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Total uterine prolapse complicated with vesicovaginal fistula: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26386

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation.

Rationale: Vesicovaginal fistula (VVF) most commonly occurs due to iatrogenic injury during surgery or obstructed labor. We report a rare case of a patient with severe pelvic organ prolapse who developed VVF even though pessary had not been used.

Patient Concerns: A 63-year-old postmenopausal woman, para 3 (all spontaneous vaginal deliveries), complained of vaginal bulging sensation and involuntary urinary leakage for 3 years. Read More

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The use of cisplatin in patients after kidney transplantation with chronic renal insufficiency: Is the benefit higher than potential risks in therapy of non-seminomatous germ cell tumors?

Medicine (Baltimore) 2021 Jun;100(24):e26381

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute.

Rationale: The use of cisplatin in patients with chronic kidney disease (CKD) is risky and depends on a number of factors. The optimal procedure in stage I of a non seminomatous germ cell tumor without proven lymphangioinvasion after orchiectomy is controversial and is the subject of a number of discussions due to the lack of randomized studies assessing individual treatment options. The adjuvant method of choice is surveillance or application of cisplatin-based chemotherapy with the risk of treatment related nephrotoxicity. Read More

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Treatment of end-stage lymphedema following radiotherapy for lymphoma: A case report.

Medicine (Baltimore) 2021 May;100(19):e25871

Department of Plastic Surgery, Korea University College of Medicine, Seoul, South Korea.

Rationale: : Despite significant advances in microsurgical techniques, simultaneous vascularized lymph node transfer (VLNT) and lymphovenous anastomosis (LVA) surgeries may be effective for treatment of end-stage lymphedema. This case report describes the successful treatment of end-stage lymphedema with VLNT and LVA.

Patient Concerns: A 72-year-old patient with bilateral lower extremity lymphedema was referred to our lymphedema clinic. Read More

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An intracapsular nephrectomy for the acquired cystic disease-associated renal cell carcinoma in renal transplant allograft: A clinical case report.

Medicine (Baltimore) 2021 May;100(19):e25858

Department of Urology.

Rationale: Acquired cystic disease-associated renal cell carcinoma (ACKD-RCC) is a unique subtype of renal cell carcinoma (RCC) and is found exclusively in patients with end-stage renal disease. We report a case of intracapsular nephrectomy (ICAN) of renal allograft with ACKD-RCC. To our knowledge, this is the first case in Asia of ICAN of renal allograft to treat ACKD-RCC. Read More

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Central auditory maturation and behavioral outcomes after cochlear implantation in prelingual auditory neuropathy spectrum disorder related to OTOF variants (DFNB9): Lessons from pilot study.

PLoS One 2021 7;16(6):e0252717. Epub 2021 Jun 7.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

The cortical auditory evoked potential (CAEP)-based P1 component acts as a biomarker for cochlear implantation (CI) outcomes in children with auditory neuropathy spectrum disorder (ANSD). To date, early intervention primarily before the age of two years and six months of CI usage is necessary and sufficient to achieve age-appropriate cortical maturation and good prognosis. However, varying degrees of neural dyssynchrony, resulting from the etiological heterogeneity of ANSD, may preclude uniform application of this hypothesis to ensure auditory cortical maturation. Read More

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COVID-19 and liver transplantation: Lessons from the first year of the pandemic.

Liver Transpl 2021 Jun 5. Epub 2021 Jun 5.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, USA.

Over the last year, novel coronavirus-19 (COVID-19) has continued to spread across the globe, causing significant morbidity and mortality among transplant candidates and recipients. Patients with end stage liver disease awaiting liver transplantation and patients with a history of liver transplantation represent vulnerable populations, especially given high rates of associated medical comorbidities in these groups and their immunosuppressed status. In addition, concerns surrounding COVID-19 risk in this patient population has affected rates of transplantation and general transplantation practices. Read More

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Open total dislocation of ankle joint without fractures: A case report.

Medicine (Baltimore) 2021 Jun;100(22):e26247

Department of Orthopedics, Affiliated Hospital of Jining Medical University, Jining City, Shandong Province, China.

Rationale: Open total dislocation of ankle joint is rare and often caused by high-energy injury. The present study describes a patient with open total lateral dislocation of ankle joint without fractures and obtained a satisfactory clinical result following early debridement and irrigation, one-stage repairment of ligaments, and plaster external fixation.

Patient Concerns: The patient, a 45-year-old male, complained of right foot pain with bleeding and limited motion. Read More

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Delayed transient obstructive hydrocephalus after cerebral aneurysm rupture: A case report.

Medicine (Baltimore) 2021 Jun;100(22):e26228

Department of Neurosurgery, Chengdu Second People's Hospital.

