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Review of wearable technologies and machine learning methodologies for systematic detection of mild traumatic brain injuries.

J Neural Eng 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurosurgery, Houston Methodist Hospital, 6550 Fannin Street, Houston, Texas, 77030-2707, UNITED STATES.

Mild traumatic brain injuries (mTBIs) are the most common type of brain injury. Timely diagnosis of mTBI is crucial in making "go/no-go" decision in order to prevent repeated injury, avoid strenuous activities which may prolong recovery, and assure capabilities of high-level performance of the subject. If undiagnosed, mTBI may lead to various short and long-term abnormalities, which include, but not limited to impaired cognitive function, fatigue, depression, irritability, and headaches. Read More

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Receipt of Screening Mammography by Insured Women Diagnosed With Breast Cancer and Impact on Outcomes.

J Natl Compr Canc Netw 2021 Jul 30. Epub 2021 Jul 30.

1Department of Radiology, University of Washington School of Medicine; and.

Background: The purpose of this study was to determine factors associated with receipt of screening mammography by insured women before breast cancer diagnosis, and subsequent outcomes.

Patients And Methods: Using claims data from commercial and federal payers linked to a regional SEER registry, we identified women diagnosed with breast cancer from 2007 to 2017 and determined receipt of screening mammography within 1 year before diagnosis. We obtained patient and tumor characteristics from the SEER registry and assigned each woman a socioeconomic deprivation score based on residential address. Read More

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The Impact of Extended Delayed Surgery for Indolent Lung Cancer or Part-solid Ground Glass Nodules.

Ann Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Massachusetts General Hospital. Electronic address:

Background: During the COVID-19 pandemic, patients with lung cancer may experience treatment delays. The objective of this study was to evaluate the impact of extended treatment delays on survival among patients with stage I typical bronchopulmonary carcinoid (BC), lepidic predominant adenocarcinoma (LPA) or invasive adenocarcinoma with a lepidic component (ADL).

Methods: Using National Cancer Data Base data (2004-2015), multivariable Cox regression analysis with penalized smoothing splines was performed to examine the association between treatment delay and all-cause mortality for stage I BC, LPA and ADL. Read More

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Treatment and Prognosis of Resectable Cervical Esophageal Cancer: A Population-based Study.

Ann Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Background: The optimal treatment strategy for resectable cervical esophageal cancer (CEC) remains controversial. This study aimed to explore prognostic factors and optimal treatment strategies in the context of staging.

Methods: In this population-based study, 1371 patients with resectable CEC were identified in the SEER database. Read More

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The chest radiographic scoring system in initial diagnosis of COVID-19: Is a radiologist needed?

Adv Clin Exp Med 2021 Jul 30. Epub 2021 Jul 30.

Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Background: Lung imaging, next to a polymerase chain reaction (PCR) test, is a key diagnostic tool in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The degree of abnormalities correlates with clinical outcome. Imaging of the lungs using chest radiography (CXR) at the peak of a pandemic is considered a basic diagnostic tool at the triage stage. Read More

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Correlation of clinical and computed tomography features of thymic epithelial tumours with World Health Organization classification and Masaoka-Koga staging.

Eur J Cardiothorac Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of Radiology, Lanzhou University Second Hospital, Gansu, China.

Objectives: Our goal was to investigate the correlation of clinical and computed tomography (CT) features of thymic epithelial tumours (TET) with the World Health Organization classification and the Masaoka-Koga staging system.

Methods: Clinical and CT imaging data from 159 patients surgically and pathologically diagnosed with TET (82 men, 77 women; mean [± standard deviation] age, 52.08 ± 11. Read More

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The bigger picture of shared decision making: A service design perspective using the care path of locally advanced pancreatic cancer as a case.

Cancer Med 2021 Jul 30. Epub 2021 Jul 30.

Medical Decision Making, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Purpose: Solutions to improve the implementation of shared decision making (SDM) in oncology often focus on the consultation, with limited effects. In this study, we used a service design perspective on the care path of locally advanced pancreatic cancer (LAPC). We aimed to understand how experiences of patients, their significant others, and medical professionals over the entire care path accumulate to support their ability to participate in SDM. Read More

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Central Precocious Puberty in a Boy with Pseudohypoparathyroidism Type 1A due to a Novel Variant, Who Had Congenital Hypothyroidism as the First Manifestation.

J Clin Res Pediatr Endocrinol 2021 Jul 30. Epub 2021 Jul 30.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Pseudohypoparathyroidism type 1A (PHP1A) is a disorder of multiple hormone resistance, mainly parathyroid hormone. It is associated with Albright hereditary osteodystrophy phenotypes. Patients with PHP1A may initially present with hypothyroidism during infancy and later develop typical PHP1A characteristics during their childhood. Read More

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Molecular Spectra and Frequency Patterns of Somatic Mutations in Arab Women with Breast Cancer.

