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Impact of the 12-gene recurrence score assay on deciding adjuvant chemotherapy for stage II and IIIA/B colon cancer: the SUNRISE-DI study.

ESMO Open 2021 May 10;6(3):100146. Epub 2021 May 10.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.

Background: Recent advances in adjuvant chemotherapy for early colon cancer have widened physicians' recommendations on the regimen and duration (3 or 6 months) of the treatment. We conducted this prospective study to evaluate whether the 12-gene recurrence score (12-RS) assay affected physicians' recommendations on adjuvant treatment selection.

Patients And Methods: Patients with stage IIIA/IIIB or stage II colon cancer were enrolled. Read More

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Confined placental mosaicism and the association with pregnancy outcome and fetal growth: a review of the literature.

Hum Reprod Update 2021 May 13. Epub 2021 May 13.

Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam 3015CN, The Netherlands.

Background: Chromosomal mosaicism can be detected in different stages of early life: in cleavage stage embryos, in blastocysts and biopsied cells from blastocysts during preimplantation genetic testing for aneuploidies (PGT-A) and later during prenatal testing, as well as after birth in cord blood. Mosaicism at all different stages can be associated with adverse pregnancy outcomes. There is an onward discussion about whether blastocysts diagnosed as chromosomally mosaic by PGT-A should be considered safe for transfer. Read More

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Provider cost of treating oral potentially malignant disorders and oral cancer in Malaysian public hospitals.

PLoS One 2021 13;16(5):e0251760. Epub 2021 May 13.

Head and Neck Cancer Research Team, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.

Oral cancer has been recognized as a significant challenge to healthcare. In Malaysia, numerous patients frequently present with later stages of cancers to the highly subsidized public healthcare facilities. Such a trend contributes to a substantial social and economic burden. Read More

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Trend Analysis of Cutaneous Squamous Cell Carcinoma of the External Lip From 1975 to 2016.

JAMA Otolaryngol Head Neck Surg 2021 May 13. Epub 2021 May 13.

Department of Otolaryngology-Head and Neck Surgery, Louisiana State University-Health Shreveport, Shreveport.

Importance: Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer and commonly affects the head and neck. Increasing regional reports of aggressive cases warrant an analysis of population-based trends of cSCC of the head and neck.

Objective: To assess demographic, clinical, and survival trends among patients with cSCC of the external lip. Read More

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Identification of spectral signature for in situ real-time monitoring of smoltification.

Appl Opt 2021 May;60(14):4127-4134

We describe the use of an optical hyperspectral sensing technique to identify the smoltification status of Atlantic salmon (Salmo salar) based on spectral signatures, thus potentially providing smolt producers with an additional tool to verify the osmoregulatory state of salmon. By identifying whether a juvenile salmon is in the biological freshwater stage (parr) or has adapted to the seawater stage (smolt) before transfer to sea, negative welfare impacts and subsequent mortality associated with failed or incorrect identification may be reduced. A hyperspectral imager has been used to collect data in two water flow-through and one recirculating production site in parallel with the standard smoltification evaluations applied at these sites. Read More

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Advanced uterine papillary serous cancer: Could there be a role for newer targeted therapeutic approaches or immune checkpoint inhibitors?

J Oncol Pharm Pract 2021 May 13:10781552211015769. Epub 2021 May 13.

Eisenhower Lucy Curci Cancer Center, Rancho Mirage, CA USA.

Background: Although now available in oncology clinics, comprehensive germline mutation testing is being performed only in a minority of patients with advanced uterine papillary serous cancer (UPSC). Some of these patients might harbor various targetable mutations, either heritable or acquired.Data sources: We conducted a retrospective cohort study involving all consecutive patients with UPSC treated at our institution from 2009-2019. Read More

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Two hepatectomy cases for initially unresectable hepatocellular carcinoma after achieving a radiological complete response to sequential therapy with lenvatinib and transcatheter arterial chemoembolization.

Hepatol Res 2021 May 13. Epub 2021 May 13.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba, Japan.

We herein report two cases of locally advanced unresectable hepatocellular carcinoma (u-HCC) that were resected after achieving a radiological complete response to initially administered lenvatinib followed by transcatheter arterial chemoembolization (LEN-TACE sequential therapy). A 78-year-old woman and an 80-year-old man with HCC of Barcelona Clinic Liver Cancer classification stage C were treated for 15 and 14 months with lenvatinib, respectively. Both patients were subsequently treated with TACE, resulting in complete remission on imaging. Read More

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Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma.

