43,871 results match your criteria stability size

Size effect of hybrid carbon nanofillers on the synergetic enhancement of the properties of HDPE-based nanocomposites.

Nanotechnology 2021 Apr 19. Epub 2021 Apr 19.

Polymer Institute, Slovak Academy of Sciences - Polymer Institute, Dubravska cesta 9, Bratislava, S, Bratislava, 845 41, SLOVAKIA.

High-density polyethylene (HDPE)-based hybrid nanocomposites containing graphene nanoplatelets (GnPs) and multiwall carbon nanotubes (MWCNTs) were fabricated using melt mixing followed by compression molding. The influences of size and weight ratio of both carbon-based nanofillers on the electrical, thermal, and mechanical properties of hybrid nanocomposites were evaluated. This study proves that the size and weight ratio of carbon-based nanofillers play a critical role in determining these properties. Read More

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Acoustic levitation and High-resolution Synchrotron X-Ray powder diffraction: a fast screening approach of niclosamide amorphous solid dispersions.

Int J Pharm 2021 Apr 16:120611. Epub 2021 Apr 16.

School of Pharmaceutical Sciences, Department of Pharmacy, University of Sao Paulo, SP, Brazil. Electronic address:

The levitation of samples in an acoustic field has been of interest in the preparation and study of amorphous solid dispersions (ASD). Here, niclosamide-polymer solutions were levitated in a multi-emitter single-axis acoustic levitator and analyzed for 10 minutes at a High-resolution synchrotron X-ray powder diffraction beamline. This assembly enabled high-quality and fast time-resolved measurements with microliter sample size and measurement of solvent evaporation and recrystallization of niclosamide (NCL). Read More

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Curcumin-loaded Pluronic F-127 Micelles as a Drug Delivery System for Curcumin-mediated Photodynamic Therapy for Oral Application.

Photochem Photobiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Restorative Dentistry, School of Dentistry, Araraquara, 14801-903, Brazil.

Antimicrobial photodynamic therapy (aPDT) is promising for oral decontamination. Curcumin has been used as photosensitizer, however, the hydrophobic properties can negatively affect aPDT. This study evaluated the aPDT efficacy using Cur-loaded Pluronic F-127 micelles against Streptococcus mutans and Candida albicans biofilms. Read More

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Detecting Malaria Hotspots in Haiti, a Low-Transmission Setting.

Am J Trop Med Hyg 2021 Apr 19. Epub 2021 Apr 19.

3Centers for Disease Control and Prevention, Division of Parasitic Disease and Malaria, Atlanta, Georgia.

In 2006, Haiti committed to malaria elimination when the transmission was thought to be low, but before robust national parasite prevalence estimates were available. In 2011, the first national population-based survey confirmed the national malaria parasite prevalence was < 1%. In both 2014 and 2015, Haiti reported approximately 17,000 malaria cases identified passively at health facilities. Read More

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Recyclable Luminescence Sensor for Dinotefuran in Water by Stable Cadmium-Organic Framework.

Anal Chem 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemistry, Key Laboratory of Advanced Energy Material Chemistry, MOE, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Due to the widespread use of dinotefuran around the world, its impact on food and environmental safety has aroused great concern, and the establishment of a rapid and convenient approach for dinotefuran detection is necessary but challenging. Herein, we synthesized a unique three-dimensional framework {[(CH)NH][Cd(BCP)]·10HO·3.5DMF} (). Read More

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Phosphorus containing porous organic polymers: synthetic techniques and applications in organic synthesis and catalysis.

Org Biomol Chem 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.

The phosphorus-containing porous organic polymer is a trending material for the synthesis of heterogeneous catalysts. Decades of investigations have established phosphines as versatile ligands in homogeneous catalysis. Recently, phosphine-based heterogeneous catalysts were synthesized to exploit the same electronic properties while leveraging extra stability and reusability. Read More

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Size-controlled Ag quantum dots decorated on binder-free hierarchical NiCoP films by magnetron sputtering to boost electrochemical performance for supercapacitors.

Nanoscale 2021 Apr 19. Epub 2021 Apr 19.

School of Physical Science and Technology & Inner Mongolia Key Laboratory of Nanoscience and Nanotechnology, Inner Mongolia University, Hohhot 010021, China.

