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Evidence-based research on effectiveness of periodontal treatment in rheumatoid arthritis patients: a systematic review and meta-analysis.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Objectives: To gauge the evidence of periodontal therapy's impact on measures of disease activity and systemic inflammatory burden in individuals with rheumatoid arthritis (RA).

Methods: A search for randomised trials and controlled cohort studies of RA patients with Periodontitis was conducted on 7 April 2019, with an update on 17 December 2020, in PubMed, Cochrane Library (CENTRAL), Embase, http://clinicaltrials.gov/, and WHO-ICTRP portal (PROSPERO: CRD42018103359). Read More

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Stabilized detonation for hypersonic propulsion.

Proc Natl Acad Sci U S A 2021 May;118(20)

Propulsion and Energy Research Laboratory, Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816;

Future terrestrial and interplanetary travel will require high-speed flight and reentry in planetary atmospheres by way of robust, controllable means. This, in large part, hinges on having reliable propulsion systems for hypersonic and supersonic flight. Given the availability of fuels as propellants, we likely will rely on some form of chemical or nuclear propulsion, which means using various forms of exothermic reactions and therefore combustion waves. Read More

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Investigation on the impact of different proportions of components in formulations on stability of a moisture sensitive drug.

Int J Pharm 2021 May 6:120690. Epub 2021 May 6.

GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore. Electronic address:

Physicochemical and mechanical properties of tablets are largely dictated by formulation compositions. Different excipients possess different tableting and moisture sorption behaviors. Therefore, this study was designed to elucidate the relative influence of the proportion of components in formulations on tablet properties. Read More

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Finite-time controller design with adaptive fixed-time anti-saturation compensator for hypersonic vehicle.

ISA Trans 2021 Apr 30. Epub 2021 Apr 30.

Shanghai Aerospace Control Technology Institute, Shanghai 201109, China. Electronic address:

An adaptive anti-saturation robust finite-time control algorithm (AARFTC) is designed for flexible air-breathing hypersonic vehicle (FAHV) under actuator saturations. Firstly, an adaptive fixed-time anti-saturation compensator (AFAC) is presented to drive system to faster leave the saturated region Compared to traditional anti-saturation compensators, the auxiliary variable of AFAC is able to realize faster and more accurate convergence when saturation disappears, which avoids the influence on convergent characteristics of tracking error. In addition, the novel adaptive law in AFAC can further shorten the duration of saturation and improve the convergent speed of tracking error via adjusting gain in AFAC according to saturation of actuator. Read More

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Engineering post-translational regulation of glutamine synthetase for controllable ammonia production in the plant-symbiont .

Appl Environ Microbiol 2021 May 7. Epub 2021 May 7.

Departments of Bioengineering and Chemical Engineering, Stanford University

Nitrogen requirements for modern agriculture far exceed the levels of bioavailable nitrogen in most arable soils. As a result, the addition of nitrogen fertilizer is necessary to sustain productivity and yields, especially for cereal crops, the planet's major calorie suppliers. Given the unsustainability of industrial fertilizer production and application, engineering biological nitrogen fixation directly at the roots of plants has been a grand challenge for biotechnology. Read More

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Immediate Implant Solution to Improve Long-Term Esthetics, Enhance Patient Satisfaction.

Compend Contin Educ Dent 2021 Apr;42(4):g1-g4

Faculty Member, Advanced Education in General Dentistry Residency Program, University of Cincinnati Medical Center; Private Practice limited to Periodontics and Dental Implants, Milford, Ohio; Diplomate, American Board of Periodontology; Diplomate, International Congress of Oral Implantologists.

Fixed prostheses offer various advantages over conventional removable devices for immediate restoration of a fractured tooth in the esthetic zone. In this case report, a fixed solution is employed through the use of a same-day provisional restoration attached to an immediately placed dental implant. Utilizing biologics and an implant system that allows for excellent primary stability, this treatment modality offers a predictable method for achieving immediate implant placement and provisionalization. Read More

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Interlocked Pins Increase Strength by a Lateral Spread of Load in Femoral Neck Fixation: a Cadaver Study.

Acta Chir Orthop Traumatol Cech 2021 ;88(2):144-152

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.

