12,204 results match your criteria standard prostate


Can Negative Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Avoid the Need for Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients? A Systematic Review and Meta-analysis with Backup Histology as Reference Standard.

Eur Urol Oncol 2021 Sep 17. Epub 2021 Sep 17.

Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

Context: The role of positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA) in the primary staging for patients with prostate cancer (PCa) is still debated.

Objective: To analyze published studies reporting the accuracy of PSMA PET/CT for detecting lymph node invasion (LNI) at pelvic lymph node dissection (PLND).

Evidence Acquisition: A search of PubMed/MEDLINE, Cochrane library's Central, EMBASE and Scopus databases, from inception to May 2021, was conducted. Read More

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September 2021

Comparison and prediction of artefact severity due to total hip replacement in 1.5 T versus 3 T MRI of the prostate.

Eur J Radiol 2021 Sep 11;144:109949. Epub 2021 Sep 11.

University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany. Electronic address:

Purpose: To evaluate image quality and diagnostic value of multiparametric prostate MRI (mpMRI) in patients with total hip replacement (THR) at 1.5 and 3 Tesla.

Methods: In this retrospective multicenter cohort study patients with uni- or bilateral THR and 1. Read More

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September 2021

EVALUATION OF EFFICACY OF EXTRACORPOREAL SHOCK WAVE THERAPY IN COMPLEX TREATMENT OF PATIENTS WITH CHRONIC NON-BACTERIAL PROSTATITIS / CHRONIC PELVIC PAIN SYNDROME.

Wiad Lek 2021 ;74(8):1834-1838

I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.

Objective: The aim: Study of hemodynamics of the prostate and evaluation of the ef f ectiveness of extracorporeal shock wave therapy (ESWT) in the complex treatment of patients with chronic prostatitis with non-inf l ammatory chronic pelvic pain syndrome (NCPPS), (NIH III B).

Patients And Methods: Materials and methods: There were 63 patients with NCPPS aged 29 to 45 years, with a disease duration of more than 3 years and low ef f i cacy of treatment against the background of standard therapy. All patients received standard therapy according to the clinical protocol. Read More

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January 2021

Dietary tomato inhibits angiogenesis in TRAMP prostate cancer but is not protective with a Western-style diet in this pilot study.

Sci Rep 2021 Sep 17;11(1):18548. Epub 2021 Sep 17.

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Prostate cancer (PCa) remains the second most diagnosed cancer worldwide. Higher body weight is associated with chronic inflammation, increased angiogenesis, and treatment-resistant tumor phenotypes. Dietary tomato reduces PCa risk, which may be due to tomato inhibition of angiogenesis and disruption of androgen signaling. Read More

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September 2021

Targeting radiation-induced upstream stimulatory factor-1 by histone deacetylase inhibitors to reverse radioresistance in prostate cancer.

Cancer Rep (Hoboken) 2021 Sep 17:e1553. Epub 2021 Sep 17.

Department of Radiation Oncology, University of Miami, Miami, Florida, USA.

Background: Ionizing radiation (IR) is a standard modality for the management of solid tumors. Apart from its killing effects, IR can induce pro-survival factors leading to radioresistance of cancer. Mechanistic understanding of radiation resistance is warranted to overcome the pro-survival effects of IR. Read More

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September 2021

3-T MRI and clinical validation of ultrasound-guided transperineal laser ablation of benign prostatic hyperplasia.

Eur Radiol Exp 2021 Sep 17;5(1):41. Epub 2021 Sep 17.

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133, Rome, Italy.

Background: Transperineal laser ablation (TPLA) of the prostate is a novel, mini-invasive option for men with lower urinary tract symptoms (LUTS) due to benign prostate hyperplasia (BPH). Our aim was to assess the impact of ultrasound-guided TPLA regarding urodynamic improvement and sexual function, monitoring clinical data, postprocedural complications and imaging findings at 3-T multiparametric magnetic resonance imaging.

Methods: Forty-four patients aged ≥ 50 affected with moderate to severe LUTS (International Prostate Symptoms score ≥ 12) due to benign prostatic obstruction and refractoriness, intolerance or poor compliance to medical therapies underwent US-guided TPLA between May 2018 and February 2020. Read More

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September 2021

Combination therapy with curcumin plus tamsulosin and finasteride in the treatment of men with benign prostatic hyperplasia: a single center, randomized control study.