Oncologist 2021 Jul 29. Epub 2021 Jul 29.

Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: The role of somatic mutations in breast cancer prognosis and management continues to be recognized. However, data on the molecular profiles of Arab women are limited.

Materials And Methods: This was a cross-sectional study based on medical chart review of all Arab women diagnosed with breast cancer at a single institution between 2010 and 2018 who underwent next-generation sequencing with Ampliseq 46-Gene or 50-Gene. Read More

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Cardiac Magnetic Resonance Follow-Up of Children After Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 With Initial Cardiac Involvement.

J Magn Reson Imaging 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatric Radiology, Medical University of Warsaw, Warsaw, Poland.

Background: Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is an inflammatory disease occurring in a small minority of children a few weeks after acute infection. Cardiac manifestations are common, but little is known about the potentially persistent heart changes after PIMS-TS.

Purpose: To analyze the frequency and type of myocardial complications of PIMS-TS with initial cardiac involvement assessed with cardiac magnetic resonance imaging (MRI), including parametric imaging, performed 3 months after hospitalization. Read More

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Assessing measurement invariance in the EORTC QLQ-C30.

Qual Life Res 2021 Jul 29. Epub 2021 Jul 29.

Department of Methodology and Statistics, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.

Purpose: We aimed to investigate measurement invariance (MI) in the European Organisation for research and treatment of cancer quality of life questionnaire core 30 (EORTC QLQ-C30) in a heterogeneous sample of patients with cancer.

Methods: Data from 12 studies within the PROFILES registry were used for secondary analyses (n = 7007). We tested MI by successive restrictions on thresholds, loadings, and intercepts across subgroups based on primary cancer sites, age, sex, time since diagnosis, and life stage, using multigroup confirmatory factor analysis (MGCFA) for ordered categorical measures. Read More

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Erythropoietin-Resistant Anemia Secondary to Zinc-Induced Hypocupremia in a Hemodialysis Patient.

Case Rep Nephrol Dial 2021 May-Aug;11(2):167-175. Epub 2021 Jul 1.

East Georgia Kidney and Hypertension, Augusta, Georgia, USA.

Excessive intake of zinc is a known but often forgotten cause of copper deficiency, and its consequences in the context of end-stage renal disease (ESRD) are not widely discussed. Zinc-induced copper deficiency (ZICD) can result in erythropoietin (EPO)-resistant anemia and may not be considered as a possible etiology when conducting the work-up. We present a case wherein an ESRD patient had been receiving excess zinc for several months and subsequently experienced EPO-resistant anemia. Read More

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An Unusual Case of Recurrent Migration of the Peritoneal Dialysis Catheter into the Inguinal Hernia Sac.

Case Rep Nephrol Dial 2021 May-Aug;11(2):152-157. Epub 2021 Jun 28.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

We herein report the first case of a patient with recurrent migration of the peritoneal dialysis (PD) catheter into the inguinal hernia sac. A 58-year-old man suffered from end-stage renal disease due to polycystic kidney disease (PKD). A year before starting PD, a PD catheter was implanted with stepwise initiation of PD using the Moncrief-Popovich technique. Read More

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CD4 Memory Stem T Cell in Peripheral Blood: A Promising Immune Index for Early Screening and Auxiliary Diagnosis of Colorectal Cancer.

Front Oncol 2021 13;11:701738. Epub 2021 Jul 13.

Clinical Laboratory, DongYang People's Hospital, Dongyang, China.

Background And Aims: Colorectal cancer (CRC) lacks obvious symptoms in the early stage of the disease, making it is easy to be misdiagnosed and remain undetected. Here, we explored the role of CD4 memory stem T cells (TSCM) in peripheral blood in the early screening and auxiliary diagnosis of CRC.

Materials And Methods: Patients diagnosed with a "colorectal mass" by colonoscopy, at the Dongyang People's Hospital (Zhejiang, China), between November 2020 and June 2021, were included in this prospective study. Read More

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Novel Visualization Methods Assisted Transurethral Resection for Bladder Cancer: An Updated Survival-Based Systematic Review and Meta-Analysis.

Front Oncol 2021 13;11:644341. Epub 2021 Jul 13.

Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.

Background: Photodynamic diagnosis and narrow-band imaging could help improve the detection rate in transurethral resection (TUR) of bladder cancer. It remained controversial that the novel visualization method assisted transurethral resection (VA-TUR) could elongate patients' survival compared to traditional TUR.