This paper reports novel binder-free and self-supported electrodes of hierarchical nickel-cobalt phosphide (NiCoP) films decorated with size-controlled Ag quantum dots by magnetron sputtering (Ag/NiCoP). Ag quantum dots with an average particle size of 7.90 nm uniformly distribute over the nanosheet-assembled architecture of NiCoP films. Read More

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Thiacalix[4]arene-Based Coordination Polymers Diverted Co9S8@CN Composites for Supercapacitor Application.

Chem Asian J 2021 Apr 19. Epub 2021 Apr 19.

Liaoning Shihua University, College of Chemistry, Chemical Engineering and Environmental Engineering, No.1 West Dandong Road, 113001, fushun, CHINA.

Metal sulfides have been recognized as promising electrodes for electrochemical energy storage owing to their remarkable electrochemical properties. Here, we demonstrate the preparation of Co9S8 nanoparticles anchored on the carbon matrix (denoted as Co9S8-X@CN (X = 1, 2)) from precursor sources, two 1D infinite coordination polymers 1 and 2. The two polymers were assembled by linking Co4-TC4A secondary building blocks (SBUs) with ligands L1 and L2, respectively (H4TC4A = p-tert-butylthiacalix[4]arene, L1 = 1,4-bis(2H-tetrazol-5-yl)benzene, L2 = 1,3-bis(2H-tetrazol-5-yl)benzene). Read More

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Cationic chitosan-modified silica nanoparticles for oral delivery of protein vaccine.

J Biomed Mater Res A 2021 Apr 19. Epub 2021 Apr 19.

Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

Mesoporous silica nanoparticles coated with Chitosan are exploited here as a potential carrier for oral vaccine delivery. Bovine serum albumin (BSA) was used as a protein antigen model to reveal the carrier property. Chitosan-coated BSA-loaded silica NPs had particle size 345 ± 60 nm with a cationic surface charge of 18. Read More

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An Amphiphilic PEGylated Peptide Dendron-Gemcitabine Prodrug-Based Nanoagent for Cancer Therapy.

Macromol Rapid Commun 2021 Apr 19:e2100111. Epub 2021 Apr 19.

Laboratory of Stem Cell Biology, and Huaxi MR Research Center (HMRRC), Department of Radiology, National Clinical Research Center for Geriatrics, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University Chengdu, Chengdu, 610041, P. R. China.

An amphiphilic peptide dendrimer conjugated with gemcitabine (GEM), PEGylated dendron-Gly-Phe-Leu-Gly-GEM (PEGylated dendron-GFLG-GEM), is developed as a nano-prodrug for breast cancer therapy. The self-assembled behavior is observed under a transmission electron microscopy and dynamic light scattering. The negatively charged surface and hydrodynamic size of the amphiphilic nanosized prodrug supported that the prodrug can maintain the stability of GEM during circulation and accumulate in the tumor tissue. Read More

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A plasmon-based nanoruler to probe the mechanical properties of synthetic and biogenic nanosized lipid vesicles.

Nanoscale Horiz 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, Florence 50019, Italy. and Consorzio Sistemi a Grande Interfase, Department of Chemistry, University of Florence, Sesto Fiorentino, Italy.

Nanosized lipid vesicles are ubiquitous in living systems (e.g. cellular compartments or extracellular vesicles, EVs) and in formulations for nanomedicine (e. Read More

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Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris.

Expert Opin Drug Deliv 2021 Apr 19. Epub 2021 Apr 19.

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, India 160 014.

: The combination therapy of Isotretinoin (ITR) and antibacterial formulations administered through topical route suffer from several limitations including reduced therapeutic efficacy and low patient-compliance.: The present study aimed to develop biocompatible lipid-based mixed micelles of ITR in combination with Clindamycin phosphate (CLIN) employing self-assembly method to improve its skin delivery, photostability, biocompatibility and pharmacodynamic efficacy.: The MTT assay and cellular uptake studies showed non-cytotoxic effect to HaCat cell lines. Read More

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Thermochemical Properties and Growth Mechanism of the Ag-Doped Germanium Clusters, AgGe with = 1-13 and λ = -1, 0, and +1.