Transl Androl Urol 2021 Aug;10(8):3432-3439

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: To perform a prospective, randomized, single center study to investigate the efficacy of combined use of curcumin, an anti-inflammatory agent, with the best standard management (BSM, tamsulosin and finasteride) in benign prostatic hyperplasia (BPH) patients.

Methods: One hundred and twenty-two consecutive patients were randomized to receive tamsulosin 0.2 mg, finasteride 5 mg, and curcumin 2,250 mg once a day (curcumin + BSM group, n=61) versus tamsulosin 0. Read More

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A randomized placebo-controlled study: Phellodendron Bawei tablets combined with standard management can improve storage symptoms, sleep quality, and medication compliance in patients with benign prostatic hyperplasia compared to placebo with standard management.

Transl Androl Urol 2021 Aug;10(8):3423-3431

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Benign prostatic hyperplasia (BPH) is a common micturition disorder in middle-aged and elderly males, and it is one of the most common urology-related diseases worldwide. However, standard therapeutic drugs (α1-receptor blockers + 5α reductase inhibitors) do not provide anti-inflammatory or anti-infective effects. The Phellodendron Bawei tablet is a proprietary Chinese medicine with anti-inflammatory and anti-infective effects. Read More

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Training Convolutional Networks for Prostate Segmentation With Limited Data.

IEEE Access 2021 27;9:109214-109223. Epub 2021 Jul 27.

Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA.

Multi-zonal segmentation is a critical component of computer-aided diagnostic systems for detecting and staging prostate cancer. Previously, convolutional neural networks such as the U-Net have been used to produce fully automatic multi-zonal prostate segmentation on magnetic resonance images (MRIs) with performance comparable to human experts, but these often require large amounts of manually segmented training data to produce acceptable results. For institutions that have limited amounts of labeled MRI exams, it is not clear how much data is needed to train a segmentation model, and which training strategy should be used to maximize the value of the available data. Read More

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Multifocal Urinary Tract Metastasis of Colorectal Carcinoma.

Pathobiology 2021 Sep 15:1-7. Epub 2021 Sep 15.

Department of Pathology, University of Szeged, Szeged, Hungary.

Introduction: Secondary urinary tract tumors are uncommon findings and mainly evolve by direct invasion from adjacent organs. Actual metastatic involvement often develops in the urinary bladder, while the upper urinary tract is infrequently affected. In addition, the lungs, breast, and prostate gland are the usual primary sites. Read More

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September 2021

Effects of Electroacupuncture on Alleviating Prostatodynia and Inflammation in Rats with Chronic Nonbacterial Prostatitis.

Authors:
Chao Zhang Ding Li

J Pain Res 2021 7;14:2757-2765. Epub 2021 Sep 7.

School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

Purpose: Chronic prostatitis (CP) is a common urinary disease characterized by a complex sequence of symptoms including prostatodynia, which results in significant physical pain and mental burden to affected patients. Currently, CP has no standard treatment. Thus, physical therapy electroacupuncture (EA) which has been successful in treating several inflammation-related pain conditions was used to determine its effect on rats with CP. Read More

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September 2021

Incremental Impact of [ Ga]Ga-PSMA-11 PET/CT in Primary N and M Staging of Prostate Cancer Prior to Curative-Intent Surgery: a Prospective Clinical Trial in Comparison with mpMRI.

Mol Imaging Biol 2021 Sep 14. Epub 2021 Sep 14.

Division of Molecular Imaging and Theranostics, Department of Nuclear Medicine and Endocrinology, University Hospital, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, Austria.

Purpose: The main objective of this prospective study was to assess the value of gallium-68 prostate-specific membrane antigen ([ Ga]Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) in primary N and M staging of intermediate- and high-risk prostate cancer (PCa) patients before planned curative-intent radical prostatectomy (RPE) and extended pelvic lymph node dissection (ePLND). The second objective was to compare the [ Ga]Ga-PSMA-11 PET/CT findings with standard of care pelvic multi-parametric magnetic resonance imaging (mpMRI) in the detection of locoregional lymph node metastases and intraprostatic prostate cancer.

