904,783 results match your criteria stage


An LC-MS-based metabolomic approach provides insights into the metabolite profiles of Ginkgo biloba L. at different developmental stages and in various organs.

Food Res Int 2022 Sep 9;159:111644. Epub 2022 Jul 9.

Nanjing Forestry University, Co-Innovation Center for Sustainable Forestry in Southern China, 159 Longpan Road, Nanjing 210037, China. Electronic address:

Ginkgo (Ginkgo biloba L.) is a tree valued for the high medicinal and nutritional value of its leaves and seeds. However, the metabolite profiles of ginkgo leaves and seeds and their changes during development have not been comprehensively analyzed, which hinders improvements in the utilization of ginkgo. Read More

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September 2022

Aging of visual mechanisms.

Prog Brain Res 2022 18;273(1):257-273. Epub 2022 Jul 18.

Department of Ophthalmology & Vision Science, University of California Davis, Sacramento, CA, United States. Electronic address:

Optical and neural changes in the aging human visual system are reviewed in terms of factors that can influence the study of light-mediated effects on circadian physiology. All aspects of early stage visual mechanisms change continuously from the first days of life, and these changes must be understood when investigating both conscious and unconscious visual responses to light throughout the life span. Read More

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Quality improvement initiative: how the setting up of an anaesthesia consultant-led perioperative outreach service addressed anaesthesia-specific issues to improve anaesthesia consult and surgery timings for hip fracture patients.

BMJ Open Qual 2022 Aug;11(3)

Department of Anaesthesia and Surgical Intensive Care, Changi General Hospital, Singapore.

Background: Surgery is recommended within 48 hours of hip fractures for better perioperative outcomes. Yet, such targets still commonly remain a challenge. Our institution is no exception. Read More

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Emergency Department Communication in Persons Living With Dementia and Care Partners: A Scoping Review.

J Am Med Dir Assoc 2022 Aug;23(8):1313.e15-1313.e46

BerbeeWalsh Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Objectives: To synthesize published research exploring emergency department (ED) communication strategies and decision-making with persons living with dementia (PLWD) and their care partners as the basis for a multistakeholder consensus conference to prioritize future research.

Design: Systematic scoping review.

Settings And Participants: PLWD and their care partners in the ED setting. Read More

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Optimising the reach of mobile health messaging programmes: an analysis of system generated data for the Kilkari programme across 13 states in India.

BMJ Glob Health 2022 Aug;6(Suppl 5)

Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Kilkari is an outbound service that makes weekly, stage-based, prerecorded calls about reproductive, maternal, neonatal and child health directly to families' mobile phones, starting from the second trimester of pregnancy and until the child is 1 year old. Since its initiation in 2012-2013, Kilkari has scaled to 13 states across India. In this analysis article, we explored the subscriber's journey from entry to programme to engagement with calls. Read More

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Optimization assisted framework for thyroid detection and classification: A new ensemble technique.

Gene Expr Patterns 2022 Aug 5:119268. Epub 2022 Aug 5.

MET's Institute of Engineering, Nashik, Maharashtra, USA.

Ultrasound (US) is an inexpensive and non-invasive technique for capturing the image of the thyroid gland and nearby tissue. The classification and detection of thyroid disorders is still in its infant stage. This study aims to present a new thyroid diagnosis approach, which consists of three phases like "(i) feature extraction, (ii) feature dimensionality reduction, and (iii) classification". Read More

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Proximal row carpectomy generates better mid- to long-term outcomes than four-corner arthrodesis for post-traumatic wrist arthritis: a meta-analysis.

Orthop Traumatol Surg Res 2022 Aug 5:103373. Epub 2022 Aug 5.

Elsan, Rue la Boétie 58, 75008 Paris, France.

Introduction: In posttraumatic wrist arthritis of intermediate severity, two main palliative procedures are used to preserve some mobility in the wrist: proximal row carpectomy (PRC) and scaphoid excision followed by four corner arthrodesis (4CA). Despite satisfactory overall results, the debate continues about which one provides the best results and long-term outcomes, particularly prevention of arthritis progression. Recent comparative studies now provide us with information about mid- and long-term results. Read More

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The anti-retrogradation properties of maize amylopectin treated by being co-crystallized with NaCl.

