Spectrochim Acta A Mol Biomol Spectrosc 2019 May 28;214:21-31. Epub 2019 Jan 28.
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt; October 6 University, Faculty of Pharmacy, October 6 City, Giza, Egypt.
A stressed study on the stability and degradation behavior under ICH forced degradation conditions of most widely used antiepileptic drug; carbamazepine (CMZ) is presented in this work. The research also includes studying spectrophotometric nature of CMZ and assaying it with mostly used spectrophotometric techniques. Six simple and sensitive spectrophotometric methods are introduced as stability indicating methods for quantitative determination of CMZ and its degradation product, one of its reported potential impurities; iminostilbene (IMS). Read More