829,071 results match your criteria stage


The assessment of circulating cell-free DNA as a diagnostic tool for breast cancer: an updated systematic review and meta-analysis of quantitative and qualitative ssays.

Clin Chem Lab Med 2021 May 5. Epub 2021 May 5.

Department of General Surgery, Affiliated Hospital of Jiangnan University (Original Area of Wuxi No. 3 People's Hospital), Wuxi, P. R. China.

Objectives: This updated meta-analysis aimed to assess the diagnostic accuracy of circulating cell-free DNA (cfDNA) in breast cancer (BC).

Content: An extensive systematic search was performed in PubMed, Scopus, Embase, and Science Direct databases to retrieve all related literature. Various diagnostic estimates, including sensitivity (SE), specificity (SP), likelihood ratios (LRs), diagnostic odds ratio (DOR), and area under the curve (AUC) of summary receiver operating characteristic (sROC) curve, were also calculated using bivariate linear mixed models. Read More

View Article and Full-Text PDF

Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models.

CPT Pharmacometrics Syst Pharmacol 2021 Apr;10(4):309-317

Department of Pharmacy, Uppsala University, Uppsala, Sweden.

This study tested the hypothesis that analyzing longitudinal item scores of the Unified Parkinson's Disease Rating Scale could allow a smaller trial size and describe a drug's effect on symptom progression. Two historical studies of the dopaminergic drug ropinirole were analyzed: a cross-over formulation comparison trial in 161 patients with early-stage Parkinson's disease, and a 24-week, parallel-group, placebo-controlled efficacy trial in 393 patients with advanced-stage Parkinson's disease. We applied item response theory to estimate the patients' symptom severity and developed a longitudinal model using the symptom severity to describe the time course of the placebo response and the drug effect on the time course. Read More

View Article and Full-Text PDF

Preoperative Nutritional Scores as Host-Related Prognostic Factors for Both Overall Survival and Postoperative Complications in Stage II - III Colorectal Cancer Patients.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 1040045, Japan.

Background: In the tumor-node-metastasis eighth edition, nutritional status and inflammatory scores are newly described as host-related prognostic factors for esophageal cancer, hepatocellular carcinoma, and pancreatic cancer. However, only age and race are listed as host-related prognostic factors for colorectal cancer.

Objective: To evaluate the prognostic significance of nutritional and inflammatory scores for postoperative outcomes in colorectal cancer patients. Read More

View Article and Full-Text PDF

Predictors of Positive Circumferential Resection Margin in Rectal Cancer: A Current Audit of the National Cancer Database.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Postdoctoral Research Fellow, Division of Colorectal Surgery, Department of Surgery, Columbia University Medical Center, New York, NY Postdoctoral Research Fellow, Division of Colorectal Surgery, Department of Surgery, Columbia University Medical Center, New York, NY Postdoctoral Research Fellow, Division of Colorectal Surgery, Department of Surgery, Columbia University Medical Center, New York, NY Chief, Division of Colorectal Surgery, Department of Surgery; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY Assistant Professor, Division of Colorectal Surgery, Department of Surgery; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY.

Background: Positive circumferential resection margin is a predictor of local recurrence and worse survival in rectal cancer. National programs aimed to improve rectal cancer outcomes were first created in 2011, and continue to evolve. The impact on circumferential resection margin during this timeframe has not been fully evaluated in the United States. Read More

View Article and Full-Text PDF

Safety of Small Circular Staplers in Double Stapling Technique Anastomosis for Sigmoid Colon and Rectal Cancer.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

From the Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan Gastroenterology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan Clinical Research Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Although smaller circular staplers are easier to insert and less likely to involve the vagina and levator ani muscles when performing double stapling technique anastomosis, surgeons often consider that larger circular staplers would be safer in reducing the risk of postoperative anastomotic strictures.

Objective: This study aimed to investigate the safety of using 25-mm circular staplers compared to 28/29-mm staplers in the double stapling technique anastomosis regarding the development of anastomotic strictures and other complications.

Design: Retrospective observational study. Read More

View Article and Full-Text PDF

The Predictive Value of Computed Tomography Enterography Index for Postoperative Intra-Abdominal Septic Complications in Patients with Crohn's Disease: Implications for Surgical Decision Making.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Department of General Surgery, Jinling Medical School of Nanjing Medical University, No. 305 East Zhongshan Road, Nanjing, PR China Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing, PR China Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing, PR China Department of General Surgery, Jinling Hospital, Medical School of Southeast University, No. 305 East Zhongshan Road, Nanjing, PR China.

Background: Postoperative intra-abdominal septic complications in patients with Crohn's Disease undergoing intestinal resection and anastomosis are frequent and difficult to manage.

