27,928 results match your criteria stages iii


NMR based CSF metabolomics in tuberculous meningitis: correlation with clinical and MRI findings.

Metab Brain Dis 2022 Jan 14. Epub 2022 Jan 14.

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.

We report the potential role of H Nuclear Magnetic Resonance (NMR) based metabolomics in tuberculous meningitis (TBM). We also correlate the significant metabolites with clinical-radiological parameters. Forty-three patients with TBM were included, and their severity of meningitis was graded as stages I to III, and patients with positive Mycobacterium tuberculosis or its nucleic acid was considered as definite TBM. Read More

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January 2022

[Biologics for connective tissue diseases and vasculitides].

Internist (Berl) 2022 Jan 14. Epub 2022 Jan 14.

Zentrum für Interdisziplinäre Klinische Immunologie, Rheumatologie und Autoimmunerkrankungen (INDIRA), Universitätsklinikum Tübingen, Tübingen, Deutschland.

Despite therapy with glucocorticoids (GC) and conventional immunosuppressants, patients with connective tissue diseases and vasculitides often develop functionally relevant and prognostically unfavourable internal organ damage. Based on new pathogenetic insights, biologics and small molecules have recently been studied as targeted therapies for collagen vascular diseases and vasculitides. The B lymphocyte stimulator antagonist belimumab has been used for the treatment of systemic lupus erythematosus (SLE) for several years and has recently also been approved as an add-on therapy for lupus nephritis. Read More

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January 2022

RENORT: a project to analyze patterns of care in radiation oncology in Spain.

Clin Transl Oncol 2022 Jan 13. Epub 2022 Jan 13.

Department of Radiation Oncology, Hospital Ruber Internacional, 28034, Madrid, Spain.

Purpose: RENORT is an application (app) developed to assess the role of radiotherapy in the treatment of cancer using the oncology information systems (OIS).

Methods/patients: The RENORT app was used to analyze the data for all patients seen and/or treated at six radiation oncology departments in Spain in 2019. This app can be used to extract the demographic data, treatment sequence, disease status, and radiotherapy treatments from the ARIA and Mosaiq OIS. Read More

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January 2022

Application of Deep Learning in Lung Cancer Imaging Diagnosis.

J Healthc Eng 2022 3;2022:6107940. Epub 2022 Jan 3.

Thoracic Surgery Department, GanZhou People's Hospital, Ganzhou 341000, China.

Lung cancer is one of the malignant tumors with the highest fatality rate and nearest to our lives. It poses a great threat to human health and it mainly occurs in smokers. In our country, with the acceleration of industrialization, environmental pollution, and population aging, the cancer burden of lung cancer is increasing day by day. Read More

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January 2022

Evaluation of the relationship among dental fear, scaling and root planing and periodontal status using periodontitis stages: A retrospective study.

J Dent Sci 2022 Jan 21;17(1):293-299. Epub 2021 Apr 21.

Department of Periodontology, Stomatological Hospital, Southern Medical University, Guangzhou, China.

Background/purpose: Patients with periodontal disease have higher dental fear levels, which may have negative effects on their clinical outcome during scaling and root planing (SRP). The present study used the new classification of periodontitis and validated questionnaires to assess the relationship among dental fear, SRP pain and periodontal status.

Materials And Methods: A total of 120 periodontitis patients were enrolled and staging according to the new classification of periodontitis. Read More

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January 2022

Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer.

J Med Life 2021 Sep-Oct;14(5):710-715

Department of Pathology, College of Medicine, University of Maisan, Maisan, Iraq.

Cancer testis antigens have been discovered in various cancers, and several studies have suggested that since they exhibit such distinct patterns of expression, these antigens might be attractive targets for cancer detection and immunotherapy. Our work attempted to clarify the function played by cancer-testis antigens in ovarian cancers, notably in the XAGE1 gene. The investigation was conducted on 74 tissue samples from newly diagnosed patients with ovarian cancer. Read More

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Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis.

Eur Heart J 2021 Nov 22. Epub 2021 Nov 22.

