107,963 results match your criteria stability studies

KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.

Biochem Biophys Res Commun 2021 Apr 16;557:192-198. Epub 2021 Apr 16.

Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China. Electronic address:

Kinesin family member 18A (KIF18A) is significantly overexpressed and is related to the poor prognosis of human cancers. However, the function of KIF18A in esophageal cancer (EC) is still unclear. Human EC cell lines were used in this study. Read More

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Ataluren metabolism: Ataluren-O-1β-acyl glucuronide is a stable circulating metabolite in mouse, rat, dog and human.

Drug Metab Pharmacokinet 2021 Mar 30;38:100393. Epub 2021 Mar 30.

PTC Therapeutics, Inc., South Plainfield, NJ, USA. Electronic address:

Ataluren is an aromatic acid derivative with a 1,2,4-oxodiazole moiety. Ataluren-O-1β-acyl glucuronide is a prominent circulatory metabolite in mice, rats, dogs, and humans following oral administration of ataluren. The objective of this paper was to evaluate the stability in vitro and in vivo of ataluren-O-1β-acyl glucuronide metabolite. Read More

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ZrCaP thermoluminescent bio glass, structure and elasticity.

J Mech Behav Biomed Mater 2021 Apr 13;119:104517. Epub 2021 Apr 13.

Department of Information Technology, Sreenidhi Institute of Science and Technology, JNT University, Hyderabad, 501301, India.

Phosphate glasses of calcium oxide have been well proved materials for various bio bones and dental implants. However, still there is a lot of scope and demand to produce efficient elastic bio implants and resource. In view of this, ZrCaP phosphate materials are prepared by using melt quenching method. Read More

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Effect of phosphonate functional group on corrosion inhibition of imidazoline derivatives in acidic environment.

J Colloid Interface Sci 2021 Apr 6;597:242-259. Epub 2021 Apr 6.

School of Petroleum Engineering, Yangtze University, Wuhan 434023, Hubei, China.

In the present study, ({2-[2-(7-Isopropyl-1,4-dimethyl-9,10-octahydro-phenanthren-1-yl)-4,5-dihydro-1-yl]-ethylamino}-methyl)-phosphonicimidazole (GSIM) was synthesized by introducing phosphonate (-PHO) group into imidazoline derivatives and its corrosion inhibition performance was studied for Q345 steel in acidic medium along with SIM using potentiodynamic polarization, EIS and SECM analysis. Surface analysis of steel samples was also performed by optical microscopy and SEM-EDS analysis after polarization tests. XPS was used to detect chemical composition of the surface passive films. Read More

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Effect of radio frequency glow-discharge treatment of titanium on human gingival fibroblasts as a function of distance.

J Biomed Mater Res B Appl Biomater 2021 Apr 19. Epub 2021 Apr 19.

Biomaterials Graduate Program, The State University of New York at Buffalo, Buffalo, New York, USA.

The mechanical stability and long-term success of an implant depends on the early healing phase and osseointegration of the bone around it. In addition, a healthy gingival tissue around the implant acts as a barrier that prevents bacteria and pathological byproducts from reaching the implant site. This study investigated the in-vitro attachment and spreading of human gingival fibroblasts (HGF) on bacterial grade polystyrene (PS) at different distances from radio-frequency glow-discharge (RFGD)-treated commercially pure titanium (cpTi) specimens. Read More

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Optimal Bounded Ellipsoid Identification With Deterministic and Bounded Learning Gains: Design and Application to Euler-Lagrange Systems.

IEEE Trans Cybern 2021 Apr 19;PP. Epub 2021 Apr 19.

This article proposes an effective optimal bounded ellipsoid (OBE) identification algorithm for neural networks to reconstruct the dynamics of the uncertain Euler-Lagrange systems. To address the problem of unbounded growth or vanishing of the learning gain matrix in classical OBE algorithms, we propose a modified OBE algorithm to ensure that the learning gain matrix has deterministic upper and lower bounds (i.e. Read More

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Metal-Amino Acid Nanofibers based Triboelectric Nanogenerator for Self-Powered Thioacetamide Sensor.

ACS Appl Mater Interfaces 2021 Apr 19. Epub 2021 Apr 19.

Nanomaterials and System Lab, Faculty of Applied Energy Systems, Major of Mechatronics Engineering, Jeju National University, Jeju 690756, South Korea.

The biomolecules offer different metal-binding sites to form a coordination polymer with structural diversity. The coordination directed one-dimensional metal-biomolecule nanofibers (Cu-Asp NFs) designed using copper as metal ion and aspartate as a ligand for triboelectric nanogenerator (TENG) is reported here. The different characterization techniques reveal the detailed characteristics of the synthesized Cu-Asp NFs. Read More

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Enhancing the Thermal Stability of NASICON Solid Electrolyte Pellets against Metallic Lithium by Defect Modification.