Methods: We performed electronic and manual searching until December 2020 to identify randomized controlled trials comparing VA-TUR with traditional TUR, which reported patients' survival data. Read More

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Hard Palate Perforation in an Elderly Man With Dementia.

Cureus 2021 Jun 23;13(6):e15872. Epub 2021 Jun 23.

Geriatrics, Monmouth Medical Center, Leon Hess Cancer Center, Long Branch, USA.

A 74-year-old male with a history of mild cognitive impairment presented to the emergency department with failure to thrive and generalized weakness. He was having difficulty swallowing leading to 30 pounds of unintentional weight loss in the last three months. His social history was significant for 12. Read More

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Low-Grade Endometrial Stromal Sarcoma in a 22-Year-Old Maiden Female: A Rare Case Report from Syria.

Case Rep Obstet Gynecol 2021 15;2021:5578686. Epub 2021 Jul 15.

Department of Pathology, Cancer Research Centre, Tishreen University, Lattakia, Syria.

Endometrial stromal sarcoma (ESS) is a rare and challenging type of endometrial tumor, constituting only about 0.2% of all uterine malignancies and occurring in women 42-58 years of age. ESS is usually misdiagnosed as leiomyoma. Read More

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An Evolutionary Approach for the Enhancement of Dermatological Images and Their Classification Using Deep Learning Models.

J Healthc Eng 2021 15;2021:8113403. Epub 2021 Jul 15.

Department of Electronics, University of Jammu, Jammu 180006, India.

Dermatological problems are the most widely spread skin diseases amongst human beings. They can be infectious, chronic, and sometimes may also lead to serious health problems such as skin cancer. Generally, rural area clinics lack trained dermatologists and mostly rely on the analysis of remotely accessible experts through mobile-based networks for sharing the images and other related information. Read More

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Automatic Breast Tumor Diagnosis in MRI Based on a Hybrid CNN and Feature-Based Method Using Improved Deer Hunting Optimization Algorithm.

Comput Intell Neurosci 2021 16;2021:5396327. Epub 2021 Jul 16.

Department of Electrical and Computer Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Breast cancer is an unusual mass of the breast texture. It begins with an abnormal change in cell structure. This disease may increase uncontrollably and affects neighboring textures. Read More

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Advanced HCC Patient Benefit From Neoantigen Reactive T Cells Based Immunotherapy: A Case Report.

Front Immunol 2021 13;12:685126. Epub 2021 Jul 13.

Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, China.

Advanced hepatocellular carcinoma (HCC) is a highly lethal disease, mainly due to the late stage at diagnosis and its rapid progression. Although patients with advanced HCC can choose targeted therapy or chemotherapy, overall, the treatment response rate is extremely low and the average survival time is one year more or less. But the application of immunotherapy have led to a paradigm shift in the treatment of HCC,such as TILs (tumor infiltrating lymphocytes),Checkpoint blockade (immune Checkpoint blockade), CAR-T(chimeric antigen receptor T cells) and TCR-T (engineered t-cell receptor T cells). Read More

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Melanoma and Sarcoidosis in Patients Receiving or Not Antineoplastic Therapy.

Case Rep Oncol 2021 May-Aug;14(2):1059-1065. Epub 2021 Jul 1.

Second Department of Medical Oncology, Agios Savvas Cancer Hospital, Athens, Greece.

Sarcoidosis and sarcoid-like reactions have been associated with many solid tumors including malignant melanoma. There are reports of melanoma patients who develop sarcoidosis without having received any antineoplastic treatment, but there are also melanoma patients who have received immunotherapy or targeted therapy and, therefore, develop drug-associated sarcoidosis. Herein, we describe 2 cases of thoracic sarcoidosis which occurred in asymptomatic patients with known malignant melanoma. Read More

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Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models.

Int J Biol Sci 2021 16;17(10):2487-2503. Epub 2021 Jun 16.

Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui, China.

Declined quality and quantity of sperm is currently the major cause of patients suffering from infertility. Male germ cell development is spatiotemporally regulated throughout the whole developmental process. While it has been known that exogenous factors, such as environmental exposure, diet and lifestyle, et al, play causative roles in male infertility, recent progress has revealed abundant genetic mutations tightly associated with defective male germline development. Read More

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Endoscopic ultrasound fine needle aspiration fine needle biopsy for pancreatic masses, subepithelial lesions, and lymph nodes.

World J Gastroenterol 2021 Jul;27(26):4194-4207

Division of Gastroenterology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, New Hyde Park, NY 11040, United States.

