18,954 results match your criteria stage eyes


Pancreaticoduodenectomy for hepatic portal lymph node metastasis after hepatic resection for hepatocellular carcinoma: A clinical case report.

Int J Surg Case Rep 2021 Apr 27;82:105921. Epub 2021 Apr 27.

Center for Pathology and Cytology, Bach Mai Hospital, Viet Nam.

Introduction: In 2018, Hepatocellular carcinoma (HCC) was predicted to be the sixth most commonly diagnosed cancer. Extra-hepatic metastasis due to HCC is a poor prognostic factor, depending on the stage of the disease.

Presentation Of Case: We report a case of a 52-years old male who had undergone Segment 5 (S5) hepatectomy for HCC of 4. Read More

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Disparity in Context: Understanding how monocular image content interacts with disparity processing in human visual cortex.

Neuroimage 2021 May 5:118139. Epub 2021 May 5.

Wu Tsai Neurosciences Institute, 290 Jane Stanford Way, Stanford, CA 94305. Electronic address:

Horizontal disparities between the two eyes' retinal images are the primary cue for depth. Commonly used Random dot stereograms (RDS) intentionally camouflage the disparity cue, breaking the correlations between monocular image structure and the depth map that are present in natural images. Because of the nonlinear nature of visual processing, it is unlikely that simple computational rules derived from RDS will be sufficient to explain binocular vision in natural environments. Read More

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Sleep in Aneurysmal Subarachnoid Hemorrhage Patients During Critical and Acute Care.

Dimens Crit Care Nurs 2021 Mar-Apr 01;40(2):118-124

Background: Nurses caring for intensive care patients diagnosed with an aneurysmal subarachnoid hemorrhage (aSAH) conduct frequent neurological assessments and vital signs over an extended period during which patients are at risk of vasospasm. The frequency of assessments can negatively impact sleep, resulting in altered thought processes and mood, including delirium. There are 2 types of sleep during the night: non-rapid eye movement (non-REM) sleep and REM sleep (also called stage R). Read More

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Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease.

Cancer Rep (Hoboken) 2021 May 7:e1409. Epub 2021 May 7.

Department of Pathology, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico.

Background: Prior ecologic studies suggest that UV exposure through sunlight to the retina might contribute to increased retinoblastoma incidence.

Aims: Our study objectives were (1) to examine the relationship between exposure to sunlight during postnatal retinal development (prior to diagnosis of sporadic disease) and the risk of retinoblastoma, and (2) to examine the relationship between sun exposure during postnatal retinal development, and the extent of disease among children with unilateral and bilateral retinoblastoma.

Methods And Results: We interviewed 511 mothers in the EpiRbMx case-control study about their child's exposure to sunlight during postnatal retinal cell division by examining three time periods prior to Rtb diagnosis coinciding with developmental stages in which outdoor activities vary. Read More

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Different types of macular telangiectasia in two eyes of a patient.

Eur J Ophthalmol 2021 May 7:11206721211016314. Epub 2021 May 7.

University of Pittsburgh School of Medicine, Medical Retina and Vitreoretinal Surgery, Pittsburg, PA, USA.

Purpose: To report a case of macular telangiectasia (MacTel) showing the features of type 3 disease in one eye and type 2 disease in the other eye.

Methods: Descriptive case report.

Case Description: A 50-year-old well-controlled diabetic man presented with complaints of distorted vision in the right eye for the past 1 year. Read More

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Foveal displacement In Eyes With Epiretinal Membrane After Vitrectomy And Membrane Peeling Dystopia fovea and epiretinal membrane.

Retina 2021 Apr 23. Epub 2021 Apr 23.

Department of Ophthalmology, Changhua Christian Hospital, Changhua City, Taiwan Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA, USA Bloomberg LP, New York, NY, USA Department of Optometry, Da-Yeh University, Changhua City, Taiwan School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.

Purpose: To investigate the foveal movement in eyes with epiretinal membrane after vitrectomy and membrane peeling.

Methods: A retrospective review of 85 eyes with epiretinal membrane treated with vitrectomy, membrane peeling and internal limiting membrane removal. Use a self-designed computer program to compare the pre-operative and post-operative images of optical coherence tomography (OCT) to measure the amount of foveal movement. Read More

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EXPRESS: Evidence for two attentional mechanisms during learning.

Q J Exp Psychol (Hove) 2021 May 6:17470218211019308. Epub 2021 May 6.

Philipps-Universitat Marburg, Faculty of Psychology, Marburg, Germany 9377.