Rationale: Obstructive hydrocephalus (OH) frequently occurs in patients with a ruptured cerebral aneurysm (CA), and it may lead to severe neurological deficits, including life-threatening brain herniation. OH generally occurs in the early stage of CA rupture, rather than in the late stage, and rarely resolves without therapy.

Patient Concerns: A 64-year-old woman with a ruptured anterior communicating artery aneurysm was treated with coil embolization. Read More

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Successful treatment of acute promyelocytic leukemia in a 92-year-old man using all-trans retinoic acid combined with oral arsenic: A case report.

Medicine (Baltimore) 2021 Jun;100(22):e26144

Department of Hematology, Yinzhou People's Hospital, Ningbo, Zhejiang, P.R. China.

Rationale: Acute promyelocytic leukemia is a special subtype of acute myeloid leukemia. The incidence of early death and complications is high. An oral regimen of all-trans retinoic acid combined with the realgar-indigo naturalis formula (RIF) without chemotherapy has provided a new strategy for the treatment of these patients. Read More

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Solitary vulvar metastasis from early-stage endometrial cancer: Case report and literature review.

Medicine (Baltimore) 2021 Jun;100(22):e25863

Unit of Surgical Gynecol Oncology.

Rationale: Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. It is usually diagnosed at early-stage and presents a favorable prognosis. Conversely, advanced or recurrent disease shows poor outcome. Read More

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Tackling COVID-19 with neutralizing monoclonal antibodies.

Cell 2021 06 26;184(12):3086-3108. Epub 2021 May 26.

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Monoclonal antibodies (mAbs) have revolutionized the treatment of several human diseases, including cancer and autoimmunity and inflammatory conditions, and represent a new frontier for the treatment of infectious diseases. In the last 20 years, innovative methods have allowed the rapid isolation of mAbs from convalescent subjects, humanized mice, or libraries assembled in vitro and have proven that mAbs can be effective countermeasures against emerging pathogens. During the past year, an unprecedentedly large number of mAbs have been developed to fight coronavirus disease 2019 (COVID-19). Read More

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Fifty years of a public cassava breeding program: evolution of breeding objectives, methods, and decision-making processes.

Theor Appl Genet 2021 Jun 4. Epub 2021 Jun 4.

International Center for Tropical Agriculture (CIAT), Cali, USA.

This paper reviews and analyzes key features from cassava breeding at the International Center for Tropical Agriculture (CIAT) over 50 years and draws lessons for public breeding efforts broadly. The breeding team, jointly with national program partners and the private processing sector, defined breeding objectives and guiding business plans. These have evolved through the decades and currently focus on four global product profiles. Read More

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Multidisciplinary Care of BRAF-Mutant Stage III Melanoma: A Physicians Perspective Review.

Oncologist 2021 Jun 3. Epub 2021 Jun 3.

Departments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Prognosis among patients with stage III melanoma can vary widely depending on the risk of disease relapse. Therefore, it is vital to optimize patient care through accurate diagnosis and staging as well as thoughtful treatment planning. A multidisciplinary team (MDT) approach, which involves active collaboration among physician specialists across a patient's disease journey, has been increasingly adopted as the standard of care for treatment of a variety of cancers, including melanoma. Read More

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Lessons on integrated knowledge translation through algorithm's utilization in homecare services: a multiple case study.

JBI Evid Implement 2021 Jun 1. Epub 2021 Jun 1.

Health Sciences Research Programs, Faculty of Medicine and Health Sciences, Université de Sherbrooke Research Centre on Aging, Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CHUS) School of Rehabilitation, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke School of Physical and Occupational Therapy, Faculty of Medicine, McGill University Centre for Medical Education, Faculty of Medicine, McGill University - Lady Meredith House, Montréal, Québec, Canada.

Aim: Integrated knowledge translation (IKT) is an increasingly recommended collaborative approach to minimize knowledge translation gap. Still, few studies have documented the impact of IKT to optimize knowledge uptake in healthcare settings. An IKT-based clinical algorithm (Algo) was deployed in Quebec (Canada) homecare services to support skill mix for selecting bathing equipment for community-dwelling adults. Read More

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Remdesivir for Early COVID-19 Treatment of High-Risk Individuals Prior to or at Early Disease Onset-Lessons Learned.

Viruses 2021 05 22;13(6). Epub 2021 May 22.

Technical University of Munich, School of Medicine, University Hospital Rechts der Isar, Department of Internal Medicine II, 81675 Munich, Germany.

After more than one year of the COVID-19 pandemic, antiviral treatment options against SARS-CoV-2 are still severely limited. High hopes that had initially been placed on antiviral drugs like remdesivir have so far not been fulfilled. While individual case reports provide striking evidence for the clinical efficacy of remdesivir in the right clinical settings, major trials failed to demonstrate this. Read More

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Targeted eHealth Intervention to Reduce Breast Cancer Survivors' Fear of Recurrence: Results from the FoRtitude Randomized Trial.