Virchows Arch 2021 May 12. Epub 2021 May 12.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Spindle cell squamous cell carcinoma (SpC-SCC) is rare, accounting for 0.4-4% of head and neck (HN) SCCs. Better understanding of HN SpC-SCC clinicopathologic characteristics, especially features that predict outcome, is needed. Read More

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Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-modified Association.

J Clin Endocrinol Metab 2021 May 13. Epub 2021 May 13.

Division of Comprehensive Oral Health/Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Purpose: To determine whether periodontal disease is positively associated with incident diabetes across the continuum of body mass levels (BMI) and test the hypothesis that the periodontal risk for incident diabetes is modified by BMI.

Methods: We included 5569 diabetes-free participants from Visit 4 (1996-1998) of the Atherosclerosis Risk in Communities (ARIC) Study and followed them until 2018. Periodontal disease status was classified by periodontal profile class (PPC)-Stages and incident diabetes was based on participant report of physician diagnosis. Read More

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COVID-19 cases with delayed absorption of lung lesion.

Open Med (Wars) 2021 27;16(1):692-695. Epub 2021 Apr 27.

The Affiliated Yangming Hospital of Ningbo University, Yuyao People's Hospital of Zhejiang Province, Yuyao, China.

Objective: Over 90% of the COVID-19 patients with computed tomographic (CT) manifestations showed radiological improvement on dissipating stage. Cases with refractory pulmonary infiltration were discussed in this study.

Methods: During hospitalization, chest CT scan and reverse transcriptase polymerase chain reaction (RT-PCR) test were repeatedly performed. Read More

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Utility metric for unsupervised feature selection.

PeerJ Comput Sci 2021 21;7:e477. Epub 2021 Apr 21.

STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Department of Electrical Engineering (ESAT), KU Leuven, Leuven, Belgium.

Feature selection techniques are very useful approaches for dimensionality reduction in data analysis. They provide interpretable results by reducing the dimensions of the data to a subset of the original set of features. When the data lack annotations, unsupervised feature selectors are required for their analysis. Read More

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Ordinal losses for classification of cervical cancer risk.

PeerJ Comput Sci 2021 23;7:e457. Epub 2021 Apr 23.

Institute for Systems and Computer Engineering, Technology and Science, Porto, Portugal.

Cervical cancer is the fourth leading cause of cancer-related deaths in women, especially in low to middle-income countries. Despite the outburst of recent scientific advances, there is no totally effective treatment, especially when diagnosed in an advanced stage. Screening tests, such as cytology or colposcopy, have been responsible for a substantial decrease in cervical cancer deaths. Read More

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Capecitabine as Maintenance Therapy for High-Risk, Resected Colorectal Cancer.

Gastrointest Tumors 2021 Apr 10;8(2):81-86. Epub 2021 Mar 10.

Department of Medicine, West Virginia University, Morgantown, West Virginia, USA.

Introduction: In 2020, colorectal cancer will be the fourth most frequently diagnosed malignant neoplasm and the second leading cause of site-specific, cancer-related deaths in the USA. Notably, 80% of the new cases are, by staging criteria, potentially curable even those with completely resected stage 4 disease. If slightly more than half the losses can be attributed to metastatic disease at presentation, then the remaining portion of deaths may be linked to disease relapse after surgery and, if applicable, adjuvant chemotherapy. Read More

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Common and Rare Histological Variants of Hepatoblastoma in Children: A Pathological Diagnosis and Review of the Literature.

Gastrointest Tumors 2021 Apr 4;8(2):41-46. Epub 2021 Feb 4.

Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India.

Hepatoblastoma (HB) is a rare tumor, but it is the most common primary liver malignancy in children and comprised of approximately 1% of all pediatric malignancies. Mostly, this tumor is sporadic in nature but can show a syndrome association. Upregulation in Wnt/β-catenin pathway can be there in 70-80% cases of HB. Read More

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Clinicopathological Analysis of 34 Cases of Primary Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Chinese Children.

Front Pediatr 2021 26;9:656307. Epub 2021 Apr 26.

Department of Pediatric Nephrology and Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

This study aimed to summarize the clinicopathological features and prognostic risk factors of primary antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in children. Clinical and prognostic data for children admitted to our center with AAV between September 2003 and September 2020 were studied retrospectively. The incidence and risk factors of end-stage renal disease (ESRD) were calculated and analyzed. Read More

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Re-positive of SARS-CoV-2 test is common in COVID-19 patients after hospital discharge. Data from high standard post-discharge quarantined patients in Macao SAR, China.

PeerJ 2021 23;9:e11170. Epub 2021 Apr 23.

Center for Disease Control and Prevention, Health Bureau, Macao SAR, China.