Int J Biol Macromol 2022 Aug 5. Epub 2022 Aug 5.

School of Science, Tianjin University of Commerce, Tianjin 300134, China.

Long-term retrogradation of amylopectin always leads to the quality deterioration of starch-based food. In this paper, the purified maize amylopectin was co-crystallized with NaCl to obtain anti-retrograded amylopectin. The results showed that the retrogradation rate of maize amylopectin dropped directly from 27. Read More

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Motion-Aligned 4D-MRI Reconstruction using Higher Degree Total Variation and Locally Low-Rank Regularization.

Magn Reson Imaging 2022 Aug 5. Epub 2022 Aug 5.

School of Electronics and Information Engineering, Harbin Institute of Technology, Harbin, China. Electronic address:

Four-dimensional magnetic resonance imaging (4D-MRI) is becoming increasingly important in radiotherapy treatment planning for its ability to simultaneously provide 3D structural information and temporal profiles of the examined tissues in a non-ionizing manner. However, the relatively long acquisition time and the resulting motion artifacts severely limit the further application of 4D-MRI. In this paper, we propose a novel motion-aligned reconstruction method based on higher degree total variation and locally low-rank regularization (maHDTV-LLR) to recover 4D MR images from the highly undersampled Fourier coefficients. Read More

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Deciphering the effect of exogenous lignocellulases addition on the composting efficiency and microbial communities.

Bioresour Technol 2022 Aug 5:127751. Epub 2022 Aug 5.

Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-saving fertilizers; Nanjing Agricultural University, Nanjing 210095, Jiangsu, People' Republic of China.

This study aimed to reveal the potential effects of exogenous lignocellulases addition on the composting efficiency and microbial communities. The lignocellulases addition at the mesophilic phase (MEP) greatly expedited the substrate conversion and the rise of temperature at the initial stage, driving the early arrival of thermophilic phase (THP), caused by the positive effects of Sphingobacterium and Brevundimonas. When being added at the THP, the potential functions and interactions of microbial communities were stimulated, especially for Thermobispora and Mycothermus, which prolonged the duration of the THP and expedited the humic acid formation. Read More

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The association between long-term glycemic control and all-cause mortality is different among older versus younger patients with diabetes mellitus and maintenance hemodialysis treatment.

Diabetes Res Clin Pract 2022 Aug 5:110033. Epub 2022 Aug 5.

Department of Nephrology, Skaraborg Hospital, Skövde; Department of Molecular and Clinical Medicine, Institute of Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, all Sweden. Electronic address:

Aims: Knowledge about association between glycated hemoglobin (HbA1c) and risk of all-cause mortality in patients with diabetes mellitus on maintenance hemodialysis (HD)-treatment is sparse. The study aims to investigate association between HbA1c and all-cause mortality in patients with diabetes and maintenance HD-treatment, separately for two age groups- above and below 75 years.

Methods: 2487 patients (mean age 66 years, 66% men) were separated in two age groups: ≤75years (n=1810) and >75years (n=677) and followed up between 2008 and 2018. Read More

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Amphibian Metamorphosis Assay: Investigation of the potential effects of five chemicals on the hypothalamic-pituitary thyroid axis of Xenopus laevis.

Regul Toxicol Pharmacol 2022 Aug 5:105241. Epub 2022 Aug 5.

Fort Environmental Laboratories Inc., 515 S. Duncan Street., Stillwater, OK, 74074, USA.

2-Ethylhexyl 4-hydroxybenzoate (2-EHHB), 4-tert-octylphenol (4-OP), 4-nonylphenol-branched (4-NP), benzyl butyl phthalate (BBP) and dibutyl phthalate (DBP) were evaluated using a 21-day Amphibian Metamorphosis Assay (AMA). Xenopus laevis larvae were exposed nominally to each chemical at 3.6, 10. Read More

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Antimicrobial Activity of Cuprous Oxide and Cupric Oxide-Coated Surfaces.

