22,938 results match your criteria stage ovarian

Intratumoural Budding is Associated with Poor Clinical Outcome in Early-Stage Clear Cell Carcinoma of Ovary.

Histopathology 2021 Jul 22. Epub 2021 Jul 22.

Department of Pathology, NYU Langone Health.

Aims: Clear cell carcinoma of ovary (CCC) is considered a high-grade malignancy by default and the role of histological grading for assessing clinical outcome is not established. We aimed to evaluate histopathological features associated with clinical outcome in CCC patients. Seventy-six cases of CCC with available clinical follow-up information were studied. Read More

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PAX8 lineage-driven T cell engaging antibody for the treatment of high-grade serous ovarian cancer.

Sci Rep 2021 Jul 21;11(1):14841. Epub 2021 Jul 21.

NIBR Biologics Center, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

High-grade serous ovarian cancers (HGSOC) represent the most common subtype of ovarian malignancies. Due to the frequency of late-stage diagnosis and high rates of recurrence following standard of care treatments, novel therapies are needed to promote durable responses. We investigated the anti-tumor activity of CD3 T cell engaging bispecific antibodies (TCBs) directed against the PAX8 lineage-driven HGSOC tumor antigen LYPD1 and demonstrated that anti-LYPD1 TCBs induce T cell activation and promote in vivo tumor growth inhibition in LYPD1-expressing HGSOC. Read More

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Effects of Sex and Estrous Cycle on the Time-Course of Incubation of Cue-Induced Craving Following Extended-Access Cocaine Self-Administration.

eNeuro 2021 Jul 21. Epub 2021 Jul 21.

Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, NJ

Cocaine addiction is a devastating public health epidemic that continues to grow. Studies focused on identifying biological factors influencing cocaine craving and relapse vulnerability are necessary in order to promote abstinence in recovering drug users. Sex and ovarian hormones are known to influence cocaine addiction liability and relapse vulnerability in both humans and rodents. Read More

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The Plasticity of Circulating Tumor Cells in Ovarian Cancer During Platinum-containing Chemotherapy.

Curr Cancer Drug Targets 2021 Jul 20. Epub 2021 Jul 20.

Department of Human Physiology and Pathophysiology, Faculty of Medicine, Ulyanovsk State University, Ulyanovsk, Russian Federation.

Background: Circulating tumor cells (CTCs) are a potential source of metastases and relapses. The data on the ovarian cancer (OC) CTCs molecular characteristics are limited.

Objective: To assess the TGFβ, CXCL2, VEGFA and ERCC1 expression in two OC CTC subpopulations before and during chemotherapy (CT), and its relation to clinical characteristics. Read More

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LncRNA PVT1 promotes the progression of ovarian cancer by activating TGF-β pathway via miR-148a-3p/AGO1 axis.

J Cell Mol Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Obstetrics and Gynaecology, Changzheng Hospital, Naval Medical University, Shanghai, China.

Ovarian cancer is a lethal gynaecologic malignancy with poor diagnosis and prognosis. The long non-coding RNA plasmacytoma variant translocation1 (PVT1) and argonaute 1 (AGO1) are associated with carcinogenesis and chemoresistance; however, the relationship between PVT1 and AGO1 and the downstream mechanisms in ovarian cancer remains poorly known. PVT1 and AGO1 expression was assessed through RT-qPCR and Western blotting in both human tissues and cell lines. Read More

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The effect of fertility-sparing surgery on sexuality and global quality of life in women with malignant ovarian germ cell and sex cord stromal tumors: an analysis of the CORSETT database of the AGO study group.

Arch Gynecol Obstet 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, University Medical Center Freiburg, Freiburg, Germany.

Purpose: Malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) are ovarian neoplasms that affect disproportionally young women. Little is known about the impact of surgical and adjuvant management of these patient's sexual life. This study investigated the effect of fertility-sparing surgery on sexual activity and global quality of life (gQoL) in women with MOGCT and SCST. Read More

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Impact of Androgens on Sexual Function in Women With Rectal Cancer - A Prospective Cohort Study.

