6,526 results match your criteria stage recurrence-free


A Co-Expression Network Reveals the Potential Regulatory Mechanism of lncRNAs in Relapsed Hepatocellular Carcinoma.

Front Oncol 2021 31;11:745166. Epub 2021 Aug 31.

Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Background: The mechanistic basis for relapsed hepatocellular carcinoma (HCC) remains poorly understood. Recent research has highlighted the important roles of long non-coding RNAs (lncRNAs) in HCC. However, there are only a few studies on the association between lncRNAs and HCC relapse. Read More

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Overexpressed GNAZ predicts poor outcome and promotes G0/G1 cell cycle progression in hepatocellular carcinoma.

Authors:
Feng Tian Daxia Cai

Gene 2021 Sep 13:145964. Epub 2021 Sep 13.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Research, Lishui Central Hospital, Zhejiang University Lishui Hospital, The Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, Zhejiang, China. Electronic address:

Aims: We aimed to investigate the role of G protein subunit alpha Z(GNAZ) in the progression and prognosis of patients with hepatocellular carcinoma (HCC).

Methods: Oncomine, GEO, TCGA, GEPIA2, Kaplan-Meier Plotter, TIMER2, Metascape, CCLE, LinkedOmics, and UALCAN databases were used to analyze the differential expression of GNAZ in HCC and normal liver tissues, relationship between GNAZ expression and prognosis of patients with HCC, and expression of GNAZ in common human HCC cell lines. Western blotting was performed to analyze GNAZ expression, while the Cell Counting Kit 8 assay was used to determine cell proliferation, and flow cytometry was used to evaluate the cell cycle and apoptosis. Read More

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September 2021

Spatiotemporal Patterns of Loco-Regional Recurrence After Breast-Conserving Surgery.

Front Oncol 2021 30;11:690658. Epub 2021 Aug 30.

Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Loco-regional recurrences (LRR) following breast-conserving surgery (BCS) remain a heterogeneous class of disease that has significant variation in its biological behavior and prognosis.

Methods: To delineate the spatiotemporal patterns of LRR after BCS, we analyzed the data of 4325 patients treated with BCS from 2006 to 2016. Clinico-pathological and treatment specific factors were analyzed using the Cox proportional hazards model to identify factors predictive for LRR events. Read More

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Increased Expression of Long Non-coding RNA H19 is Associated With Colon Cancer Recurrence.

J Surg Res 2021 Sep 11;269:59-68. Epub 2021 Sep 11.

Price Institute of Surgical Research, Hiram C. Polk Jr. MD Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky. Electronic address:

Background: Colon cancer is a leading cause of cancer-related death. Long non-coding (Lnc) RNAs are critical mediators of tumor biology. H19 is a well-characterized lncRNA involved in p53 regulation and cancer progression. Read More

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September 2021

Outcome of pretransplant melanoma after solid organ transplantation: an observational study.

Transpl Int 2021 Sep 14. Epub 2021 Sep 14.

Service de Dermatologie, Hôpital Universitaire Edouard Herriot, Hospices Civils de Lyon, Lyon, France.

Background: The number of patients with a history of melanoma who are waiting a solid organ transplantation (SOT) is increasing. Few recommendations exist on the timing to transplantation after melanoma diagnosis. The aim of this study was to assess the melanoma recurrence-free survival after pretransplant melanoma (PTM). Read More

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September 2021

Laparoscopic and open surgery in patients with transverse colon cancer: short-term and oncological outcomes.

BJS Open 2021 Sep;5(5)

Department of Health Information System Management Technology Room, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.

Background: Studies evaluating the outcomes after laparoscopic resections of transverse colon cancers are scant. This manuscript aimed to compare surgical and oncological outcomes after laparoscopic (Lap) and open procedures for transverse colon carcinomas.

