74,176 results match your criteria stage iii


Clinical characteristics and overall survival prognostic nomogram for oligodendroglioma: a SEER population-based analysis.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Department of medicine, TaikangXianlin Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210046, China. Electronic address:

Objective: The aim of this study was to investigate demographics, outcomes, and prognostic factors of all oligodendroglioma cases from the Surveillance, Epidemiology, and End Results (SEER) database and to build a clinical prognosis model for the prediction of survival time for oligodendroglioma patients.

Methods: Cases diagnosed between 1975 and 2016 were selected from the SEER Program. Age, sex, race, insurance, year of diagnosis, marital status, tumor location, tumor size, summary stage, surgery method, and use of radiotherapy and chemotherapy were evaluated with respect to overall survival by univariate and multivariate analysis. Read More

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Prognostic value of preoperative psoas muscle index as a measure of nutritional status in patients with esophageal cancer receiving neoadjuvant therapy.

Nutrition 2021 Mar 6;90:111232. Epub 2021 Mar 6.

First Department of Surgery, Faculty of Medicine University of Yamanashi, Yamanashi, Japan.

Objectives: It has been reported that preoperative nutritional status in some gastrointestinal cancers has a significant effect on postoperative prognosis. However, there are few reports on esophageal cancer, especially for esophageal cancer patients who have undergone neoadjuvant therapy and surgery. Psoas muscle index (PMI) is widely known as an index for assessing preoperative nutritional status, and has recently been reported for its prognostic value in many malignancies. Read More

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Non-tendinous healing after repairing of retracted rotator cuff tear- An Imaging Study.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Myongji Hospital, 697-24 Hwajung-dong, Deokyang-gu, Goyang-si, Gyeonggi-do 412-270, Republic of Korea.

Background: Follow-up magnetic resonance imaging (MRI) after rotator cuff repair can sometimes demonstrate healing with non-tendinous tissue that extends from the footprint to the retracted tendon end, which is inferred as fibrous tissue formation. The aim was to investigate this particular finding and its significance.

Methods: There were 494 eligible cases of healed superior medium- to massive-sized rotator cuff repairs, after the exclusion of re-tears. Read More

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Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy.

Radiother Oncol 2021 May 5. Epub 2021 May 5.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, United States.

This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation- coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement. Read More

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Serum angiopoietin-2 levels in dogs with splenic haemangiosarcoma, haemangioma, and splenitis.

Acta Vet Hung 2021 May 5. Epub 2021 May 5.

2Companion Animal Cancer Research Unit, Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.

Haemangioma (HA) and haemangiosarcoma (HSA) are among the most common splenic neoplasms in dogs. The survival time in splenic HSA is short, probably due to the lack of proper biological markers allowing early detection. We investigated the serum angiopoietin-2 (Ang-2) concentrations in 9 healthy dogs and 40 dogs with abnormal splenic masses. Read More

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Gastrointestinal and oncologic outcomes of pediatric gastrointestinal lymphoma following upfront resection or biopsy of bowel masses.

Pediatr Surg Int 2021 May 8. Epub 2021 May 8.

Department of Paediatric Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Purpose: Complete upfront resection of pediatric gastrointestinal lymphomas is recommended over biopsy whenever feasible, but either approach may have adverse sequelae. We sought to compare gastrointestinal and oncological outcomes of pediatric gastrointestinal lymphomas who underwent attempted upfront resection or biopsy of the presenting bowel mass.

Methods: We retrospectively reviewed charts of children with gastrointestinal lymphomas treated on LMB89 and LMB96 protocols from 2000 to 2019 who underwent upfront gastrointestinal surgery, and compared resection and biopsy groups. Read More

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Prevalence of transthyretin amyloidosis in patients with heart failure and no left ventricular hypertrophy.

ESC Heart Fail 2021 May 8. Epub 2021 May 8.

Department of Cardiology, IIS - Fundación Jiménez Díaz University Hospital - Quironsalud, Av. Reyes Católicos, 2, Madrid, 28040, Spain.