We sought to provide evidence for a combined effect of two attentional mechanisms during associative learning. Participants' eye movements were recorded as they predicted the outcomes following different pairs of cues. Across the trials of an initial stage, a relevant cue in each pair was consistently followed by one of two outcomes, while an irrelevant cue was equally followed by either of them. Read More

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Oncologic outcomes of human papillomavirus-associated oropharynx carcinoma treated with surgery alone: A 12-institution study of 344 patients.

Cancer 2021 May 6. Epub 2021 May 6.

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Background: The oncologic outcomes of surgery alone for patients with American Joint Committee on Cancer 7th edition (AJCC 7th) pN2a and pN2b human papillomavirus-associated oropharynx squamous cell carcinoma (HPV+OPSCC) are not clear.

Methods: The authors performed a 12-institution retrospective study of 344 consecutive patients with HPV+OPSCC (AJCC 7th pT0-3 N3 M0) treated with surgery alone with 6 months or more of follow-up using univariate and multivariate analyses.

Results: The 2-year outcomes for the entire cohort were 91% (182 of 200) disease-free survival (DFS), 100% (200 of 200) disease-specific survival (DSS), and 98% (200 of 204) overall survival (OS). Read More

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Complexity of EEG Dynamics for Early Diagnosis of Alzheimer's Disease Using Permutation Entropy Neuromarker.

Comput Methods Programs Biomed 2021 Apr 16;206:106116. Epub 2021 Apr 16.

Department of Electrical and Electronics Engineering, Dicle University, Diyarbakir, Turkey.

Background And Objective: Electroencephalogram (EEG) is one of the most demanded screening tools that investigates the effects of Alzheimer's Disease (AD) on human brain. Identification of AD in early stage gives rise to efficient treatment in dementia. Mild Cognitive Impairment (MCI) is considered as a conversion stage. Read More

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Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling.

Mol Oncol 2021 May 5. Epub 2021 May 5.

Key Laboratory of Antibody Engineering of Guangdong Higher Education Institutes, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to a high rate of tumour metastasis and disease recurrence. In physiological conditions, tetraspanins interact with specific partner proteins in tetraspanin-enriched microdomains and regulate their subcellular localizations and function. However, the function of Tspan5 in pathological processes, particularly in cancer biology, and its clinical significance are still unclear. Read More

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The Relationship Between Keratoconus Stage and the Thickness of the Retinal Layers

Turk J Ophthalmol 2021 04;51(2):75-82

Kayseri City Hospital, Clinic of Ophthalmology, Kayseri, Turkey

Objectives: To examine the relationship between keratoconus (KC) stage and the thickness of the retinal layers.

Materials And Methods: Retinal layer thicknesses were compared between 85 eyes of 85 KC patients and 40 eyes of 40 controls similar in age, sex, and axial length. KC patients were staged as stage 1, 2, or 3 according to the Amsler-Krumeich staging system, and segmentation of the retinal layers was performed with spectral domain optical coherence tomography automatic segmentation program. Read More

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Ocular syphilis - a case series of four patients.

J Dtsch Dermatol Ges 2021 May 5. Epub 2021 May 5.

University Hospital and Clinic for Dermatology and Venereology, University Hospital Halle (Saale) of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Ocular manifestations of syphilis with visual impairment symptoms may occur already at the stage of secondary syphilis. They may also be the only manifestation of syphilis and mimic other diseases of the eye. Therefore, in all patients with uveitis, optic neuritis, optic atrophy, acute ocular muscle paresis, or loss of visual acuity, syphilis infection should be ruled out, even if the medical history does not initially raise suspicion. Read More

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Automated Explainable Multidimensional Deep Learning Platform of Retinal Images for Retinopathy of Prematurity Screening.

JAMA Netw Open 2021 May 3;4(5):e218758. Epub 2021 May 3.

Joint Shantou International Eye Center of Shantou University, the Chinese University of Hong Kong, Shantou, Guangdong, China.

Importance: A retinopathy of prematurity (ROP) diagnosis currently relies on indirect ophthalmoscopy assessed by experienced ophthalmologists. A deep learning algorithm based on retinal images may facilitate early detection and timely treatment of ROP to improve visual outcomes.

Objective: To develop a retinal image-based, multidimensional, automated, deep learning platform for ROP screening and validate its performance accuracy. Read More

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A Pilot Study of Changes in the Level of Catecholamines and the Activity of α-2-Macroglobulin in the Tear Fluid of Patients with Parkinson's Disease and Parkinsonian Mice.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia.

Development of differential and early (preclinical) diagnostics of Parkinson's disease (PD) is among the priorities in neuroscience. We searched for changes in the level of catecholamines and α-2-macroglobulin activity in the tear fluid (TF) in PD patients at an early clinical stage. It was shown that TF in patients is characterized by an increased level of noradrenaline mainly on the ipsilateral side of pronounced motor symptoms (72%, = 0. Read More

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SWATH Based Quantitative Proteomics Reveals Significant Lipid Metabolism in Early Myopic Guinea Pig Retina.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.