Objective: This study sought to explore the value of preoperative computed tomography enterography to predict intra-abdominal septic complications.

Design: This was a retrospective and prospective observational study. Read More

View Article and Full-Text PDF

Antifibrotic Therapy: Is There a Role in Myositis-Interstitial Lung Disease?

Respiration 2021 May 5:1-10. Epub 2021 May 5.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Interstitial lung disease (ILD) is a cause of substantial morbidity and mortality amongst autoimmune diseases, including myositis. Despite first-line therapy with immunosuppression, many inflammatory ILDs advance to a fibrotic stage. In such patients, progressive fibrosis may be amenable to treatment with antifibrotic medications, which were initially studied and approved for the treatment of idiopathic pulmonary fibrosis. Read More

View Article and Full-Text PDF

Collateral ligament sprains of the metacarpophalangeal joint of the long fingers: Results of a surgical series of 15 patients.

Orthop Traumatol Surg Res 2021 May 2. Epub 2021 May 2.

Institut Montpelliérain de la Main et du Membre Supérieur, Clinique Saint-Roch, 560 Avenue du Colonel Pavelet, 34070 Montpellier, France.

Introduction Collateral ligament sprains of the metacarpophalangeal joint (MP) of the long fingers are rare and mostly treated conservatively. Clinical examination to diagnose the severity of these injuries is mandatory. The purpose of our study is to report the results of 15 patients treated surgically. Read More

View Article and Full-Text PDF

Popliteal Artery Thrombosis in a Young Patient Secondary to Proximal Tibial Osteochondroma.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Division of Interventional Radiology, Department of Radiology, Mayo Clinic Health System Northwest Wisconsin, 1400 Bellinger St, Eau Claire WI 54701. Electronic address:

Popliteal artery occlusion is mainly seen in elderly patients with late stage atherosclerotic occlusive disease. In young, nonsmoking patients, popliteal artery occlusion can be caused by a variety of other etiologies. The diagnosis is suspected clinically and confirmed with ultrasound, computed tomography angiogram(CTA) or angiography, which can also aid in understanding the underlying cause. Read More

View Article and Full-Text PDF

Associations of clinical frailty with severity of limb threat and outcomes in chronic limb-threatening ischaemia.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Department of Cardiovascular Sciences, University of Leicester, UK; Leicester Vascular Institute, University Hospitals of Leicester NHS Trust, UK; National Institute for Health Research Leicester Biomedical Research Centre - The Glenfield Hospital, Leicester, UK.

Objective: Investigate the relationship of frailty and severity of chronic limb-threatening ischaemia (CLTI), and their comparative associations with one-year outcomes, in patients presenting to a vascular limb salvage (VaLS) clinic.

Methods: This retrospective cohort study utilised data collected from a prospectively maintained VaLS clinic database. Patients aged ≥50 presenting to the VaLS clinic with CLTI between February 2018 and April 2019 were included. Read More

View Article and Full-Text PDF

Limitations of using the National Cancer DataBase to examine the effect of policy change on stage at presentation at the population-level.

J Am Acad Dermatol 2021 May 2. Epub 2021 May 2.

Division of Urological Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

View Article and Full-Text PDF

Can 3D pseudo-continuous arterial spin labeling perfusion imaging be applied to predict early response to chemoradiotherapy in patients with advanced nasopharyngeal carcinoma?

Radiother Oncol 2021 May 2. Epub 2021 May 2.

GE Healthcare, MR Research China, Beijing, 100176, China.

Background And Purpose: Chemoradiotherapy (CRT) has been widely applied in patients with advanced nasopharyngeal carcinoma (ANPC). However, limited imaging modality exists on the evaluation of early response to CRT. The purpose of this study was therefore to investigate whether 3D pseudo-continuous arterial spin labeling (3D pCASL) perfusion imaging could predict early response to CRT in ANPC patients. Read More

View Article and Full-Text PDF

CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish.

Immunol Lett 2021 May 2. Epub 2021 May 2.

SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

The number and function of T cells are abnormal as observed in cystic fibrosis (CF) patients and CF mouse models, and our previous work shows that the CFTR mutant leads to deficiency of primitive and definitive hematopoietic in zebrafish. However, the functions and underlying mechanisms of CFTR in T cell development during early embryogenesis have not been explored. Here, we report that the genetic ablation of CFTR in zebrafish resulted in abrogated embryonic T lymphopoiesis, which was ascribed to impaired thymic homing and expansion of hematopoietic stem cells (HSCs). Read More

View Article and Full-Text PDF

The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.