PURPOSE OF THE STUDY To improve the important torsional, bending and compressive stability in femoral neck fixation, locking plates have been the latest contribution. However, increased strength by restricted fracture motion may come at expense of an altered load distribution and failure patterns. Within locking plate technology, the important intermediate fracture compression may principally be achieved by multiple sliding screws passing through a sideplate fixed to the femur or connected to an interlocking plate not fixed to the femur laterally, sliding "en bloc" with the plate. Read More

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Comparison of long-term skeletal stability following maxillary advancement using rigid external distraction in growing and non-growing patients with cleft lip and palate: a systematic review and meta-analysis.

Eur J Orthod 2021 May 5. Epub 2021 May 5.

Department of Oral & Maxillofacial Surgery, Armed Forces Medical College, Pune, India.

Objectives: To compare the long-term skeletal stability following maxillary advancement using Rigid External Distraction (RED) in growing and non-growing patients with Cleft Lip and Palate (CLP).

Methods: Data sources: A systematic literature search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines from database inception till August 2020 in MEDLINE-PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Science Direct, Google Scholar and a manual search in the institutional library. Study eligibility criteria, participants and intervention: All available literature published in English, with a minimum of six human subjects with well-defined age range either 7-14. Read More

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Biomechanical and Mechanostat analysis of a titanium layered porous implant for mandibular reconstruction: The effect of the topology optimization design.

Mater Sci Eng C Mater Biol Appl 2021 May 24;124:112056. Epub 2021 Mar 24.

College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310023, China; Key Laboratory of Special Purpose Equipment and Advanced Processing Technology, Ministry of Education and Zhejiang Province, Zhejiang University of Technology, Hangzhou 310023, China; National International Joint Research Center of Special Purpose Equipment and Advanced Processing Technology, Zhejiang University of Technology, Hangzhou 310023, China.

A porous scaffold/implant is considered a potential method to repair bone defects, but its mechanical stability and biomechanics during the repair process are not yet clear. A mandibular titanium implant was proposed and designed with layered porous structures similar to that of the bone tissue, both in structure and mechanical properties. Topology was used to optimize the design of the porous implant and fixed structure. Read More

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Development of an L-band resonator optimized for fast scan EPR imaging of the mouse head.

Magn Reson Med 2021 May 3. Epub 2021 May 3.

Davis Heart and Lung Research Institute, and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.

Purpose: To develop a novel resonator for high-quality fast scan electron paramagnetic resonance (EPR) and EPR/NMR co-imaging of the head and brain of mice at 1.25 GHz.

Methods: Resonator dimensions were scaled to fit the mouse head with maximum filling factor. Read More

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MicroRNA Expression Changes and Integrated Pathways Associated With Poor Outcome in Canine Osteosarcoma.

Front Vet Sci 2021 15;8:637622. Epub 2021 Apr 15.

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

MicroRNAs (miRNA) are small non-coding RNA molecules involved in post-transcriptional gene regulation. Deregulation of miRNA expression occurs in cancer, and miRNA expression profiles have been associated with diagnosis and prognosis in many cancers. Osteosarcoma (OS), an aggressive primary tumor of bone, affects ~10,000 dogs each year. Read More

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Transition to turbulence via flame patterns in viscoelastic Taylor-Couette flow.

Eur Phys J E Soft Matter 2021 May 2;44(5):63. Epub 2021 May 2.

Normandie Université, UNIHAVRE, Laboratoire Ondes et Milieux Complexes (LOMC), UMR 6294, CNRS, B.P. 540, 76058, Le Havre Cedex, France.

Transition to inertio-elastic turbulence in Taylor-Couette flow with shear-thinning and viscoelastic polymer solutions is investigated when the rotation rate of the inner cylinder is increased and the outer cylinder is fixed. In two polymer solutions of PEO with elastic number [Formula: see text], the first instability of the circular Couette flow appears as spirals propagating in opposite directions along the axis of cylinders. Just above the onset of the spirals pattern, the localized solitons of the strong radial inflow called flame-like flow appear abruptly inside waves. Read More

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Temporal instability assessment of injury severities of motor vehicle drivers at give-way controlled unsignalized intersections: A random parameters approach with heterogeneity in means and variances.