J Sex Med 2021 Jul 18. Epub 2021 Jul 18.

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; Department of Surgery, Ersta Hospital, Stockholm, Sweden.

Background: Women treated for rectal cancer are at risk of sexual dysfunction and impaired ovarian androgen production.

Aim: To investigate a possible association between serum levels of endogenous androgens and sexual function in women with rectal cancer.

Methods: Women diagnosed with stage I-III rectal cancer were consecutively included and prospectively followed with the Female Sexual Function Index (FSFI) questionnaire from baseline to 2 years postoperatively and blood samples for hormone analyses, baseline to 1 year. Read More

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Acute renal disease in patients with ovarian peritoneal carcinomatosis treated with cytoreduction and HIPEC: the influence of surgery and the cytostatic agent used.

Langenbecks Arch Surg 2021 Jul 20. Epub 2021 Jul 20.

Peritoneal Carcinomatosis Unit, Department of Surgery, Hospital Universitario Virgen De La Arrixaca, Carretera del Palmar S/N, El Palmar, 30123, Murcia, Spain.

Background: The main objective of this study was to evaluate the differences between cisplatin and paclitaxel in the development of postoperative renal toxicity, using as a reference the RIFLE (Risk, Injury, Insufficiency, Loss, and End-stage renal function) and AKIN (Acute Kidney Injury Network) criteria in patients with primary or recurrent ovarian cancer with peritoneal dissemination treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods: One hundred fifty-two patients who were treated between December 2007 and June 2017 were analyzed.

Results: Patients who received previous platinum-based chemotherapy had higher baseline creatinine levels than those who had not (p = 0. Read More

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Comprehensive Profiling of Hypoxia-Related miRNAs Identifies miR-23a-3p Overexpression as a Marker of Platinum Resistance and Poor Prognosis in High-Grade Serous Ovarian Cancer.

Cancers (Basel) 2021 Jul 4;13(13). Epub 2021 Jul 4.

Angelo Nocivelli' Institute of Molecular Medicine, ASST Spedali Civili di Brescia, University of Brescia, 25121 Brescia, Italy.

The onset of chemo-resistant recurrence represents the principal cause of high-grade serous ovarian carcinoma (HGSOC) death. HGSOC masses are characterized by a hypoxic microenvironment, which contributes to the development of this chemo-resistant phenotype. Hypoxia regulated-miRNAs (HRMs) represent a molecular response of cancer cells to hypoxia and are involved in tumor progression. Read More

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Identification of a Novel Tumor Microenvironment Prognostic Signature for Advanced-Stage Serous Ovarian Cancer.

Cancers (Basel) 2021 Jul 3;13(13). Epub 2021 Jul 3.

Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistrasse 15, 81377 Munich, Germany.

(1) Background: The tumor microenvironment is involved in the growth and proliferation of malignant tumors and in the process of resistance towards systemic and targeted therapies. A correlation between the gene expression profile of the tumor microenvironment and the prognosis of ovarian cancer patients is already known. (2) Methods: Based on data from The Cancer Genome Atlas (379 RNA sequencing samples), we constructed a prognostic 11-gene signature (, , , , , , , , , and ) for Fédération Internationale de Gynécologie et d'Obstétrique stage III and IV serous ovarian cancer through lasso regression. Read More

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Changes in Stem Cell Regulation and Epithelial Organisation during Carcinogenesis and Disease Progression in Gynaecological Malignancies.

Cancers (Basel) 2021 Jul 3;13(13). Epub 2021 Jul 3.

Department of Obstetrics and Gynaecology, University Hospital, LMU Munich, Marchioninistr 15, 81377 Munich, Germany.