Department of Medicine, University of Chicago Medicine, 5841 South Maryland Avenue, MC 6092, 60637 Chicago, IL, USA.

Aims: The complementary studies FIDELIO-DKD and FIGARO-DKD in patients with type 2 diabetes and chronic kidney disease (CKD) examined cardiovascular and kidney outcomes in different, overlapping stages of CKD. The purpose of the FIDELITY analysis was to perform an individual patient-level prespecified pooled efficacy and safety analysis across a broad spectrum of CKD to provide more robust estimates of safety and efficacy of finerenone compared with placebo.

Methods And Results: For this prespecified analysis, two phase III, multicentre, double-blind trials involving patients with CKD and type 2 diabetes, randomized 1:1 to finerenone or placebo, were combined. Read More

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November 2021

Assessing and disclosing test results for 'mild cognitive impairment': the perspective of old age psychiatrists in Scotland.

BMC Geriatr 2022 Jan 12;22(1):50. Epub 2022 Jan 12.

Society and Ethics Research, Wellcome Connecting Science, Cambridge, UK.

Background: Mild cognitive impairment (MCI) is a condition that exists between normal healthy ageing and dementia with an uncertain aetiology and prognosis. This uncertainty creates a complex dynamic between the clinicians' conception of MCI, what is communicated to the individual about their condition, and how the individual responds to the information conveyed to them. The aim of this study was to explore clinicians' views around the assessment and communication of MCI in memory clinics. Read More

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January 2022

A comprehensive profiling of soluble immune checkpoints from the sera of patients with non-small cell lung cancer.

J Clin Lab Anal 2022 Jan 12:e24224. Epub 2022 Jan 12.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

Background: Immunotherapy was widely used for the treatment of non-small cell lung cancer (NSCLC). However, whether inhibition of immune checkpoints individually or simultaneously could improve the therapeutic efficacy of NSCLC remains to be investigated. Here, we explored the aberrant levels of several checkpoints and evaluated their potential diagnostic values for NSCLC. Read More

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January 2022

ENDOSCOPIC CHARACTERISTICS OF PATIENTS WITH COMPLETE PATHOLOGICAL RESPONSE AFTER NEOADJUVANT CHEMOTHERAPY FOR GASTRIC AND ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMAS.

Arq Bras Cir Dig 2022 5;34(3):e1616. Epub 2022 Jan 5.

A.C. Camargo Cancer Center, Endoscopy Unit, São Paulo, SP, Brazil.

Background: Gastric and esophagogastric junction adenocarcinoma are responsible for approximately 13.5% of cancer-related deaths. Given the fact that these tumors are not typically detected until they are already in the advanced stages, neoadjuvancy plays a fundamental role in improving long-term survival. Read More

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January 2022

Prospective urinary albumin/creatinine ratio for diagnosis, staging, and organ response assessment in renal AL amyloidosis: results from a large cohort of patients.

Clin Chem Lab Med 2022 Jan 13. Epub 2022 Jan 13.

Amyloidosis Research and Treatment Center, Foundation Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Policlinico San Matteo, Pavia, Italy.

Objectives: Quantification of 24 h-proteinuria is the gold standard for diagnosing, staging, and monitoring of patients with renal AL amyloidosis. However, 24 h-urine collection is cumbersome and may result in preanalytical error. In this prospective study, we investigated the role of urinary albumin/creatinine ratio (UACR) (cut-off: 300 mg/g) identifying renal involvement, evaluated a UACR-based staging system (UACR cut-off: 3,600 mg/g) and assessed whether UACR response (UACR decrease >30% without worsening in eGFR >25%) predicts renal outcome in 531 patients with newly-diagnosed AL amyloidosis. Read More

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January 2022

Systematic review and meta-analysis: the value of MRI chemical-shift imaging in the evaluation of bone quality in patients with osteoporosis.

Ann Palliat Med 2021 Dec;10(12):12706-12715

Department of Orthopedics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Background: Osteoporosis is a systemic skeletal disease with no obvious symptoms in its early stages. The decreases in bone density and bone mass are associated with the deterioration of bony microstructure in the body, due to a variety of reasons. The current assessment criteria for osteoporosis are still not perfect. Read More

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December 2021

Towards a metagenomics machine learning interpretable model for understanding the transition from adenoma to colorectal cancer.