Accid Anal Prev 2021 Apr 29;156:106151. Epub 2021 Apr 29.

Queensland University of Technology (QUT), Science and Engineering Faculty, School of Civil and Environmental Engineering, Australia.

Unsignalized intersections are highly susceptible to traffic crashes compared to signalized ones. By taking into account temporal stability and unobserved heterogeneity, this study investigates the determinants of the injury severity of drivers involved in crashes at unsignalized intersections controlled by give-way (yield) signs. Mixed logit models with three approaches were employed, namely random parameters, random parameters with heterogeneity in means, and random parameters with heterogeneity in means and variances. Read More

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Evaluation of anteroposterior and vertical stability 25 years after Angle class II division 1 treatment with cervical headgear.

J Orofac Orthop 2021 Apr 30. Epub 2021 Apr 30.

Department of Orthodontics, Federal University of Bahia, Av. Araújo Pinho, 62, Canela, Salvador, Bahia, Brazil.

Purpose: The goal was to investigate long-term (minimum 20 years) skeletal and dental changes in Angle class II division 1 patients treated with full-fixed orthodontic appliances and cervical pull headgear.

Methods: A longitudinal retrospective study was performed with 20 orthodontic patients, who were treated exclusively by one experienced clinician and whose treatment had been completed a minimum of 20 years ago. Former patients who had been treated from the mid-1970s to the early 1990s were actively sought. Read More

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Dissipative Light Bullets in Kerr Cavities: Multistability, Clustering, and Rogue Waves.

Phys Rev Lett 2021 Apr;126(15):153902

Faculté des Sciences, Université libre de Bruxelles (U.L.B), CP. 231, 1050 Brussels, Belgium.

We report the existence of stable dissipative light bullets in Kerr cavities. These three-dimensional (3D) localized structures consist of either an isolated light bullet (LB), bound together, or could occur in clusters forming well-defined 3D patterns. They can be seen as stationary states in the reference frame moving with the group velocity of light within the cavity. Read More

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Finger Rescue Using the Induced Membrane Technique for Osteomyelitis of the Hand.

J Hand Surg Asian Pac Vol 2021 Jun;26(2):235-239

Department of Orthopedic Surgery, Kansai Medical University Hirakata Hospital, Hirakata, Japan.

The induced membrane technique is now commonly used for large diaphyseal bone defects. Recently, several papers reported using the induced membrane technique for hand surgery. We applied this technique with some modifications to treat osteomyelitis of the phalanges. Read More

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Efficient Route Management Method for Mobile Nodes in 6TiSCH Network.

Sensors (Basel) 2021 Apr 28;21(9). Epub 2021 Apr 28.

Department of Information Convergence Engineering, Pusan National University, Busan 46241, Korea.

The combination of time slotted access and channel hopping technology in IEEE 802.15 TSCH networks enables high reliability and low power operation to meet the stability and real-time requirements of industrial applications. Basically, TSCH and RPL, a routing protocol for TSCH, are proposed for static nodes that generate fewer control messages, so they allow collisions in shared cells when they exchange control messages. Read More

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Formulations for Bacteriophage Therapy and the Potential Uses of Immobilization.

Pharmaceuticals (Basel) 2021 Apr 13;14(4). Epub 2021 Apr 13.

Fixed Phage Ltd., Glasgow G20 0SP, UK.

The emergence of antibiotic-resistant pathogens is becoming increasingly problematic in the treatment of bacterial diseases. This has led to bacteriophages receiving increased attention as an alternative form of treatment. Phages are effective at targeting and killing bacterial strains of interest and have yielded encouraging results when administered as part of a tailored treatment to severely ill patients as a last resort. Read More

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Preparation of Ag NPs and Its Multifunctional Finishing for Cotton Fabric.

Polymers (Basel) 2021 Apr 19;13(8). Epub 2021 Apr 19.

Department of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, China.

