1,694 results match your criteria stable inheritance

Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation.

Nat Commun 2021 May 11;12(1):2694. Epub 2021 May 11.

Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

N-Methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for synaptic plasticity and memory. Receptor activation involves glycine- and glutamate-stabilized closure of the GluN1 and GluN2 subunit ligand binding domains that is allosterically regulated by the amino-terminal domain (ATD). Using single molecule fluorescence resonance energy transfer (smFRET) to monitor subunit rearrangements in real-time, we observe a stable ATD inter-dimer distance in the Apo state and test the effects of agonists and antagonists. Read More

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Francis Galton's regression towards mediocrity and the stability of types.

Stud Hist Philos Sci 2021 Jan 16;86:6-19. Epub 2021 Jan 16.

The Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv University, Ramat Aviv, 6997801, Tel Aviv, Israel.

A prevalent narrative locates the discovery of the statistical phenomenon of regression to the mean in the work of Francis Galton. It is claimed that after 1885, Galton came to explain the fact that offspring deviated less from the mean value of the population than their parents did as a population-level statistical phenomenon and not as the result of the processes of inheritance. Arguing against this claim, we show that Galton did not explain regression towards mediocrity statistically, and did not give up on his ideas regarding an inheritance process that caused offspring to revert to the mean. Read More

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January 2021

A biomimetic peptide has no effect on the isotopic fractionation during in vitro silica precipitation.

Sci Rep 2021 May 6;11(1):9698. Epub 2021 May 6.

University of Bristol, School of Earth Sciences, Wills Memorial Building, Queen's Road, Brsitol, BS8 1RJ, UK.

The stable isotopic composition of diatom silica is used as a proxy for nutrient utilisation in natural waters. This approach provides essential insight into the current and historic links between biological production, carbon cycling and climate. However, estimates of isotopic fractionation during diatom silica production from both laboratory and field studies are variable, and the biochemical pathways responsible remain unknown. Read More

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Bivalve molluscs as model systems for studying mitochondrial biology.

Integr Comp Biol 2021 May 4. Epub 2021 May 4.

Department of Biological, Geological, and Environmental Sciences, University of Bologna, Italy.

The class Bivalvia is a highly successful and ancient taxon including ∼25,000 living species. During their long evolutionary history bivalves adapted to a wide range of physicochemical conditions, habitats, biological interactions, and feeding habits. Bivalves can have strikingly different size, and despite their apparently simple body plan, they evolved very different shell shapes, and complex anatomic structures. Read More

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Molecular Cytogenetic and Agronomic Characterization of the Similarities and Differences Between Wheat- Trin. and Wheat- Keng 3Ns (3D) Substitution Lines.

Front Plant Sci 2021 31;12:644896. Epub 2021 Mar 31.

College of Agronomy, Northwest A&F University, Xianyang, China.

Keng (2 = 2 = 14, NsNs) and Trin. (2 = 4 = 28, NsNsXmXm) are valuable resources for wheat breeding improvement as they share the Ns genome, which contains diverse resistance genes. To explore the behaviors and traits of Ns chromosomes from the two species in wheat background, a series of wheat- and wheat- substitution lines were developed. Read More

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Photodynamic Therapy (PDT) for Retinal Hemangioblastoma: Treatment Outcomes in 17 Consecutive Patients.

Ophthalmol Retina 2021 Apr 20. Epub 2021 Apr 20.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Purpose: To report the efficacy of photodynamic therapy (PDT) for management of retinal hemangioblastoma.

Design: Retrospective case series.

Participants: Seventeen patients with retinal hemangioblastoma treated with PDT. Read More

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Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers.

PLoS Genet 2021 04 22;17(4):e1009418. Epub 2021 Apr 22.

Division of Biological Sciences, University of Montana, Missoula Montana, United States of America.

Centromeres are essential mediators of chromosomal segregation, but both centromeric DNA sequences and associated kinetochore proteins are paradoxically diverse across species. The selfish centromere model explains rapid evolution by both components via an arms-race scenario: centromeric DNA variants drive by distorting chromosomal transmission in female meiosis and attendant fitness costs select on interacting proteins to restore Mendelian inheritance. Although it is clear than centromeres can drive and that drive often carries costs, female meiotic drive has not been directly linked to selection on kinetochore proteins in any natural system. Read More

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Homozygous Familial Hypercholesterolemia.

J Atheroscler Thromb 2021 Apr 18. Epub 2021 Apr 18.

Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute.

Familial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated pathway and most of them exhibit autosomal dominant inheritance. Homozygotes of FH (HoFH) may have plasma LDL-C levels, which are at least twice as high as those of heterozygous FH (HeFH) and therefore four times higher than normal levels. Prevalence of HoFH had been estimated as 1 in 1,000,000 before but more recent genetic analysis surveys predict 1 in 170,000 to 300,000. Read More

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The epiallelic potential of transposable elements and its evolutionary significance in plants.

Philos Trans R Soc Lond B Biol Sci 2021 Jun 19;376(1826):20200123. Epub 2021 Apr 19.

Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Normale Supérieure, PSL Research University, 75005 Paris, France.

DNA provides the fundamental framework for heritability, yet heritable trait variation need not be completely 'hard-wired' into the DNA sequence. In plants, the epigenetic machinery that controls transposable element (TE) activity, and which includes DNA methylation, underpins most known cases of inherited trait variants that are independent of DNA sequence changes. Here, we review our current knowledge of the extent, mechanisms and potential adaptive contribution of epiallelic variation at TE-containing alleles in this group of species. Read More

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The regulation mechanisms and the Lamarckian inheritance property of DNA methylation in animals.

Mamm Genome 2021 Apr 15. Epub 2021 Apr 15.

College of Animal Science and Technology, Northwest A&F University, Yangling, Xi'an, Shaanxi, 712100, People's Republic of China.

DNA methylation is a stable and heritable epigenetic mechanism, of which the main functions are stabilizing the transcription of genes and promoting genetic conservation. In animals, the direct molecular inducers of DNA methylation mainly include histone covalent modification and non-coding RNA, whereas the fundamental regulators of DNA methylation are genetic and environmental factors. As is well known, competition is present everywhere in life systems, and will finally strike a balance that is optimal for the animal's survival and reproduction. Read More

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Microinjection of Corn Planthopper, Peregrinus maidis, Embryos for CRISPR/Cas9 Genome Editing.

J Vis Exp 2021 03 26(169). Epub 2021 Mar 26.

Department of Entomology and Plant Pathology, North Carolina State University;

The corn planthopper, Peregrinus maidis, is a pest of maize and a vector of several maize viruses. Previously published methods describe the triggering of RNA interference (RNAi) in P. maidis through microinjection of double-stranded RNAs (dsRNAs) into nymphs and adults. Read More

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Structure of levitated Si-Ge melts studied by high-energy x-ray diffraction in combination with reverse Monte Carlo simulations.

J Phys Condens Matter 2021 Apr 7. Epub 2021 Apr 7.

ICMN, 1b rue de la Férollerie, Orleans, 45071, FRANCE.

The short-range order in liquid Si, Ge and binary Six-Ge1-x alloys (x = 0.25, 0.50, 0. Read More

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CRISPR/Cas9 Guided Mutagenesis of Confers Increased Rice ( L.) Grain Length by Regulating Cysteine Proteinase Inhibitor and Ubiquitin-Related Proteins.

Int J Mol Sci 2021 Mar 22;22(6). Epub 2021 Mar 22.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, Guangxi University, Nanning 530004, China.

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas9)-mediated genome editing has become an important way for molecular breeding in crop plants. To promote rice breeding, we edited the () gene for obtaining valuable and stable long-grain rice mutants. Furthermore, isobaric tags for the relative and absolute quantitation (iTRAQ)-based proteomic method were applied to determine the proteome-wide changes in the mutants compared with wild type (WT). Read More

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Mitotic inheritance of DNA methylation: more than just copy and paste.

J Genet Genomics 2021 Feb 19. Epub 2021 Feb 19.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:

Decades of investigation on DNA methylation have led to deeper insights into its metabolic mechanisms and biological functions. This understanding was fueled by the recent development of genome editing tools and our improved capacity for analyzing the global DNA methylome in mammalian cells. This review focuses on the maintenance of DNA methylation patterns during mitotic cell division. Read More

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February 2021

The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio).

Sci Total Environ 2021 Mar 17;779:146404. Epub 2021 Mar 17.

Man-Technology-Environment Research Centre (MTM), School of Science and Technology, Örebro University, Fakultetsgatan 1, S-701 82 Örebro, Sweden.