Procedures: A total of 81 patients (mean age: 64. Read More

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September 2021

Fabrication of stable multivariate metal-organic frameworks with excellent adsorption performance toward bisphenols from environmental samples.

Talanta 2021 Dec 21;235:122818. Epub 2021 Aug 21.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.

As a type of environmental endocrine disrupting chemicals, bisphenols (BPs) have a certain embryonic toxicity and teratogenicity, which can significantly increase the risks of breast cancer, prostate cancer, leukemia and other cancers. In this work, stable multivariate metal-organic frameworks (UiO-66-NH/TCPP) were synthesized via in situ one-pot method and used as miniaturized dispersive solid-phase extraction (dμSPE) sorbents for extraction of trace BPs from environmental samples. The phase purity, crystal morphology and physical properties of UiO-66-NH/TCPP samples were varied by adjusting the mass ratio of TCPP. Read More

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December 2021

Comparison between F-DCFPyL PET and MRI for the detection of transition zone prostate cancer.

Prostate 2021 Sep 13. Epub 2021 Sep 13.

Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China.

Background: We aimed to compare the diagnostic performance of F-DCFPyL positron emission tomography (PET) and multiparameter magnetic resonance imaging (mp-MRI) in detecting transition zone (TZ) prostate cancer (PCa).

Methods: This retrospective study included 20 patients who underwent F-DCFPyL PET/MRI and 32 patients who underwent F-DCFPyL PET/CT and MRI from January 2019 to June 2020. All patients had TZ lesions and underwent prostate biopsies. Read More

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September 2021

Lymphocyte-to-monocyte ratio is a predictor of clinically significant prostate cancer at prostate biopsy.

Prostate 2021 Sep 13. Epub 2021 Sep 13.

Department of Urology, Seoul National University Boramae Medical Center, Seoul, Korea.

Background: Inflammation plays critical roles at different stages of carcinogenesis and cancer progression. Several previous studies showed conflicting results for the predictive role of systemic inflammation markers in the detection of clinically significant prostate cancers (CSPCs). We aimed to determine the predictive roles of lymphocyte-to-monocyte (LMR) and eosinophil-to-lymphocyte ratios (ELR) in the detection of CSPC at standard 12-core transrectal ultrasound-guided prostate biopsy (12-core-TRUS-Bx) using our large-cohort database. Read More

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September 2021

Bioelectric Impedance Analysis Test Improves the Detection of Prostate Cancer in Biopsy Candidates: A Multifeature Decision Support System.

Front Oncol 2021 27;11:555277. Epub 2021 Aug 27.

Department of Information Engineering & Research Center "E. Piaggio", University of Pisa, Pisa, Italy.

Prostate cancer (PCa) gold-standard diagnosis relies on prostate biopsy, which is currently overly recommended since other available noninvasive tools such as prostate-specific antigen (PSA) multiparametric MRI (mMRI) showed low diagnostic accuracy or high costs, respectively. The aim of the study was to determine the accuracy of a novel Bioelectric Impedance Analysis (BIA) test endorectal probe for the selection of patients candidate to prostate biopsy and in particular the clinical value of three different parameters such as resistance (R), reactance (Xc), and phase angle (PA) degree. One-hundred twenty-three consecutive candidates to prostate biopsy and 40 healthy volunteers were enrolled. Read More

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Radium-223 in combination with enzalutamide in metastatic castration-resistant prostate cancer: a multi-centre, phase II open-label study.

Ther Adv Med Oncol 2021 6;13:17588359211042691. Epub 2021 Sep 6.

Cancer Trials Ireland, Dublin, Ireland.

Background: Radium-223 and enzalutamide are approved agents for patients with metastatic castration-resistant prostate cancer (mCRPC). Combining radium-223 and enzalutamide to improve outcomes is of clinical interest due to their differing modes of action and non-overlapping toxicity profiles.

Methods: This phase II study enrolled patients with mCRPC and bone metastases. Read More

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September 2021

Median Duration of Hospital Stay after Early Removal of Foley's Catheter among Patients Undergoing Transurethral Resection of Prostate: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Jul 30;59(239):688-691. Epub 2021 Jul 30.

Department of Surgery, National Medical College, Birgunj, Nepal.