J Hosp Infect 2022 Aug 5. Epub 2022 Aug 5.

Department of Chemical Engineering and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, Virginia, 24061, USA. Electronic address:

Background: Disease can be spread through contact with contaminated surfaces (fomites). For example, fomites have been implicated in the spread of meticillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Antimicrobial surface treatments are a potential method of reducing disease transmission from fomites, and broad-spectrum activity is desirable. Read More

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Natural copper isotopic abnormity in maternal serum at early pregnancy associated to risk of spontaneous preterm birth.

Sci Total Environ 2022 Aug 5:157872. Epub 2022 Aug 5.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Spontaneous preterm birth (SPB) has drawn public attention due to its increasing incidence and adverse effects on fetal growth. Effect of copper (Cu) imbalance in maternal bodies on the risk of SPB remains a subject of debate, and the related mechanisms are still unraveled. Here we applied natural stable copper isotopes to explore the underlying association and mechanism of copper imbalance with SPB using a nested case-control study. Read More

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Monoclonal antibody sequence variants disguised as fragments: identification, characterization, and their removal by purification process optimization.

J Pharm Sci 2022 Aug 5. Epub 2022 Aug 5.

Biopharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, US.

During early stage development of a therapeutic IgG1 monoclonal antibody, high levels of low molecular weight (LMW) peaks were observed by high performance size-exclusion chromatography and capillary electrophoresis. Further characterization of the LMW peak enriched HPSEC fractions using reversed phase liquid chromatography coupled to mass spectrometry showed these LMW species were 47 kDa and 50 kDa in size. However, the measured masses could not be matched to any fragments resulting from peptide bond hydrolysis. Read More

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The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD): A Korean Chronic Kidney Disease Cohort.

J Prev Med Public Health 2022 Jul 1;55(4):313-320. Epub 2022 Jul 1.

Department of Internal Medicine, National Medical Center, Seoul, Korea.

The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was launched in 2011 with the support of the Korea Disease Control and Prevention Agency. The study was designed with the aim of exploring the various clinical features and characteristics of chronic kidney disease (CKD) in Koreans, and elucidating the risk factors for CKD progression and adverse outcomes of CKD. For the cohort study, nephrologists at 9 tertiary university-affiliated hospitals participated in patient recruitment and follow-up. Read More

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Reduction of DUSP4 contributes to podocytes oxidative stress, insulin resistance and diabetic nephropathy.

Biochem Biophys Res Commun 2022 Jul 30;624:127-133. Epub 2022 Jul 30.

From the Research Center of the Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Québec, Canada; Division of Endocrinology, Department of Medicine, Université de Sherbrooke, Québec, Canada. Electronic address:

Podocytes are insulin-sensitive cells, and their loss is critical in diabetic nephropathy (DN) progression that could lead to end-stage kidney disease. We have previously shown that decreased DUSP4 expression caused elevated JNK phosphorylation in the diabetic kidney and worsened DN characteristics. Yet, the role of DUSP4 in diabetic podocyte insulin resistance and the progression of DN remains unclear. Read More

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Effects of temporary rearing with organic selenium on the muscle flavor and texture properties of largemouth bass (Micropterus salmonides).

Food Chem 2022 Jul 20;397:133747. Epub 2022 Jul 20.

Institute of Agricultural Products Processing and Nuclear Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan 430064, China; Key Laboratory of Cold Chain Logistics Technology for Agro-product, Ministry of Agriculture and Rural Affairs, Wuhan 430064, China.

In this study, the influences of organic selenium (Se, 0.002 mg/L) on the muscle flavor and texture properties of Micropterus salmonides under fasting temporary rearing (8 weeks) was investigated. Electronic nose and headspace solid-phase microextraction-gas chromatography-mass spectrometry analysis suggested that organic Se regulated the types and contents of volatile compounds, especially aldehydes and ketones, which were increased in the early temporary rearing but decreased in the late stage. Read More

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First-in-human phase I study of TQ-B3139 (CT-711) in advanced non-small cell lung cancer patients with ALK and ROS1 rearrangements.