The pyrethroid insecticide permethrin is widely used for agricultural and domestic purposes. Previous data indicated that it acts as a developmental neurotoxicant and can induce transgenerational effects in non-target organisms. However, associated underlying mechanisms remain unclear. Read More

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A novel allele of SIR2 reveals a heritable intermediate state of gene silencing.

Genetics 2021 Mar 13. Epub 2021 Mar 13.

Department of Molecular and Cell Biology; University of California, Berkeley; Berkeley, CA.

Genetic information acquires additional meaning through epigenetic regulation, the process by which genetically identical cells can exhibit heritable differences in gene expression and phenotype. Inheritance of epigenetic information is a critical step in maintaining cellular identity and organismal health. In Saccharomyces cerevisiae, one form of epigenetic regulation is the transcriptional silencing of two mating-type loci, HML and HMR, by the SIR-protein complex. Read More

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Targeted mutagenesis of two homologous ATP-binding cassette subfamily G (ABCG) genes in tomato confers resistance to parasitic weed Phelipanche aegyptiaca.

J Plant Res 2021 May 11;134(3):585-597. Epub 2021 Mar 11.

Department of Plant Pathology and Weed Research, Newe Ya'ar Research Center, Agricultural Research Organization (ARO), Ramat Yishay, Israel.

Phelipanche aegyptiaca and Orobanche spp. are obligate plant root-parasitic weeds that cause extensive damage in agricultural crop plants. Their germination requires exposure to strigolactones (SLs) exuded by the host plant roots. Read More

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Chromosome inheritance and meiotic stability in allopolyploid Brassica napus.

G3 (Bethesda) 2021 Feb;11(2)

Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.

Homoeologous recombination, aneuploidy, and other genetic changes are common in resynthesized allopolyploid Brassica napus. In contrast, the chromosomes of cultivars have long been considered to be meiotically stable. To gain a better understanding of the underlying mechanisms leading to stabilization in the allopolyploid, the behavior of chromosomes during meiosis can be compared by unambiguous chromosome identification between resynthesized and natural B. Read More

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February 2021

Descriptive epidemiology of clinically significant occupational poisonings, United States, 2008-2018.

Clin Toxicol (Phila) 2021 Mar 11:1-9. Epub 2021 Mar 11.

Division of Clinical Toxicology, Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA, USA.

Introduction: References listing common occupational poisons often include agents that were observed decades prior to the introduction of worker protective laws and regulations. Current causes of work-related acute poisonings have not been characterized. This study's primary objective was to describe the most common poisons and routes of exposure responsible for clinically significant occupational poisonings. Read More

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Differential contributions of static and time-varying functional connectivity to human behavior.

Netw Neurosci 2021 1;5(1):145-165. Epub 2021 Feb 1.

Helen Wills Neuroscience Institute, University of California, Berkeley.

Measures of human brain functional connectivity acquired during the resting-state track critical aspects of behavior. Recently, fluctuations in resting-state functional connectivity patterns-typically averaged across in traditional analyses-have been considered for their potential neuroscientific relevance. There exists a lack of research on the differences between traditional "static" measures of functional connectivity and newly considered "time-varying" measures as they relate to human behavior. Read More

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February 2021

CRISPR/Cas9-Mediated Generation of Pathogen-Resistant Tomato against and Powdery Mildew.

Int J Mol Sci 2021 Feb 13;22(4). Epub 2021 Feb 13.

Division of Applied Life Science (BK21 FOUR Program), Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-701, Korea.

Tomato is one of the major vegetable crops consumed worldwide. (TYLCV) and fungal sp. are devastating pathogens causing yellow leaf curl disease and powdery mildew. Read More

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February 2021

Disruption of egg-specific protein causes female sterility in Bombyx mori.

Insect Sci 2021 Feb 24. Epub 2021 Feb 24.

Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.

Yolk proteins are the main source of nutrients during embryonic and early larval development in oviparous animals. Therefore, vitellogenesis is crucial for reproduction. The silkworm, Bombyx mori, is a model lepidopteran insect in which there are three yolk proteins: vitellin, 30-kDa protein, and egg-specific protein (Esp). Read More

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February 2021

A case report of congenital idiopathic hypogonadotropic hypogonadism caused by novel mutation of GNRHR gene.

Medicine (Baltimore) 2021 Feb;100(5):e24007

Peking University Shenzhen Hospital.

Rationale: This study aimed to investigate the genetic mutation characteristics of congenital idiopathic hypogonadotropic hypogonadism (IHH) through the clinical features and genetic analysis of 2 patients with IHH in 1 pedigree.