Aims: As evidenced by scintigraphy imaging, the prevalence of transthyretin (TTR) cardiac amyloidosis in heart failure patients with preserved ejection fraction (HFpEF) and left ventricular hypertrophy (LVH) ranges between 13% and 19%. The natural evolution of cardiac amyloidosis begins with the deposition of amyloid material in the myocardium, with LVH ensuing at later stages. With current imaging modalities, it is possible to detect TTR cardiac amyloidosis before the hypertrophic stage. Read More

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Mindfulness-based stress reduction for breast cancer survivors (MBSR(BC)): evaluating mediators of psychological and physical outcomes in a large randomized controlled trial.

J Behav Med 2021 May 7. Epub 2021 May 7.

Moffitt Cancer Center, Tampa, FL, 33612, USA.

MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). The cognitive mechanisms of "how" MBSR(BC) works was addressed in a recent study that found that there was strong consistent evidence that reduced emotional reactivity is a mediator and moderate consistent evidence that mindfulness, rumination, and worry were mediators. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased fear of breast cancer recurrence, and perceived stress. Read More

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Patient with respiratory distress, facial oedema and refractory hypokalaemia.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Medical Unit, National Hospital for Respiratory Disease, Welisara, Sri Lanka.

Small cell lung carcinoma, when associated with co-occurrence of complications such as paraneoplastic syndrome and superior vena cava syndrome, poses a greater management challenge to the clinical team. We report a 56-year-old man who was eventually diagnosed with stage III small cell lung carcinoma, presenting with respiratory distress, facial and upper body oedema, proximal muscle weakness, hypokalaemia, new-onset hypertension and hyperglycaemia. His medical management was complicated by associated superior vena cava syndrome and Cushing's syndrome leading to refractory hypokalemia, immunosuppression and depression. Read More

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Thoracic radiotherapy and concurrent almonertinib for unresectable stage III EGFR-mutated non-small-cell lung cancer: a phase 2 study.

BMC Cancer 2021 May 7;21(1):511. Epub 2021 May 7.

Department of Thoracic Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, People's Republic of China.

Background: Concurrent chemo-radiotherapy remains the standard treatment in unresectable stage III non-small-cell lung cancer (NSCLC) patients. Several studies have shown a potential value of concurrent epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) with thoracic radiotherapy in EGFR-mutated population, but a high risk of radiation pneumonitis raised a major concern. This study intends to explore the safety and efficacy of concurrent almonertinib, a new third-generation EGFR-TKI, with radiotherapy in locally advanced EGFR-mutated NSCLC patients. Read More

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The Danish metastatic melanoma database (DAMMED): A nation-wide platform for quality assurance and research in real-world data on medical therapy in Danish melanoma patients.

Cancer Epidemiol 2021 May 4;73:101943. Epub 2021 May 4.

Department of Oncology, Odense University Hospital, Odense, Denmark.

Background: Clinical trials enroll patients with specific diseases based on certain pre-defined eligibility criteria. Disease registries are crucial to evaluate the efficacy and safety of new expensive oncology medicines in broad non-trial patient populations.

Methods: We provide detailed information on the structure, including variables, and the scientific results from a nation-wide Danish database covering advanced melanoma, illustrating the importance of continuous real-world data registration. Read More

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Prognostic impact of dimensional factors in pT1 gastric cancer.

Surg Oncol 2021 Apr 22;38:101584. Epub 2021 Apr 22.

Department of Gastroenterological Surgery, Yokohama City University, School of Medicine. Japan.

Background: The significance of the dimensional factors (tumor diameter, area and volume) as the prognostic factor has not been precisely evaluated in pT1 gastric cancer.

Objectives: This study aimed to identify the clinical impact and to confirm the clinical feasibility of the dimensional factors as prognostic factors in pT1 gastric cancer.

Methods: We analyzed prognostic factors for disease-specific survival (DSS), overall survival (OS) using clinicopathological factors by univariate and multivariate analyses and the pattern of recurrence in 2011 pT1 gastric cancer (mucosal and submucosal cancers) undergoing R0 gastrectomy. Read More

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Cell Surface Area to Volume Relationship During Apoptosis and Apoptotic Body Formation.

