Gene 2021 Sep 13:145964. Epub 2021 Sep 13.
Key Laboratory of Imaging Diagnosis and Minimally Invasive Research, Lishui Central Hospital, Zhejiang University Lishui Hospital, The Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, Zhejiang, China. Electronic address:
Aims: We aimed to investigate the role of G protein subunit alpha Z(GNAZ) in the progression and prognosis of patients with hepatocellular carcinoma (HCC).
Methods: Oncomine, GEO, TCGA, GEPIA2, Kaplan-Meier Plotter, TIMER2, Metascape, CCLE, LinkedOmics, and UALCAN databases were used to analyze the differential expression of GNAZ in HCC and normal liver tissues, relationship between GNAZ expression and prognosis of patients with HCC, and expression of GNAZ in common human HCC cell lines. Western blotting was performed to analyze GNAZ expression, while the Cell Counting Kit 8 assay was used to determine cell proliferation, and flow cytometry was used to evaluate the cell cycle and apoptosis. Read More