During the pandemic of COVID-19, Macau faces tremendous pressure because it is a famous gambling and tourism city with the world's highest population density. The Macau government implemented decisive public health intervention to control the transmission of COVID-19, and there were only two independent outbreaks in Macau. In the second outbreak, all 35 cases were infected in foreign countries. Read More

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Hypoxic isolated abdominal perfusion breaks through chemoresistance in recurrent FIGO stage IIIC and IV ovarian cancer.

Mol Clin Oncol 2021 Jun 27;14(6):129. Epub 2021 Apr 27.

Department of Surgical Oncology, Medias Klinikum Burghausen, D-84489 Burghausen, Germany.

To overcome drug resistance in relapsed ovarian cancer, an isolated perfusion system was used to generate a higher local exposure to cytostatic drugs. In addition to cisplatin as the cytostatic agent of choice, the present study combined adriamycin and mitomycin in a three drugs regime due to their increased cytotoxicity under hypoxia. A total of 107 patients, including 87 patients with relapses after previous platinum-containing therapies, 46 stage IIIC and 41 stage IV cases, were enrolled in the present study. Read More

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SOX9 is associated with advanced T-stages of clinical stage II colon cancer in young Mexican patients.

Oncol Lett 2021 Jul 27;22(1):497. Epub 2021 Apr 27.

Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, 80010 Culiacán, Sinaloa, Mexico.

Colorectal cancer (CRC) is one of the most common malignancies worldwide and includes colon cancer (CC) and rectal cancer (RC). Regarding CC, the development of novel molecular biomarkers for the accurate diagnosis and prognosis, as well as the identification of novel targets for therapeutic intervention, are urgently needed. SRY-related high-mobility group box 9 (SOX9), a transcription factor, is involved in development, and has been associated with the progression of human cancer. Read More

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Increased Collagen Type V α2 (COL5A2) in Colorectal Cancer is Associated with Poor Prognosis and Tumor Progression.

Onco Targets Ther 2021 5;14:2991-3002. Epub 2021 May 5.

Minhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, People's Republic of China.

Purpose: Colorectal cancer (CRC) is the third most common cancer in males and the second in females worldwide with very poor prognosis. Extracellular matrix proteins like collagens play important roles in cancer progression. Collagen type V α2 (COL5A2) is increased in several cancers but its role in cancer remains unclear. Read More

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Anterior Segment Findings in Ocular Myocysticercosis in Children: Is it non- specific?

Nepal J Ophthalmol 2021 Jan;13(25):141-145

Nirwana Netralaya, Athkhambhwa, Sasaram- 821115, Bihar, India.

Ocular cysticercosis is a preventable cause of blindness. Medical therapy has been recommended for the retro-orbital and extraocular muscle form. Surgical management is largely done in cases with conjunctival or lid affliction. Read More

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January 2021

Pathologic Risk Factor in Retinoblastoma: An Institutional Experience Based on Analysis of Enucleated Eyes.

Nepal J Ophthalmol 2021 Jan;13(25):91-97

Universal College of Medical Sciences- Teaching Hospital, Bhairahawa, Nepal.

Background: Mortality resulting from the metastasis of retinoblastoma is uncommon in the developed world, however it still constitutes a major problem in developing countries like Nepal. The cases of retinoblastoma with increased risk of metastasis even after enucleation can be predicted from the histopathological examination of the enucleated specimen. We conducted this study aiming to assess the frequency and spectrum of high-risk histological features in enucleated specimens of retinoblastoma. Read More

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January 2021

Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis.

Clin Microbiol Rev 2021 Jun 12;34(3). Epub 2021 May 12.

Public Health Research Institute (PHRI) at New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

SUMMARYSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million COVID-19-positive cases and a mortality rate of about 2.2%, as of 10 December 2020. About 20% of COVID-19 patients exhibit moderate to severe symptoms. Read More

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Descriptive epidemiology of nasopharyngeal carcinoma at Tikur Anbessa Hospital, Ethiopia.

BMC Cancer 2021 May 12;21(1):540. Epub 2021 May 12.

Department of Otorhinolaryngology, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.

Background: Nasopharyngeal cancer is distinguished from other cancers of the head and neck in its epidemiology, histopathology, clinical characteristics, and therapeutic outcome. Its unique clinico-epidemiologic pattern of the disease is an area focus for this investigation. Accordingly, the study investigated the demographic and histologic characteristics, as well as the clinical stage at presentation of nasopharyngeal carcinoma patients at Tikur Anbessa Specialized hospital. Read More

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Genome-wide analysis of DNA methylation and risk of cardiovascular disease in a Chinese population.

BMC Cardiovasc Disord 2021 May 12;21(1):240. Epub 2021 May 12.

National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital, National Center for Cardiovascular Diseases, 167 Beilishi Road, Beijing, 100037, People's Republic of China.