Cell Rep 2021 May;35(5):109075

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8501, Japan; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan. Electronic address:

In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal organization of bipotential gonads and their progenitors is poorly understood. Here, using lineage tracing in mice, we find that the gonads originate from a T primitive streak through WT1 posterior intermediate mesoderm and appear to share origins anteriorly with the adrenal glands and posteriorly with the metanephric mesenchyme. Read More

View Article and Full-Text PDF

Task-induced brain functional connectivity as a representation of schema for mediating unsupervised and supervised learning dynamics in language acquisition.

Brain Behav 2021 May 5:e02157. Epub 2021 May 5.

Faculty of Humanities and Social Sciences, Jissen Women's University, Tokyo, Japan.

Introduction: Based on the schema theory advanced by Rumelhart and Norman, we shed light on the individual variability in brain dynamics induced by hybridization of learning methodologies, particularly alternating unsupervised learning and supervised learning in language acquisition. The concept of "schema" implies a latent knowledge structure that a learner holds and updates as intrinsic to his or her cognitive space for guiding the processing of newly arriving information.

Methods: We replicated the cognitive experiment of Onnis and Thiessen on implicit statistical learning ability in language acquisition but included additional factors of prosodic variables and explicit supervised learning. Read More

View Article and Full-Text PDF

The prognostic value of weight and body composition changes in patients with non-small-cell lung cancer treated with nivolumab.

J Cachexia Sarcopenia Muscle 2021 May 5. Epub 2021 May 5.

Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center +, Maastricht, The Netherlands.

Background: It is not well known to what extent effectiveness of treatment with immune checkpoint inhibitors in stage IV non-small-cell lung cancer (NSCLC) is influenced by weight loss and changes in body composition. Therefore, the goal of this study was to evaluate body composition changes in relation to early weight change and overall survival (OS) in stage IV NSCLC patients treated with second-line nivolumab.

Methods: All patients with stage IV NSCLC, who were treated with second-line nivolumab between June 2015 and December 2018 at Maastricht University Medical Center, were evaluated. Read More

View Article and Full-Text PDF

Drug Release from Thermo-Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants.

Adv Healthc Mater 2021 May 5:e2100069. Epub 2021 May 5.

Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cµ), Department of Chemistry and Biology, School of Science and Technology, University of Siegen, Adolf-Reichwein-Str. 2, Siegen, 57076, Germany.

Despite decades of biomedical advances, the colonization of implant devices with bacterial biofilms is still a leading cause of implant failure. Clearly, new strategies and materials that suppress both initial and later stage bacterial colonization are required in this context. Ideal would be the implementation of a bactericidal functionality in the implants that is temporally and spatially triggered in an autonomous fashion at the infection site. Read More

View Article and Full-Text PDF

A nonrandomised pilot study to examine the feasibility and acceptability of reflexology in patients undergoing hospital-based haemodialysis (solitude study).

J Ren Care 2021 May 5. Epub 2021 May 5.

School of Nursing and Midwifery, Queen's University, Belfast, UK.

Background: Patients with end-stage kidney disease, receiving haemodialysis can experience complications-hypotension, headache, muscle cramp, chest pain, nausea and vomiting. Patients who experience all or some of these symptoms will often report reduced health-related quality of life (HRQOL) and poor sleep quality, which may lead to increased morbidity and mortality.

Objective: The objective of this pilot study is to evaluate the feasibility of a larger randomised controlled trial to determine the effect of foot reflexology on a cohort of patients undergoing hospital-based haemodialysis. Read More

View Article and Full-Text PDF

Ocular syphilis - a case series of four patients.

J Dtsch Dermatol Ges 2021 May 5. Epub 2021 May 5.

University Hospital and Clinic for Dermatology and Venereology, University Hospital Halle (Saale) of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Ocular manifestations of syphilis with visual impairment symptoms may occur already at the stage of secondary syphilis. They may also be the only manifestation of syphilis and mimic other diseases of the eye. Therefore, in all patients with uveitis, optic neuritis, optic atrophy, acute ocular muscle paresis, or loss of visual acuity, syphilis infection should be ruled out, even if the medical history does not initially raise suspicion. Read More

View Article and Full-Text PDF

Relationship between blood neutrophil-lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in IgA nephropathy patients.

J Clin Lab Anal 2021 May 5:e23774. Epub 2021 May 5.

Department of Nephrology, Ningbo Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China.

Background: The study aimed to explore the relationship between neutrophil-lymphocyte ratio(NLR) in peripheral blood and renal tubular atrophy/interstitial fibrosis and to evaluate the clinical significance of NLR in IgA nephropathy (IgAN) patients.

Methods: A Total of 263 IgAN patients were included. The participants were categorized into four groups based on quartile of NLR. Read More

View Article and Full-Text PDF

The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs.

J Vet Intern Med 2021 May 5. Epub 2021 May 5.