Cell Physiol Biochem 2021 May;55(S1):161-170

Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain,

Apoptosis is a programmed form of cell death culminating in packing cell content and corpse dismantling into membrane sealed vesicles called apoptotic bodies (ABs). Apoptotic bodies are engulfed and disposed by neighboring and immune system cells without eliciting a noxious inflammatory response, thus preventing sterile tissue damage. AB formation requires a total surface area larger than the apparent, initial cell's surface area. Read More

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Correlations between DW-MRI and F-FDG PET/CT parameters in head and neck squamous cell carcinoma following definitive chemo-radiotherapy.

Cancer Rep (Hoboken) 2021 May 7:e1360. Epub 2021 May 7.

School of Biomedical Engineering and Imaging Sciences, St Thomas' Hospital, King's College, London, UK.

Background: Posttreatment diffusion-weighted magnetic resonance imaging (DW-MRI) and 18F-fluorodeoxygluocose ( F-FDG) positron emission tomography (PET) with computed tomography (PET/CT) have potential prognostic value following chemo-radiotherapy (CRT) for head and neck squamous cell carcinoma (HNSCC). Correlations between these PET/CT (standardized uptake value or SUV) and DW-MRI (apparent diffusion coefficient or ADC) parameters have only been previously explored in the pretreatment setting.

Aim: To evaluate stage III and IV HNSCC at 12-weeks post-CRT for the correlation between SUV and ADC values and their interval changes from pretreatment imaging. Read More

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Regional Gas Exchange Measured by Xe Magnetic Resonance Imaging Before and After Combination Bronchodilators Treatment in Chronic Obstructive Pulmonary Disease.

J Magn Reson Imaging 2021 May 7. Epub 2021 May 7.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

Background: Hyperpolarized Xe magnetic resonance imaging (MRI) provides a non-invasive assessment of regional pulmonary gas exchange function. This technique has demonstrated that chronic obstructive pulmonary disease (COPD) patients exhibit ventilation defects, reduced interstitial barrier tissue uptake, and poor transfer to capillary red blood cells (RBCs). However, the behavior of these measurements following therapeutic intervention is unknown. Read More

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[Ventral penis curvature correction in children with hypospadias].

Urologiia 2021 May(2):74-77

Urological-andrological Department, Russian Childrens Hospital, Moscow, Russia.

Objective: Our study aims to improve hypospadias in children by successfully correcting ventral penile curvature.

Materials And Methods: From 2014 to 2018, 424 patients with ventral penile curvature of 15-60 degrees were treated. All patients were divided into 3 groups depending on the form of hypospadias: Group I consists of 303 patients with subcoronal and midshaft hypospadias; Group II - 48 patients with midshaft hypospadias who earlier underwent urethroplasty; Group III - 73 patients with chordee without hypospadias. Read More

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Stage-dependent conditional survival and failure hazard of non-metastatic nasopharyngeal carcinoma after intensity-modulated radiation therapy: Clinical implications for treatment strategies and surveillance.

Cancer Med 2021 May 6. Epub 2021 May 6.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: Conditional survival (CS) and failure hazard estimations can provide important dynamic prognostic information for clinical decision-making and surveillance counseling. The current study aimed to investigate the CS and dynamic failure hazard in non-metastatic nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT).

Methods: Conditional overall survival (COS) and progression-free survival (CPFS) estimates adjusted for age and gender against each AJCC 8th stage were calculated. Read More

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Laparoscopic Heller-Dor Is an Effective Treatment for Esophageal-Gastric Junction Outflow Obstruction.

J Gastrointest Surg 2021 May 6. Epub 2021 May 6.

Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, School of Medicine, Clinica Chirurgica 3, Azienda Ospedale Università di Padova, Padova, Italy.

Background: The treatment of esophagogastric junction outflow obstruction (EGJOO) currently mirrors that of achalasia, but this is based on only a few studies on small case series. The aim of this prospective, controlled study was to assess the outcome of laparoscopic Heller-Dor (LHD) in patients with EGJOO, as compared with patients with esophageal achalasia.

Materials And Methods: Between 2016 and 2019, patients with manometric diagnosis of idiopathic EGJOO and patients with radiological stage I achalasia, both treated with LHD, were compared. Read More

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Smile attractiveness in class III patients after orthodontic camouflage or orthognathic surgery.