Bin Liu Jucai Yang

ACS Omega 2021 Apr 31;6(14):9813-9827. Epub 2021 Mar 31.

School of Chemical Engineering, Inner Mongolia Key Laboratory of Theoretical and Computational Chemistry Simulation, Inner Mongolia University of Technology, Hohhot 010051, People's Republic of China.

A systematic investigation of the silver-doped germanium clusters AgGe with = 1-13 in the neutral, anionic, and cationic states is performed using the unbiased global search technique combined with a double-density functional scheme. The lowest-energy minima of the clusters are identified based on calculated energies and measured photoelectron spectra (PES). Total atomization energies and thermochemical properties such as electron affinity (EA), ionization potential (IP), binding energy, hardness, and highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gap are obtained and compared with those of pure germanium clusters. Read More

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Three-Dimensional Network Pd-Ni/γ-AlO Catalysts for Highly Active Catalytic Hydrogenation of Nitrobenzene to Aniline under Mild Conditions.

ACS Omega 2021 Apr 1;6(14):9780-9790. Epub 2021 Apr 1.

Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, 438West Hebei Street, Qinhuangdao 066004, China.

In view of the current situation of high cost and low catalytic efficiency of the commercial Pd-based catalysts, adding transition metals (Ni, Co, etc.) to form the Pd-M bimetallic catalyst not only reduces the consumption of Pd but also greatly improves the catalytic activity and stability, which has attracted increasing attention. In this work, the three-dimensional network Pd-Ni bimetallic catalysts were prepared successfully by a liquid-phase in situ reduction method with the hydroxylated γ-AlO as the support. Read More

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Experimental Study on the Polymer/Graphene Oxide Composite as a Fluid Loss Agent for Water-Based Drilling Fluids.

ACS Omega 2021 Apr 30;6(14):9750-9763. Epub 2021 Mar 30.

School of Engineering and Technology, China University of Geosciences (Beijing), Haidian District, Beijing 100083, China.

The wellbore instability caused by the penetration of drilling fluids into the formation is a vital problem in the drilling process. In this study, we synthesized a polymer/graphene oxide composite (PAAN-G) as a fluid loss additive in water-based drilling fluids. The three monomers (acrylamide (AM), 2-acrylamide-2-methyl-1-propane sulfonic acid (AMPS), -vinylpyrrolidone (NVP)) and graphene oxide (GO) were copolymerized using aqueous free radical polymerization. Read More

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In-vitro and in-silico evaluation of the anti-chikungunya potential of leaf extract and their synthesized silver nanoparticles.

Virusdisease 2021 Apr 11:1-6. Epub 2021 Apr 11.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak, (Hr) India.

Chikungunya is a notorious viral infection, which affects a large segment of world populations in absence of vaccines and antivirals. The current study evaluates of anti-chikungunya activities of leaves extract and their green synthesized silver nanoparticles. Green synthesized nanoparticles were well characterized for their size and stability by dynamic light scattering (DLS), zeta potential, scanning electron microscopy (SEM) and their functional groups were analyzed by FTIR. Read More

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Effect of Enzymatic Hydrolysis on the Zinc Binding Capacity and Gastrointestinal Stability of Peptides Derived From Pumpkin (.) Seeds.

Front Nutr 2021 31;8:647782. Epub 2021 Mar 31.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.

Zinc is a crucial micronutrient for maintaining body immune system and metabolism function. However, insufficient intake from diet may lead to zinc deficiency and impair normal body function. In addition, conventional zinc salts supplementation has the disadvantage of low bioavailability since the zinc ions may be easily chelated by dietary fiber or phytate commonly found in diets rich in plants, and form precipitates that cannot be absorbed. Read More

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Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View.

Front Cell Dev Biol 2021 1;9:658481. Epub 2021 Apr 1.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, United States.

Initially identified in , the Hippo signaling pathway has emerged as an evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ size by simultaneously inhibiting cell proliferation and promoting cell death. Deregulation of Hippo pathway activity has been implicated in a wide range of human cancers. The core Hippo pathway consists of a kinase cascade: an upstream kinase Hippo (Hpo)/MST1/2 phosphorylates and activates a downstream kinase Warts (Wts)/Lats1/2, leading to phosphorylation and inactivation of a transcriptional coactivator Yki/YAP/Taz. Read More

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Production and characterization of graphene from carbonaceous rice straw by cost-effect extraction.