Background: Systemic studies of association of genome-wide DNA methylated sites with cardiovascular disease (CVD) in prospective cohorts are lacking. Our aim was to identify DNA methylation sites associated with the risk of CVD and further investigate their potential predictive value in CVD development for high-risk subjects.

Methods: We performed an epigenome-wide association study (EWAS) to identify CpGs related to CVD development in a Chinese population. Read More

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Normal delivery: physiologic support and medical interventions. Guidelines of the French National Authority for Health (HAS) with the collaboration of the French College of Gynecologists and Obstetricians (CNGOF) and the French College of Midwives (CNSF).

J Matern Fetal Neonatal Med 2021 May 12:1-10. Epub 2021 May 12.

Department of Obstetrics and Gynecology, Maternité Aliénor d'Aquitaine, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.

Objective: To define for women at low obstetric risk methods of management that respect the rhythm and the spontaneous course of giving birth as well as each woman's preferences.

Methods: These clinical practice guidelines were developed through professional consensus based on an analysis of the literature and of the French and international guidelines available on this topic.

Results: Labor should be monitored with a partograph (professional consensus). Read More

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[Analysis of the clinical characteristics and prognosis of 36 cases of newly diagnosed multiple myeloma patients with bone marrow monoclonal plasma cell ratio of less than 10].

Zhonghua Xue Ye Xue Za Zhi 2021 Apr;42(4):295-301

Peking Union Medical College, Chinese Academy of Medical Sciences & Department of Hematology, Peking Union Medical College Hospital, Beijing 100730, China.

To improve the understanding of newly diagnosed multiple myeloma (NDMM) patients with bone marrow (BM) monoclonal plasma cell ratio of less than 10%. The clinical characteristics, laboratory examination, response to treatment, and prognosis of 36 NDMM patients with BM plasma cell ratio of less than 10% at Peking Union Medical College Hospital from January 2009 to December 2017 were summarized retrospectively. In the same period, other age- and gender-matched 72 NDMM patients were selected as the control group, whose BM plasma cell ratio was equal to or greater than 10%. Read More

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[Expression of tuftelin protein and its clinical value in HBV-related liver cancer tissues].

Zhonghua Gan Zang Bing Za Zhi 2021 Apr;29(4):338-343

Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China.

To analyze the expression of tuftelin protein (TUFT1) and its clinical value in hepatocellular carcinoma (HCC)-related liver cancer tissues. The biological information data of TUFT1 mRNA expression in liver cancer and non-cancer tissues were analyzed from the TCGA and Oncomine database. After the approval of the ethics committee, the self-pairing method was used to collect the postoperative cancer and para-carcinoma tissues of 132 HCC cases hospitalized between January 2009 and December 2014. Read More

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[Clinical efficacy and safety analysis of camrelizumab combined with apatinib as a second-line therapy for unresectable hepatocellular carcinoma: a multicenter retrospective study].

Zhonghua Gan Zang Bing Za Zhi 2021 Apr;29(4):326-331

Department of Infectious Diseases and Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

To analyze the clinical efficacy and safety of camrelizumab combined with apatinib as a second-line therapy for unresectable hepatocellular carcinoma (HCC). Ninety-four cases with mid-and advanced-stage HCC who received camrelizumab combined with apatinib as second-line treatment were enrolled. Routine blood test, blood biochemical indexes, tumor stage, tumor imaging characteristics, previous treatment strategies and other clinical data before treatment were documented. Read More

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Uterine Rescue in High-Risk Gestational Trophoblastic Neoplasia Treated with EMA-CO by Uterine Arteries Embolization due to Arteriovenous Malformations.

Rev Bras Ginecol Obstet 2021 Apr 12;43(4):323-328. Epub 2021 May 12.

Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Complete hydatidiform mole (CHM) is a rare type of pregnancy, in which 15 to 20% of the cases may develop into gestational trophoblastic neoplasia (GTN). The diagnostic of GTN must be done as early as possible through weekly surveillance of serum hCG after uterine evacuation. We report the case of 23-year-old primigravida, with CHM but without surveillance of hCG after uterine evacuation. Read More

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Congenital Absence of the Patellar Tendon: A Report of 2 Cases.

JBJS Case Connect 2021 04 14;11(2). Epub 2021 Apr 14.

Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, New York.

Case: Isolated unilateral congenital patellar tendon absence is a rare condition that has not been well described. We report on 2 patients with congenital patellar tendon absence that underwent soft-tissue reconstruction of their patellar tendon. We present the clinical and radiographic features, surgical management with both single-stage and multistage approaches, and postoperative outcomes for the treatment of this condition. Read More

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