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Relation of Computed Tomography-Based Static Axial Radioulnar Incongruence Measurements under General Anaesthesia and Dynamic, In Vivo RUI during the Walk in Canine Elbow Joints with and without Medial Coronoid Process Disease.

Vet Comp Orthop Traumatol 2021 Aug 3. Epub 2021 Aug 3.

Small Animal Clinic, Freie University, Berlin, Germany.

Objective:  This study aimed to evaluate the correlation of static axial radioulnar incongruence (sRUI) measured under general anaesthesia with the real dynamic RUI (dRUI) during walking.

Study Design:  This was a prospective clinical study that included 6 sound elbows (5 dogs) and 7 medial coronoid process disease (MCPD) affected elbows (6 dogs).

Materials And Methods:  Static axial radioulnar incongruence was measured using the sphere fitting technique on computed tomography-based three-dimensional (3D) models of radius and ulna. Read More

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Teledentistry and forensic odontology: Cross-sectional observational comparative pilot study.

Forensic Sci Int 2021 Jul 28;326:110932. Epub 2021 Jul 28.

Dental department, University Hospital of Montpellier, Univ Montpellier, Montpellier, France; Systematic Health Care, EA 4129, University of Lyon 1, Lyon, France.

Forensic dentistry is the branch of forensic science concerned with the study of teeth and jaws. To facilitate the work of experts, new comparative identification tools are emerging, with digital techniques such as the intra-oral camera, which are revolutionising current techniques in forensic dentistry.

Objective: The aim of this study is to evaluate the diagnostic quality of the post-mortem odontogram carried out remotely via a video of the oral cavity using an intra-oral camera. Read More

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Clinical efficacy and safety of Janus kinase inhibitors for COVID-19: A systematic review and meta-analysis of randomized controlled trials.

Int Immunopharmacol 2021 Jul 31;99:108027. Epub 2021 Jul 31.

Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan. Electronic address:

Objectives: This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to investigate the clinical efficacy and safety of Janus kinase (JAK) inhibitors for COVID-19 patients.

Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to July 12, 2021. Read More

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On the evaluation of edgeless diode detectors for patient-specific QA in high-dose stereotactic radiosurgery.

Phys Med 2021 Jul 31;89:20-28. Epub 2021 Jul 31.

Centre for Medical Radiation Physics, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia.

Purpose: In this work, the potential of an innovative "edgeless" silicon diode was evaluated as a response to the still unmet need of a reliable tool for plan dosimetry verification of very high dose, non-coplanar, patient-specific radiosurgery treatments. In order to prove the effectiveness of the proposed technology, we focused on radiosurgical treatments for functional disease like tremor or pain.

Methods: The edgeless diodes response has been validated with respect to clinical practice standard detectors by reproducing the reference dosimetry data adopted for the Treatment Planning System. Read More

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High-affinity ZnT8 autoantibodies by electrochemiluminescence assay improve risk prediction for type 1 diabetes.

J Clin Endocrinol Metab 2021 Aug 3. Epub 2021 Aug 3.

Barbara Davis Center for Diabetes University of Colorado School of Medicine, Aurora, CO.

Background: The risk of progression to type 1 diabetes (T1D) in subjects positive only for ZnT8 autoantibody (ZnT8A) is currently not known.

Methods: We developed an electrochemiluminescence (ECL) assay to detect high-affinity ZnT8A and validated it in three populations: 302 patients newly diagnosed with T1D, 135 non-diabetic children positive for ZnT8A by standard radio-binding assay (RBA) among 23400 children screened by the Autoimmunity Screening for Kids (ASK), and 123 non-diabetic children multiple autoantibody positive or single ZnT8A positive by RBA participating in the Diabetes Autoimmunity Study in the Young (DAISY).

Results: In 302 patients with T1D at diagnosis, the positivity for ZnT8A was 62% in both RBA and ECL. Read More

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Impact of including the cause of missing records on genetic evaluations for growth in commercial pigs.

J Anim Sci 2021 Aug 3. Epub 2021 Aug 3.

Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.