Clin Oral Investig 2021 May 6. Epub 2021 May 6.

Department of Orthodontics, Ingá University Center Uningá, Rod PR 317, Maringá, PR, 6114 -87035-510, Brazil.

Objective: The study's objective was to compare the smile attractiveness in patients with class III malocclusion treated with orthodontic camouflage or orthognathic surgery.

Material And Methods: The sample consisted of 30 patients with class III malocclusion treated without extractions divided into two groups, according to the treatment performed: G1, orthodontic camouflage, consisting of 15 patients (9 female; 6 male) with mean initial age of 21.26 years (SD = 7. Read More

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A comparative test of the gamete dynamics theory for the evolution of anisogamy in Bryopsidales green algae.

R Soc Open Sci 2021 Mar 3;8(3):201611. Epub 2021 Mar 3.

Department of Evolution, Ecology and Behaviour, University of Liverpool, Liverpool L69 7ZB, UK.

Gamete dynamics theory proposes that anisogamy arises by disruptive selection for gamete numbers versus gamete size and predicts that female/male gamete size (anisogamy ratio) increases with adult size and complexity. Evidence has been that in volvocine green algae, the anisogamy ratio correlates positively with haploid colony size. However, green algae show notable exceptions. Read More

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Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality.

Burns 2020 Dec 15. Epub 2020 Dec 15.

Fujian Provincial Key Laboratory of Burn and Trauma, Fujian Burn Institute, Fujian Burn Medical Center, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China. Electronic address:

Background: Patients with severe burns often show systemic coagulation changes in the early stage and even develop extensive coagulopathy. Previous studies have confirmed that soluble TREM-like transcript-1 (sTLT-1) mediates a novel mechanism of haemostasis and thrombosis in inflammatory vascular injury. At present, the role of sTLT-1 in patients with severe burns is not well known. Read More

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December 2020

The effects of topical erythropoietin on non-surgical treatment of periodontitis: a preliminary study.

BMC Oral Health 2021 May 6;21(1):240. Epub 2021 May 6.

Department of Periodontics, School of Dentistry, Faculty of Dentistry, Tehran University of Medical Sciences, North Kargar Street, Tehran, Iran.

Background: The purpose of periodontal treatments is to reduce inflammation, restore gingival health and clinical attachment level gain by controlling microbial plaque formation and other etiological factors. One of the drugs that has been tested in many areas and shown good anti-inflammatory properties is erythropoietin (EPO). We evaluated the effect of this drug on the improvement of periodontitis after the phase I treatment. Read More

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Incorporation of Patient-Reported Outcomes Measurement Information System to assess quality of life among patients with breast cancer initiating care at an academic center.

Cancer 2021 May 6. Epub 2021 May 6.

University of California San Francisco, San Francisco, California.

Background: Symptom burden and reduced quality of life (QOL) are considerable hurdles in oncology. The authors used the Patient-Reported Outcomes Measurement Information System (PROMIS), which assesses physical and psychosocial health, to establish a mean symptom burden, examine potential drivers, and characterize severe symptom burden in breast cancer patient subgroups with the goal of characterizing stage IV patient QOL and triaging patients to individualized supportive care services.

Methods: New patients at the University of California San Francisco Breast Care Center received questionnaires with 8 PROMIS domains: depression, anxiety, fatigue, sleep-related impairment, sleep disturbance, cognitive function, cognitive abilities, and physical function. Read More

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Percutaneous gastrostomy compared with esophageal stenting for the treatment of esophageal cancer with dysphagia.

J Vasc Interv Radiol 2021 May 3. Epub 2021 May 3.

Minimally Invasive and Interventional Department, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan, China. Electronic address:

Purpose: To compare the outcomes of self-expandable metal stent and percutaneous gastrostomy (PG) for treatment of patients with esophageal cancer (EC) and dysphagia.

Materials And Methods: This retrospective observational study consisted of 113 patients with EC and dysphagia who underwent either stent insertion (n = 47) or PG (n = 66) at a single center between June 2014 and June 2018.

Results: There were 63 men and 50 women with the mean age of 76. Read More

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The significant sex-biased expression pattern of Sp-Wnt4 provides novel insights into the ovarian development of mud crab (Scylla Paramamosain).