Gynaecological malignancies represent a heterogeneous group of neoplasms with vastly different aetiology, risk factors, molecular drivers, and disease outcomes. From HPV-driven cervical cancer where early screening and molecular diagnostics efficiently reduced the number of advanced-stage diagnosis, prevalent and relatively well-treated endometrial cancers, to highly aggressive and mostly lethal high-grade serous ovarian cancer, malignancies of the female genital tract have unique presentations and distinct cell biology features. Recent discoveries of stem cell regulatory mechanisms, development of organoid cultures, and NGS analysis have provided valuable insights into the basic biology of these cancers that could help advance new-targeted therapeutic approaches. Read More

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A Novel HCC Prognosis Predictor EEF1E1 Is Related to Immune Infiltration and May Be Involved in EEF1E1/ATM/p53 Signaling.

Front Oncol 2021 2;11:700972. Epub 2021 Jul 2.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: EEF1E1 has been reported to play a role in ovarian cancer, breast cancer, non-small cell lung cancer and other cancers, but its role and mechanism in hepatocellular carcinoma (HCC) are still unknown.

Methods: EEF1E1 expression in human HCC was analyzed the GTEx and TCGA database. Logistic regression analysis was used to analyze the clinicopathological correlation of EEF1E1 expression. Read More

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Updated reference values in pelvic ultrasonography for a Spanish population of healthy girls between 6 and 12 years old.

Endocrinol Diabetes Metab 2021 Jul 4;4(3):e00233. Epub 2021 Feb 4.

Pediatric Endocrine Department Parc Tauli Sabadell Hospital Universitari Sabadell Spain.

Background: Pelvic ultrasonography (PUS) of the uterus and ovaries allows the diagnosis of changes in sexual development. However, the reference values used in Spain originate from old studies conducted in other countries.

Objective: To determine reference uterine and ovarian measurements by PUS and according to pubertal status and bone age in a Spanish population of healthy girls aged between 6 and 12 years. Read More

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NTNG1 Modulates Cisplatin Resistance in Epithelial Ovarian Cancer Cells via the GAS6/AXL/Akt Pathway.

Front Cell Dev Biol 2021 1;9:652325. Epub 2021 Jul 1.

Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Cisplatin resistance is a challenge in the treatment of epithelial ovarian cancer. Here, clinical data showed that the level of netrin-G1 (NTNG1) in cisplatin-resistant cancer was higher than that in cisplatin-sensitive cancer (2.2-fold, = 0. Read More

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Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors.

Front Oncol 2021 1;11:694441. Epub 2021 Jul 1.

Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Aim: To retrospectively investigate the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section (IFS) of ovarian tumors.

Patients And Methods: Women with ovarian tumors that underwent IFS in one tertiary medical center were recruited from January 2010 to December 2018. Demographic and clinical data of these women were retrieved from medical records in the hospital's centralized database. Read More

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Expression of 20-hydroxyecdysone-related genes during gonadal development of Teleogryllus emma (Orthoptera: Gryllidae).

Arch Insect Biochem Physiol 2021 Jul 17:e21824. Epub 2021 Jul 17.

Laboratory of Animal Reproduction and Development, College of Life Science, Shaanxi Normal University, Xi'an, China.

Insect gonads develop under endocrine signals. In this study, we assessed the characters of partial complementary DNAs encoding the Teleogryllus emma orthologs of 20-hydroxyecdysone (20E)-related genes (RXR, E75, HR3, Hsc70, and Hsp90) and analyzed their expression patterns in both nymph and adult crickets. 20E treatment suppressed expression of TeEcR, TeRXR, TeE75, TeHR3, TeHsc70, and TeHsp90. Read More

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Inhibition of c-Myc using 10058-F4 induces anti-tumor effects in ovarian cancer cells via regulation of FOXO target genes.

Eur J Pharmacol 2021 Jul 13;908:174345. Epub 2021 Jul 13.

Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Ovarian cancer, characterized by rapid growth and asymptomatic development in the early stage, is the fifth common cancer in women. The deregulated expression of c-Myc in more than 50% of human tumors including ovarian cancer makes this oncogenic master transcription factor a potential therapeutic target for cancer treatment. In the present study, we evaluated the anti-tumor effects of 10058-F4, a small molecule c-Myc inhibitor, on ovarian cancer cells. Read More

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Clinical outcomes of patients with endometrioid epithelial ovarian cancer following surgical treatment.