Patient Concerns: A 23-year-old girl presented with primary amenorrhea, sparse pubic hair, lack of breast development, and delayed sexual development.

Diagnoses: Combined with the clinical characteristics, auxiliary examinations, and molecular genetic analysis, the patient was diagnosed as IHH. Read More

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February 2021

Colonization dynamics of Pantoea agglomerans in the wheat root habitat.

Environ Microbiol 2021 Apr 18;23(4):2260-2273. Epub 2021 Feb 18.

Institute of General Microbiology, Christian-Albrechts University of Kiel, Am Botanischen Garten 11, Kiel, 24118, Germany.

Plants are colonized by microbial communities that have diverse implications for plant development and health. The establishment of a stable plant-bacteria interaction depends on a continuous coexistence over generations. Transmission via the seed is considered as the main route for vertical inheritance of plant-associated bacteria. Read More

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A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA.

Genome Biol Evol 2021 Mar;13(3)

Department of Biological, Geological, and Environmental Sciences, University of Bologna, Italy.

Mitochondrial DNA (mtDNA) is present in multiple copies within an organism. Since these copies are not identical, a single individual carries a heterogeneous population of mtDNAs, a condition known as heteroplasmy. Several factors play a role in the dynamics of the within-organism mtDNA population: among them, genetic bottlenecks, selection, and strictly maternal inheritance are known to shape the levels of heteroplasmy across mtDNAs. Read More

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Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability.

Am J Hum Genet 2021 02;108(2):269-283

Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37235, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, 94158; Bakar Institute for Computational Health Sciences, University of California, San Francisco, CA, 94158. Electronic address:

Topologically associating domains (TADs) are fundamental units of three-dimensional (3D) nuclear organization. The regions bordering TADs-TAD boundaries-contribute to the regulation of gene expression by restricting interactions of cis-regulatory sequences to their target genes. TAD and TAD-boundary disruption have been implicated in rare-disease pathogenesis; however, we have a limited framework for integrating TADs and their variation across cell types into the interpretation of common-trait-associated variants. Read More

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February 2021

Sustained benefits of cognitive training in children with inattention, three-year follow-up.

PLoS One 2021 4;16(2):e0246449. Epub 2021 Feb 4.

Research Division, Cortica Healthcare, San Rafael, California, United States of America.

The goal of this study was to test for long-term benefits three years after the completion of a cognitive training intervention (Project: EVO™) in a subset of children with Sensory Processing Dysfunction (SPD). Our initial findings revealed that children with SPD who also met research criteria for Attention Deficit Hyperactivity Disorder (SPD+IA) showed a significant decrease in parent-observed inattentive behaviors, which remained stable in a nine-month follow-up assessment. Forty nine caregivers of participants who completed the Project: EVO™ training were contacted to be included in this follow up study. Read More

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February 2021

Non-perfectly matching small RNAs can induce stable and heritable epigenetic modifications and can be used as molecular markers to trace the origin and fate of silencing RNAs.

Nucleic Acids Res 2021 02;49(4):1900-1913

University of Edinburgh, Institute of Molecular Plant Sciences, Max Born Crescent, Edinburgh EH9 3BF, UK.

Short non-coding RNA molecules (sRNAs) play a fundamental role in gene regulation and development in higher organisms. They act as molecular postcodes and guide AGO proteins to target nucleic acids. In plants, sRNA-targeted mRNAs are degraded, reducing gene expression. Read More

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February 2021

Non-genetic inheritance restraint of cell-to-cell variation.

Elife 2021 Feb 1;10. Epub 2021 Feb 1.

Department of Physics and Astronomy, The Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, United States.

Heterogeneity in physical and functional characteristics of cells (e.g. size, cycle time, growth rate, protein concentration) proliferates within an isogenic population due to stochasticity in intracellular biochemical processes and in the distribution of resources during divisions. Read More

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February 2021

Stable inheritance of Sinorhizobium meliloti cell growth polarity requires an FtsN-like protein and an amidase.

Nat Commun 2021 01 22;12(1):545. Epub 2021 Jan 22.

Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universität Marburg, Marburg, Germany.

In Rhizobiales bacteria, such as Sinorhizobium meliloti, cell elongation takes place only at new cell poles, generated by cell division. Here, we show that the role of the FtsN-like protein RgsS in S. meliloti extends beyond cell division. Read More

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January 2021