Endoscopic ultrasound tissue acquisition, in the form of both fine needle aspiration (EUS-FNA) and fine needle biopsy (EUS-FNB), is utilized for pancreatic mass lesions, subepithelial lesions, and lymph node biopsy. Both procedures are safe and yield high diagnostic value. Despite its high diagnostic yield, EUS-FNA has potential limitations associated with cytological aspirations, including inability to determine histologic architecture, and a small quantitative sample for further immunohistochemical staining. Read More

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A hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment.

Int J Drug Policy 2021 Jul 26:103359. Epub 2021 Jul 26.

Department of Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, Oregon, United States.

Background: Reaching World Health Organization hepatitis C (HCV) elimination targets requires diagnosis and treatment of people who use drugs (PWUD) with direct acting antivirals (DAAs). PWUD experience challenges engaging in HCV treatment, including needing multiple provider and laboratory appointments. Women, minoritized racial communities, and homeless individuals are less likely to complete treatment. Read More

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The role of fibrosis index FIB-4 in predicting liver fibrosis stage and clinical prognosis: A diagnostic or screening tool?

J Formos Med Assoc 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. Electronic address:

This review evaluates the ability of the fibrosis index based on four factors (FIB-4) identifying fibrosis stages, long-time prognosis in chronic liver disease, and short-time outcomes in acute liver injury. FIB-4 was accurate in predicting the absence or presence of advanced fibrosis with cut-offs of 1.0 and 2. Read More

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Racial disparities in survival among women with endometrial cancer in an equal access system.

Gynecol Oncol 2021 Jul 26. Epub 2021 Jul 26.

John P. Murtha Cancer Center Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address:

Objective: The mortality rate for Black women with endometrial cancer (EC) is double that of White women, although the incidence rate is lower among Black women. Unequal access to care may contribute to this racial disparity. This study aimed to assess whether survival varied between non-Hispanic Black (NHB) and non-Hispanic White (NHW) women with EC in the Military Health System (MHS) which provides equal access care to its beneficiaries despite racial/ethnic background. Read More

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Hemophagocytic Syndrome in a Pregnant Renal Transplant Recipient Associated With Cytomegalovirus Infection.

Exp Clin Transplant 2021 Jul;19(7):739-743

From the Department of Nephrology, Dialysis and Kidney Transplantation, Fattouma Bourguiba University Hospital of Monastir, Tunisia.

Hemophagocytic syndrome is a disorder of the mononuclear phagocytic system resulting in uncontrolled hemophagocytosis and cytokine overproduction. We report the first case of hemophagocytic syndrome, which occurred in a pregnantfemale patient 14 years after kidney transplant who displayed an atypical presentation and who had septic shock following cytomegalovirus infection. The patient, a-39-year-old woman at 27 weeks gestation with end-stage renal disease of unknown etiology, was admitted 14 years after living-donor kidney transplant (donor was her father) with high-grade fever, cough, and pancytopenia. Read More

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Prognosis of lung cancer associated with cystic airspaces: A propensity score matching analysis.

Lung Cancer 2021 Jul 17;159:111-116. Epub 2021 Jul 17.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China. Electronic address:

Objective: The association between the morphological characteristics and survival outcome of lung cancer associated with cystic airspaces (LCCAs) is unclear due to rarity of this disease. The current study attempted to compare the survival outcome between LCCAs and non-LCCAs and investigate the correlation between imaging features and prognosis of LCCA.

Method: Of 10,835 patients diagnosed with non-small cell lung carcinoma (NSCLC) between January 2015 and December 2016, 123 patients with LCCA were included. Read More

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Cross-diagnostic evaluation of minor physical anomalies in psychiatric disorders.

J Psychiatr Res 2021 Jul 20;142:54-62. Epub 2021 Jul 20.

Department of Psychiatry, National Institute for Mental Health and Neurosciences (NIMHANS), Bangalore, India. Electronic address:

Background: Minor physical anomalies (MPA) are markers of impaired neurodevelopment during the prenatal stage. Assessing MPA across psychiatric disorders may help understand their shared nature. In addition, MPA in family members would indicate a shared liability and endophenotype potential. Read More

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Reduction in healthcare services during the COVID-19 pandemic: Patient screening based on symptoms is an effective strategy for avoiding delayed laryngeal cancer diagnosis.

Am J Otolaryngol 2021 Jul 24;42(6):103162. Epub 2021 Jul 24.

Otolaryngology Unit, Azienda USL-IRCCS di Reggio Emilia, Italy.

Objective: Restriction in healthcare services during the COVID-19 pandemic caused delays in the diagnosis and treatment of several diseases. To overcome the risk of missed diagnosis of head and neck cancers, before deleting the scheduled appointments, we have introduced a selection of the patients by examining the clinical presenting issue and previous medical history. The aim of this study is to show the effects of the abovementioned strategy on the diagnosis and management of laryngeal cancer. Read More

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