J Surg Oncol 2021 Jul 16. Epub 2021 Jul 16.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background: Endometrioid epithelial ovarian cancer (EEOC) is rare, and its management poorly defined. We examined factors associated with 5-year progression-free survival (PFS) after surgery for EEOC.

Methods: Retrospective study: treatment and outcomes of all EEOC patients undergoing initial surgery at, or presenting to, our institution within 3 months of initial surgery, 1/2002-9/2017. Read More

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Clinical significance of miR-139-5p and FGF2 in ovarian cancer.

J BUON 2021 May-Jun;26(3):663-669

Department of Obstetrics, Gaomi People's Hospital, Gaomi, China.

Purpose: To estimate the expression and clinical significance of miR-139-5p and fibroblast growth factor 2 (FGF2) in ovarian cancer (OC).

Methods: Of the 198 female patients undergoing surgical treatment in our hospital, 101 patients with ovarian tumor resection were allocated in a study group and 97 with ovarian resection for benign lesions were allocated in a control group. MiR-139-5p and FGF2 expression was quantified, and associations between miR-139-5p and FGF2 and clinicopathological features of OC were analyzed, as well as their diagnostic performances (receiver operating characteristic (ROC) curve). Read More

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Tubo-Ovarian High-Grade Serous Carcinomas Commonly Express CA19.9.

Histopathology 2021 Jul 16. Epub 2021 Jul 16.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom.

Tubo-ovarian high-grade serous carcinoma (HGSC) is one of the leading causes of cancer death in women worldwide and frequently presents at advanced stage (1). Many cases are unresectable at diagnosis due to extensive disease affecting multiple sites and in such cases when a disseminated tubo-ovarian HGSC is suspected, a percutaneous core biopsy is often undertaken prior to neoadjuvant chemotherapy being administered (2). Read More

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Management of ovarian immature teratoma grade-II in pregnancy, two cases report and literature review.

Clin Case Rep 2021 Jul 10;9(7):e04456. Epub 2021 Jul 10.

Cancer Research Center Mashhad University of Medical Sciences Mashhad Iran.

Postoperative chemotherapy during pregnancy after first trimester is essential for patients with initial disease stage 1, grade 2 ovarian immature teratoma and it associates with lower disease progression and recurrence. Read More

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Transcriptome-based stemness indices analysis reveals platinum-based chemo-theraputic response indicators in advanced-stage serous ovarian cancer.

Bioengineered 2021 Dec;12(1):3753-3771

Department of Gynecology and Obstetrics, Southwest Hospital, Army Medical University, Chongqing, China.

Serous ovarian cancer (SOC) is a main histological subtype of ovarian cancer, in which cancer stem cells (CSC) are responsible for its chemoresistance. However, the underlying modulation mechanisms of chemoresistance led by cancer stemness are still undefined. We aimed to investigate potential drug-response indicators among stemness-associated biomarkers in advanced SOC samples. Read More

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December 2021

A way to reduce the occurrence of intraoperative capsule rupture in presumed clinically early-stage ovarian cancer with adhesions to abdominal wall.

J Minim Invasive Gynecol 2021 Jul 12. Epub 2021 Jul 12.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China. Electronic address:

Objective: To present a procedure to reduce the occurrence of intraoperative capsule rupture in presumed clinically early-stage ovarian cancer with adhesions to abdominal wall.

Design: Stepwise presentation of the procedure with narrated video footage SETTING: : The occurrence of intraoperative capsule rupture exerts a negative effect on the prognosis of early-stage ovarian cancer [1, 2]. Thus, to reduce intraoperative capsule rupture is important to improve the oncologic outcome of such patients. Read More

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Upfront cytoreductive surgery versus neoadjuvant chemotherapy in advanced epithelial ovarian cancer in Indian patients.