To explore the combination of silver nanoparticles (Ag NPs) prepared in a green manner with cotton fabrics and the washing durability of the fabric after the combination. In this paper, the natural material, honeysuckle extract, was used as a reducing agent to prepare the Ag NPs' solution. The structure and size of Ag NPs were analyzed using ultraviolet-visible spectrophotometry (UV-vis), transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray powder diffraction (XRD), and Fourier transform infrared (FT-IR) spectroscopy characterization. Read More

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On a Discrete SEIR Epidemic Model with Two-Doses Delayed Feedback Vaccination Control on the Susceptible.

Vaccines (Basel) 2021 Apr 18;9(4). Epub 2021 Apr 18.

Faculty of Science and Technology, Institute of Research and Development of Processes IIDP, University of the Basque Country, Barrio Sarriena, 48940 Leioa, Spain.

A new discrete susceptible-exposed-infectious-recovered (SEIR) epidemic model is presented subject to a feedback vaccination effort involving two doses. Both vaccination doses, which are subject to a non-necessarily identical effectiveness, are administrated by respecting a certain mutual delay interval, and their immunity effect is registered after a certain delay since the second dose. The delays and the efficacies of the doses are parameters, which can be fixed in the model for each concrete experimentation. Read More

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Detection of Epstein-Barr virus encoded RNA in fixed cells and tissues using CRISPR/Cas-mediated RCasFISH.

Anal Biochem 2021 Apr 26;625:114211. Epub 2021 Apr 26.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, 100730, PR China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, PR China; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, 100730, PR China. Electronic address:

Identification of Epstein-Barr virus (EBV)-infected cells is critical for the diagnosis and clinical management of EBV-associated diseases. EBV-encoded RNA (EBER) located in the nucleus is a reliable marker due to its high levels of expression and inherent stability in tissue specimens. EBER in situ hybridization has long been the gold standard for detecting tumor-associated latent EBV infection and is valuable in determining the primary site and radiation fields of EBV-related malignancies. Read More

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Reconstruction of the cranial cruciate ligament using a semitendinosus autograft in a lapine model.

Vet Surg 2021 Apr 29. Epub 2021 Apr 29.

Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, USA.

Objective: To clarify and improve a cranial cruciate ligament (CrCL) deficient stifle stabilization technique using a semitendinosus tendon (ST) autograft fixed with an interference fit screw (IFS) in a closed-joint trauma lapine osteoarthritis (OA) model.

Study Design: Experimental OA model.

Animals: Forty-one Flemish Giant rabbits. Read More

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Challenges of Using Resonance Frequency Analysis to Identify Stability of a Dental Implant Placed in the Mandible.

Int J Oral Maxillofac Implants 2021 Mar-Apr;36(2):e7-e21

Purpose: This numerical study examined the efficacy and challenges of using resonance frequency analysis to identify the stability of implants placed in mandibles. The study also examined the feasibility of using angular stiffness as an alternative index to quantify dental implant stability in mandibles.

Materials And Methods: A finite element model consisting of a mandible, an implant, an abutment, and a bonding layer (between the implant and the mandible) was created in commercially available software ANSYS. Read More

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Quantifying electron-correlation effects in small coinage-metal clusters calculations.

Phys Chem Chem Phys 2021 Apr;23(16):9832-9842

Instituto de Física, Universidade Federal de Goiás, 74.001-970, Goiânia, GO, Brazil.

We investigate many-electron correlation effects in neutral and charged coinage-metal clusters Cun, Agn, and Aun (n = 1-4) via ab initio calculations using fixed-node diffusion Monte Carlo (FN-DMC) simulations, density functional theory (DFT), and the Hartree-Fock (HF) method. From very accurate FN-DMC total energies of the clusters and the HF results in the infinity large complete-basis-set limit, we obtain correlation energies in these strongly correlated many-electron clusters involving d orbitals. The obtained bond lengths of the clusters, atomic binding and dissociation energies, ionization potentials, and electron affinities are in satisfactory agreement with the available experiments. Read More

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[The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in Beagle dogs].

Shanghai Kou Qiang Yi Xue 2021 Feb;30(1):17-22

School of Stomatology, Zhejiang Chinese Medical University. Hangzhou 310053, Zhejiang Province, China.

Purpose: Low-magnitude, high-frequency(LMHF) loading has been confirmed to play an important role in bone healing. The present study aimed to evaluate the effect of LMHF loading applied directly to titanium dental implants on peri-implant bone healing and implant.