J Natl Cancer Inst 2021 May 31. Epub 2021 May 31.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.

Background: Fear of recurrence (FoR) is a prevalent concern among breast cancer survivors (BCS) yet few accessible interventions exist. This study evaluated a targeted eHealth intervention, "FoRtitude," to reduce FoR using cognitive behavioral skills training and telecoaching.

Methods: BCS (N = 196) were recruited from an academic medical center and 3 National Cancer Institute Community Oncology Research Program community sites, had stage 0-III breast cancer, were 1-10 years post-primary treatment, with moderate to high FoR and familiarity with the internet. Read More

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Revisiting early-stage COVID-19 strategy options.

Philip Machanick

F1000Res 2020;9:327. Epub 2020 May 4.

Computer Science, Rhodes University, Makhanda, Eastern Cape, 6140, South Africa.

: Early-stage interventions in a potential pandemic are important to understand as they can make the difference between runaway exponential growth that is hard to turn back and stopping the spread before it gets that far. COVID19 is an interesting case study because there have been very different outcomes in different localities. These variations are best studied after the fact if precision is the goal; while a pandemic is still unfolding less precise analysis is of value in attempting to guide localities to learn lessons of those that preceded them. Read More

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Successful management of the hepatocellular carcinoma with inferior vena cava tumor thrombus: A case report.

Medicine (Baltimore) 2021 May;100(21):e26081

Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy.

Rationale: Hepatocellular carcinoma (HCC) with inferior vena cava tumor thrombus (IVCTT) is traditionally considered an advanced-stage cancer with a poor prognosis. There is no standard treatment for patients diagnosed as HCC with IVCTT.

Patient Concerns: A 52-year-old man was admitted to our hospital because of suspected hepatic mass during a health examination. Read More

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Early critical cortical infarction by anti-angiotensin II type 1 receptor antibody: A case report and literature review.

Medicine (Baltimore) 2021 May;100(21):e25958

Department of Internal Medicine.

Rationale: Anti-angiotensin II type 1 receptor antibodies (AT1R-Abs) have been demonstrated to increase the risk of antibody-mediated rejection. We report a case of AT1R-Ab mediated rejection which caused early critical cortical infarction.

Patient Concerns: A 52-year-old man with end-stage kidney disease underwent preemptive kidney transplantation (KT) from his wife. Read More

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Rosuvastatin and Colchicine combined myotoxicity: lessons to be learnt.

CEN Case Rep 2021 May 24. Epub 2021 May 24.

Department of Nephrology, General Hospital of Livadeia, Livadeia, Greece.

Statins and colchicine co-administration consists of a potentially catastrophic drug-drug interaction since it provokes myotoxicity, myopathy and various degrees of rhabdomyolysis. Lipophilic statins and colchicine are biotransformed in the liver, primarily via CYP3A4 enzyme system leading to elevated blood levels of both agents and resulting in increased potential for combined myotoxicity. Hence, it would be of great clinical importance not only the awareness of this devastating complication but also the more advantageous type of statin that we should choose to achieve the recommended therapeutic goals regarding LDL levels with minimal myopathy risk. Read More

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MRI and CT bladder segmentation from classical to deep learning based approaches: Current limitations and lessons.

Comput Biol Med 2021 May 18;134:104472. Epub 2021 May 18.

ETS Montreal, QC, Canada. Electronic address:

Precise determination and assessment of bladder cancer (BC) extent of muscle invasion involvement guides proper risk stratification and personalized therapy selection. In this context, segmentation of both bladder walls and cancer are of pivotal importance, as it provides invaluable information to stage the primary tumor. Hence, multiregion segmentation on patients presenting with symptoms of bladder tumors using deep learning heralds a new level of staging accuracy and prediction of the biologic behavior of the tumor. Read More

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Management of prolonged first stage of labour in a low-resource setting: lessons learnt from rural Malawi.

BMC Pregnancy Childbirth 2021 May 22;21(1):398. Epub 2021 May 22.

Athena Institute, Faculty of Science, VU University Amsterdam, Amsterdam, The Netherlands.

Background: Caesarean sections without medical indication cause substantial maternal and perinatal ill-health, particularly in low-income countries where surgery is often less safe. In presence of adequate labour monitoring and by appropriate use of evidence-based interventions for prolonged first stage of labour, unnecessary caesarean sections can be avoided. We aim to describe the incidence of prolonged first stage of labour and the use of amniotomy and augmentation with oxytocin in a low-resource setting in Malawi. Read More

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Surgical treatment of carpal tunnel syndrome in advanced-stage upper extremity lymphedema: A case report.