Future Oncol 2021 Jul 15. Epub 2021 Jul 15.

Department of Surgical Oncology, DR BRA-IRCH, All India Institute of Medical Sciences, New Delhi, 110029, India.

In cases of ovarian carcinoma, primary cytoreductive surgery (CRS) is the standard treatment up to stage IIIB, but patient selection for neoadjuvant chemotherapy (NACT) in selected cases is controversial. A total of 200 patients with advanced ovarian cancer were analyzed retrospectively, according to specific selection criteria. Primary CRS was performed in 95 patients (47. Read More

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Impact of the Time Interval Between Primary Debulking Surgery and Start of Adjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer.

Cancer Manag Res 2021 6;13:5413-5422. Epub 2021 Jul 6.

Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Aim: To investigate whether the time interval between primary debulking surgery (PDS) and initiating adjuvant chemotherapy affects survival in patients with epithelial ovarian cancer (EOC).

Methods: We retrospectively reviewed FIGO stage IIB to IV EOC patients who received PDS followed by adjuvant chemotherapy in our hospital between January 2008 and December 2016. The optimal cut-off time interval to chemotherapy related to survival was determined using the Contal and O'Quigley method and Cox hazard models. Read More

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Disparities in ovarian cancer treatment and overall survival according to race: An update.

Gynecol Oncol 2021 Jul 12. Epub 2021 Jul 12.

Division of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA. Electronic address:

Objective: To determine whether guideline non-adherence is associated with Black race.

Methods: A retrospective review of National Cancer Database records of women diagnosed with epithelial ovarian cancer from 2012 to 2016 who identified as "White" or "Black" was performed. Exposure was adherence or non-adherence to National Comprehensive Cancer Network guidelines for treatment. Read More

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Laser-assisted hatching in lower grade cleavage stage embryos improves blastocyst formation: results from a retrospective study.

J Ovarian Res 2021 Jul 15;14(1):94. Epub 2021 Jul 15.

Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000, Hangzhou, P.R. China.

Background: Laser-assisted hatching (LAH) has been widely applied to facilitate blastocyst hatching in IVF-ET treatment, however, the effect of LAH on subsequent development and clinical outcomes of the lower grade cleavage stage embryos (LGCE) remains unknown. Our study aimed at evaluating the effect of LAH on blastocyst formation and the clinical pregnancy outcomes of LGCE embryos after transfer.

Methods: A total of 608 cycles of IVF/ICSI treatment from November 2017 to September 2019 were included in our study as follows: 296 in the LAH group and 312 in the N-LAH group. Read More

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Clinicopathological features of different subtypes in adenomyosis: Focus on early lesions.

PLoS One 2021 14;16(7):e0254147. Epub 2021 Jul 14.

Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan.

Background: The aim of this study is to investigate the clinicopathological features of intrinsic and extrinsic subtypes in adenomyosis. In particular, we focused on the early lesions of adenomyosis.

Methods: This is a single-center, prospective study of women who elected surgery for adenomyosis at the Department of Gynecology, Nara Medical University Hospital, Kashihara, Japan, from April 2008 to March 2018. Read More

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N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages.

EMBO Rep 2021 Jul 14:e51981. Epub 2021 Jul 14.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.

Glutaminolysis is known to correlate with ovarian cancer aggressiveness and invasion. However, how this affects the tumor microenvironment is elusive. Here, we show that ovarian cancer cells become addicted to extracellular glutamine when silenced for glutamine synthetase (GS), similar to naturally occurring GS-low, glutaminolysis-high ovarian cancer cells. Read More

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Severe male factor in fertilization: definition, prevalence, and treatment. An update.

Asian J Androl 2021 Jul 6. Epub 2021 Jul 6.

Clinica Valle Giulia, GeneraLife IVF Centers, Via G. De Notaris, Rome 2B 00197, Italy.

Infertility affects 10%-15% of couples worldwide. Of all infertility cases, 20%-70% are due to male factors. In the past, men with severe male factor (SMF) were considered sterile. Read More

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