Eur J Pharm Sci 2021 Apr 24;163:105860. Epub 2021 Apr 24.
Innovation Study Center in Pharmaceutical Technologies (NITFar), Pharmaceutical Sciences Department, Federal University of Santa Catarina, Campus Trindade, 88040-970, Florianópolis, SC, Brazil; Programa de Pós-Graduação em Farmácia, Federal University of Santa Catarina, Campus Trindade, 88040-970, Florianópolis, SC, Brazil. Electronic address:
The purpose of this study was to associate the poorly water-soluble antihypertensive drugs candesartan cilexetil (CC) and hydrochlorothiazide (HCTZ) as fixed-dose combination, in the form of ternary Amorphous Solid Dispersions (ASD), using hydroxypropylmethylcellulose acetate succinate (HPMCAS) type M as polymeric carrier. The potential of the system to generate and to maintain supersaturation of both drugs was also evaluated. The ASDs were prepared by ball milling technique and solid-state characterization was performed by differential scanning calorimetry (DSC), Fourier transformed infrared spectroscopy (FTIR) and X-ray powder diffraction (XRPD). Read More