Medicine (Baltimore) 2021 May;100(20):e25872

Department of Plastic Surgery, Korea University College of Medicine, Seoul, South Korea.

Rationale: Despite significant advances in microsurgical techniques, simultaneous release of transverse carpal ligament (TCL) and lymphovenous anastomosis (LVA) surgeries may be effective for treatment of carpal tunnel syndrome (CTS) and advanced-stage lymphedema. This case report describes the successful treatment of lymphedema with LVA in a patient with CTS and advanced-stage lymphedema.

Patient Concerns: A 60-year-old female patient was referred to our lymphedema clinic with a 12-year history of chronic, acquired, right upper extremity lymphedema and CTS following right mastectomy and axillary lymph node dissection and adjuvant chemoradiotherapy for treating breast cancer. Read More

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Recommendations for Assessment of Environmental Exposures in Longitudinal Life Course Studies Such as the National Children's Study.

Front Pediatr 2021 29;9:629487. Epub 2021 Apr 29.

Icahn School of Medicine at Mount Sinai School, New York, NY, United States.

An important step toward understanding the relationship between the environment and child health and development is the comprehensive cataloging of external environmental factors that may modify health and development over the life course. Our understanding of the environmental influences on health is growing increasingly complex. Significant key questions exist as to what genes, environment, and life stage mean to defining normal variations and altered developmental trajectories throughout the life course and also across generations. Read More

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Pericardiocentesis Simulation Model: Low Cost, Easy to Assemble, Effective Task Trainer.

Cureus 2021 Apr 13;13(4):e14475. Epub 2021 Apr 13.

Pediatrics and Neonatology, Children's Hospital at Montefiore, New York, USA.

Pericardial effusion is a potentially lethal condition. If it is discovered early, it can be treated by pericardiocentesis under controlled condition with imaging by experienced care providers. If it is diagnosed at a later stage with clinical compromise, then an emergent procedure might be necessary. Read More

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Auricular Vagus Neuromodulation-A Systematic Review on Quality of Evidence and Clinical Effects.

Front Neurosci 2021 30;15:664740. Epub 2021 Apr 30.

Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States.

The auricular branch of the vagus nerve runs superficially, which makes it a favorable target for non-invasive stimulation techniques to modulate vagal activity. For this reason, there have been many early-stage clinical trials on a diverse range of conditions. These trials often report conflicting results for the same indication. Read More

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The COVID-19-designated hospitals in China: preparing for public health emergencies.

Emerg Microbes Infect 2021 Dec;10(1):998-1001

Department of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, People's Republic of China.

The designated hospitals are another health approach besides Fangcang shelter hospitals and newly built temporary hospitals for responding to COVID-19 epidemic in China. Faced with the emergency situation, about 1512 hospitals from 363 cities have been designated in China to tackle the spread of COVID-19. They were local hospitals repurposed by the Chinese government as a regional public health response. Read More

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December 2021

Setting-up a cross-border action-research project to control malaria in remote areas of the Amazon: describing the birth and milestones of a complex international project (Malakit).

Malar J 2021 May 11;20(1):216. Epub 2021 May 11.

Centre d'Investigation Clinique Antilles-Guyane, Inserm 1424, Centre Hospitalier de Cayenne Andrée Rosemon, Cayenne, French Guiana.

Background: In French Guiana, gold miners working illegally represents a major reservoir of malaria. This mobile population, mainly of Brazilian descent, enters the French Guianese forest from neighbouring countries, Suriname and Brazil. A complex and innovative intervention was piloted as a cooperation with the three involved countries involved to control malaria in this specific population. Read More

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Care Disparities Across the Health Care Continuum for Older Adults: Lessons From Multidisciplinary Perspectives.

Am Soc Clin Oncol Educ Book 2021 Mar;41:1-10

Department of Oncology and Metabolism, University of Sheffield Medical School, Sheffield, United Kingdom.

Older adults comprise a considerable proportion of patients with cancer in the world. Across multiple cancer types, cancer treatment outcomes among older age groups are often inferior to those among younger adults. Cancer care for older individuals is complicated by the need to adapt treatment to baseline health, fitness, and frailty, all of which vary widely within this age group. Read More

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Collapsing focal segmental glomerulosclerosis in a patient with oral cavity cancer: A case report.

Medicine (Baltimore) 2021 May;100(18):e25857

Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National University Medical School.

Rationale: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerular diseases, leading to end-stage renal disease. Among the 5 variants of FSGS, the collapsing variant is rare and has the worst prognosis. Solid and hematologic malignancies are associated with glomerular diseases, such as membranous nephropathy, minimal change disease, and FSGS. Read More

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