Department of Cardiology, Anicura Istituto Veterinario Novara, Granozzo con Monticello, Italy.

Background: There is no commonly shared severity score for myxomatous mitral valve disease (MMVD) based on routinely acquired echocardiographic variables.

Hypothesis/objectives: To propose an easy-to-use echocardiographic classification of severity of MMVD in dogs.

Animals: Five hundred and sixty dogs with MMVD. Read More

View Article and Full-Text PDF

Serum potassium levels and prognosis in HBV-associated decompensated cirrhosis.

J Clin Lab Anal 2021 May 5:e23775. Epub 2021 May 5.

Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.

Background: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV-related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV-DeCi patients.

Methods: Retrospective study included 155 subjects. Read More

View Article and Full-Text PDF

Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3.

Mov Disord 2021 May 5. Epub 2021 May 5.

IXICO Plc, London, United Kingdom.

Background: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity.

Objective: The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease.

Methods: We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers and 63 healthy controls. Read More

View Article and Full-Text PDF

Unveiling the CHO surfaceome: identification of cell surface proteins reveals cell aggregation relevant mechanisms.

Biotechnol Bioeng 2021 May 5. Epub 2021 May 5.

Institute of Applied Biotechnology, University of Applied Sciences Biberach, Hubertus-Liebrecht-Str. 35, 88400, Biberach, Germany.

Chinese hamster ovary (CHO) suspension cells are the main production hosts for biopharmaceuticals. For the improvement of production processes, it is essential to understand the interaction between CHO cells and their microenvironment. While the cellular membrane is the crucial surface barrier between the inner and outer cell compartments, the subgroup of cell surface proteins (surfaceome) is of particular interest due to its potential to react to external factors and initiate cell communication and interaction pathways. Read More

View Article and Full-Text PDF

Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? A systematic review.

Age Ageing 2021 May;50(3):725-732

Department of Cardiology, Blacktown Hospital, Western Sydney Local Health District, Sydney, Australia.

Background: Frailty is strongly associated with adverse cardiovascular outcomes; however, the underlying pathophysiological processes are largely unknown. Vascular endothelial dysfunction (VED) is the earliest stage of cardiovascular disease (CVD) progression and predicts long-term CVD outcomes. Both these conditions share an elevated inflammatory state as a common pathological factor. Read More

View Article and Full-Text PDF

Breast cancer survival and its prognostic factors in the United Arab Emirates: A retrospective study.

PLoS One 2021 5;16(5):e0251118. Epub 2021 May 5.

Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Background: Data on breast cancer survival and its prognostic factors are lacking in the United Arab Emirates (UAE). Sociodemographic and pathologic factors have been studied widely in western populations but are very limited in this region. This study is the first to report breast cancer survival and investigate prognostic factors associated with its survival in the UAE. Read More

View Article and Full-Text PDF

A nomogram prediction of overall survival based on lymph node ratio, AJCC 8th staging system, and other factors for primary pancreatic cancer.

PLoS One 2021 5;16(5):e0249911. Epub 2021 May 5.

Department of Gastroenterology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Background: As a malignant tumor with poor prognosis, accurate and effective prediction of the prognosis of pancreatic cancer (PC) is crucial.

Methods: A total of 12,909 patients diagnosed with pancreatic cancer were selected from the Surveillance, Epidemiology, and End Results program between 2004 and 2016. The sex, age, ethnicity, marital status, metastasis status, radiotherapy, chemotherapy, tumor size, regional nodes examined, regional nodes positive of each patient were recorded. Read More

View Article and Full-Text PDF

Clinical significance of central systolic blood pressure in LV diastolic dysfunction and CV mortality.

PLoS One 2021 5;16(5):e0250653. Epub 2021 May 5.

Division of Cardiology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.

Background And Aims: Cardiovascular (CV) disease is the major cause of death in patients with end-stage kidney disease (ESKD). Left ventricular (LV) diastolic dysfunction reflects LV pressure overload and is common in patients with ESKD. Recently, there have been studies on the usefulness of central blood pressure (BP); however, the relationship between central BP and LV diastolic dysfunction is not clear in dialysis patients with preserved systolic function. Read More

View Article and Full-Text PDF

Breast surgery for young women with early-stage breast cancer: Mastectomy or breast-conserving therapy?

Medicine (Baltimore) 2021 May;100(18):e25880

Department of General Surgery.

Abstract: Whether breast-conserving therapy (BCT) should be chosen as a local treatment for young women with early-stage breast cancer is controversial. This study compared the survival benefits of BCT or mastectomy in young women under 40 with early-stage breast cancer and further explored age-stratified outcomes. This study investigated whether there is a survival benefit when young women undergo BCT compared with mastectomy. Read More

View Article and Full-Text PDF