3 Biotech 2021 May 2;11(5):205. Epub 2021 Apr 2.

Department of Biological Engineering, College of Engineering, Inha University, Incheon, 402-751 Republic of Korea.

This paper describes the synthesis of graphene-based activated carbon from carbonaceous rice straw fly ash in an electrical furnace and the subsequent potassium hydroxide extraction. The produced graphene has a proper morphological structure; flakes and a rough surface can be observed. The average size of the graphene was defined as up to 2000 nm and clarification was provided by high-resolution microscopes (FESEM and FETEM). Read More

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Comparing the stability of retinol in liposomes with cholesterol, β-sitosterol, and stigmasterol.

Food Sci Biotechnol 2021 Mar 27;30(3):389-394. Epub 2021 Mar 27.

School of Bioconvergence, Kyungnam University, Kyungnamdaehak-ro 7, Changwon, 51767 Korea.

In this study, cholesterol (CH), β-sitosterol (SI), and stigmasterol (ST) were explored to improve the stability of retinol in the liposome bilayer. Retinol was incorporated into liposomes composed of soybean-derived L-α-phosphatidylcholine (PC) and 10% sterol (w/w), which were prepared as multilamellar vesicles. Under all conditions, the efficiency of retinol incorporation into liposomes was higher than 99%, and the average particle size of liposomes was similar to that of PC alone. Read More

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Glycoconjugate vaccines against serovars and species: existing and emerging methods for their analysis.

Biophys Rev 2021 Apr 10:1-26. Epub 2021 Apr 10.

School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, LE12 5RD UK.

The global spread of enteric disease, the increasingly limited options for antimicrobial treatment and the need for effective eradication programs have resulted in an increased demand for glycoconjugate enteric vaccines, made with carbohydrate-based membrane components of the pathogen, and their precise characterisation. A set of physico-chemical and immunological tests are employed for complete vaccine characterisation and to ensure their consistency, potency, safety and stability, following the relevant World Health Organization and Pharmacopoeia guidelines. Variable requirements for analytical methods are linked to conjugate structure, carrier protein nature and size and acetyl content of polysaccharide. Read More

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Reconstruction of the weight-bearing heel with nonsensate reverse sural artery flaps.

Injury 2021 Apr 7. Epub 2021 Apr 7.

Department of Orthopaedic Surgery, Korea University Anam Hospital, Seoul, South Korea. Electronic address:

Background: The reverse sural artery flap (RSAF) is widely used to reconstruct foot and ankle defects. Although it is commonly used in a nonsensate type, there has been controversy as to whether it provides sufficient stability and durability when applied to weight-bearing heels. The aim of this study was to evaluate patient outcomes after weight-bearing heel coverage using a nonsensate RSAF. Read More

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Precise engineering of hybrid molecules-loaded macromolecular nanoparticles shows and antitumor efficacy toward the treatment of nasopharyngeal cancer cells.

Drug Deliv 2021 Dec;28(1):776-786

Department of Radiation Oncology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

Cancers continue to be the second leading cause of death worldwide. Despite the development and improvement of surgery, chemotherapy, and radiotherapy in cancer management, effective tumor ablation strategies are still in need due to high cancer patient mortality. Hence, we have established a new approach to achieve treatment-actuated modifications in a tumor microenvironment by using synergistic activity between two potential anticancer drugs. Read More

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December 2021

Predicting cow milk quality traits from routinely available milk spectra using statistical machine learning methods.

J Dairy Sci 2021 Apr 14. Epub 2021 Apr 14.

Teagasc, Animal & Grassland Research and Innovation Centre, Moorepark, Fermoy, Co. Cork, P61 P302 Ireland. Electronic address:

Numerous statistical machine learning methods suitable for application to highly correlated features, as those that exist for spectral data, could potentially improve prediction performance over the commonly used partial least squares approach. Milk samples from 622 individual cows with known detailed protein composition and technological trait data accompanied by mid-infrared spectra were available to assess the predictive ability of different regression and classification algorithms. The regression-based approaches were partial least squares regression (PLSR), ridge regression (RR), least absolute shrinkage and selection operator (LASSO), elastic net, principal component regression, projection pursuit regression, spike and slab regression, random forests, boosting decision trees, neural networks (NN), and a post-hoc approach of model averaging (MA). Read More

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Characterization and optimization of de-esterified Tragacanth-chitosan nanocomposite as a potential carrier for oral delivery of insulin: In vitro and ex vivo studies.