It is of interest to evaluate crossbred pigs for hot carcass weight (HCW) and birth weight (BW); however, obtaining a HCW record is dependent on livability (LIV) and retained tag (RT). The purpose of this study is to analyze how HCW evaluations are affected when herd removal and missing identification are included in the model and examine if accounting for the reasons for missing traits improves the accuracy of predicting breeding values. Pedigree information was available for 1,965,077 purebred and crossbred animals. Read More

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Total Content of Piperidine Analysis in Artane by RP-HPLC Using Pre-Column Derivatization with 4-Toluene Sulfonyl Chloride.

J Chromatogr Sci 2021 Aug 3. Epub 2021 Aug 3.

Hunan Key Lab of Biomedical Materials and Devices, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412008, China.

A simple, sensitive and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method was established for the determination of piperidine and piperidine hydrochloride in artane, using pre-column derivatization with 4-toluenesulfonyl chloride. The RP-HPLC method was carried out on a Inertsil C18 column (250 × 4.6 mm I. Read More

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Carbapenem and colistin-resistant bacteria in North Lebanon: Coexistence of mcr-1 and NDM-4 genes in Escherichia coli.

J Infect Dev Ctries 2021 Jul 31;15(7):934-342. Epub 2021 Jul 31.

Genomic Surveillance and Biotherapy Laboratory, Faculty of Sciences, Lebanese University, Lebanon.

Introduction: The increasing incidence of infections caused by multidrug-resistant bacteria is considered a global health problem. This study aimed to investigate this resistance in Gram-negative bacteria isolated from patients hospitalized in North-Lebanon.

Methodology: All isolates were identified using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Read More

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Optimizing Fog Harps.

ACS Appl Mater Interfaces 2021 Aug 3. Epub 2021 Aug 3.

Department of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.

It has recently been demonstrated that harps harvest substantively more fog water than conventional mesh nets, but the optimal design for fog harps remains unknown. Here, we systematically vary key parameters of a scale-model fog harp, the wire material, wire pitch, and wire length, to find the optimal combination. We found stainless steel to not only be the best hydrophilic wire material but also nearly be as effective as Teflon-coated wires. Read More

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Accuracy of saliva and nasopharyngeal sampling for detection of SARS-CoV-2 in community screening: a multicentric cohort study.

Eur J Clin Microbiol Infect Dis 2021 Aug 3. Epub 2021 Aug 3.

Virologie, AP-HP, Hôpital Saint Louis, 75010, Paris, France.

Nasopharyngeal sampling for nucleic acid amplification testing (NAAT) is the standard diagnostic test of coronavirus disease 2019. Our objectives were to assess, in real-life conditions, the diagnostic accuracy of a nasopharyngeal point-of-care antigen (Ag) test and of saliva NAAT for detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in ambulatory care. This was a prospective cohort study from 19 October through 18 December 2020 in two community COVID-19 screening centers in Paris, France. Read More

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Patterns of Metastatic Disease in Patients with Cancer Derived from Natural Language Processing of Structured CT Radiology Reports over a 10-year Period.

Radiology 2021 Aug 3:210043. Epub 2021 Aug 3.

From the Department of Radiology (R.K.G.D., P.I.C.A., M.T., N.G., K.J., H.H.), Human Pathology and Pathogenesis Program, Center for Molecular Oncology (A.L.), Department of Strategy and Innovation (H.N., P.R., L.G., K.N.), and Biostatistics Service, Department of Epidemiology and Biostatistics (C.J.F., N.S., V.S.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; and School of Computing, Queens University, Kingston, Canada (K.L., K.B., F.Z., A.S.).

Background Patterns of metastasis in cancer are increasingly relevant to prognostication and treatment planning but have historically been documented by means of autopsy series. Purpose To show the feasibility of using natural language processing (NLP) to gather accurate data from radiology reports for assessing spatial and temporal patterns of metastatic spread in a large patient cohort. Materials and Methods In this retrospective longitudinal study, consecutive patients who underwent CT from July 2009 to April 2019 and whose CT reports followed a departmental structured template were included. Read More

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Outcomes of Osteosarcoma in Children Without High-Dose Methotrexate: Could It Be Less Toxic Without Effecting Survival Rates?

J Adolesc Young Adult Oncol 2021 Aug 2. Epub 2021 Aug 2.

Department of Pediatric Hematology Oncology, Marmara University, Marmara Faculty of Medicine, Istanbul, Turkey.