Methods: The mandibular premolars and molars were extracted from six male Beagle dogs. Read More

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February 2021

Supersaturating drug delivery systems containing fixed-dose combination of two antihypertensive drugs: Formulation, in vitro evaluation and molecular metadynamics simulations.

Eur J Pharm Sci 2021 Apr 24;163:105860. Epub 2021 Apr 24.

Innovation Study Center in Pharmaceutical Technologies (NITFar), Pharmaceutical Sciences Department, Federal University of Santa Catarina, Campus Trindade, 88040-970, Florianópolis, SC, Brazil; Programa de Pós-Graduação em Farmácia, Federal University of Santa Catarina, Campus Trindade, 88040-970, Florianópolis, SC, Brazil. Electronic address:

The purpose of this study was to associate the poorly water-soluble antihypertensive drugs candesartan cilexetil (CC) and hydrochlorothiazide (HCTZ) as fixed-dose combination, in the form of ternary Amorphous Solid Dispersions (ASD), using hydroxypropylmethylcellulose acetate succinate (HPMCAS) type M as polymeric carrier. The potential of the system to generate and to maintain supersaturation of both drugs was also evaluated. The ASDs were prepared by ball milling technique and solid-state characterization was performed by differential scanning calorimetry (DSC), Fourier transformed infrared spectroscopy (FTIR) and X-ray powder diffraction (XRPD). Read More

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Electrodeposition immobilized molybdenum disulfide quantum dots and their electrochemiluminescence application in the detection of melamine residues in milk powder.

Anal Methods 2021 Apr 26. Epub 2021 Apr 26.

The Key Lab of Health Chemistry & Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering & Materials Science, Soochow University, Suzhou 215123, P. R. China.

In this paper, one-step hydrothermal and electrodeposition methods were used to prepare a MoS2 quantum dot (QD) solid-phase electrochemiluminescent (ECL) electrode for the detection of melamine residues in milk powder. With the assistance of chitosan, MoS2 QDs fixed by the one-step electrodeposition method show better ECL performance than those by traditional deposition methods due to better dispersibility and stability. Based on the quenching of the MoS2 QDs ECL signal by melamine, quantitative detection of melamine in the sample was performed. Read More

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One-Piece Titanium Implants: Retrospective Case Series.

Case Rep Dent 2021 8;2021:6688355. Epub 2021 Apr 8.

Dental Practice, 37213 Witzenhausen, Germany.

Purpose: One-piece titanium implants are not routinely used for reconstruction after tooth loss. Several limitations seemed to be apparent although the concept provides a straightforward approach for different clinical situations. A clinical documentation of five prosthetic restorations with one-piece titanium implants serving as a relevant treatment option in dental surgery is pursued. Read More

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Biomechanical Changes of Adjacent and Fixed Segments Through Cortical Bone Trajectory Screw Fixation versus Traditional Trajectory Screw Fixation in the Lumbar Spine: A Finite Element Analysis.

World Neurosurg 2021 Apr 22. Epub 2021 Apr 22.

Department of Orthopedics & Spine Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Electronic address:

Objective: The finite element method was used to investigate the biomechanical adjustments of adjacent and fixed segments after lumbar fusion and fixation with traditional trajectory (TT) and cortical bone trajectory (CBT) screws.

Methods: The model used was a validated nonlinearly L3-S1 finite element model. Interbody fusion cages and 2 types of screws were used to work on the L4-L5. Read More

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Exponential stabilization of fixed and random time impulsive delay differential system with applications.

Math Biosci Eng 2021 03;18(3):2384-2400

Department of Mathematics and General Sciences, Prince Sultan University, Riyadh 11586, Saudi Arabia.

In this work, we study the problem of p-th moment global exponential stability for functional differential equations and scalar chaotic delayed equations under random impulsive effects. Meanwhile, the p-th moment global exponential synchronization for the proposed equations is also discussed, whereas the main results are proved by using Lyapunov function and Razumikhin technique. Furthermore, the impact of fixed and random time impulses are presented by applying the results to Mackey Glass blood cell production model and Ikeda bistable resonator model. Read More

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