Most of the previous myopic animal studies employed a single-candidate approach and lower resolution proteomics approaches that were difficult to detect minor changes, and generated limited systems-wide biological information. Hence, a complete picture of molecular events in the retina involving myopic development is lacking. Here, to investigate comprehensive retinal protein alternations and underlying molecular events in the early myopic stage, we performed a data-independent Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH) based proteomic analysis coupled with different bioinformatics tools in pigmented guinea pigs after 4-day lens-induced myopia (LIM). Read More

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Estimation of the Closest In-Path Vehicle by Low-Channel LiDAR and Camera Sensor Fusion for Autonomous Vehicles.

Sensors (Basel) 2021 Apr 30;21(9). Epub 2021 Apr 30.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 333, Korea.

In autonomous driving, using a variety of sensors to recognize preceding vehicles at middle and long distances is helpful for improving driving performance and developing various functions. However, if only LiDAR or cameras are used in the recognition stage, it is difficult to obtain the necessary data due to the limitations of each sensor. In this paper, we proposed a method of converting the vision-tracked data into bird's eye-view (BEV) coordinates using an equation that projects LiDAR points onto an image and a method of fusion between LiDAR and vision-tracked data. Read More

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COVID-19, Isolation, Quarantine: On the Efficacy of Internet-Based Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive-Behavioral Therapy (CBT) for Ongoing Trauma.

Brain Sci 2021 Apr 30;11(5). Epub 2021 Apr 30.

De Sanctis Clinical Center, 00166 Rome, Italy.

Literature points to cognitive-behavioural therapy (CBT) and eye movement desensitization and reprocessing (EMDR) as evidence-based therapies for trauma-related disorders. Treatments are typically administered in a vis-à-vis setting with patients reporting symptoms of a previously experienced trauma. Conversely, online-therapies and ongoing trauma have not received adequate attention. Read More

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The Pupal Pigmentation Pattern and Pupal Development in the Species of Howard (Hymenoptera: Aphelinidae).

Insects 2021 Apr 30;12(5). Epub 2021 Apr 30.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Species identification of on the basis of adult morphology is extremely difficult, especially in the group, with several cryptic species. Pupal pigmentation could be used as one of the taxonomic characters for species, and in some instances, pupal pigmentation actually provided the first clue to the distinctness of cryptic species. The present study investigated the full-grown larvae or younger pupae of species, and pupal pigmentation and pupal development were observed and photographed. Read More

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Awareness of diabetic retinopathy among diabetic patients.

J Pak Med Assoc 2021 Feb;71(2(B)):651-655

Foundation University Medical College, Islamabad, Pakistan.

Objective: To assess the awareness of diabetic patients about diabetic retinopathy.

Methods: The cross-sectional study was conducted at the Ophthalmology Department, Fauji Foundation Hospital, Rawalpindi, Pakistan, from April 2018 to April 2019, and comprised diabetic patients of either gender aged 21-80 years. A pre-tested semi-structured questionnaire was used to collect data on socio-demographic, diabetes and diabetic retinopathy characteristics. Read More

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February 2021

Surgical Treatment of Bilateral Optic Nerve Sheath Meningioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 May 3. Epub 2021 May 3.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Even though intracranial meningiomas commonly invade the optic canals, true optic nerve sheath meningiomas are extremely rare. They are insidious lesions that frequently grow in 4 stages, leading to progressive visual loss.1-4  Frequently, management includes observation for asymptomatic patients, and fractioned stereotactic radiotherapy with progressive visual loss. Read More

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Cyclic alternating pattern in obstructive sleep apnea: A preliminary study.

J Sleep Res 2021 May 3:e13350. Epub 2021 May 3.

Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, UK.

Obstructive sleep apnea is linked to cardiovascular disease, metabolic disorders and dementia. The precise nature of the association between respiratory events in obstructive sleep apnea, cortical or subcortical arousals, and cognitive, autonomic and oxidative stress consequences remains incompletely elucidated. Previous studies have aimed to understand the relationship between obstructive sleep apnea and arousal patterns, as defined by the cyclic alternating pattern, but results have been inconsistent, in part likely due to the presence of associated comorbidities. Read More

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Agreement between the newly developed OCT glaucoma staging system and the standardized visual field glaucoma staging system 2.

Eur J Ophthalmol 2021 May 2:11206721211014378. Epub 2021 May 2.

Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.

Purpose: The purpose of this research was to assess the agreement between the new optical coherence tomography (OCT) glaucoma staging system (GSS) and the visual field (VF) GSS 2 (GSS2).