ACS Appl Mater Interfaces 2021 Apr 19. Epub 2021 Apr 19.

Beijing Advanced Innovation Center for Materials Genome Engineering, Key Laboratory for Renewable Energy, Beijing Key Laboratory for New Energy Materials and Devices, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

All-solid-state batteries (ASSBs) are expected to address the battery safety issues fundamentally by replacing the flammable electrolyte with solid electrolytes (SEs). However, recent studies report that the thermal runaway happened for NASICON-type SEs when they contact with Li metal at high temperature and indicate that the ASSBs may not be totally safe. Here, the thermal stability of a NASICON-type LiAlTi(PO) (LATP) SE pellet against metallic lithium is quantified in a quasi-practical situation. Read More

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Validation of the AtlasTMCampylobacter Detection Assay: AOAC Performance Tested MethodSM 032101.

J AOAC Int 2021 Apr 19. Epub 2021 Apr 19.

Molecular Epidemiology, Inc. and IEH Laboratories and Consulting Group, Inc., 15300 Bothell Way NE, Lake Forest Park, WA 98155, USA.

Background: Campylobacter spp. is a major causal agent for diarrheal illness in humans. Detection of Campylobacter spp. Read More

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Inferring adaptive codon preference to understand sources of selection shaping codon usage bias.

Mol Biol Evol 2021 Apr 19. Epub 2021 Apr 19.

Milner Centre for Evolution and Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Alternative synonymous codons are often used at unequal frequencies. Classically, studies of such codon usage bias (CUB) attempted to separate the impact of neutral from selective forces by assuming that deviations from a predicted neutral equilibrium capture selection. However, GC biased gene conversion (gBGC) can also cause deviation from a neutral null. Read More

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Coordination Properties of Hydroxyisophthalic Acids: Topological Correlations, Synthesis, Structural Analysis, and Properties of New Complexes.

Chemistry 2021 Apr 19. Epub 2021 Apr 19.

Samara State Technical University Faculty of Chemical Technology, Samara Center for Theoretical Materials Science, Molodogvardeyskaya St. 244, 443100, Samara, RUSSIAN FEDERATION.

Hydroxyisophthalic acids are valuable polytopic ligands for the design of functional materials based on coordination polymers due to the variety of charges and coordination modes they possess. Here we describe synthesis, thermal stability, non-linear optical and spectroscopic properties of five novel coordination compounds [K 2 L(H 2 O) 2 ], [MgL(H 2 O) 2 ]·3H 2 O, [CaL(H 2 O) 3 ], [SrL(H 2 O) 3 ]·H 2 O, [BaL(H 2 O)(H 2 O) 5 ] and one salt (NH 4 ) 2 L·2H 2 O with 4,5,6-trihydroxyisophthalic acid ( H 2 L ), which has not been tested in the assembling crystalline coordination networks before.  Peculiarities of the structural organization of the compounds were analyzed and compared with those for other hydroxyisophthalates. Read More

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Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris.

Expert Opin Drug Deliv 2021 Apr 19. Epub 2021 Apr 19.

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, India 160 014.

: The combination therapy of Isotretinoin (ITR) and antibacterial formulations administered through topical route suffer from several limitations including reduced therapeutic efficacy and low patient-compliance.: The present study aimed to develop biocompatible lipid-based mixed micelles of ITR in combination with Clindamycin phosphate (CLIN) employing self-assembly method to improve its skin delivery, photostability, biocompatibility and pharmacodynamic efficacy.: The MTT assay and cellular uptake studies showed non-cytotoxic effect to HaCat cell lines. Read More

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A Novel Green Approach to Synthesize Curcuminoid-Layered Double Hydroxide Nanohybrids: Adroit Biomaterials for Future Antimicrobial Applications.

ACS Omega 2021 Apr 30;6(14):9600-9608. Epub 2021 Mar 30.

Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Soratha Mawatha, Nugegoda 10250, Sri Lanka.

Thermal instability, photodegradation, and poor bioavailability of natural active ingredients are major drawbacks in developing effective natural product-based antimicrobial formulations. These inherited issues could be fruitfully mitigated by the introduction of natural active ingredients into various nanostructures. This study focuses on the development of a novel green mechanochemical synthetic route to incorporate curcuminoids into Mg-Al-layered double hydroxides. Read More

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Sustainable Synthesis of MOF-5@GO Nanocomposites for Efficient Removal of Rhodamine B from Water.

ACS Omega 2021 Apr 30;6(14):9587-9599. Epub 2021 Mar 30.

Department of Chemistry, University of Delhi, Delhi 110007, India.