Osteosarcoma (OS) is the most common primary bone sarcoma in childhood. High-dose methotrexate, doxorubicine, cisplatin, and/or ifosfamide combinations are used as standard treatment in chemotherapy and could cause serious toxicity. Another alternative chemotherapy protocol is consisting of epirubicin, ifosfamide, and cisplatin (ECI), which we use in our center. Read More

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Factors affecting the placement of agricultural best management practices in the agricultural conservation planning framework (ACPF) toolbox in the mid-atlantic region.

J Environ Qual 2021 Aug 3. Epub 2021 Aug 3.

Dep. Ecosystem Science and Management, Pennsylvania State Univ., University Park, PA, 16802.

There has been a recent push to conduct spatially explicit landscape planning at finer hydrologic unit scales to mitigate diffuse pollution. The Agricultural Conservation and Planning Framework (ACPF) helps identify potential locations for agricultural conservation practices by using high-resolution soils and elevation data. This spatially explicit approach attempts to identify runoff and nutrient pathways, but output may be influenced by user-specified parameters and the properties of the digital elevation model (DEM) being used. Read More

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New-onset cardiovascular risk factors following liver transplantation: A cohort analysis in Singapore.

Ann Acad Med Singap 2021 Jul;50(7):548-555

Department of Dietetics, Singapore General Hospital, Singapore.

Introduction: The aims of this study were to establish weight change, incidence of non-alcoholic fatty liver disease (NAFLD) and cardiovascular risk factors (CvRF) in liver transplant recipients (LTRs).

Methods: Eighty-three patients whose mean (standard deviation [SD]) age was 55.6 (8. Read More

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Trajectories of reward availability moderate the impact of brief alcohol interventions on alcohol severity in heavy-drinking young adults.

Alcohol Clin Exp Res 2021 Aug 2. Epub 2021 Aug 2.

Brian Borsari, Mental Health Service (116B), San Francisco VA Health Care System, Ph.D, San Francisco, CA, 94143, USA.

Background: Behavioral economic theory predicts that low access to environmental reward is a risk factor for alcohol use disorder (AUD). The Substance-Free Activity Session (SFAS) is a behavioral economic supplement to standard brief alcohol interventions that attempts to increase environmental reward and may therefore have beneficial effects, particularly for individuals with low levels of environmental reward.

Methods: Participants were 393 college students who reported at least 2 heavy drinking episodes in the past month. Read More

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Impact of climate change on biodiversity loss: global evidence.

Environ Sci Pollut Res Int 2021 Aug 3. Epub 2021 Aug 3.

Iqra University, Karachi, Pakistan.

The present study investigates the impact of climate change on biodiversity loss using global data consisting of 115 countries. In this study, we measure biodiversity loss using data on the total number of threatened species of amphibians, birds, fishes, mammals, mollusks, plants, and reptiles. The data were compiled from the Red List published by the International Union for Conservation of Nature (IUCN). Read More

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A novel standardized distraction test to evaluate lower eyelid tension using three-dimensional stereophotogrammetry.

Quant Imaging Med Surg 2021 Aug;11(8):3735-3748

Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.

Background: Standardized pre-operative assessment of the lower eyelid tension is essential to determine the optimal surgical technique. However, quantitative analysis using the conventional distraction test is inaccurate and user-dependent. Our purpose was to introduce a novel, standardized three-dimensional distraction test for measuring lower eyelid tension and to determine its standard values in a Caucasian population. Read More

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New algorithm for corneal densitometry assessment based on anterior segment optical coherence tomography.

Eye (Lond) 2021 Aug 2. Epub 2021 Aug 2.

Institute of Clinic Ophthalmology, Clinic Hospital of Barcelona, University of Barcelona, Barcelona, Spain.

Purpose: To describe a new algorithm to measure corneal densitometry based on images obtained by swept source anterior segment ocular coherence tomography (SS-AS-OCT) and establish standard densitometry values in a group of normal eyes.

Methods: A total of 111 healthy participants (195 eyes) were enrolled in this study. Using a MATLAB designed algorithm, the cornea was segmented into three layers: anterior, posterior and mid-stroma, and it was divided into two concentric areas, 0-2 and 2-4 mm, resulting in nine areas for the analysis. Read More

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Laparoscopic-assisted transanal pull-through for hirschsprung's children older than 3 years: A case series.