Eur J Cancer 2022 Aug 5;173:238-249. Epub 2022 Aug 5.

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. Electronic address:

Background: TQ-B3139 is a novel ALK tyrosine kinase inhibitor (TKI) against a broad range of ALK mutations. The aim of this first-in-human phase I trial was to investigate the safety, tolerability, pharmacokinetics, and clinical efficacy of TQ-B3139 in ALK or ROS1 positive advanced NSCLC patients.

Methods: Following a 3 + 3 design, patients received escalating daily dose of TQ-B3139 (50-800 mg) continuously in 28-day cycles. Read More

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Optimizing the use of patients' individual outcome information - Development and usability tests of a Chronic Kidney Disease dashboard.

Int J Med Inform 2022 Jul 29;166:104838. Epub 2022 Jul 29.

St. Antonius Hospital, Department of Internal Medicine, Nieuwegein, the Netherlands; Leiden University Medical Centre, Department of Internal Medicine, Leiden, the Netherlands.

Background: Reporting individual clinical and patient-reported outcomes to patients during consultations may add to patients' disease knowledge and activation and stimulate Shared Decision Making (SDM). These outcomes can be presented over time in a clear way by the means of dashboarding. We aimed to systematically develop a Chronic Kidney Disease (CKD) dashboard designed to support consultations, test its usability and explore conditions for optimal use in practice. Read More

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Translation, cross-cultural adaptation, and validation of the Swedish version of the female genital self-image scale.

Sex Reprod Healthc 2022 Jul 30;33:100758. Epub 2022 Jul 30.

Department of Obstetrics and Gynecology in Norrköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden. Electronic address:

Objective: The objective of the study was to translate and culturally adapt the Female Genital Self-Image Scale (FGSIS-7) into a valid and reliable Swedish version, and to test the instrument.

Methods: The instrument was translated into Swedish in a three-stage process of translation, back-translation and synthesis. The face validity of the pre-final translation was tested in a cognitive debriefing with a test group of eight women, while construct validity was tested in a group of six subject matter experts. Read More

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Sex disparities in lung cancer survival rates based on screening status.

Lung Cancer 2022 Aug 1;171:115-120. Epub 2022 Aug 1.

Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building I Room 1401, Boston, MA 02115, United States; Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02115, United States; Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, United States.

Objective: Low dose computed tomography (LDCT) became the standard method for lung cancer (LC) screening in 2013. However, it is unclear whether there are differences in survival rates based on sex and whether the differences depend on screening status. We aimed to evaluate the LC survival rates between females and males based on screening. Read More

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Conditional GANs based system for fibrosis detection and quantification in Hematoxylin and Eosin whole slide images.

Med Image Anal 2022 Jul 19;81:102537. Epub 2022 Jul 19.

Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.

Assessing the degree of liver fibrosis is fundamental for the management of patients with chronic liver disease, in liver transplants procedures, and in general liver disease research. The fibrosis stage is best assessed by histopathologic evaluation, and Masson's Trichrome stain (MT) is the stain of choice for this task in many laboratories around the world. However, the most used stain in histopathology is Hematoxylin Eosin (HE) which is cheaper, has a faster turn-around time and is the primary stain routinely used for evaluation of liver specimens. Read More

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PLCζ can stably regulate Ca fluctuations in early embryo.

Theriogenology 2022 Jun 21;191:16-21. Epub 2022 Jun 21.

College of Animal Science and Technology, Shihezi University, Shihezi, 832000, PR China. Electronic address:

Phospholipase C zeta (PLCζ) is an important inducer of Ca oscillations in mammalian sperm. To explore the influence of PLCζ on early embryonic Ca fluctuations during sperm-egg binding, this study used PLCζ from sheep sperm to construct an early embryonic Ca fluctuation model. First, sheep MII oocytes were cultivated and screened using microinjection technology. Read More

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Relations of neuropsychiatric symptoms with disease stage, sex, and daily function in mild cognitive impairment and dementia due to Alzheimer's disease: A cross-sectional study.