Methods: All consecutive patients who underwent resection for a cancer located in the transverse colon between 2003 and 2019 were reviewed. Read More

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September 2021

Is Adjuvant Chemotherapy Beneficial to All Patients With pT3N0M0 Stage Gastric Cancer?

Front Oncol 2021 26;11:712432. Epub 2021 Aug 26.

Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Background: The efficacy and benefits of adjuvant chemotherapy (AC) for patients with gastric cancer pT3N0M0 remain controversial.

Methods: We prospectively collected and retrospectively analyzed 235 patients with pT3N0M0 gastric cancer who underwent radical resection between February 2010 and January 2016. Patients were divided into two groups: the surgery-alone (SA) group (n = 82) and the AC group (n = 153). Read More

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The Ratio of CD86+/CD163+ Macrophages Predicts Postoperative Recurrence in Stage II-III Colorectal Cancer.

Front Immunol 2021 26;12:724429. Epub 2021 Aug 26.

Department of Medical Oncology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.

Tumor-associated macrophages (TAMs) are pivotal for tumor progression and metastasis. We investigated the stromal CD86+TAM/CD163+TAM (CD86/CD163) ratio as a novel prognostic biomarker for stage II-III colorectal cancer (CRC). Two independently clinical cohorts of stage II-III CRC were retrospectively enrolled in this study. Read More

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Clinical outcomes of surgical resection for recurrent lesion after curative esophagectomy for esophageal squamous cell carcinoma: a nationwide, large-scale retrospective study.

Esophagus 2021 Sep 12. Epub 2021 Sep 12.

Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: Several studies have reported the efficacy of resection for recurrent lesions. However, they involved a limited number of subjects. This study aimed to identify a subset of patients who benefit from surgical resection of recurrent lesions after curative esophagectomy for esophageal squamous cell carcinoma. Read More

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September 2021

Organ Preservation in Rectal Cancer Patients Treated with Total Neoadjuvant Therapy.

Dis Colon Rectum 2021 Aug 18. Epub 2021 Aug 18.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York Department of Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer Center, New York.

Background: Retrospective studies suggest that watch-and-wait is a safe alternative to total mesorectal excision in selected patients with a clinical complete response after chemoradiotherapy.

Objective: Determine the proportion of rectal cancer patients who may benefit from watch-and-wait.

Design: Retrospective analysis of data from prospectively maintained databases. Read More

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ALBI grade: Evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma.

JHEP Rep 2021 Oct 5;3(5):100347. Epub 2021 Aug 5.

Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.

Hepatocellular carcinoma (HCC) usually arises in the context of a chronically damaged liver. Liver functional estimation is of paramount importance in clinical decision making. The Child-Pugh score (CPS) can be used to categorise patients into 3 classes (A to C) based on the severity of liver functional impairment according to 5 parameters (albumin, bilirubin, prothrombin time, presence of ascites and hepatic encephalopathy). Read More

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October 2021

Identification and validation of a ferroptosis-related gene signature predictive of prognosis in breast cancer.

Aging (Albany NY) 2021 Sep 9;13(undefined). Epub 2021 Sep 9.

Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Ferroptosis, a novel form of regulated cell death, is closely associated with the occurrence and development of malignant tumors. Here, we utilized a bioinformatics approach to identify ferroptosis-related genes to establish a robust and reliable prognostic signature in breast cancer (BC). Univariate Cox regression and LASSO regression analyses of patient's survival and gene expression data identified a prognostic signature consisting of 10 ferroptosis-related genes (FRGs). Read More

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September 2021

Distinct tumour antigen-specific T-cell immune response profiles at different hepatocellular carcinoma stages.

BMC Cancer 2021 Sep 8;21(1):1007. Epub 2021 Sep 8.

Biomedical Information Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.

Background: Cancer-testis antigens (CTAs) and tumour-associated antigens (TAAs) are frequently expressed in hepatocellular carcinoma (HCC); however, the role of tumour-antigen-specific T cell immunity in HCC progression is poorly defined. We characterized CTA- and TAA-specific T cell responses in different HCC stages and investigated their alterations during HCC progression.

