancer survivors has gained some attention in the literature, to our knowledge, a review of the evidence on changes in income due to cancer has yet to be undertaken. In this paper, we describe a scoping review protocol to review the evidence on the effect of a cancer diagnosis on the income of individuals diagnosed with cancer during adulthood (≥18 years). The purpose is to summarise existing evidence, identify gaps in current research and highlight priority areas for future research. Read More

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September 2021

Wound healing activity of the hydroethanolic extract of the leaves of Mart. Ex Reis.

J Tradit Complement Med 2021 Sep 30;11(5):446-456. Epub 2021 Mar 30.

Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, zip code 38400-902, Uberlândia, MG, Brazil.

Background And Aim: has analgesic, healing, antioxidant and anti-inflammatory properties. This study evaluated effect of the hydroalcoholic extract of leaves on skin wound repair.

Experimental Procedure: Wounds were induced on mice and treated with the extract. Read More

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September 2021

Alternative mechanisms for delivery of medication in South Africa: A scoping review.

S Afr Fam Pract (2004) 2021 08 24;63(1):e1-e8. Epub 2021 Aug 24.

Division of Family Medicine and Primary Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town.

Background: The number of people in South Africa with chronic conditions is a challenge to the health system. In response to the coronavirus infection, health services in Cape Town introduced home delivery of medication by community health workers. In planning for the future, they requested a scoping review of alternative mechanisms for delivery of medication to patients in primary health care in South Africa. Read More

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The beneficial effects of on cardiovascular and metabolic disease risk.

Pharm Biol 2021 Dec;59(1):1161-1171

Faculty of Medicine, Macau University of Science & Technology, Macau, China.

Context: Various herbal medicines are thought to be useful in the management of cardiometabolic disease and its risk factors. (Curtis) P. Karst. Read More

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December 2021

The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study.

J Menopausal Med 2021 Aug;27(2):66-78

Clinical Research Australia, Perth, Australia.

Objectives: There is preliminary evidence suggesting saffron may effectively treat menopausal symptoms. The aim of this study was to examine the tolerability and efficacy of a standardised saffron extract (affron®) on menopausal complaints in perimenopausal women.

Methods: In this 12-week, parallel-group, double-blind, randomised controlled trial, 86 perimenopausal women experiencing menopausal complaints received either a placebo or 14 mg of a saffron extract (affron®), twice daily. Read More

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A pooled prevalence of fetal alcohol spectrum disorders in South Africa: a systematic review and meta-analysis protocol.

Arch Public Health 2021 Aug 30;79(1):156. Epub 2021 Aug 30.

Department of Global Health, Schools of Medicine and Public Health, University of Washington, Seattle, WA, USA.

Background: Fetal Alcohol Spectrum Disorder (FASD) remains a global public health problem. South Africa is estimated to have the highest recorded prevalence of FASD. However, no study has systematically evaluated the available prevalence studies to provide estimates that may facilitate effective planning and delivery of prevention and management services. Read More

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An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study.

Sleep Med 2021 10 11;86:7-18. Epub 2021 Aug 11.

College of Science, Health, Engineering and Education, Murdoch University, Perth, Western Australia, 6150, Australia.

Objective/background: To validate and extend on previous positive findings of the sleep-enhancing effects of saffron supplementation in adults with unsatisfactory sleep.

Patients/methods: In this 28-day, 3-arm, parallel-group, double-blind, randomised controlled trial, 120 adults with unsatisfactory sleep received either a placebo, 14 mg, or 28 mg of a standardised saffron extract (affron®), 1 h before bed. Outcome measures included the Pittsburgh Sleep Diary (with sleep quality ratings as the primary outcome measure), Insomnia Symptom Questionnaire (ISQ), Profile of Mood States, Restorative Sleep Questionnaire, the Functional Outcomes of Sleep Questionnaire, and evening salivary melatonin and cortisol concentrations. Read More

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October 2021

Effectiveness of psychological interventions in prison to reduce recidivism: a systematic review and meta-analysis of randomised controlled trials.

Lancet Psychiatry 2021 09;8(9):759-773

Department of Psychiatry, University of Oxford, Oxford, UK. Electronic address:

Background: Repeat offending, also known as criminal recidivism, in people released from prison has remained high over many decades. To address this, psychological treatments have been increasingly used in criminal justice settings; however, there is little evidence about their effectiveness. We aimed to evaluate the effectiveness of interventions in prison to reduce recidivism after release. Read More

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September 2021