J Psychosom Res 2022 Jul 23;161:110994. Epub 2022 Jul 23.

Institute of Neuroscience, Chongqing Medical University, Chongqing, China. Electronic address:

Objective: To reveal the relations between neuropsychiatric symptoms (NPS), stages of cognitive impairment, sex, and daily function in patients with mild cognitive impairment (MCI) and dementia due to Alzheimer's disease (AD).

Methods: A cross-sectional study was conducted from 2014 to 2021 on 1154 patients. Cognitive function, disease severity, NPS, and daily function were evaluated by Mini-mental State Examination, Clinical Dementia Rating Scale, Neuropsychiatric Inventory, and Activities of Daily Living (ADL) respectively. Read More

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Lung infection of avian pathogenic Escherichia coli co-upregulates the expression of cSP-A and cLL in chickens.

Res Vet Sci 2022 Aug 1;152:99-106. Epub 2022 Aug 1.

Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, Anhui, China. Electronic address:

The host innate defense-pathogen interaction in the lung has always been a topic of concern. The respiratory tract is a common entry route for Avian pathogenic Escherichia coli (APEC). Chicken surfactant protein A (cSP-A) and chicken lung lectin (cLL) can bind to the carbohydrate moieties of various microorganisms. Read More

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Initial screening of gastric cancer using oral contrast-enhanced trans-abdominal ultrasonography in rural asymptomatic individuals.

Cancer Epidemiol 2022 Aug 5;80:102236. Epub 2022 Aug 5.

Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China. Electronic address:

Background & Aims: Initial screening for high-risk population of gastric cancer (GC) is needed in rural areas of large-population countries. This study aims to explore the feasibility of applying noninvasive ultrasonography as an initial screening strategy to improve the early diagnosis and prevention of GC.

Methods: Oral contrast-enhanced trans-abdominal ultrasonography (OCTU) was initially applied to screen around 15,000 residents from 24 different rural villages of Changxing Island in Shanghai, China, facilitating the identification of high-risk population for further endoscopy examination. Read More

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Disparities in Psychosocial Distress Screening and Management of Lung and Ovarian Cancer Survivors.

JCO Oncol Pract 2022 Aug 8:OP2200078. Epub 2022 Aug 8.

American College of Surgeons, Commission on Cancer, Chicago, IL.

Purpose: Since 2016, the American College of Surgeons' Commission on Cancer (CoC) has required routine distress screening (DS) of cancer survivors treated in their accredited facilities to facilitate early identification of survivors with psychosocial concerns. Lung and ovarian cancer survivors have relatively low 5-year survival rates and may experience high levels of distress. We examined the extent to which ovarian and lung cancer survivors received CoC-mandated DS and whether DS disparities exist on the basis of diagnosis, sociodemographic factors, or facility geography (urban/rural). Read More

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Clinicopathology and Treatment Patterns of Head and Neck Cancers in Ethiopia.

JCO Glob Oncol 2022 Aug;8:e2200073

Surveillance and Health Service Research, American Cancer Society, Atlanta, GA.

Purpose: Head and neck cancers are the third most common cancers treated with radiation in Ethiopia. There is, however, a lack of published data on clinical and pathological characteristics and treatment patterns of head and neck cancers in the country. The objective of the study was to assess clinical and pathological characteristics and treatment patterns of head and neck cancers at Tikur Anbessa Specialized Hospital, which housed the only radiotherapy facility in Ethiopia during the study period. Read More

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Dwiroopa punicae Causing Leaf Spot Disease on Pomegranate in Guizhou, China.

Plant Dis 2022 Aug 8. Epub 2022 Aug 8.

Plant Pathology, Guizhou University, Guiyang, Guizhou, China, 550025;

Punica granatum 'Tunisia' is widely planted in several areas of Kaiyang County, Guizhou Province, China. Symptoms of leaf spot and fruit rot were observed in April 2020. Infected pomegranate leaves exhibited scattered, oval, yellow-to-brown spots (2-5 mm), and numerous melanized pycnidia were observed in the center of the lesions. Read More

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