Methods: Fifty-eight HCC patients, 15 liver cirrhosis patients, 15 chronic hepatitis B patients and 10 heathy controls were enrolled in total. Read More

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September 2021

Prognostic significance of EZH2 and ARID1A expression in urothelial carcinoma: an immunohistochemical study.

J Histotechnol 2021 Sep 8:1-8. Epub 2021 Sep 8.

Urology Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.

Enhancer of zeste homolog 2 () and AT-rich interactive domain 1A () expression in urothelial carcinoma (UC) has not been well studied. is a novel tumor suppressor gene coding for a chromatin remodeling protein that is mutated in urinary bladder cancer. The enhancer of zeste homolog 2 () is a transcriptional repressor involved in gene silencing. Read More

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September 2021

Prognostic Role of Programmed Death Ligand-1 on Tumor-Infiltrating Immune Cells in "High-Risk" Patients Following Radical Cystectomy: A Retrospective Cohort Study.

Front Oncol 2021 20;11:706503. Epub 2021 Aug 20.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: The aim of this study is to investigate the prognostic role of programmed death ligand-1 (PD-L1) on tumor-infiltrating immune cells (TIICs) in patients after radical cystectomy (RC) for bladder cancer (BCa).

Materials And Methods: We retrospectively reviewed 92 "high-risk" (≥pT3a and/or pN+) patients who underwent RC for BCa, without adjuvant chemotherapy (AC), between April 2014 and December 2019. PD-L1 on TIICs was measured only using the VENTANA (SP-142) immunohistochemistry assay. Read More

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Dysfunction of apoptosis and autophagy correlates with local recurrence in esophageal squamous cell carcinoma after definitive chemoradiation.

Cancer Cell Int 2021 Sep 6;21(1):466. Epub 2021 Sep 6.

Department of Clinical Oncology, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuhan, 430060, China.

Objective: Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence is the main cause of treatment failure. The changes in apoptosis and autophagy in recurrent tumors of patients with ESCC following dCRT have been poorly estimated. Thus, this study aimed to investigate the expressions of key regulators of apoptosis and autophagy in matched paired samples of primary and recurrent ESCC. Read More

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September 2021

Role of Recurrent Laryngeal Nerve Lymph Node Dissection in Surgery of Early-Stage Esophageal Squamous Cell Carcinoma.

Ann Surg Oncol 2021 Sep 3. Epub 2021 Sep 3.

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: In esophageal cancer surgery, it is difficult to perform thorough dissection of lymph nodes along the recurrent laryngeal nerve (RLN-LN). However, there are limited data regarding the necessity of RLN-LN dissection in surgery for superficial esophageal squamous carcinoma (focused on T1b tumor) and its role in locoregional control and accurate nodal staging.

Methods: Between 2001 and 2016, 567 patients with pT1N0 and 927 patients with cT1N0 squamous cell carcinoma were identified in a prospectively maintained, single institution esophagectomy registry. Read More

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September 2021

Characterization of CD66b and its relationship between immune checkpoints and their synergistic impact in the prognosis of surgically resected lung adenocarcinoma.

Lung Cancer 2021 Aug 28;160:84-91. Epub 2021 Aug 28.

Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Electronic address:

Objectives: CD66b positive tumor-infiltrating neutrophils (TINs) are key immunity cells in the tumor microenvironment (TME). However, their relationship with clinicopathological features, immune checkpoints (ICs), and prognostic value remains undetermined in lung adenocarcinoma (LUAD). In this study, we aimed to characterize the infiltration by TINs and the prognostic significance in patients with surgically resected LUAD. Read More

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Construction of methylation-associated nomogram for predicting the recurrence-free survival risk of stage I-III lung adenocarcinoma.

Future Oncol 2021 Sep 3. Epub 2021 Sep 3.