Sci Rep 2022 Jan 10;12(1):450. Epub 2022 Jan 10.

Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), Hospital Virgen del Rocio, 41013, Seville, Spain.

Gut microbiome is gaining interest because of its links with several diseases, including colorectal cancer (CRC), as well as the possibility of being used to obtain non-intrusive predictive disease biomarkers. Here we performed a meta-analysis of 1042 fecal metagenomic samples from seven publicly available studies. We used an interpretable machine learning approach based on functional profiles, instead of the conventional taxonomic profiles, to produce a highly accurate predictor of CRC with better precision than those of previous proposals. Read More

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January 2022

Overview of the Development and Use of Akt Inhibitors in Prostate Cancer.

J Clin Med 2021 Dec 29;11(1). Epub 2021 Dec 29.

Department of Urology, University of Rennes, 35000 Rennes, France.

Deregulation of the PI3K-Akt-mTOR pathway plays a critical role in the development and progression of many cancers. In prostate cancer, evidence suggests that it is mainly driven by PTEN loss of function. For many years, the development of selective Akt inhibitors has been challenging. Read More

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December 2021

Can Public Health Interventions Change Immediate and Long-Term Dietary Behaviours? Encouraging Evidence from a Pilot Study of the U.K. Change4Life Sugar Swaps Campaign.

Nutrients 2021 Dec 24;14(1). Epub 2021 Dec 24.

Faculty of Science and Engineering, Anglia Ruskin University, Chelmsford CM1 1SQ, UK.

The aim of this pilot study was to evaluate the effectiveness of the U.K. Change4Life Sugar Swaps campaign for improving nutritional intake in a small sample of families prior to the 2015 nationwide launch. Read More

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December 2021

Influences of Climate Change and Variability on Estuarine Ecosystems: An Impact Study in Selected European, South American and Asian Countries.

Int J Environ Res Public Health 2022 Jan 5;19(1). Epub 2022 Jan 5.

Center for Geopolitical and Strategic Studies & Institute for Global Innovation and Development, East China Normal University, Shanghai 200062, China.

It is well-known that climate change significantly impacts ecosystems (at the macro-level) and individual species (at the micro-level). Among the former, estuaries are the most vulnerable and affected ecosystems. However, despite the strong relations between climate change and estuaries, there is a gap in the literature regarding international studies across different regions investigating the impacts of climate change and variability on estuaries in different geographical zones. Read More

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January 2022

Early Diagnosis of Multiple Sclerosis Using Swept-Source Optical Coherence Tomography and Convolutional Neural Networks Trained with Data Augmentation.

Sensors (Basel) 2021 Dec 27;22(1). Epub 2021 Dec 27.

Miguel Servet Ophthalmology Innovation and Research Group (GIMSO), Department of Ophthalmology, Aragon Institute for Health Research (IIS Aragon), Miguel Servet University Hospital, University of Zaragoza, 50018 Zaragoza, Spain.

Background: The aim of this paper is to implement a system to facilitate the diagnosis of multiple sclerosis (MS) in its initial stages. It does so using a convolutional neural network (CNN) to classify images captured with swept-source optical coherence tomography (SS-OCT).

Methods: SS-OCT images from 48 control subjects and 48 recently diagnosed MS patients have been used. Read More

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December 2021

Phototheranostics of Cervical Neoplasms with Chlorin e6 Photosensitizer.

Cancers (Basel) 2022 Jan 2;14(1). Epub 2022 Jan 2.

University Clinical Hospital No. 1, Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 119435 Moscow, Russia.