Introduction: Transurethral resection of the prostate requires a catheter in situ post-surgery. Early removal of catheter can reduce the length of hospital stay reducing the healthcare cost. It can also reduce the risk of infection due to prolonged catheterization. Read More

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Automatic radiotherapy delineation quality assurance on prostate MRI with deep learning in a multicentre clinical trial.

Phys Med Biol 2021 Sep 10. Epub 2021 Sep 10.

Institute of Medical Physics, University of Sydney School of Physics, Sydney, New South Wales, AUSTRALIA.

Volume delineation quality assurance (QA) is particularly important in clinical trial settings where consistent protocol implementation is required, as outcomes will affect future as well current patients. Currently, where feasible, this is conducted manually, which is time consuming and resource intensive. Although previous studies mostly focused on automating delineation QA on CT, magnetic resonance imaging (MRI) is being increasingly used in radiotherapy treatment. Read More

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September 2021

Systematic biopsy should not be omitted in the era of combined magnetic resonance imaging/ultrasound fusion-guided biopsies of the prostate.

Int Urol Nephrol 2021 Sep 9. Epub 2021 Sep 9.

Department of Urology and Andrology, Klinikum Klagenfurt, Feschnigstrasse 11, 9020, Klagenfurt, Austria.

Purpose: To evaluate prostate cancer detection rates with classical trans-rectal ultrasound-guided systematic 10-core biopsies (SB), targeted biopsies (TB) guided by magnetic resonance (MR)/US fusion imaging and their combination in biopsy-naïve and patients with previously negative prostate biopsies. We compared pathology results after radical prostatectomy with biopsy findings.

Methods: Consecutive patients with prostate imaging-reporting and data system lesions grade ≥ 3 submitted to MRI/US-guided TB and subsequent standard 10-core SB between December 2015 and June 2019 were analyzed. Read More

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September 2021

Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer.

Cancers (Basel) 2021 Sep 5;13(17). Epub 2021 Sep 5.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan.

Despite the significant advances in the treatment of high-risk prostate cancer, patients with very high-risk features such as being locally advanced (clinical stage T3-4 or minimal nodal involvement), having a high Gleason pattern, or with oligometastasis may still have a poor prognosis despite aggressive treatment. Multidisciplinary treatment with both local and systemic therapies is thought to be effective, however, unfortunately, there is still no standard treatment. However, in recent years, local definitive therapy using a combination of radiotherapy and androgen deprivation is being supported by several randomized clinical trials. Read More

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September 2021

Intraoperative Digital Analysis of Ablation Margins (DAAM) by Fluorescent Confocal Microscopy to Improve Partial Prostate Gland Cryoablation Outcomes.

Cancers (Basel) 2021 Aug 30;13(17). Epub 2021 Aug 30.

Department of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy.

Partial gland cryoablation (PGC) aims at destroying prostate cancer (PCa) foci while sparing the unaffected prostate tissue and the functionally relevant structures around the prostate. Magnetic Resonance Imaging (MRI) has boosted PGC, but available evidence suggests that ablation margins may be positive due to MRI-invisible lesions. This study aimed at determining the potential role of intraoperative digital analysis of ablation margins (DAAM) by fluoresce confocal microscopy (FCM) of biopsy cores taken during prostate PGC. Read More

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Combined Transfer Learning and Test-Time Augmentation Improves Convolutional Neural Network-Based Semantic Segmentation of Prostate Cancer from Multi-Parametric MR Images.

Comput Methods Programs Biomed 2021 Aug 28;210:106375. Epub 2021 Aug 28.

Biomedical Translational Imaging Centre, Nova Scotia Health Authority and IWK Health Centre, Halifax, NS, Canada; Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada. Electronic address:

Purpose: Multiparametric MRI (mp-MRI) is a widely used tool for diagnosing and staging prostate cancer. The purpose of this study was to evaluate whether transfer learning, unsupervised pre-training and test-time augmentation significantly improved the performance of a convolutional neural network (CNN) for pixel-by-pixel prediction of cancer vs. non-cancer using mp-MRI datasets. Read More

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Extraperitoneal Single-Port Robot-Assisted Radical Prostatectomy.

J Endourol 2021 Sep;35(S2):S100-S105

Department of Urology, University of Rochester Medical Center, Rochester, New York, USA.