Sanquan College of Xinxiang Medical University/Experimental Teaching Center of Biology & Basic Medicine, Xinxiang 453514, China.

The aim of our study was to investigate a methylation-associated predictor for prognosis in patients with stage I-III lung adenocarcinoma (LUAD). A DNA methylation-based signature was developed via univariate, least absolute shrinkage and selection operator and multivariate Cox regression models. We identified a 14-site methylation signature that was correlated with recurrence-free survival of stage I-III lung adenocarcinoma patients. Read More

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September 2021

Five-Fraction Prone Accelerated Partial Breast Irradiation: Long-Term Oncologic, Dosimetric, and Cosmetic Outcome.

Pract Radiat Oncol 2021 Aug 30. Epub 2021 Aug 30.

Department of Radiation Oncology, NYU Langone Health, New York, NY. Electronic address:

Purpose/objective(s): Randomized data support accelerated partial breast irradiation (APBI) for early-stage breast cancer with variable techniques and cosmesis outcomes. We have treated patients with 5-fraction prone external beam APBI for over a decade and herein report acute and late outcomes.

Materials/methods: Patients receiving APBI 600cGy x 5 between 2010-2019 were included. Read More

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Whole-body hyperthermia combined with chemotherapy and intensity-modulated radiotherapy for treatment of advanced nasopharyngeal carcinoma: a retrospective study with propensity score matching.

Int J Hyperthermia 2021 ;38(1):1304-1312

Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, PR China.

Background: Several studies have reported the combination of intracavity or cervical lymph node hyperthermia with chemoradiotherapy (CRT) to improve clinical outcomes in nasopharyngeal carcinoma (NPC), but the combination with whole-body hyperthermia (WBH) for treating NPC is unexplored. We aimed to assess the efficacy of the combination of radiotherapy, chemotherapy and WBH in patients with locoregionally advanced NPC.

Methods: Between July 2008 and November 2012, 239 newly diagnosed NPC patients were enrolled in a pre-propensity score-matched cohort, including 193 patients who received CRT (CRT group) and 46 who underwent CRT with WBH (HCRT group). Read More

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September 2021

Recurrence risk of occult micrometastases and isolated tumor cells in early stage endometrial cancer: A case control study.

Gynecol Oncol Rep 2021 Aug 14;37:100846. Epub 2021 Aug 14.

The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Objectives: To determine whether previously undetected occult micrometastasis (MM) or isolated tumor cells (ITC) is associated with increased recurrence odds in stage I-II endometrioid adenocarcinoma.

Methods: Women with recurrent stage I/II EC who had complete pelvic and para-aortic were identified as the outcome of interest. A case-control study was designed with the exposure defined as occult MM/ITC not seen on original nodal pathology. Read More

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CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes.

J Immunother Cancer 2021 Aug;9(8)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Background: Dedifferentiated liposarcoma (DDLPS) is one of the most common soft tissue sarcoma subtypes and is devastating in the advanced/metastatic stage. Despite the observation of clinical responses to inhibitors, little is known about the immune microenvironment in relation to patient prognosis.

Methods: We performed a retrospective study of 61 patients with DDLPS. Read More

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Endometrial Cancer Characteristics and Risk of Recurrence.

Am J Clin Pathol 2021 Aug 31. Epub 2021 Aug 31.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Virginia Tech Carilion, Roanoke, VA,USA.

Objectives: To describe clinicopathologic characteristics and survival outcomes of endometrial adenocarcinomas stratified by mismatch repair (MMR) status.

Methods: Single-institution, retrospective study of all women with endometrioid adenocarcinomas treated from January 2012 through December 2017. Patients were categorized into one of three groups based on MMR testing: intact MMR expression (MMR+), probable MMR mutation (MMR-), or MLH1 hypermethylation (hMLH1+). Read More

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Partial breast irradiation versus whole breast radiotherapy for early breast cancer.