Herein, a metal-organic framework (MOF-5) is synthesized by a solvothermal process and graphene oxide (GO) is prepared from the improved Hummer's method. The synthesis of MOF-5@GO nanocomposites is one-pot process a grinding method and employed for the removal of Rhodamine B (RhB) dye. The removal efficiency of RhB is found to be 60. Read More

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High-throughput nuclear magnetic resonance measurement of citrate in serum and plasma in the clinical laboratory.

Pract Lab Med 2021 May 18;25:e00213. Epub 2021 Mar 18.

Laboratory Corporation of America Holdings (Labcorp), Morrisville, NC, USA.

Objectives: Despite reports highlighting citrate association with different diseases, serum citrate is scarcely used for diagnosis. Existing methods to quantify citrate are limited by their complexity and practicality of implementation. A simple and rapid NMR-based method to measure circulating citrate is described here, and its analytical performance evaluated. Read More

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Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View.

Front Cell Dev Biol 2021 1;9:658481. Epub 2021 Apr 1.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, United States.

Initially identified in , the Hippo signaling pathway has emerged as an evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ size by simultaneously inhibiting cell proliferation and promoting cell death. Deregulation of Hippo pathway activity has been implicated in a wide range of human cancers. The core Hippo pathway consists of a kinase cascade: an upstream kinase Hippo (Hpo)/MST1/2 phosphorylates and activates a downstream kinase Warts (Wts)/Lats1/2, leading to phosphorylation and inactivation of a transcriptional coactivator Yki/YAP/Taz. Read More

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Dynamic Histone H3 Modifications Regulate Meiosis Initiation via Respiration.

Front Cell Dev Biol 2021 1;9:646214. Epub 2021 Apr 1.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, College of Life Sciences, University of Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China.

Meiosis is essential for genetic stability and diversity during sexual reproduction in most eukaryotes. Chromatin structure and gene expression are drastically changed during meiosis, and various histone modifications have been reported to participate in this unique process. However, the dynamic of histone modifications during meiosis is still not well investigated. Read More

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Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma.

Front Oncol 2021 26;11:653846. Epub 2021 Mar 26.

Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Exosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs . Read More

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investigation of gastrointestinal stability and toxicity of 3-hyrdoxypropionaldehyde (reuterin) produced by .

Toxicol Rep 2021 31;8:740-746. Epub 2021 Mar 31.

Food Science Department, Food and Agriculture Faculty, Laval University, Quebec, Quebec, Canada.

Reuterin (3-hyrdoxypropionaldehyde (3-HPA)) is a highly potent metabolite of , which has applications in food, health, and veterinary sectors. Similar to other natural antimicrobial compounds, the approval of reuterin as a bio-preservative or therapeutic agent by regulatory agencies relies on sufficient data on its cytotoxicity and behavior in the gastrointestinal environment. Although the antimicrobial activity of reuterin has been broadly studied, its safety and toxicity are yet to be explored in detail. Read More

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Interspinous Process (ISP) Devices in Comparison to the Use of Traditional Posterior Spinal Instrumentation.

Cureus 2021 Mar 14;13(3):e13886. Epub 2021 Mar 14.

Neurosurgery, Hoag Memorial Hospital, Newport Beach, USA.

A systematic literature review was conducted on studies comparing interspinous process (ISP) devices to traditional methods of posterior spinal instrumentation (pedicle screw-rod construct), in terms of indications of use, complications, pain assessment, estimated blood loss, length of hospital stay, reoperation rates, and return to work. The objective was to analyze, evaluate and summarize the current published literature on the proposed efficacy and clinical and surgical long-term outcomes of the ISP device in comparison to the traditional posterior spinal instrumentation (pedicle screw-rod construct). The ISP device is a minimally invasive and less disruptive alternative to traditional methods of posterior spinal instrumentation (pedicle screw-rod construct). Read More

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Comparing a Mixed Model Approach to Traditional Stability Estimators for Mapping Genotype by Environment Interactions and Yield Stability in Soybean [ (L.) Merr.].

Front Plant Sci 2021 31;12:630175. Epub 2021 Mar 31.

Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, United States.

Identifying genetic loci associated with yield stability has helped plant breeders and geneticists begin to understand the role and influence of genotype by environment (GxE) interactions in soybean [ (L.) Merr.] productivity, as well as other crops. Read More

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Changes in DNA Methylation in Plants Exposed Over Multiple Generations to Gamma Radiation.

Front Plant Sci 2021 31;12:611783. Epub 2021 Mar 31.

Biosphere Impact Studies, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.

Previous studies have found indications that exposure to ionising radiation (IR) results in DNA methylation changes in plants. However, this phenomenon is yet to be studied across multiple generations. Furthermore, the exact role of these changes in the IR-induced plant response is still far from understood. Read More

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The binding mechanism of ivermectin and levosalbutamol with spike protein of SARS-CoV-2.

Struct Chem 2021 Apr 12:1-8. Epub 2021 Apr 12.

Department of Chemistry, Jagannath University, Dhaka, 1100 Bangladesh.