Methods: This is a cross-sectional study of 161 eyes of 110 patients with controlled primary openangle glaucoma (POAG). All eyes were subjected to VF examination using standard automated perimetry and Humphrey field analyzer II 750. Read More

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Detection of Motor Dysfunction With Wearable Sensors in Patients With Idiopathic Rapid Eye Movement Disorder.

Front Bioeng Biotechnol 2021 15;9:627481. Epub 2021 Apr 15.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.

Patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at high risk for conversion to synucleinopathy and Parkinson disease (PD). This can potentially be monitored by measuring gait characteristics of iRBD patients, although quantitative data are scarce and previous studies have reported inconsistent findings. This study investigated subclinical gait changes in polysomnography-proven iRBD patients compared to healthy controls (HCs) during 3 different walking conditions using wearable motor sensors in order to determine whether gait changes can be detected in iRBD patients that could reflect early symptoms of movement disorder. Read More

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Polysomnographic nighttime features of narcolepsy: A systematic review and meta-analysis.

Sleep Med Rev 2021 Apr 5;58:101488. Epub 2021 Apr 5.

Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Mental Health Center, Translational Neuroscience Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Polysomnographic studies have been conducted to explore nighttime sleep features in narcolepsy, but their relationship to narcolepsy is still imperfectly understood. We conducted a systematic review of the literature exploring polysomnographic differences between narcolepsy patients and healthy controls (HCs) in EMBASE, MEDLINE, All EBM databases, CINAHL, and PsycINFO. 108 studies were identified for this review, 105 of which were used for meta-analysis. Read More

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Clinical use of machine learning-based pathomics signature for diagnosis and survival prediction of bladder cancer.

Cancer Sci 2021 May 1. Epub 2021 May 1.

Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Traditional histopathology performed by pathologists by the naked eye is insufficient for accurate and efficient diagnosis of bladder cancer (BCa). We collected 643 H&E-stained BCa images from Shanghai General Hospital and The Cancer Genome Atlas (TCGA). We constructed and cross-verified automatic diagnosis and prognosis models by performing a machine learning algorithm based on pathomics data. Read More

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Plasma miR-26a-5p is a biomarker for retinal neurodegeneration of early diabetic retinopathy.

Eye (Lond) 2021 Apr 30. Epub 2021 Apr 30.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.

Purpose: Retinal neurodegeneration is an early pathological change in diabetic retinopathy (DR). Early-stage retinal neurodegeneration is usually asymptomatic. This study aims to identify circulating microRNAs (miRNAs) as sensitive biomarkers for early retinal neurodegeneration. Read More

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Intra-cortical functional connectivity predicts arousal to noxious stimuli during sleep in humans.

J Neurosci 2021 Apr 30. Epub 2021 Apr 30.

Central Integration of Pain (NeuroPain) Lab - Lyon Neuroscience Research Center, INSERM U1028; CNRS, UMR5292; Université Claude Bernard; Bron, F-69677, France.

Nociceptive stimuli disrupt sleep, but may, or may not, entail an arousal. While arousal reactions go along with the activation of a widespread cortical network, the factors enabling such activation remain unknown. Here we used intracranial EEG (iEEG) in humans to test the relation between the cortical activity immediately preceding a noxious stimulus and the capacity of such a stimulus to trigger arousal. Read More

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Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets.

Eye Vis (Lond) 2021 May 1;8(1):15. Epub 2021 May 1.

Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, Yunnan Province, China.

Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading cause of visual loss in working-age individuals in many industrialized countries. It has been traditionally regarded as a purely microvascular disease in the retina. However, an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the retina. Read More

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Swedish parents' experiences and their need for support when having a child with congenital cataract: A qualitative study.

J Pediatr Nurs 2021 Apr 27;60:109-115. Epub 2021 Apr 27.

Department of Health Sciences, Red Cross University College, Box 1059, SE 141 21 Huddinge, Sweden. Electronic address:

Purpose: To explore parents' experiences of living with a child with congenital cataract, with the intention of identifying how to improve the parental support.

Design And Method: A qualitative descriptive design using semi-structured interviews. The parents were interviewed when the children were aged 12-24 months. Read More

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Fluroxypyr-1-methylheptyl ester interferes with the normal embryogenesis of zebrafish by inducing apoptosis, inflammation, and neurovascular toxicity.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Apr 27;247:109069. Epub 2021 Apr 27.

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Fluroxypyr-1-methylheptyl ester (FPMH) is a synthetic auxin herbicide used to regulate the growth of post-emergence broad-leaved weeds. Although acute exposure to FPMH increases the mortality of several fish species in the juvenile stage, the developmental toxicity of FPMH in aquatic vertebrates has not yet been investigated. In the present study, we assessed the developmental toxicity of FPMH using zebrafish models that offer many advantages for studying toxicology. Read More

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