Cochrane Database Syst Rev 2021 08 30;8:CD007077. Epub 2021 Aug 30.

School of Medicine, The University of Queensland, Brisbane, Australia.

Background: Breast-conserving therapy for women with breast cancer consists of local excision of the tumour (achieving clear margins) followed by radiotherapy (RT). Most true recurrences occur in the same quadrant as the original tumour. Whole breast radiotherapy (WBRT) may not protect against the development of a new primary cancer developing in other quadrants of the breast. Read More

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Stromal Neutrophil Extracellular Trap Density Is an Independent Prognostic Factor for Cervical Cancer Recurrence.

Front Oncol 2021 11;11:659445. Epub 2021 Aug 11.

Department of Gynecologic Oncology, Maternal and Child Health Hospital of Hubei Province, Huazhong University of Science and Technology, Wuhan, China.

Background: Emerging evidence indicates that the tumor microenvironment influences tumor progression and patient prognosis through various inflammatory cells. Polymorphonuclear neutrophils (PMNs) and their functional structures termed neutrophil extracellular traps (NETs) are prominent constituents of several malignant tumors and affect the tumor microenvironment and cancer evolution. Here, we investigate the prognostic value of PMNs and NETs for recurrence in patients with cervical cancer. Read More

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Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival.

J Immunother Cancer 2021 Aug;9(8)

Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA

Background: Several therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding of their benefit‒risk profiles in order to make informed treatment decisions. Herein we characterize adjuvant nivolumab select (immune-related) treatment-related adverse events (TRAEs) and evaluate possible associations between safety and recurrence-free survival (RFS) in the phase III CheckMate 238 trial.

Methods: Patients with resected stage IIIB-C or IV melanoma received nivolumab 3 mg/kg every 2 weeks (n=452) or ipilimumab 10 mg/kg every 3 weeks for four doses and then every 12 weeks (n=453) for up to 1 year or until disease recurrence, unacceptable toxicity, or consent withdrawal. Read More

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The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement.

Pharmaceuticals (Basel) 2021 Aug 8;14(8). Epub 2021 Aug 8.

Department of Urology, Soonchunhyang University School of Medicine, Seoul 04404, Korea.

Background: The mTOR signaling pathway is inactivated by AMPK's tumor-suppressing function. It is recognized that ubiquitin conjugating enzyme 2O (UBE2O), which directly targets AMPK for ubiquitination and degradation, is intensified in human cancers.

Methods: This study investigated the clinical data about prostate cancer. Read More

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Current Landscape and Open Questions on Adjuvant Therapies in Melanoma.

Dermatol Pract Concept 2021 Jul 1;11(Suppl 1):e2021165S. Epub 2021 Jul 1.

Medical Oncology, Department of Precision Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Italy.

Melanoma is a form of skin cancer that is frequently diagnosed at early stages. In most cases, surgical resection is curative. In case of thicker melanomas (> pT1b) without clinical or instrumental evidence of metastasis, a sentinel lymph node biopsy is recommended for staging purposes. Read More

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The Prognostic Value of FGFR3 Expression in Patients with T1 Non-Muscle Invasive Bladder Cancer.

Cancer Manag Res 2021 20;13:6567-6578. Epub 2021 Aug 20.

Department of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Purpose: Fibroblast growth factor receptor 3 (FGFR3) alterations are frequent in non-muscle-invasive bladder cancer (NMIBC), although current data regarding the prognostic and therapeutic relevance are inconsistent. We analyzed the prognostic role of FGFR3 mRNA expression in stage T1 NMIBC.

Patients And Methods: The mRNA expression of FGFR3 and cyclin-dependent kinase inhibitor 2A (CDKN2A) was measured by RT-qPCR in 80 patients with stage T1 NMIBC treated with transurethral resection of the bladder and correlated with clinical data and KRT5 and KRT20 expression, used as surrogate markers for basal and luminal subtypes, respectively. Read More

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