In this study, we have investigated the binding mechanism of two FDA-approved drugs (ivermectin and levosalbutamol) with the spike protein of SARs-CoV-2 using three different computational modeling techniques. Molecular docking results predict that ivermectin shows a large binding affinity for spike protein (- 9.0 kcal/mol) compared to levosalbutamol (- 4. Read More

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In extruded feline diets, thiamine degraded at a similar rate when stored at -20°C, compared to room temperature.

Can Vet J 2021 Apr;62(4):374-378

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1 (DiSabatino, Kritikos, Monteith, Verbrugghe); Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30605, USA (Parr).

Thiamine is an essential dietary nutrient in cats; however, studies on the stability of thiamine in pet food are limited. The objective of this study was to analyze thiamine concentrations in commercial feline extruded diets over time at room and freezing temperatures. Twelve diets were split in half and thiamine concentrations were assessed using fluorometry. Read More

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A systematic review of the factors associated with the course of borderline personality disorder symptoms in adolescence.

Borderline Personal Disord Emot Dysregul 2021 Apr 19;8(1):12. Epub 2021 Apr 19.

Department of Clinical Psychology, Institute of Psychology, Faculty of Philosophy, Vilnius University, Universiteto st. 9, LT-01513, Vilnius, Lithuania.

Background: Research on personality pathology in adolescence has accelerated during the last decade. Among all of the personality disorders, there is strong support for the validity of borderline personality disorder (BPD) diagnosis in adolescence with comparable stability as seen in adulthood. Researchers have put much effort in the analysis of the developmental pathways and etiology of the disorder and currently are relocating their attention to the identification of the possible risk factors associated with the course of BPD symptoms during adolescence. Read More

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Physicochemical characterization of dapagliflozin and its solid-state behavior in stress stability test.

Drug Dev Ind Pharm 2021 Apr 19:1-32. Epub 2021 Apr 19.

Department of Physical Medicine and Rehabilitation, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.

As an active pharmaceutical ingredient, dapagliflozin propanediol monohydrate has been used in the solvated form consisting of dapagliflozin compounded with (S)-propylene glycol and monohydrate at a (1:1:1) ratio. However, dapagliflozin propanediol loses the solvent's reduced lattice structure at slightly higher temperatures. Due to its sensitive solid-state stability, the temperature and humidity are strictly controlled during the production and storage of dapagliflozin. Read More

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Complexation of Lanthanides and Heavy Actinides with Aqueous Sulfur-Donating Ligands.

Inorg Chem 2021 Apr 18. Epub 2021 Apr 18.

Colorado School of Mines, 1500 Illinois Street, Golden, Colorado 80401, United States.

The separation of trivalent lanthanides and actinides is challenging because of their similar sizes and charge densities. S-donating extractants have shown significant selectivity for trivalent actinides over lanthanides, with single-stage americium/lanthanide separation efficiencies for some thiol-based extractants reported at >99.999%. Read More

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Comparison of different fixation techniques for periprosthetic fractures: a biomechanical study of a new implant.

Int Orthop 2021 Apr 17. Epub 2021 Apr 17.

Department of Biomechanical Engineering, Afyon Kocatepe University, Afyonkarahisar, Turkey.

Introduction: The ideal treatment method for periprosthetic fractures is controversial due to the risks of current methods. Single-cortex screw fixation in prosthesis may lead to implant failure. Therefore, we aimed to develop an implant that lowers the risk for complications. Read More

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Preparation of Pickering emulsion gels based on κ-carrageenan and covalent crosslinking with EDC: Gelation mechanism and bioaccessibility of curcumin.

Food Chem 2021 Mar 29;357:129726. Epub 2021 Mar 29.

Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China; School of Food and Biological Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China. Electronic address:

Pickering emulsions stabilized by zein/carboxymethyl dextrin nanoparticles were added to the κ-carrageenan-based gel matrix to prepare emulsion gels via EDC - induced covalent crosslinking. Texture, WHC and freeze-thaw stability of the emulsion gels increased after crosslinking. The Confocal laser scanning microscope and SEM suggested that droplet clusters could be observed in gel with higher concentration of emulsion. Read More

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Interaction of pharmaceutical metabolites with blood proteins and membrane lipids in the view of bioconcentration: A preliminary study based on in vitro assessment.

Sci Total Environ 2021 Apr 9;783:146987. Epub 2021 Apr 9.

Department of Environmental Analysis, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.

Pharmaceuticals pose a real threat to the environment, which has been proven in many studies to date. However, still little is known about the transformation products (TPs) of these compounds, which can also interact with organisms, causing adverse effects like noticeable toxicity or bioconcentration. Many recent works confirm that metabolites of pharmaceuticals are present in the environment, and preliminary studies suggest that they may be equally dangerous to or even more so than their parent compounds. Read More

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