BMC Neurosci 2007 Jul 2;8:46. Epub 2007 Jul 2.
Brain Research Institute, University of Zurich, Zurich, Switzerland.
Background: Development of neural networks requires that synapses are formed, eliminated and stabilized. At the neuromuscular junction (NMJ), agrin/MuSK signaling, by triggering downstream pathways, causes clustering and phosphorylation of postsynaptic acetylcholine receptors (AChRs). Postnatally, AChR aggregates are stabilized by molecular pathways that are poorly characterized. Read More