(1) Purpose: Improving the treatment effectiveness of intraepithelial neoplasia of the cervix associated with human papillomavirus infection, based on the application of the method of photodynamic therapy with simultaneous laser excitation of fluorescence to clarify the boundaries of cervical neoplasms. (2) Methods: Examination and treatment of 52 patients aged 22 to 53 years with morphologically and cytologically confirmed mild to severe intraepithelial cervix neoplasia, preinvasive, micro-invasive, and squamous cell cervix carcinoma. All patients were carriers of human papillomavirus infection. Read More

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January 2022

Pre- and Perioperative Inflammatory Biomarkers in Older Patients Resected for Localized Colorectal Cancer: Associations with Complications and Prognosis.

Cancers (Basel) 2021 Dec 29;14(1). Epub 2021 Dec 29.

Department of Medicine, Copenhagen University Hospital, DK-2730 Herlev, Denmark.

The association between pre- and perioperative inflammatory biomarkers, major complications, and survival rates after resection of colorectal cancer (CRC) in older patients is largely unknown. The aim was to investigate age-dependent differences in these associations. Serum CRP, IL-6, and YKL-40 were measured preoperatively and on the first and second day after resection of CRC (stages I-III) in 210 older (≥70 years) and 191 younger patients (<70 years). Read More

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December 2021

Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease.

Cancers (Basel) 2021 Dec 24;14(1). Epub 2021 Dec 24.

Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.

Fibropolycystic liver disease is characterized by hyperproliferation of the biliary epithelium and the formation of multiple dilated cysts, a process associated with unfolded protein response (UPR). In the present study, we aimed to understand the mechanisms of cyst formation and UPR activation in hepatocytic c-Jun N-terminal kinase 1/2 () knockout mice. Floxed JNK1/2 () and animals were sacrificed at different time points during progression of liver disease. Read More

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December 2021

Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level.

Cancers (Basel) 2021 Dec 22;14(1). Epub 2021 Dec 22.

Bordeaux University, CNRS/IN2P3, CENBG, UMR 5797, 33170 Gradignan, France.

The Geant4-DNA low energy extension of the Geant4 Monte Carlo (MC) toolkit is a continuously evolving MC simulation code permitting mechanistic studies of cellular radiobiological effects. Geant4-DNA considers the physical, chemical, and biological stages of the action of ionizing radiation (in the form of x- and γ-ray photons, electrons and β-rays, hadrons, α-particles, and a set of heavier ions) in living cells towards a variety of applications ranging from predicting radiotherapy outcomes to radiation protection both on earth and in space. In this work, we provide a brief, yet concise, overview of the progress that has been achieved so far concerning the different physical, physicochemical, chemical, and biological models implemented into Geant4-DNA, highlighting the latest developments. Read More

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December 2021

The pan-immune-inflammation value and systemic immune-inflammation index in advanced melanoma patients under immunotherapy.

J Cancer Res Clin Oncol 2022 Jan 10. Epub 2022 Jan 10.

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.

Purpose: To evaluate the pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII) in patients with cutaneous melanoma (CM) under immune checkpoint inhibitor (ICI) therapy.

Methods: PIV and SII were calculated before the start of ICI therapy and at time of progression/death in patients with metastatic CM (stage III/IV). Sex-age-matched CM patients in stage I/II and healthy subjects (HC) served as controls. Read More

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January 2022

Shear Wave Elastography of the Coracohumeral Ligament With Frozen Shoulder in Different Stages.

J Ultrasound Med 2022 Jan 10. Epub 2022 Jan 10.

Department of Ultrasound, Baoji High-Tech Hospital, Baoji, China.

Objectives: To study the shear wave elastography (SWE) of the coracohumeral ligament (CHL) in different stages of frozen shoulder and to analyze its correlation with the visual analogue scale (VAS) score and shoulder range of motion (ROM).

Methods: Sixty-four patients with frozen shoulder were divided into three stages: stage I (freezing phase), stage II (frozen phase), and stage III (thawing phase). The SWE of the CHL of the affected and healthy sides was measured and compared in the different stages. Read More

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January 2022

Lamb's tripe extract and vitamin B capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study.

World J Clin Cases 2021 Dec;9(34):10472-10483

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Military Medical University, Xi'an 710032, Shaanxi Province, China.