J Biomed Mater Res A 2021 Apr 18. Epub 2021 Apr 18.

Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Oral administration of insulin is one of the most challenging topics within this area, because insulin is degraded in stomach before it enters the bloodstream. In this study, for the first time, a nano-carrier for controlled and targeted oral delivery of insulin was developed using de-esterified Tragacanth and chitosan. The fabricated nanoparticles were synthesized using coacervation technique and their properties were optimized using response surface methodology. Read More

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Commissioning of an ultra-high dose rate pulsed electron beam medical LINAC for FLASH RT pre-clinical animal experiments and future clinical human protocols.

Med Phys 2021 Apr 18. Epub 2021 Apr 18.

Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland.

Purpose: To present the acceptance and the commissioning, to define the reference dose, and to prepare the reference data for a quality assessment (QA) program of an ultra-high dose rate (UHDR) electron device in order to validate it for pre-clinical animal FLASH radiotherapy (FLASH RT) experiments and for FLASH RT clinical human protocols.

Methods: The Mobetron device was evaluated with electron beams of 9 MeV in conventional (CONV) mode and of 6 MeV and 9 MeV in UHDR mode (nominal energy). The acceptance was performed according to the acceptance protocol of the company. Read More

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Coconut oil-based resveratrol nanoemulsion: Optimization using response surface methodology, stability assessment and pharmacokinetic evaluation.

Food Chem 2021 Apr 5;357:129721. Epub 2021 Apr 5.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Phytochemicals are widely studied for therapeutic applications and nanostructured delivery systems for phytochemicals are under spotlight. Resveratrol is a promising candidate for neurodegenerative disorders. In the present study, we aimed to formulate nanoemulsion of resveratrol by ultrasonication process using response surface methodology. Read More

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The mechanisms of gravity-constrained aggregation in natural colloidal suspensions.

J Colloid Interface Sci 2021 Mar 29;597:126-136. Epub 2021 Mar 29.

Department of Hydrogeology, Institute of Geosciences, Friedrich Schiller University Jena, 07749, Germany. Electronic address:

Colloidal settlement in natural aqueous suspensions is effectively compensated by diffusive movement if particles resist aggregation - a state known as colloidal stability. However, if the settling velocity increases upon aggregation, complex structural features emerge from the directional movement induced by gravity. We present a comprehensive modeling study on the evolution of an aggregated three-dimensional structure due to diffusion, surface interactions, and gravity. Read More

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Microplastics generated from a biodegradable plastic in freshwater and seawater.

Water Res 2021 Apr 6;198:117123. Epub 2021 Apr 6.

Department of Chemistry, Biomaterials and Textiles, RISE Research Institutes of Sweden, SE-501 15 Borås, Sweden. Electronic address:

Biodegradable polymers have been regarded as a promising solution to tackle the pollutions caused by the wide use of conventional polymers. However, during the biodegradation process, the material fragmentation leads to microplastics. In this work, the formation of microplastics from biodegradable poly (butylene adipate-co-terephthalate) (PBAT) in different aquatic environments was investigated and compared with the common non-biodegradable low-density polyethylene (LDPE). Read More

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Polymeric lipid hybrid nanoparticles as a delivery system enhance the antitumor effect of Emodin in vitro and in vivo.

J Pharm Sci 2021 Apr 14. Epub 2021 Apr 14.

College of Pharmacy, Jinan University, Guangzhou, 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, Guangzhou, 510632, China; Cancer Research Institute of Jinan University, Guangzhou, 510632, China; Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China. Electronic address:

This study aimed to evaluate the therapeutic efficacy of Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) for breast cancer. The size, Zeta potential, surface morphology, encapsulation efficiency, stability, in vitro drug release of E-PLNs prepared by the nanoprecipitation method were characterized. The uptake, in-vitro cytotoxicities and apoptosis of free drug, E-PLNs were investigated against MCF-7 cells. Read More

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