Robot-assisted radical prostatectomy (RARP) is currently the standard minimally invasive procedure for the surgical management of localized prostate cancer. It has been shown that the minimally invasive robotic approach offers comparable oncologic and functional outcomes with potential advantages, including decreased blood loss, shorter hospital stay, and recovery period when compared with open surgery. Generally, the transperitoneal RARP approach is the most commonly performed among robotic surgeons, owing to its wider space and early adoption. Read More

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September 2021

Novel potent anti-STEAP1 bispecific antibody to redirect T cells for cancer immunotherapy.

J Immunother Cancer 2021 Sep;9(9)

Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Background: The prognosis for metastatic Ewing sarcoma family of tumors (EFT) is still poor despite high-dose chemotherapy and radiation treatment. Immunotherapies hold promise, but cancer antigen-targeting immunotherapies have largely failed to induce effective T cell receptor-mediated antitumor response. However, T cell-engaging bispecific antibodies (T-BsAbs) have yet to be adequately explored. Read More

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September 2021

The effectiveness of high-dose-rate brachytherapy with external beam radiotherapy for clinically locally advanced and node-positive prostate cancer: long-term results of a retrospective study.

Int J Clin Oncol 2021 Sep 7. Epub 2021 Sep 7.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: No standard treatment exists for locally advanced prostate cancer (PC). This study evaluated the long-term treatment outcomes and toxicity in patients with clinically locally advanced and/or lymph node (LN)-positive PC who underwent high-dose-rate brachytherapy (HDR-BT) with external beam radiotherapy (EBRT).

Methods: The treatment outcomes and toxicities of 152 patients with PC who underwent HDR-BT with EBRT and had at least 2 years of observation were examined. Read More

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September 2021

Clinical Impact of the Predict Prostate Risk Communication Tool in Men Newly Diagnosed with Nonmetastatic Prostate Cancer: A Multicentre Randomised Controlled Trial.

Eur Urol 2021 Sep 4. Epub 2021 Sep 4.

Department of Surgery, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Background: Predict Prostate is a freely available online personalised risk communication tool for men with nonmetastatic prostate cancer. Its accuracy has been assessed in multiple validation studies, but its clinical impact among patients has not hitherto been assessed.

Objective: To assess the impact of the tool on patient decision-making and disease perception. Read More

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September 2021

Diffusion-weighted imaging in prostate cancer.

MAGMA 2021 Sep 7. Epub 2021 Sep 7.

Department of Radiology, Kawasaki Medical School, 577 Matsushima, Kurashiki city, Okayama, 701-0192, Japan.

Diffusion-weighted imaging (DWI), a key component in multiparametric MRI (mpMRI), is useful for tumor detection and localization in clinically significant prostate cancer (csPCa). The Prostate Imaging Reporting and Data System versions 2 and 2.1 (PI-RADS v2 and PI-RADS v2. Read More

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September 2021

Impact of Hypofractionated Radiotherapy on Patient-reported Outcomes in Prostate Cancer: Results up to 5 yr in the CHHiP trial (CRUK/06/016).

Eur Urol Oncol 2021 Aug 17. Epub 2021 Aug 17.

The Institute of Cancer Research, London, UK.

Background: Moderate hypofractionation is the recommended standard of care for localised prostate cancer following the results of trials including Conventional or Hypofractionated High Dose Intensity Modulated Radiotherapy in Prostate Cancer (CHHiP). Evaluation of long-term patient-reported outcomes (PROs) is important to confirm safety and enhance patient information.

Objective: To determine whether 5-yr PROs from the CHHiP quality of life (QoL) substudy confirm 2-yr findings and assess patterns over follow-up. Read More

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An Updated Systematic Review on Focal Therapy in Localized Prostate Cancer: What Has Changed over the Past 5 Years?

Eur Urol 2021 Sep 3. Epub 2021 Sep 3.

Department of Operating Rooms, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.

Context: Focal therapy is a promising, minimally invasive strategy to selectively treat localized prostate cancer. A previous systematic review indicated that there is growing evidence for favorable functional outcomes, but that oncological effectiveness was yet to be defined.

Objective: To assess the effectiveness of focal therapy in patients with localized prostate cancer in terms of functional and oncological outcomes. Read More

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September 2021