Background: Chronic atrophic gastritis (AG) with intestinal metaplasia (IM) significantly increases the risk of gastric cancer. Some medicines have showed definite therapeutic effects in AG and IM regression.

Aim: To validate the efficacy of Lamb's tripe extract and vitamin B capsule (LTEVB) initial therapy and celecoxib rescue therapy for IM and AG. Read More

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December 2021

Shifting From Tokenism to Meaningful Adolescent Participation in Research for Obesity Prevention: A Systematic Scoping Review.

Front Public Health 2021 23;9:789535. Epub 2021 Dec 23.

School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Traditionally, adolescent participation in research has been tokenistic. Adolescents are rarely afforded the opportunity to influence decision-making in research designed to prevent obesity. Engaging adolescents in meaningful decision-making may enhance research translation. Read More

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December 2021

Clinical Significance of Serum-Derived Exosomal LINC00917 in Patients With Non-Small Cell Lung Cancer.

Front Genet 2021 24;12:728763. Epub 2021 Dec 24.

Department of Respiratory Disease, Qingdao Huangdao District Central Hospital, Qingdao, China.

In this study, we aimed to explore the diagnostic potential of serum-based exosomal long intergenic noncoding RNA 917 (LINC00917) in non-small cell lung cancer (NSCLC). Exosomes were extracted from NSCLC patients' serum samples. Exosomal LINC00917 expression levels were compared, by qRT-PCR, between cancer patients and healthy controls, as well as sub-populations of cancer patients. Read More

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December 2021

Referrals and Decision-Making Considerations Involved in Selecting a Surgeon for Rectal Cancer Treatment in the Midwest United States.

Dis Colon Rectum 2022 Jan 4. Epub 2022 Jan 4.

Department of Epidemiology - University of Iowa College of Public Health, Iowa City, Iowa Department of Surgery - University of Iowa Hospitals and Clinics, Iowa City, Iowa Center for Access & Delivery Research and Evaluation, VA Office of Rural Health, Veterans Rural Health Resource Center - Iowa City VA Health Care System, Iowa City, Iowa Department of Internal Medicine - University of Iowa Hospitals and Clinics, Iowa City, Iowa Iowa Cancer Registry - University of Iowa, Iowa City, Iowa.

Background: Despite evidence of superior outcomes for rectal cancer at high-volume, multi-disciplinary cancer centers, many patients undergo surgery in low-volume hospitals.

Objectives: Examine former rectal cancer patients' considerations when selecting their surgeon, and evaluate which considerations were associated with surgery at high-volume hospitals.

Design: We surveyed patients about what they considered when deciding on a cancer surgeon to complete this retrospective cohort study. Read More

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January 2022

BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.

Biol Psychiatry 2021 Nov 10. Epub 2021 Nov 10.

Department of Anesthesiology and Perioperative Medicine, University of Rochester, Rochester, New York. Electronic address:

Background: Declining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer's disease (AD). Emerging studies implicate impairment of the endosome-lysosome pathway as a significant factor in the pathogenesis of these diseases. Previously, we demonstrated that BAG3 regulates phosphorylated tau clearance. Read More

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November 2021

Robotic versus laparoscopic low anterior resection following neoadjuvant chemoradiation therapy for stage II-III locally advanced rectal cancer: a single-centre cohort study.

J Robot Surg 2022 Jan 9. Epub 2022 Jan 9.

Department of Surgery, Clarunis-University Center for Gastrointestinal and Liver Diseases, Postfach, 4002, Basel, Switzerland.

Neoadjuvant chemo-radiotherapy (nCRT) of locally advanced rectal cancer is associated with challenging surgical treatment and increased postoperative morbidity. Robotic technology overcomes laparoscopy limitations by enlarged 3D view, improved anatomical transection accuracy, and physiologic tremor reduction. Patients with UICC stage II-III rectal cancer, consecutively referred to our institution between March 2015 and June 2020 (n = 102) were treated with robotic (Rob-G, n = 38) or laparoscopic (Lap-G, n = 64) low anterior resection (LAR) for total meso-rectal excision (TME) following highly standardized and successful nCRT treatment. Read More

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January 2022