Afr J Paediatr Surg 2021 Oct-Dec;18(4):210-214

Department of Surgery, Pediatric Surgery Unit, Faculty of Medicine, Cairo University Specialized Pediatric Hospital, Cairo University, Cairo, Egypt.

Context: Hirschsprung's disease (HD) is a congenital anomaly affecting the enteric nervous system commonly the rectosigmoid region. Treatment is surgical where the aganglionic segment is resected, and bowel continuity is restored by a coloanal anastomosis. In 1999, Georgeson et al. Read More

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The association between the salivary cortisol level of mothers, children's temperament, and early childhood caries.

J Indian Soc Pedod Prev Dent 2021 Apr-Jun;39(2):196-201

Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R, Iran.

Background: Multiple factors can affect early childhood caries (ECC). Maternal stress and child's temperament, as predictors of child behavior, are among factors that may be associated with ECC.

Objectives: The aim of this study was to evaluate the association between the salivary cortisol level of mothers as an indicator of maternal stress, child's temperament, and ECC. Read More

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Five-year outcomes of eyes initially enrolled in the 2-year BEVORDEX trial of bevacizumab or dexamethasone implants for diabetic macular oedema.

Br J Ophthalmol 2021 Aug 2. Epub 2021 Aug 2.

Department of Ophthalmology, The University of Sydney Save Sight Institute, Sydney, New South Wales, Australia.

Background: The BEVORDEX trial compared outcomes of eyes with diabetic macular oedema (DMO) randomised to receive either intravitreal dexamethasone (DEX-) implant or bevacizumab over 2 years. We assessed long-term efficacy and safety outcomes 5 years from enrolment.

Methods: Patients received standard clinical care after they finished the study. Read More

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Monogenic and polygenic causes of low and extremely low LDL-C levels in patients referred to specialty lipid clinics: Genetics of low LDL-C.

J Clin Lipidol 2021 Jul 17. Epub 2021 Jul 17.

Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd, MC 8537, Dallas, TX 75390, United States. Electronic address:

Background: In clinical setting, current standard-of-care does not include genetic testing for patients with low (<50 mg/dL) and extremely low (<20 mg/dL) levels of serum low-density lipoprotein-cholesterol (LDL-C).

Objective: We aimed identify the underlying molecular cause - both monogenic and polygenic - of low and extremely low LDL-C levels in a cohort of patients presenting to specialty lipid clinics.

Methods: Whole exome sequencing was done in patients with low or extremely low LDL-C not due to any secondary causes. Read More

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Pneumococcal conjugate vaccine dose-ranging studies in humans: A systematic review.

Vaccine 2021 Jul 30. Epub 2021 Jul 30.

KEMRI-Wellcome Trust Research Programme (KWTRP), Centre for Geographic Medical Research - Coast (CGMRC), Kilifi, Kenya; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK.

Background: Streptococcus pneumoniae is one of the most common bacterial pathogens of infants and young children. Antibody responses against the pneumococcal polysaccharide capsule are the basis of vaccine-mediated protection. We examined the relationship between the dose of polysaccharide in pneumococcal conjugate vaccines (PCVs) and immunogenicity. Read More

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Primary ovarian high-grade endometrial stromal sarcoma: a case report.

J Med Case Rep 2021 Aug 3;15(1):387. Epub 2021 Aug 3.

Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.

Background: Primary ovarian high-grade endometrial stromal sarcoma is a very rare disease. Even though it has poor prognosis, the gold standard treatment has not been established owing to its rarity. This report aimed to present therapeutic options for primary ovarian high-grade endometrial stromal sarcoma. Read More

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Financial Incentives for Preventing Postpartum return to Smoking (FIPPS): study protocol for a three-arm randomised controlled trial.

Trials 2021 Aug 2;22(1):512. Epub 2021 Aug 2.

Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, UK.

Background: Financial incentives are an effective way of helping women to stop smoking during pregnancy. Unfortunately, most women who stop smoking at this time return to smoking within 12 months of the infant's birth. There is no evidence for interventions that are effective at preventing postpartum smoking relapse. Read More

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Analysis of the assessment of antimicrobial susceptibility. Non-typhoid Salmonella in meat and meat products as model (systematic review).