Int J Biol Macromol 2021 May 3;183:490-501. Epub 2021 May 3.

Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou 515063, China; STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou 515063, China. Electronic address:

The wingless-type MMTV integration site family member-4 (Wnt4), a member of the wingless-related integration site (Wnt) family, is widely accepted as a key regulator of ovarian development in mammals. In this study, a full-length cDNA of Wnt4 (designated as Sp-Wnt4) was cloned, characterized, and functionally studied in mud crab (Scylla paramamosain). The full-length cDNA of Sp-Wnt4 consists of 2659 bp with an open reading frame (ORF) encoding 359 amino acids, a 907 bp 5'-UTR and a 672 bp 3'-UTR. Read More

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Primary cytoreductive surgery for advanced stage endometrial cancer: A systematic review and meta-analysis.

Am J Obstet Gynecol 2021 May 3. Epub 2021 May 3.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Objective: Endometrial cancer uncommonly presents at an advanced stage, and little prospective evidence exists to guide management. We aimed to summarize evidence on primary cytoreductive surgery (PCS) in the treatment of advanced stage endometrial cancer.

Data Sources: MEDLINE, Embase, and Scopus databases were searched from inception to September 11, 2020, using search terms representing the themes "endometrial cancer," "advanced stage," and "primary cytoreductive surgery". Read More

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Comparison of Breast Cancer Staging Systems After Neoadjuvant Chemotherapy.

Ann Surg Oncol 2021 May 6. Epub 2021 May 6.

Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Background: No consensus exists for optimal staging following neoadjuvant chemotherapy (NAC). We compared the performance of the American Joint Committee on Cancer (AJCC) pathologic prognostic staging system, Residual Cancer Burden (RCB) Index, and the Neo-Bioscore in breast cancer patients after NAC.

Methods: Patients with stage I-III breast cancer who received NAC at Dana-Farber Cancer Institute from 2004 to 2014 were identified. Read More

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Hyperthermic Intraperitoneal Chemotherapy for Ovarian and Colorectal Cancer: A Review.

JAMA Oncol 2021 May 6. Epub 2021 May 6.

Center for Gynecologic Oncology Amsterdam, The Netherlands Cancer Institute, Amsterdam.

Importance: The peritoneal surface is a common site of disease in ovarian and colorectal cancer. Peritoneal metastases carry a poor prognosis, despite maximal therapeutic efforts, including surgical removal of tumor deposits and intravenous chemotherapy. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a single intraoperative procedure that delivers chemotherapy directly into the abdominal cavity, leading to high intracellular drug concentration at the peritoneal surface. Read More

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Annual Screening Mammography Associated With Lower Stage Breast Cancer Compared With Biennial Screening.

AJR Am J Roentgenol 2021 May 6:1-8. Epub 2021 May 6.

Department of Radiology, Division of Breast Imaging, Breast Care Center, University of Michigan Rogel Cancer Center, Ann Arbor, MI.

The purpose of this study was to compare breast cancer characteristics and treatment regimens among women undergoing annual versus nonannual screening mammography. In this retrospective, institutional review board-approved, HIPAA-compliant cohort study, a breast cancer database was queried for patients who received a mammographic or clinical diagnosis of breast cancer during 2016-2017. Annual versus biennial and annual versus nonannual (biennial and triennial) mammography screening cohorts were compared using tests or Wilcoxon rank sum tests for continuous variables and chi-square or Fisher exact tests for categoric variables. Read More

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Detecting Sensitive Mobility Features for Parkinson's Disease Stages Via Machine Learning.

Mov Disord 2021 May 6. Epub 2021 May 6.

Laboratory for Early Markers Of Neurodegeneration (LEMON), Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel.

Background: It is not clear how specific gait measures reflect disease severity across the disease spectrum in Parkinson's disease (PD).

Objective: To identify the gait and mobility measures that are most sensitive and reflective of PD motor stages and determine the optimal sensor location in each disease stage.

Methods: Cross-sectional wearable-sensor records were collected in 332 patients with PD (Hoehn and Yahr scale I-III) and 100 age-matched healthy controls. Read More

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