BMC Microbiol 2021 Aug 2;21(1):223. Epub 2021 Aug 2.

Laboratorio de Microbiología de Alimentos. Grupo de Biotecnología Ambiental e Industrial (GBAI), Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.

Background: The scientific publications of antimicrobial susceptibilities and resistance must be precise, with interpretations adjusted to the standard. In this frame, knowledge of antimicrobial resistance is fundamental in pathogenic microorganisms such as Salmonella spp., known for many annual deaths worldwide. Read More

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Directed stimulation of the dentato-rubro-thalamic tract for deep brain stimulation in essential tremor: a blinded clinical trial.

Neuroradiol J 2021 Aug 2:19714009211036689. Epub 2021 Aug 2.

Department of Neurosurgery, Mayo Clinic, USA.

Objective: Observational studies utilising diffusion tractography have suggested a common mechanism for tremor alleviation in deep brain stimulation for essential tremor: the decussating portion of the dentato-rubro-thalamic tract. We hypothesised that directional stimulation of the dentato-rubro-thalamic tract would result in greater tremor improvement compared to sham programming, as well as comparable improvement as more tedious standard-of-care programming.

Methods: A prospective, blinded crossover trial was performed to assess the feasibility, safety and outcomes of programming based solely on dentato-rubro-thalamic tract anatomy. Read More

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The effect of postoperative steroid dosing on readmission rates following radiofrequency ablation tonsillectomy.

Int J Pediatr Otorhinolaryngol 2021 Jul 29;149:110862. Epub 2021 Jul 29.

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, Cincinnati, Ohio, USA; Division of Pediatric Otolaryngology - Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address:

Objective: To examine the effect of postoperative steroid dosage on postoperative telephone calls, emergency department (ED) visits, and hemorrhage rates for two groups receiving different steroid dosing following radiofrequency ablation tonsillectomy.

Study Design: Retrospective chart review between January 1, 2014 and January 1, 2019.

Setting: Tertiary care pediatric hospital. Read More

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Synthesis, biological evaluation (antioxidant, antimicrobial, enzyme inhibition, and cytotoxic) and molecular docking study of hydroxy methoxy benzoin/benzil analogous.

Bioorg Chem 2021 Jul 16;115:105183. Epub 2021 Jul 16.

Department of Biostatistics and Medical Informatics, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.

In this work, due to the biological activity evaluation, a series of hydroxy methoxy benzoins (1-8), benzils (10-16) and methoxy benzoin/benzil-O-β-d-glucosides (17-28) were synthesized. Antioxidant (FRAP, CUPRAC, DPPH), antimicrobial (16 microorganisms, and two yeast), enzyme inhibition (α-amylase, α-glucosidase, AChE, BChE, and tyrosinase) of all synthesized benzoin/benzil analogs were investigated. Benzoins (1-8) showed the most effective antioxidant properties compared to all three methods. Read More

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IncobotulinumtoxinA Efficacy/Safety in Upper-Limb Spasticity in Pediatric Cerebral Palsy: Randomized Controlled Trial.

Pediatr Neurol 2021 May 21;123:10-20. Epub 2021 May 21.

LMU Klinikum Munich, Division of Pediatric Neurology & LMU Center for Children with Medical Complexity, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.

Background: This randomized phase 3 study with double-blind main period (MP) and open-label extension (OLEX; NCT02002884) assessed incobotulinumtoxinA safety and efficacy for pediatric upper-limb spasticity treatment in ambulant/nonambulant (Gross Motor Function Classification System [GMFCS] I-V) patients, with the option of combined upper- and lower-limb treatment.

Methods: Patients were aged two to 17 years with unilateral or bilateral spastic cerebral palsy (CP) and Ashworth Scale (AS) score ≥2 in treatment-selected clinical patterns. In the MP, patients were randomized (2:1:1) to incobotulinumtoxinA 8, 6, or 2 U/kg body weight (maximum 200, 150, 50 U/upper limb), with optional lower-limb injections in one of five topographical distributions (total body dose ≤16 to 20 U/kg, maximum 400 to 500 U, depending on body weight and GMFCS level). Read More

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